Outcomes of the chondral lesions of knee treated by microfracture technique and effective factors on the results

Objectives: The aim of this study was to evaluate the results of the microfracture technique in the treatment of chondral lesions.Materials and methods: A retrospective study was performed in 26 patients who had treated by arthroscopic microfracture technique for chondral lesions in the femoral condils between January 2003 and 2007september in our department. There were 11 females and 15 males with mean age of 37.2 years (range from 23 to 56 years). The average time between beginning of complaints and operation were 9.7 months (range from 3 to 35 months). The average of chondral lesions size were 1,6 cm2 (range from 0.7 to 2.4 mm2). The average follow-up period was 24.3 months (ranged from 10 to 44 months). Patients assessed according to subjective patient satisfaction and Lisholm scale at preoperative and postoperative time.Results: The mean Lysholm score increased from a preoperative 56.9 (range from 43 to 72) to a postoperative 77.9 (range from 62 to 100) (p<0.05). The rating was excellent in 9 patients (34.6%), good in 7 (27%) and fair in 10 (38.4%) according to Lysholm scale. All patients were satisfied with their knee function. The results of MRI taken at postoperative sixth month were proportional with patient’s satisfaction and Lysholm scores.Conclusion: Patients with excellent or good results had short symptom period, small chondral lesion and young age. Applied early microfracture technique in treatment of chondral lesions was a low cost, effective and successful treatment modalit

The Effect of Occupational Groups and Use of Alcohol and Smoking in Thrace on Semen Parameters

DergiPark: 378981tmsjAims: Research of the effect of alcohol and smoking of the male spouses of infertile couples and their occupational groups on sperm quality. Methods: 686 male cases who have applied to Trakya University, Faculty of Medicine, Department of Assisted Reproductive Techniques, Infertility Polyclinic were included in the assessment. As a result of the spermiogram test, every patient’s sperm count, motility and morphology were assessed. Occupational groups, usage of alcohol and smoking were enquired to each case. Mann Whitney U, Willcoxon Test was employed in the statistical analyses and the risk ratios were calculated.Results: Out of the 686 people, 353 were smokers (51.4%) and 333 were non-smokers (48.6%). The number of people who smoked and also consumed alcohol was 59 (8.6%). In terms of occupation, 132 people were unemployed (%19.2), 23 were being exposed to heat (%3.3), 256 had to stand while working (%37.3), 31 were being exposed to radiation and chemicals (%4.5), 199 had to be both stand and sitting while working (%29) and 45 had to sit while working (%6.5). As a result of our study, while no correlation between smoking and the sperm count and morphology could be observed, the sperm motility of the smoking group has been observed to be lower. However, no significant difference in terms of semen analysis could be observed between, just drinkers, both drinker and smokers and non-smokers and drinkers groups. Smokers and those who both smoke and have a job where they have to be sitting have a significantly lower sperm motility. When the sperm quality is observed amongst occupational groups in terms of alcohol, the sperm motility of the people who were only exposed to radiation and chemicals have significantly increased in the alcohol consumers.Conclusion: Semen quality is affected by numerous genetic and environmental factors. Smoking, alcohol consumption and being employed in certain occupational groups are just a few of many risk factor

ANALYSIS OF THE FACTORS WHICH INFLUENCE PARTICIPATION OF UNIVERSITY STUDENTS IN RECREATIONAL ACTIVITIES

The purpose of this study is to find out recreational tendencies of university students, the factors which prevent them from participating in recreational activities and whether these factors differ according to some variables. 200 students, 96 males and 104 females, studying in three different faculties (faculty of theology, faculty of education and faculty of sport sciences) of Samsun Ondokuz Mayıs University during 2016-2017 Academic Year participated in the study voluntarily. Leisure Constraints Scale was used as data collection tool. SPSS 22.0 was used in the statistical analysis of our data. Factor analysis was conducted on the data obtained, followed by Anova Test, Kruskal Wallis Test, Mann-Whitney-U test and T Test according to the data set. When the results of our study were examined, no statistically significant difference was found between age groups in terms of lack of access and friends, lack of information, lack of time and lack of facility, and between genders in terms of lack of facility, lack of time, individual psychology and lack of information (p&gt;0.05). Statistically significant difference was found between faculties in terms of lack of knowledge and individual psychology, between genders in terms of access and lack of friends (p&lt;0.05). As a conclusion, it can be seen that there are differences between students studying in different faculties in terms of lack of knowledge about recreational activities, problems in finding facilities and individual psychology.   Article visualizations

Re-evaluation of the symptoms of Hirayama disease through anatomical perspective

Hirayama disease is a rare disease of the anterior horn motor neuron caused by compression of the cervical spinal cord when the neck is flexed. Cervical myelopathy may accompany the disease. It is characterized by symmetrical or asymmetrical muscle weakness and atrophy of muscles innervated by lower cervical and upper thoracic motor neurons. We recorded two male cases of Hirayama disease between the ages of 15 and 21 based on magnetic resonance imaging (MRI) features obtained from the cervical neutral state and from the flexion position which appeared in the right upper extremity. Loss of strength and atrophy in the right upper extremities was existent in clinical findings of these patients. When MRI was taken in the flexion position, there were dilated veins as hypointense signal void on T2 weighted series in posterior epidural area. The contrast enhancement was seen on these veins. It was observed that the posterior dura was displaced anteriorly and the anterior subarachnoid space was narrow. In cases which show clinical findings such as atrophy and loss of strength, having normal MRI results obtained in the neutral position makes it difficult to diagnose Hirayama Disease. In case of a suspicion of Hirayama disease the diagnosis can be made more easily by MRI taken in the flexion position. These case reports aim to bring Hirayama disease to mind and optimize the management of affected individuals

Gilbert sendromlu hastalarda aort sertliğinin değerlendirilmesi: Artmış bilirubin düzeyinin koruyucu etkisi

Amaç: Gilbert sendromu (GS) indirekt bilirubin artışıyla karakterize otozomal resesif bir hastalıktır. Gilbert sendromunda aterosklerotik kalp hastalığı insidansı azalmıştır. Biz bu çalışmada GS’nin varlığı ve nabız dalga hızı (NDH) arasındaki ilişkiyi incelemeyi amaçladık. Yöntemler: Bu çalışmaya hastanemiz iç hastalıkları kliniğine başvuran 32 kadın (yaş: 27.12±7.27) ve 26 erkek (yaş: 26.63±5.84) olmak üzere toplam 58 GS’li hasta alındı. Kontrol grubu olarak benzer yaş grubunda olan 35 kadın (yaş: 27.33±8.06, p=0.716) ve 23 erkek (yaş: 27.38±6.91, p=0.923) olmak üzere 58 sağlıklı katılımcı çalışmaya dahil edildi. Her iki grubun NDH’si sağ karotis ve femoral arterlerden ölçüldü. Bulgular: Gilbert sendromu grubunun yaş ortalaması 26.03±8.22 yıl ve sağlıklı grubun yaş ortalaması 26.60±5.84 yıl idi. Gilbert sendromu grubunun diyastolik kan basıncı (67.76±8.59 mmHg) ve NDH’si (5.63±1.12 m/s) kontrol grubundan (71.72±7.28 mmHg, p=0.008; 6.18±1.22 m/s, p=0.014) anlamlı olarak daha düşüktü. Gilbert sendromu gru- bunun yüksek yoğunluklu lipoprotein düzeyi (1.4±0.3 mmol/L) kontrol grubundan (1.2±0.3 mmol/L mmol/L, p=0.029) anlamlı şekilde daha yüksekti. Sonuç: Biz bu çalışmada, GS’li hastaların NDH değerlerini sigara içmeyen, yaş uyumlu sağlıklı bireylerden düşük bulduk.Objective: Gilbert’s syndrome (GS) is an autosomal reces- sive disease that is characterized by an increase in indirect bilirubin (IB). The incidence of atherosclerotic heart disease is decreased in GS. This study aimed to investigate the relation between pulse wave velocity (PWV) and the presence of GS. Methods: The study included 58 GS patients (32 females, age; 27.12±7.27 years, 26 males, age; 26.63±5.84 years) admitted to the internal medicine clinic of the hospital. The control group included 58 healthy individuals (35 females [27.33±8.06 years old, p=0.716] and 23 males [27.38±6.91 years old, p=0.923]). PWV of both groups was measured from the right carotid and femoral arteries. Results: Mean age of the GS group was 26.03±8.22 years, while that of the healthy group was 26.60±5.84 years. The GS group’s diastolic blood pressure and PWV were significantly lower than those of the control group: 67.76±8.59 mmHg vs 71.72±7.28 mmHg; p=0.008, and 5.63±1.12 m/s vs 6.18±1.22 m/s; p=0.014 respectively. The GS group’s high density lipo- protein (HDL) level was significantly higher than that of the control group: 1.4±0.3 mmol/L vs 1.2±0.3 mmol/L, p=0.029. Conclusion: This study found PWV among GS patients to be lower than that among non-smoking and aged-matched healthy controls

Pure motor stroke secondary to cerebral infarction of recurrent artery of heubner after mild head trauma: A case report

BACKGROUND: The recurrent Heubner's artery is the distal part of the medial striate artery. Occlusion of the recurrent artery of Heubner, classically contralateral hemiparesis with fasciobrachiocrural predominance, is attributed to the occlusion of the recurrent artery of Heubner and is widely known as a stroke syndrome in adults. However, isolated occlusion of the deep perforating arteries following mild head trauma also occurs extremely rarely in childhood. CASE REPORT: Here we report the case of an 11-year-old boy with pure motor stroke. The brain MRI showed an acute ischemia in the recurrent artery of Heubner supply area following mild head trauma. His fasciobrachial hemiparesis and dysarthria were thought to be secondary to the stretching of deep perforating arteries leading to occlusion of the recurrent artery of Heubner. CONCLUSION: Post-traumatic pure motor ischemic stroke can be secondary to stretching of the deep perforating arteries especially in childhood. © 2016 Ali Yilmaz, Zahir Kizilay, Ayca Ozkul, Bayram Çirak

Special education teachers’ knowledge about genetic disorders

Bu çalışmanın amacı özel eğitim öğretmenlerinin genetik hastalıklar konusunda bilgi düzeylerinin belirlenmesidir. Total olarak 83 özel eğitimde çalışan öğretmen çalışmaya dahil edilmiştir. Hücre bölünmesi katılımcılar arasında en fazla bilinen bilgi olarak tespit edilmiştir (33.7%). Bununla birlikte katılımcıların çoğu genetik danışmanlık (80.7%), prenatal genetik tanı (79.5%), polygenic kalıtım (72.3%), mitokondriyal kalıtım (71.1%), otozomal dominant and resesif genler (65.1% and 63,9% respectively) konusunda bilgilerinin olmadığını belirtmişlerdir. Katılımcıların büyük çoğunluğu Down sendromu (69.9%) Rh faktörü (31.3%), diabet (27.7%), kas distrofisi (24.1%) ve albinizm (24.1%) konularında bilgiye sahip olduklarını belirtmişlerdir. Sonuçlarımız katılımcıların büyük bir çoğunluğunun yeterli genetik bilgiye sahip olmadıklarını göstermiştir.The purpose of this work is to determine the knowledge level of the special education teachers about genetic disorders. A total of 83 teachers’ from working on special education centers were used. Knowledge of cell division was the highest among participants (33.7%). However, majority of the participants specified that they had no information about genetic counselling (80.7%), prenatal genetic diagnosis (79.5%), polygenic inheritance (72.3%), mitochondrial inheritance (71.1%), autosomal dominant and recessive genes (65.1% and 63,9% respectively). The majority of the participants were mostly aware of Down syndrome (69.9%) followed by Rh factor (31.3%), diabetes (27.7%), muscular dystrophy (24.1%) and albinism (24.1%). Our results showed that the majority of respondents were lack of adequately enough genetic knowledge

Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin

BACKGROUND. Arthrogryposis, defined as congenital, joint contractures in 2 or more body areas, is a clinical sign rather than a specific disease diagnosis. To date, more than 400 different disorders have been described that present with arthrogryposis, and variants of more than 220 genes have been associated with these disorders; however, the underlying molecular etiology remains unknown in the considerable majority of these cases. METHODS. We performed whole exome sequencing (WES) of 52 patients with clinical presentation of arthrogryposis from 48 different families. RESULTS. Affected individuals from 17 families (35.4%) had variants in known arthrogryposis-associated genes, including homozygous variants of cholinergic gamma nicotinic receptor (CHRNG, 6 subjects) and endothelin converting enzyme-like 1 (ECELI, 4 subjects). Deleterious variants in candidate arthrogryposis-causing genes (fibrillin 3 [FBN3], myosin IXA [MY09A], and pleckstrin and Sec7 domain containing 3 [PSD3]) were identified in 3 families (6.2%). Moreover, in 8 families with a homozygous mutation in an arthrogryposis-associated gene, we identified a second locus with either a homozygous or compound heterozygous variant in a candidate gene (myosin binding protein C, fast type (MYBPC2] and vacuolar protein sorting 8 [VPS8], 2 families, 4.2%) or in another disease-associated genes (6 families, 12.5%), indicating a potential mutational burden contributing to disease expression. CONCLUSION. In 58.3% of families, the arthrogryposis manifestation could be explained by a molecular diagnosis; however, the molecular etiology in subjects from 20 families remained unsolved by WES. Only 5 of these 20 unrelated subjects had a clinical presentation consistent with amyoplasia; a phenotype not thought to be of genetic origin. Our results indicate that increased use of genome-wide technologies will provide opportunities to better understand genetic models for diseases and molecular mechanisms of genetically heterogeneous disorders, such as arthrogryposis. FUNDING. This work was supported in part by US National Human Genome Research Institute (NHGRI)/National Heart, Lung, and Blood Institute (NHLBI) grant U54HG006542 to the Baylor-Hopkins Center for Mendelian Genomics, and US National Institute of Neurological Disorders and Stroke (NINDS) grant RO1NS058529 to J.R. Lupski.US NHGRI/NHLBI [U54HG006542]; US NINDSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS058529]; CPRIT training Program [RP140102]; Medical Genetics Research Fellowship Program [T32 GM07526]; NATIONAL HUMAN GENOME RESEARCH INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Human Genome Research Institute (NHGRI) [U54HG006542] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [T32GM007526] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS058529] Funding Source: NIH RePORTERWe thank the patients and their families who participated in this study. This work was supported in part by US NHGRI/NHLBI grant U54HG006542 to the Baylor-Hopkins Center for Mendelian Genomics and US NINDS grant R01NS058529 to J.R. Lupski. W.L. Charng is supported by CPRIT training Program RP140102, and T. Harel is supported by the T32 GM07526 Medical Genetics Research Fellowship Program

Giant arachnoid granulation in a patient with benign intracranial hypertension (2009: 1b)

We report magnetic resonance (MR), computed tomography (CT) and angiographic imaging of an unusual giant arachnoid granulation 7(GAG) in the superior sagittal sinus in a man with headache and vertigo. Intrasinus pressure measurements revealed a significant pressure gradient across the lesion. MR imaging is useful to identify GAG and dural sinus thrombosis, whereas dural sinus pressure measurement in certain cases of GAGs can be used to evaluate the lesion as the cause of the patient's symptoms

Lumbar spinal schwannoma with retroperitoneal invasion: a case report

Schwannom periferik sinir kılıfının schwann hücrelerinden köken alan nadir bir tümördür. Genellikle baş, boyun ve üst extremitelerde yerleşirler. Nadiren de posterior mediasten ve retroperitonda yerleşebilirler. 47 yaşinda bayan bir hasta rektal dolgunluk hissi ve bel ağrisi yakinmalari ile başvurdu. Yapilan radyolojik incelemeler sonucu pelvik retroperitoneal yerleşimli solid bir kitle tanisi ile yatirildi. Kadin Hastaliklari ve Doğum Kliniği ile Nöroşirürji Kliniğinin birlikte yaptiği cerrahi uygulama ile total olarak çikartilan kitlenin histopatolojik incelemesi Schwannom olarak rapor edildi. Kismi çikartilan destrükte olmuş L5 korpusu nedeniyle lumbosakral bölge enstrümante edilip stabillendi ve kemik greft ile füzyon yapildi. Postoperatif dönemde sorunu olmayan hasta takip edilmek üzere taburcu edildi.SUMMARY Schwannomas or neurilemmomas are encapsulated tumours arising from the neural sheath of peripheral nerves. They are usually located in the head and neck or in the upper extremities, but may appear in the posterior mediastinum and more rarely in the retroperitoneum. A 47 year-old-female complaining of pelvic and lumbar pain has been admitted with the diagnosis of retroperitoneal pelvic solitary mass after radiologic evaluation. The mass has been resected totally through an anterior abdominopelvic incision and histopathology evaluation reported to be the schwannoma. Lumbosacral instrumentation and fusion with bone graft have been performed following the resection of the mass and destructed L5 vertebrae corpus. Postoperative period went uneventful