Fluvial stratigraphy and palaeoenvironments in the Pasinler Basin, eastern Turkey

Valley floor sediments from the Pasinler Basin, eastern Turkey, provide evidence for Pleistocene and Holocene floodplain conditions. Three terrace surfaces are present. Evidence for tectonic processes active during the Late Neogene are widespread within the basin but do not appear to have substantially influenced the detail of the Holocene palaeoenvironmental record. Significant changes in hydrology are recorded, with more stable floodplain conditions occurring at around 9,000, 5,500 and 4,000 cal. yr. BP. Incision occurred sometime after approximately 4,000 BP, probably as a response to dual climatic and human controls. Comparisons with key sites in the Anatolian region and beyond suggest these changes are part of a regional climatic pattern, perhaps influenced by changes in the East African Monsoon. Differences in the details of the records across the region reflect the characteristics of the local environment, which, increasingly in the latter Holocene, includes human activity

Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities

Antioxidant vitamins C and E have protective properties in genetic hypertension associated with enhanced oxidative stress. This study investigated whether vitamins C and/or E modulate vascular function by regulating enzymatic activities of endothelial nitric oxide synthase (eNOS) and NAD(P)H oxidase using thoracic aortas of 20- to 22-week-old male spontaneously hypertensive rats (SHR) and their matched normotensive counterparts, Wistar-Kyoto rats (WKY). SHR aortas had impaired relaxant responses to acetylcholine but not to sodium nitroprusside, despite an 2-fold increase in eNOS activity and NO release. The levels of superoxide anion (O2 ), a potent NO scavenger, and NAD(P)H oxidase activity were also 2-fold higher in SHR aortas. Mechanical but not pharmacological inactivation of endothelium (by rubbing and 100 mol/L L-NAME, respectively) significantly abrogated O2 in both strains. Treatments of SHR aortas with NAD(P)H oxidase inhibitors, namely diphenyleneiodinium and apocynin, significantly diminished O2 production. The incubation of SHR aortas with different concentrations of vitamin C (10 to 100 mol/L) and specifically with high concentrations of vitamin E (100 mol/L) improved endothelial function, reduced superoxide production as well as NAD(P)H oxidase activity, and increased eNOS activity and NO generation in SHR aortas to the levels observed in vitamin C- and E-treated WKY aortas. Our results reveal endothelial NAD(P)H oxidase as the major source of vascular O2 in SHR and also show that vitamins C and E are critical in normalizing genetic endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities

Endothelial progenitor cells: Potential novel therapeutics for ischaemic stroke

Stroke is classified into two main groups depending on its aetiology; ischaemic stroke and haemorrhagic stroke which successively develop from the occlusion or rupture of an artery leading to the brain. Despite being the leading cause of human cerebral damage, there is currently no medical therapy for haemorrhagic stroke and thrombolysis with recombinant tissue plasminogen activator remains the only approved pharmacotherapy for ischaemic stroke. However, due to its short therapeutic window (first 4.5 h of stroke onset) and increased risk of haemorrhage beyond this point, globally each year less than 1% of patients receive this therapy. Since, endothelial dysfunction, associated with inflammation and vascular permeability, remains the key early event in the pathogenesis of stroke, endogenous element(s) capable of countering this defect may help maintain vascular homeostasis and explain the overt differences observed in patients’ functional outcome. Accumulating evidence indicate that bone marrow-derived endothelial progenitor cells (EPCs) equipped with an inherent capacity to repair endothelial damage and differentiate into few other cell lines represent one such element. Indeed, EPC-based cell therapy, backed by rigorous preclinical, translational and early proof-of-concept, safety and feasibility clinical studies, is now considered as an important novel therapeutic approach. However, several questions relating to optimal cell dosage, delivery route and immediate and sufficient availability of cells remain to be addressed before its efficacious translation to clinical practice. In this context, ex vivo expansion of EPCs leading to an abundant generation of functional outgrowth endothelial cells offers a great opportunity to address these issues and create a novel off-the-shelf type of therapeutic product

Geomorphological insight into changing tectonic regime, Pasinler Basin, Turkey

The Pasinler Basin, in the East Anatolian Contractional Province, features a suite of geomorphological zones, visible in the field, air photographs and Landsat and SRTM DEM imagery. These zones reflect past and current tectonically influenced processes. Collins et al: Geomorphological insight into changing tectonic regime, Pasinler Basin, Turkey. 2 of 26 Remnants of the Erzurum-Kars plateau representing Mio-Pliocene volcanism, associated with transtensional tectonics, have been modified by two stages of drainage development: an earlier, shallow valley network, which was modified following uplift and tilting to form the present system characterised by deep narrow valleys that supply alluvial fan complexes. These fans discharge onto the present, aggradation-dominated basin floor. Initial normal faulting induced massive slope failures on the basin’s northern margin. This extensional phase within the basin was reversed by the Late Pleistocene, with thrust faults modifying and producing landforms, and affecting sediment sequences, along both the north and south basin margins. The shift from a transtensional regime and associated volcanism to normal faulting in the Pliocene-Early Pleistocene, and then to the present compression-dominated regime appears to correspond with regional tectonic changes resulting from collision of the Arabian microplate and the subsequent westward movement of the Anatolian microplate

E-COMMERCE AND ITS CONCEPTION BY GAZIANTEP INDUSTRY

21. century is called as Knowledge and Communication Age. In this age, countries develop some policies about electronic structuring which enable them to be a knowledge society. Given these developments states start to cast their classical bureaucratic structure and tend to work ‘E-Commerce’ structure which is easier, speeder and cheaper. So, the nature of local enterprises started to modify. The main aim of E-Commerce activities is to satisfy consumer needs. Thus, the private sector has a chance and obligation to provide some important subsets of e-commerce activities to the consumer. The main aim of this study is to show that how industrial undertaking use knowledge and communication technologies to provide expansion in Gaziantep industries. Survey data was analyzed using SPSS (Statical Package for Social Sciences) 13.0 statistics program in order to reach at this aim

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells

The production of reactive oxygen species (ROS) within endothelial cells may have several effects, including alterations in the activity of paracrine factors, gene expression, apoptosis, and cellular injury. Recent studies indicate that a phagocyte-type NAD(P)H oxidase is a major source of endothelial ROS. In contrast to the high-output phagocytic oxidase, the endothelial enzyme has much lower biochemical activity and a different substrate specificity (NADH.NADPH). In the present study, we (1) cloned and characterized the cDNA and predicted amino acid structures of the 2 major subunits of rat coronary microvascular endothelial cell NAD(P)H oxidase, gp91-phox and p22-phox; (2) undertook a detailed comparison with phagocytic NADPH oxidase sequences; and (3) studied the subcellular location of these subunits in endothelial cells. Although these studies revealed an overall high degree of homology (.90%) between the endothelial and phagocytic oxidase subunits, the endothelial gp91-phox sequence has potentially important differences in a putative NADPH-binding domain and in putative glycosylation sites. In addition, the subcellular location of the endothelial gp91-phox and p22-phox subunits is significantly different from that reported for the neutrophil oxidase, in that they are predominantly intracellular and collocated in the vicinity of the endoplasmic reticulum. This first detailed characterization of gp91-phox and p22-phox structure and location in endothelial cells provides new data that may account, in part, for the differences in function between the phagocytic and endothelial NAD(P)H oxidases

Trend in global trade and ıts ımpacts on labor

Globalization is one of the defining features of the contemporary world, but there is considerable controversy regarding its nature, impact, and future trends. Globalization has resulted in rapidly growing international flows of import and export goods, capital and direct invenstments. The services sector nowadays has expanded in scope beyond thetraditional activities in finance, transport, travel and telecommunication and audio-visual services to a host of professional services such as software and information services, engineering and legal services, e-commerce and other internet-based service offerings. After post second world war period, this growth of services have shown a dramatic increase in most of the developed countries of the world. Improving information and communicating technologies (ICT) intensified international interaction, increased competition and volume of global trade, while creating new challenges for labor. The purpose of his study is to show the dynamics of globalisation and its effects on international trade and labor force, providing some policy outcomes for he world in general, and Turkey.Küreselleşme günümüz dünyasının açıklayıcı özelliklerinden birini oluşturmaktadır ama yinede küreselleşmenin yapısı, etkileri ve gelecek trendleri üzerine önemli tartışmalar yaşanmaktadır. Küreselleşme uluslararası ithalat ve ihracat ürünlerinin, paranın ve doğrudan yatırımların uluslararası hareketinin gelişmesi sonucunda oluşmuştur. Hizmet sektörü günümüzde uluslararası bir çok alanda özellikle finans, ulaşım, seyahat ve teleküminasyon ve e-hizmet, e-ticaret ve bilgi topluma dayalı geniş bir uygulama faaliyetleri kapsamaktadır. Özellikle ikinci dünya savaşından sonra gelişmiş ülkelerin bir çoğunda büyük bir artış hızı göstermektedir. Bilgi ve iletişim teknolojilerinin(ICT) gelişmesi, uluslararası etkileşimin şiddetini arttırmakta bu da işçilik için yeni tehditler oluştururken rekabet ve küresel ticaret oranlarını arttırmaktadır. Bu çalışmanın amacı küreselleşmenin dinamiklerini ve küreselleşmenin uluslararası ticaret ve işgücü üzerindeki etkisini dünya genelinde ve Türkiye’deki çeşitli politikalar neticesinde göstermekti

Prognostic, diagnostic and therapeutic potential of endothelial progenitor cells for patients with ischaemic stroke: Hype or Hope

Ischaemic stroke is a debilitating disease with immense personal, societal and economic impact. Thrombolysis with recombinant tissue plasminogen activator remains the only approved pharmacotherapy for this disease. As each year less than 1% of eligible patients receive this therapy worldwide, efficacious new therapeutics are desperately needed. Emerging evidence suggest endothelial progenitor cells (EPCs), capable of repairing damaged vasculature, as one such therapeutics. However, questions regarding their optimal dose, delivery route and in vivo survivability remain largely unanswered. Outgrowth endothelial cells, generated in large numbers by ex vivo expansion of EPCs, enable effective assessment of these issues and may eventually serve as off-the-shelf therapeutics. Correlations between circulating EPC levels and stroke outcome imply that EPCs may also serve as clinical biomarkers for stroke. This viewpoint briefly evaluates the current evidence, pinpoints the gaps in the literature and proposes new directions for research