Prognostic Impact of Tricuspid Regurgitation in Patients Undergoing Aortic Valve Surgery for Aortic Stenosis.

BackgroundThe prognostic significance of tricuspid regurgitation (TR) and right ventricular (RV) function in patients undergoing aortic valve replacement (AVR) for severe aortic stenosis (AS) is unknown. The aim of the present study was to evaluate the impact of TR and RV systolic dysfunction on early and late mortality in this setting.MethodsThis was a prospective single-center observational study. 465 consecutive patients who were referred to AVR for severe AS were investigated. Significant TR was defined as TR≥moderate by transthoracic echocardiography.ResultsAt baseline, significant TR was present in 26 (5.6%) patients. Patients with TR presented with a higher EuroSCORE I (p = 0.001), a higher incidence of previous cardiac surgery (pConclusionsTR, RV dysfunction, age, and concomitant CABG are associated with outcome in patients undergoing AVR for severe AS. This finding underlines the importance of a thorough echocardiographic evaluation with particular consideration of the right heart in these patients

Operative data.

<p>Values are expressed as numbers or frequency (%). CABG indicates coronary artery bypass graft; TV, tricuspid valve.</p><p>Operative data.</p

Overall survival in patients with versus without significant TR.

<p>TR indicates tricuspid regurgitation.</p

Causes of death.

<p>Values are expressed as numbers or frequency (%).</p><p>Causes of death.</p

Operative data.

<p>Values are expressed as numbers or frequency (%). CABG indicates coronary artery bypass graft; TV, tricuspid valve.</p><p>Operative data.</p

Multivariate regression analysis of factors influencing overall mortality.

<p>CABG indicates coronary artery bypass graft; TR, tricuspid regurgitation; RV, right ventricle</p><p>Multivariate regression analysis of factors influencing overall mortality.</p