Prediction of the preeclampsia: a view of biochemical markers

Preeclampsia is a diverse, multiorgan group of related disease processes that occurs in up to 5%-8% of pregnancies after 20 weeks’ gestation and it is one of the leading causes of maternal and fetal morbidity and mortality. Many molecular mechanisms are contributed to the pathogenesis of preeclampsia. Although it is unknown whether the mechanisms act independently or have synergistic effects. This review describes review of primary papers investigating blood based biomarker such as PAP-A, Inhibin A, sFlt1, and PP13 in general and first trimester biochemical markers and combinations of them specifically for preeclampsia

A Study on Classroom Communıcatıon Skılls of Instructors Lecturıng in Undergraduate, Graduate and Postgraduate Programs at The Facultıes of Educatıon

Araştırmada farklı düzeyde eğitim verilen (lisans, yüksek lisans ve doktora) eğitim fakültelerinde çalışan öğretim elemanlarının sınıf içi iletişim becerilerinin incelenmesi amaçlanmıştır. Bu doğrultuda nicel araştırma yöntemlerinden ilişkisel tarama modeli uygulanmıştır. Araştırmanın çalışma grubu, seçkisiz olmayan örnekleme yöntemlerinden amaçlı örnekleme yöntemiyle belirlenmiş ve üç üniversitede öğrenim gören öğrencilerden veri toplanmıştır. Veri toplama aracı olarak iletişim becerileri ölçeği (Karagöz ve Kösterelioğlu, 2008) kullanılmıştır. Analiz sonuçlarında farklı düzeyde eğitim veren eğitim fakültelerinde iletişim becerileri açısından “saygı”, “ifade becerisi” ve “demokratik tutum” alt boyutlarında anlamlı bir fark gözlenemezken, “değer”, “engeller” ve “motivasyon” alt boyutlarında, öğretim düzeyi farklılaşan üniversitelere göre anlamlı farklar gözlenmiştir. Özellikle öğretmenin öğretim ortamında iyi bir model oluşturmasını, sıcak ve coşkulu olmasını, mesajın kaynağa etkili şekilde ulaşmasını belirlemeye çalışan “motivasyon” boyutu lisans düzeyinde eğitim veren üniversitede daha yüksek, doktora düzeyinde ise daha düşük bulunmuştur. “Değer” ve “engeller” alt boyutlarında ise, verilen eğitimin derecesi yükseldikçe öğretim elemanlarının iletişiminin arttığı görülmektedir. Öğretim elemanlarının iletişim becerileri konusundaki farkındalıklarını artırması için gerekli önlemler alınarak iletişim becerisi eğitimi verilmesi önerilmektedirThis research study aims to examine the communication skills of the instructors of the educational faculties providing undergraduate, graduate and doctorate levels of education. In this study, a relational screening model as part of quantitative research methods was applied. The study group of the study was determined by purposeful sampling method. Communication skills scale (Karagöz and Köstereklioğlu, 2008) was used as the data collection tool. According to the results gained in this study, there is no significant difference regarding communication skills and sub-dimensions of respect, expression skills and democratic attitudes at higher education institutions providing different levels of education. However, there was a significant difference in sub-dimensions of value, obstacles and motivation at the universities where teaching levels differed. In particular, the motivational dimension that helps the teacher create a good model in the teaching environment makes him or her warm and enthusiastic, and that determines the effective communication of the message was found to be lower in B.A. level. Results also reveal that the higher the level of education increases, the better the instructor communication skills considering the dimension of value and obstacles Results also provide teacher trainers with important implications in terms of developing communications skill

Steam platformu için oyun öneri sistemi

Increasing number of choices and competition in the markets, force companies to differ in services they provide to their customers. Offering better services have a positive impact on customer loyalty, and to do so, companies should understand their customers’ interests and act accordingly. One popular method for this purpose is building recommendation engines to make personalized suggestions. In this project, collaborative filtering methods with implicit feedback are used to make recommendations to users of the Steam platform. The recommendation systems are built using two different matrix factorization techniques, Alternating Least Squares and Bayesian Personalized Ranking. Different models are created with implicit playtime data of the users and the results are evaluated by using Precision at k metric. Additionally, similar items that are offered by the models are analyzed. Results show that the models are considerably successful at finding personal choices and similar items. The best model finds the item in the libraries of 33% of the users

Swarm and entropic modeling for landmine detection robots

Even at the dawn of the 21st century, landmines still pose a global threat. Buried just inches below the surface, combatants and noncombatants alike are all at risk of stepping on a mine. Their very nature is such that these furtive weapons do not discriminate, making it an urgent task to tackle the problem. According to the U.S.State Department [1], based on an estimate reported just a few years ago, there are well over 100 million anti-personnel mines around the world. The existence of these passive weapons causes a disruption in the development of already impoverished regions, as well as maiming or killing countless innocent passers-by. Since the ratification of the anti-personnel mine total ban treaty in 1997, their detection, removal, and elimination have become a top priority. Nevertheless, at the current rate, given the manpower and the man-hours that could be dedicated to the removal of these sleeping arms, it would take centuries. The concerns regarding the speed of removal and safety of the disposers eventually bring us to the discussion of the proposed method. Nature already provided good solutions to manage groups of less able beings: fish schools, ant swarms, animal packs, bird flocks, and so on.With the growing desire of humans to create intelligent systems, these biosystems are being thoroughly inspected [3-10] and implemented [11-14] in various studies. In this study a robotic agent is referred to as a drone, the group of robotic agents is referred to as a swarm, and the agent with mapping abilities is referred to as the alpha drone

A distributed behavioral model for landmine detection robots

Lecture Notes in Engineering and Computer ScienceThis paper presents a distributed navigation, detection and swarming model for a group of minimalist identical robotic agents. Decision making process of agents is weight based in contrast to widely used precedence based rules. The group is indirectly controlled by an alpha agent that has more sophisticated systems. Computer simulations of the proposed behavioral model generated promising results

Türkiye karikatüründe ekonominin işlenişi (1923-1960)

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2012.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Harun Yeni.Yeni, Harun. HIST 200-05YENİ HIST 200-05/A 2011-1

Çocukluk çağı kanserlerinde vitamin B12 ve folik asit seviyeleri

Purpose: Vitamin B12 and folic acid have some basic functions in the synthesis, repair and expression of DNA of which susceptibility to damage is a major concern in carcinogenesis. We have examined the relationship between childhood cancers and vitamin B12 and folic acid levels in the present study. Materials and Methods: Between November 2013 and December 2015 newly diagnosed 125 patients with solid tumors and 113 patients with lymphoproliferative/ myeloproliferative malignant diseases and 63 controls were enrolled into the study. Vitamin B12, folic acid and homocysteine levels were measured as a part of diagnostic evaluation at the time of diagnosis. Results: Vitamin B12 and folic acid levels were found to be significantly lower in children with malignant diseases compared to the control group. Homocysteine levels however were statistically higher than those of the control group. Folic acid levels were significantly lower in lymphoproliferative/myeloproliferative malignant diseases group compared to the solid tumor group. Conclusion: Lower vitamin B12 and folic acid levels can be used as supportive markers at the time of diagnosis of cancer. This relationship needs to be proved in future studies with larger series.Amaç: Vitamin B12 ve folik asit DNA sentezi, tamiri ve ekspresyonunda önemli görevler alırlar. Bu çalışmada çocukluk çağı kanserleri ile vitamin B12 ve folik asit düzeyleri arasındaki ilişki araştırıldı. Gereç ve Yöntem: Kasım 2013 ve Aralık 2015 arasında yeni tanı alan solid tümörlü 125, lenfoproliferatif/miyeloproliferatif malign hastalığı olan 113 hasta ve 63 kontrol çalışmaya dahil edildi. Vitamin B12 ve folik asit düzeyleri tanısal çalışmaların bir parçası olarak tanı anında ölçüldü. Bulgular: Vitamin B12 ve folik asit düzeyleri malign hastalığı olan çocuklarda kontrol grubuna oranla anlamlı olarak düşük bulundu. Homosistein düzeyleri ise kontrol grubuna göre istatistiksel olarak daha yüksekti. Folik asit düzeyleri lenfoproliferatif/miyeloproliferatif malign hastalığı olanlarda solid tümör grubuna oranla daha düşüktü. Sonuç: Düşük vitamin B12 ve folik asit düzeyleri kanser tanısında destekleyici belirteçler olarak kullanılabilir. Bu ilişkinin gelecekte daha geniş serilerle ortaya konması gerekmektedir

A distributed behavioral model for landmine detection robots

This paper presents a distributed navigation, detection and swarming model for a group of minimalist identical robotic agents. Decision making process of agents is weight based in contrast to widely used precedence based rules. The group is indirectly controlled by an alpha agent that has more sophisticated systems. Computer simulations of the proposed behavioral model generated promising results

Lamin protein gene expression in childhood acute myeloid leukemias

WOS: 000445937400016Purpose: The aim of this study is to evaluate the prognostic value and expression pattern of lamin A/C, lamin B1 and B2 in childhood acute myeloid leukemias, which are thought to be related with cell proliferation and apoptosis. Materials and Methods: Twenty-five patients diagnosed with acute myeloid leukemia (AML) and 35 control cases were included in the study. Real Time-Polymerase Chain Reaction (RT-PCR) method was used to detect lamin A/C, lamin B1 and lamin B2 protein gene expression at the time of the diagnosis and at the end of the induction treatment. Results: At the time of the diagnosis, lamin B1 protein gene expression was lower in AML patients when compared to the control group. When lamin protein expression levels at the time of diagnosis and after induction therapy were compared, the lamin A/C and B2 protein gene expressions were lower after the administration of induction chemotherapy. AML patients with hepatomegaly when compared to patients without hepatomegaly, had only increased lamin A/C protein gene expression. Patients with splenomegaly had both increased lamin A/C and lamin B2 protein gene expressions when compared to the patients without splenomegaly. Conclusion: In childhood acute myeloid leukemias, lamin B1 protein gene expression could be used as a diagnostic marker, while decrease in the lamin A/C and B2 protein gene expressions after induction could be used as a marker for response to therapy

Lamin Protein Gene Expression in Childhood Acute Lymphoblastic Leukemia

WOS: 000489130000005Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. The identification of prognostic factors has become essential in design and analysis of modern therapeutic trials. The aim of this study is to present the expression patterns of lamin A/C, lamin B1 and B2 and their prognostic value in childhood acute lymphoblastic leukemias, which are thought to be related with cell proliferation and apoptosis. The study was carried out between January 2008 and March 2014 at the Cukurova University Faculty of Medicine, Division of Pediatric Oncology and sixty-four patients diagnosed with ALL and 35 control cases were included in the study. Real Time-Polymerase Chain Reaction (RT-PCR) method was used to detect lamin NC, lamin B1 and lamin B2 protein expression at the time of the diagnosis and at the end of the induction treatment. At the time of the diagnosis, lamin B1 protein gene expression was lower in ALL patients when compared to the control group (p=0.001). When lamin gene expression levels at the time of diagnosis and after induction therapy were compared, the lamin A/C and B2 gene expressions were significantly lower after the administration of induction chemotherapy (both values p=0.0001). The decrease in lamin B1 gene expression was not statistically significant (p=0.403). When the lamin expression levels in the control group were compared with the levels after induction chemotheraphy, lamin expressions were found to be significantly lower (all p values 0.0001). In childhood ALL, lamin B1 protein gene expression could be used as a diagnostic marker, while decrease in the lamin A/C and B2 protein gene expressions after induction could be used as a marker for response to therapy. Our study is the first to show in lamin protein gene expression relationship with diagnosis and prognosis in ALL in literature. Comprehensive multicenter studies are needed with a larger cohort of patients to reach more reliable results.Cukurova University Research Projects Funding Unit [TF2013LTP34 (ID715)]This work was supported by 'Cukurova University Research Projects Funding Unit' with Project number TF2013LTP34 (ID715)