Safety function analysis in an industrial production process

Dissertação para obtenção do Grau de Mestre em Engenharia e Gestão IndustrialAim: The purpose of this work was to identify and assess safety features on a production line of paper manufacturer called Renova. The assessment includes technical as well as organisational factors. The study was carried out through the evaluation of safety functions (SF), either present or absent in the system analyzed. Methods: The methodology applied was the SFA (Safety Function Analysis), which was developed by Harms-Ringdahl in 2001 and was updated further, in 2011 (draft version). The analytical framework was applied in two processes (raw material loading and transversal cut of log) of a production line (Line H4) of Renova. Results: In the first process analyzed (raw material loading), 47 safety functions (SF) were identified and evaluated, whereas 36 SF were assessed in the second case (transversal cut of log). The evaluation has shown that most of the SF considered are in good condition and being well monitored, therefore they do not need any improvements. In contrast, this work has also identified a number of safety functions that need essential improvements. Conclusions: As a consequence of this SFA analysis, the author proposes a number of specific recommendations to improve safety and the system’s performance in general. Since Renova is a manufacturer of paper products, fire safety is of paramount importance and one of the most relevant recommendations is perhaps the implementation of thermo graphic tests to identify possible hot spots that may originate a fire

Transcritical Carbon Dioxide Charge-Discharge Energy Storage with Integration of Solar Energy

New and improved energy storage technologies are required to overcome non-dispatchability, which is the main challenge for the successful integration of large shares of renewable energy within energy supply systems. Energy storage is proposed to tackle daily variations on the demand side, i.e., storing low-price energy during off-peak or valley periods for utilization during peak periods. Regarding electrical energy storage, several technologies are available with different potentials for scalability, density, and cost. A recent approach for grid-scale applications is based on transcritical carbon dioxide charge and discharge cycles in combination with thermal energy storage systems. This alternative to pumped-hydro and compressed air energy storage has been discussed in scientific literature, where different configurations have been proposed and their efficiency and costs calculated. The potential of the concept has been demonstrated to be an economical alternative, including hybrid concepts with solar thermal storage. Even at low temperatures, the addition of solar energy has proved to be cost effective. This paper explores the effect of introducing solar-based high temperature heat on the performance of different configurations of “Transcritical carbon dioxide ‒ thermal energy storage system” cycles. A base-cycle with 8-hour discharge time is compared with different layouts. Discussions include details on the models, parametric analyses -including solar technology alternatives-, and simulation results. Round trip efficiency of the base case, without solar support and at pressure ratio of 9.4, is 52%. When solar input is considered, the efficiency is above 60%, increasing the turbine inlet temperature to 950 K. Estimated levelized cost of electricity values are in the range of pumped hydro and compressed air energy storage, 90-140 USD/MWh in agreement with other works on this thermal storage technology. The global analysis shows clear advantages for advancing in the study and definition of this technology for exploitation of synergies at different power ranges, integrated with mid/high temperature solar power plants and with smaller-scale renewable installations.Unión Europea. Fondo Europeo de Desarrollo Regional SOE1 / P3 / P0429E

Storage lipids and proteins of Euterpe edulis seeds

Comparative studies on fatty acid and protein composition of the endosperm and embryo of palmito (Euterpe edulis Martius) were conducted using gas-liquid chromatography and sodium dodecyl sulfate–polyacrylamide gel electrophoresis. On a dry weight basis, the embryo contained extremely lower amounts of lipids and proteins than did the endosperm, which was associated with the scarce lipid and protein bodies previously reported in axis and cotyledon. The fatty acid composition also exhibited differences between both tissues: (I) the fatty acid diversity was greater in embryo than in endosperm; (II) embryo and endosperm contained predominantly linoleic, palmitic, oleic and stearic acids even though the relative values were different for each tissue. As compared to other palm species, the higher fatty acid unsaturation in Euterpe edulis seed could be involved in the previously reported short longevity and recalcitrant behavior during storage. Proteins of both tissues were heterogeneous in molecular mass. Some proteins were tissue-specific, but other were common, among them a highly glycosylated protein which migrated at about 55 kDa. We hypothesize that the latter, also reported in all previously studied palm species, is one of the proteins characterizing the Arecaceae family.Fil: Panza, Víctor. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales. Instituto de Recursos Biológicos; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Pighín, Darío Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Lainez, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Pollero, Ricardo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Maldonado, Sara Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales. Instituto de Recursos Biológicos; Argentin

Exercise-induced left septal fascicular block: an expression of severe myocardial ischemia

The electrocardiogram (ECG) criteria for the left septal fascicular block (LSFB) are not universally accepted and many other denominations can be seen in literature: focal septal block, septal focal block, left septal fascicular block, left anterior septal block, septal fascicular conduction disorder of the left branch, left septal Purkinje network block, left septal subdivision block of the left bundle branch, anterior conduction delay, left median hemiblock, left medial subdivision block of the left bundle branch, middle fascicle block, block of the anteromedial division of the left bundle branch of His, and anteromedial divisional block. During exercise stress test, fascicular blocks (left anterior and posterior) seem to indicate severe coronary artery narrowing of left main coronary or proximal left anterior descending artery disease1 and transient exercise-induced left septal fascicular block has been reported a few times2,3. 54-year-old male, with a history of essential arterial systemic hypertension, primary hyperlipidemia and six-month typical chest pain during exercise (Class II – Canadian Cardiovascular Society) underwent an exercise stress test. During the exercise stress test, ECG demonstrated abrupt prominent anterior forces, an increase in R wave amplitude from V1 to V4, extreme left axis deviation and minor ST segment depression in DII, DIII and aVF (Figure 1). The post-exercise period showed progressive return of the QRS axis in both frontal and horizontal planes and the ST depression worsened by 1 mm. Coronary angiogram (Figure 2A) showed a critical proximal left anterior descending artery lesion. An exercise stress test done three months after coronary artery bypass surgery grafting was normal (Figure 2B)

The antibacterial action of microcin J25: evidence for disruption of cytoplasmic membrane energization in Salmonella newport

Microcin J25 (MccJ25) is a cyclic peptide of 21 unmodified amino acid residues produced by a fecal strain of Escherichia coli. It has previously been shown that the antibiotic activity of this peptide is mainly directed to Enterobacteriaceae, including several pathogenic E. coli, Salmonella and Shigella strains. In this paper we show that MccJ25 acts on the cytoplasmic membrane of Salmonella newport cells producing alteration of membrane permeability, and the subsequent gradient dissipation, that initiate the inhibition of process, such as oxygen consumption. These results, taken together with our in vitro observations [Rintoul et al. (2000) Biochim. Biophys. Acta 1509, 65–72], strongly suggest that the disruption of the cytoplasmic membrane gradient is closely related to the bactericidal activity of MccJ25 in S. newport.Fil: Rintoul, Maria Regina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Fernandez, Beatriz Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Salomon, Raul Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Farias, Ricardo Norberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Morero, Roberto Dionisio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentin

Resultados posterior al tratamiento antiparasitario utilizando los medicamentos de los lineamientos del Minsal en niños menores de 5 años de El Porvenir, Santa Ana, en el periodo de Enero a Julio de 2017

Se describen los resultados del tratamiento antiparasitario aplicando lo establecido en las guías clínicas del MINSAL; en los 168 niños menores de 5 años del municipio El Porvenir que consultaron en la UCSFI El Porvenir en el período de Enero a Julio del 2017. El parasitismo intestinal en niños menores de 5 años es una de las enfermedades con mayor prevalencia en el municipio de El Porvenir, estando dentro de las primeras 5 causas de consulta. Se incluyen dentro del estudio a 50 niños en quienes se confirma parasitismo intestinal en base a los resultados obtenidos mediante un primer examen general de heces, donde se observa mayor prevalencia de protozoarios, específicamente de amebiasis, en más de la mitad de los niños que conforman la muestra. Posterior a ello se evalúa el tratamiento antiparasitario brindado mediante el análisis de los resultados de un examen general de heces como mínimo 4 semanas posterior al tratamiento obtenido en 26 pacientes y el grado de cumplimiento de los lineamientos por parte institucional y apego terapéutico por el paciente. Como resultado de la investigación se obtiene que no se cumplen las guías clínicas en su totalidad por diferentes causas, sin embargo se presentan tasas de curación por arriba del 75% al utilizar los medicamentos disponibles en la institució