Realistic calculations of Kbar-N-N, Kbar-N-N-N, and Kbar-Kbar-N-N quasibound states

Binding energies and widths of three-body KbarNN, and of four-body KbarNNN and KbarKbarNN nuclear quasibound states are calculated in the hyperspherical basis, using realistic NN potentials and subthreshold energy dependent chiral KbarN interactions. Results of previous K^-pp calculations are reproduced and an upper bound is placed on the binding energy of a K^-d quasibound state. A self consistent handling of energy dependence is found to restrain binding, keeping the calculated four-body ground-state binding energies to relatively low values of about 30 MeV. The lightest strangeness -2 particle-stable Kbar nuclear cluster is most probably KbarKbarNN. The calculated Kbar N -> pi Y conversion widths range from approximately 30 MeV for the KbarNNN ground state to approximately 80 MeV for the KbarKbarNN ground state.Comment: v3 matching journal publicatio

Multicenter Experience with Nonischemic Multiport Laparoscopic and Laparoendoscopic Single-Site Partial Nephrectomy Utilizing Bipolar Radiofrequency Ablation Coagulator

Objective. To investigate feasibility of multiport and laparoendoscopic single-site (LESS) nonischemic laparoscopic partial nephrectomy (NI-LPN) utilizing bipolar radiofrequency coagulator. Methods. Multicenter retrospective review of 60 patients (46 multiport/14 LESS) undergoing NI-LPN between 4/2006 and 9/2009. Multiport and LESS NI-LPN utilized Habib 4X bipolar radiofrequency coagulator to form a hemostatic zone followed by nonischemic tumor excision and renorrhaphy. Demographics, tumor/perioperative characteristics, and outcomes were analyzed. Results. 59/60 (98.3%) successfully underwent NI-LPN. Mean tumor size was 2.35 cm. Mean operative time was 160.0 minutes. Mean estimated blood loss was 131.4 mL. Preoperative/postoperative creatinine (mg/dL) was 1.02/1.07 (P = .471). All had negative margins. 12 (20%) patients developed complications. 3 (5%) developed urine leaks. No differences between multiport and LESS-PN were noted as regards demographics, tumor size, outcomes, and complications. Conclusion. Initial experience demonstrates that nonischemic multiport and LESS-PN is safe and efficacious, with excellent short-term preservation of renal function. Long-term data are needed to confirm oncological efficacy

Toward 6G Vehicle-to-Everything Sidelink: Nonorthogonal Multiple Access in the Autonomous Mode

The cellular vehicle-to-everything (C-V2X) sidelink technology, specified in the long-term evolution (LTE) and further improved in the 5G new radio (NR) standards to facilitate direct data exchange between vehicles, will play a crucial role in revolutionizing transportation systems. However, the demand for very high reliability and ultralow latency services especially challenges the sidelink resource allocation mechanism when performed by distributed vehicles, in the so-called autonomous mode. One of the major causes of ­performance degradation is the resource allocation mechanism, which was designed for orthogonal multiple access (OMA) and can generate interference and collisions under high load conditions. In this context, here we argue in favor of the use of non-OMA (NOMA) as a game changer for the sidelink in the upcoming 6G V2X, and the purpose of this article is to provide a reference for further intriguing studies in the field. Additionally, the gain achievable over conventional allocation schemes by enabling NOMA through the use of successive interference cancelation (SIC) at the receiver is measured through realistic simulations conducted when considering the latest C-V2X specifications

In Silico Analysis of Single Nucleotide Polymorphism (SNPs) in Human β-Globin Gene

Single amino acid substitutions in the globin chain are the most common forms of genetic variations that produce hemoglobinopathies- the most widespread inherited disorders worldwide. Several hemoglobinopathies result from homozygosity or compound heterozygosity to beta-globin (HBB) gene mutations, such as that producing sickle cell hemoglobin (HbS), HbC, HbD and HbE. Several of these mutations are deleterious and result in moderate to severe hemolytic anemia, with associated complications, requiring lifelong care and management. Even though many hemoglobinopathies result from single amino acid changes producing similar structural abnormalities, there are functional differences in the generated variants. Using in silico methods, we examined the genetic variations that can alter the expression and function of the HBB gene. Using a sequence homology-based Sorting Intolerant from Tolerant (SIFT) server we have searched for the SNPs, which showed that 200 (80%) non-synonymous polymorphism were found to be deleterious. The structure-based method via PolyPhen server indicated that 135 (40%) non-synonymous polymorphism may modify protein function and structure. The Pupa Suite software showed that the SNPs will have a phenotypic consequence on the structure and function of the altered protein. Structure analysis was performed on the key mutations that occur in the native protein coded by the HBB gene that causes hemoglobinopathies such as: HbC (E→K), HbD (E→Q), HbE (E→K) and HbS (E→V). Atomic Non-Local Environment Assessment (ANOLEA), Yet Another Scientific Artificial Reality Application (YASARA), CHARMM-GUI webserver for macromolecular dynamics and mechanics, and Normal Mode Analysis, Deformation and Refinement (NOMAD-Ref) of Gromacs server were used to perform molecular dynamics simulations and energy minimization calculations on β-Chain residue of the HBB gene before and after mutation. Furthermore, in the native and altered protein models, amino acid residues were determined and secondary structures were observed for solvent accessibility to confirm the protein stability. The functional study in this investigation may be a good model for additional future studies

Interleukin (IL)-17A and IL-17F and asthma in Saudi Arabia: mRNA transcript levels and gene polymorphisms

Asthma is a multifactorial disorder and both genetic and environmental factors contribute to its development. The present study explored cytokines interleukin (IL)-17A and IL17F levels as usable parameters for the diagnosis of asthmatics Saudi patients. Blood samples were collected from 100 asthma patients and 100 matched controls. The transcript mRNA levels in whole blood were determined by real-time reverse-transcription polymerase chain reaction. Expression studies showed that levels of IL17A and IL17F were significantly higher in asthma patients compared to controls [IL17A: 1.112 (2.088) vs 0.938 (1.363)]; IL17F: 0.707 (1.33) vs 0.667 (0.590). The mRNA transcripts of IL17A and IL17F were positively and significantly correlated in all subjects examined in this study: controls as well as asthma patients (r = 0.455, P < 0.01 for controls and r = 0.644, P < 0.01 for patients). These findings suggest that asthma is characterized by an elevation of cytokines IL17A and IL17F and the measurement of their expression can be a valuable parameter for the diagnosis of asthma.Keywords: Asthma, interleukin-17F (IL17F), interleukin-17A (IL17A), gene expression, real time-polymerase chain reaction (RT-PCR), Saudi Arabia.African Journal of Biotechnology Vol. 12(23), pp. 3615-362

Pull out all the stops : textual analysis via punctuation sequences

Whether enjoying the lucid prose of a favourite author or slogging through some other writer’s cumbersome, heavy-set prattle (full of parentheses, em dashes, compound adjectives, and Oxford commas), readers will notice stylistic signatures not only in word choice and grammar but also in punctuation itself. Indeed, visual sequences of punctuation from different authors produce marvellously different (and visually striking) sequences. Punctuation is a largely overlooked stylistic feature in stylometry, the quantitative analysis of written text. In this paper, we examine punctuation sequences in a corpus of literary documents and ask the following questions: Are the properties of such sequences a distinctive feature of different authors? Is it possible to distinguish literary genres based on their punctuation sequences? Do the punctuation styles of authors evolve over time? Are we on to something interesting in trying to do stylometry without words, or are we full of sound and fury (signifying nothing)