4,360 research outputs found

    Art. XII.—Some Further Gleanings from the Si-yu-ki

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    The neural correlates of speech motor sequence learning

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    Speech is perhaps the most sophisticated example of a species-wide movement capability in the animal kingdom, requiring split-second sequencing of approximately 100 muscles in the respiratory, laryngeal, and oral movement systems. Despite the unique role speech plays in human interaction and the debilitating impact of its disruption, little is known about the neural mechanisms underlying speech motor learning. Here, we studied the behavioral and neural correlates of learning new speech motor sequences. Participants repeatedly produced novel, meaningless syllables comprising illegal consonant clusters (e.g., GVAZF) over 2 days of practice. Following practice, participants produced the sequences with fewer errors and shorter durations, indicative of motor learning. Using fMRI, we compared brain activity during production of the learned illegal sequences and novel illegal sequences. Greater activity was noted during production of novel sequences in brain regions linked to non-speech motor sequence learning, including the BG and pre-SMA. Activity during novel sequence production was also greater in brain regions associated with learning and maintaining speech motor programs, including lateral premotor cortex, frontal operculum, and posterior superior temporal cortex. Measures of learning success correlated positively with activity in left frontal operculum and white matter integrity under left posterior superior temporal sulcus. These findings indicate speech motor sequence learning relies not only on brain areas involved generally in motor sequencing learning but also those associated with feedback-based speech motor learning. Furthermore, learning success is modulated by the integrity of structural connectivity between these motor and sensory brain regions.R01 DC007683 - NIDCD NIH HHS; R01DC007683 - NIDCD NIH HH

    Descriptions, Biology, and Notes on the Identification of Some Trogoderma Larvae

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    For several years members of the dermestid beetle genus Trogoderma have attracted widespread attention, particularly since T. granariurn Everts, the khapra beetle, became established as an introduced pest in Arizona, California, Mexico, and New Mexico. This species has been the object of a control program to remove it as a hazard to stored grain and to prevent its spread to parts of the country where it is not known to occur. Species of Trogoderma other than the khapra beetle may also build up to damaging numbers in stored products. Information has been obtained on these species, as well as on granariurn, during the course of these studies

    Correspondence between Dr. Koch and Dr. Beal

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    Letters discussing Dr. Koch\u27s appearance at technique seminar, Manipulative Treatment of Heart Disease , at Dallas AOA Convention

    Accessory to dissipate heat from transcranial magnetic stimulation coils

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    Background: Transcranial magnetic stimulation (TMS) produces magnetic pulses by passing a strong electrical current through coils of wire. Repeated stimulation accumulates heat, which places practical constraints on experimental design. New Method: We designed a condensation-free pre-chilled heat sink to extend the operational duration of transcranial magnetic stimulation coils. Results: The application of a pre-chilled heat sink reduced the rate of heating across all tests and extended the duration of stimulation before coil overheating, particularly in conditions where heat management was problematic. Comparison with Existing Method: Applying an external heat sink had the practical effect of extending the operational time of TMS coils by 5.8 to 19.3 minutes compared to standard operating procedures. Conclusion: Applying an external heat sink increases the quantity of data that can be collected within a single experimental session

    Improving Collection Dynamics by Monotonic Filtering

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    The effect of cereal type and micronisation on the concentration of lactic acid in the production of fermented liquid feed for pigs

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    The use of fermented liquid feeds (FLF) is gaming popularity in Europe as a means of improving the gut health of pigs and improvmg the stability and safety of liquid feed in ad libitum feeding systems with modern liquid feeding systems it is often advantageous to ferment the cereal component of the diet and use this as a base to which other components are added to formulate a range of diets for the whole unit. The exception to this may be diets for newly weaned pigs where it is normal (in the UK) for processed cereals to be used
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