Communicating through notation: Michael Finnissy’s Second String Quartet from composition to performance

This article looks behind the scenes at the notational and interpretative issues arising from the compositional and rehearsal processes embodied in the Second String Quartet by Michael Finnissy, written for the Kreutzer Quartet in 2006-07. The relationship between the individual parts and corporate whole, as represented by the score, or quasi-score, or even the absence of a score, has been of central importance in all of Finnissy’s quartet music to date. Recorded evidence from the rehearsal of the piece is evaluated from both ‘insider’and ‘outsider’ perspectives to demonstrate the extent to which players need to devise new interpretative strategies in response to the specific demands of the notation. Examination of composer-performer interactions reveals how the limits of notation can provide creative tension and imaginative interpretation that contribute to a developing contemporary performance practice

Creative layers and continuities: a case study of Nicole Lizée and the Kronos Quartet

This study examines the creative layers and continuities evident within the composition and rehearsal processes of Nicole Lizée’s Golden Age of the Radiophonic Workshop (Fibre-Optic Flowers), written for the Kronos Quartet in 2012. Lizée’s compositional approach to the historic and the new, and the mechanical and the human, are interpreted through Simon Emmerson’s three themes of combination, transformation, and control, and his three “impulses within composition” that combine live and acousmatic soundworlds – integration, antithesis, and co-existence. These concepts also help to articulate the way the players engage with the physical, psychological, and expressive demands of the piece. Discussions arising from the Kronos Quartet rehearsing the piece with the composer reveal how extensions are made to the performers’ mind and body experiences when they are required both to initiate and integrate sounds emanating from unfamiliar, analogue machines into their acoustic, yet amplified soundworld. Creative layers and continuities are seen to evolve from compositional experimentation and from composer–performer and co-performer dialogues in rehearsal in the BBC Maida Vale studio prior to the world premiere at a BBC Prom concert on 24 July 2012

Why Do Cascade Sizes Follow a Power-Law?

We introduce random directed acyclic graph and use it to model the information diffusion network. Subsequently, we analyze the cascade generation model (CGM) introduced by Leskovec et al. [19]. Until now only empirical studies of this model were done. In this paper, we present the first theoretical proof that the sizes of cascades generated by the CGM follow the power-law distribution, which is consistent with multiple empirical analysis of the large social networks. We compared the assumptions of our model with the Twitter social network and tested the goodness of approximation.Comment: 8 pages, 7 figures, accepted to WWW 201

A continuous model for microtubule dynamics with catastrophe, rescue and nucleation processes

Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in the polymerization of microtubules from tubulin dimers. Our model is an extension of various mathematical models developed earlier formulated in order to capture and unify the various aspects of tubulin polymerization including the dynamic instability, growth of microtubules to saturation, time-localized periods of nucleation and depolymerization as well as synchronized oscillations exhibited by microtubules under various experimental conditions. Our model, while attempting to use a minimal number of adjustable parameters, covers a broad range of behaviors and has predictive features discussed in the paper. We have analyzed the resultant behaviors of the microtubules changing each of the parameter values at a time and observing the emergence of various dynamical regimes.Comment: 25 pages, 12 figure

A modified version of the Bayley Scales of Infant Development-II for cognitive matching of infants with and without Down syndrome

Background Many measures of infants' early cognitive development, including the BSID-II (The Bayley Scales of Infant Development), mix together test items that assess a number of different developmental domains including language, attention, motor functioning and social abilities, and some items contribute to the assessment of more than one domain. Consequently, the scales may lead to under- or over-estimates of cognitive abilities in some clinical samples and may not be the best measure to use for matching purposes. Method To address this issue we created a modified form of the BSID-II (the BSID-M) to provide a ‘purer’ assessment of the general cognitive capacities in infants with Down syndrome (DS) from 6 to 18 months of age. We excluded a number of items that implicated language, motor, attentional and social functioning from the original measure. This modified form was administered to 17 infants with Down syndrome when 6, 12 and 18 months old and to 41 typically developing infants at 4, 7 and 10 months old. Results The results suggested that the modified form continued to provide a meaningful and stable measure of cognitive functioning and revealed that DS infants may score marginally higher in terms of general cognitive abilities when using this modified form than they might when using the standard BSID-II scales. Conclusions This modified form may be useful for researchers who need a ‘purer’ measure with which to match infants with DS and other infants with intellectual disabilities on cognitive functioning

Enhanced motivational interviewing for reducing weight and increasing physical activity in adults with high cardiovascular risk: the MOVE IT three-arm RCT.

BACKGROUND: Motivational interviewing (MI) enhanced with behaviour change techniques (BCTs) and deployed by health trainers targeting multiple risk factors for cardiovascular disease (CVD) may be more effective than interventions targeting a single risk factor. OBJECTIVES: The clinical effectiveness and cost-effectiveness of an enhanced lifestyle motivational interviewing intervention for patients at high risk of CVD in group settings versus individual settings and usual care (UC) in reducing weight and increasing physical activity (PA) were tested. DESIGN: This was a three-arm, single-blind, parallel randomised controlled trial. SETTING: A total of 135 general practices across all 12 South London Clinical Commissioning Groups were recruited. PARTICIPANTS: A total of 1742 participants aged 40-74 years with a ≥ 20.0% risk of a CVD event in the following 10 years were randomised. INTERVENTIONS: The intervention was designed to integrate MI and cognitive-behavioural therapy (CBT), delivered by trained healthy lifestyle facilitators in 10 sessions over 1 year, in group or individual format. The control group received UC. RANDOMISATION: Simple randomisation was used with computer-generated randomisation blocks. In each block, 10 participants were randomised to the group, individual or UC arm in a 4 : 3 : 3 ratio. Researchers were blind to the allocation. MAIN OUTCOME MEASURES: The primary outcomes are change in weight (kg) from baseline and change in PA (average number of steps per day over 1 week) from baseline at the 24-month follow-up, with an interim follow-up at 12 months. An economic evaluation estimates the relative cost-effectiveness of each intervention. Secondary outcomes include changes in low-density lipoprotein cholesterol and CVD risk score. RESULTS: The mean age of participants was 69.75 years (standard deviation 4.11 years), 85.5% were male and 89.4% were white. At the 24-month follow-up, the group and individual intervention arms were not more effective than UC in increasing PA [mean 70.05 steps, 95% confidence interval (CI) -288 to 147.9 steps, and mean 7.24 steps, 95% CI -224.01 to 238.5 steps, respectively] or in reducing weight (mean -0.03 kg, 95% CI -0.49 to 0.44 kg, and mean -0.42 kg, 95% CI -0.93 to 0.09 kg, respectively). At the 12-month follow-up, the group and individual intervention arms were not more effective than UC in increasing PA (mean 131.1 steps, 95% CI -85.28 to 347.48 steps, and mean 210.22 steps, 95% CI -19.46 to 439.91 steps, respectively), but there were reductions in weight for the group and individual intervention arms compared with UC (mean -0.52 kg, 95% CI -0.90 to -0.13 kg, and mean -0.55 kg, 95% CI -0.95 to -0.14 kg, respectively). The group intervention arm was not more effective than the individual intervention arm in improving outcomes at either follow-up point. The group and individual interventions were not cost-effective. CONCLUSIONS: Enhanced MI, in group or individual formats, targeted at members of the general population with high CVD risk is not effective in reducing weight or increasing PA compared with UC. Future work should focus on ensuring objective evidence of high competency in BCTs, identifying those with modifiable factors for CVD risk and improving engagement of patients and primary care. TRIAL REGISTRATION: Current Controlled Trials ISRCTN84864870. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 69. See the NIHR Journals Library website for further project information. This research was part-funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London

Silicon: a benefit or a detriment to plant physiology for Creeping bent (Agrostis stolonifera L.), Sheep's fescue (Festuca ovina L.) and Perennial ryegrass (Lolium perenne L.)?

Silicon shows alleviatory effects in many previous studies involving abiotic and biotic stress factors. A germination trial for the optimum concentration of ERA-3 initially showed an optimum dilution factor of 2,500:1 (Distilled water: ERA-3). Over one hundred individuals of each species of Agrostis stolonifera L., Festuca ovina L. and Lolium Perenne L. were all grown for eight weeks in closed hydroponic systems, in warmed greenhouse conditions (15°C). When solely tested, the effects on all three species showed contrasting results to what was expected. In all three selected species, silicon significantly reduced the shoot area, and photosynthetic efficiency (measured as Fv/Fm ratio) as well as reduced tillering. However, predictions of organism density (mass unit-2) and pH condition were true, with increased density when silicon was added and acidic and neutral-alkaline for non-silicon and silicon treatments respectively were seen. Further research needs to be conducted on this product, concerning the cellular level characteristics and effects that the ERA-3 silicon has upon grass physiology. The decrease in organism growth and health suggest that the silicon used has toxicity effects. Highlights: ERA-3 silicon did not promote shoot growth or maintain shoot photosynthetic efficiency. ERA-3 silicon caused reduced number of tillers in all three sample species. ERA-3 creates a more alkaline environment, needing a non-reacting pH buffer to adjust pH. Further research is necessary into cellular level physiology effects of ERA-3 silicon

Educational outcomes in extremely preterm children : neuropsychological correlates and predictors of attainment

This study assessed the impact of extremely preterm birth on academic attainment at 11 years of age, investigated neuropsychological antecedents of attainment in reading and mathematics, and examined early predictors of educational outcomes. Children born extremely preterm had significantly poorer academic attainment and a higher prevalence of learning difficulties than their term peers. General cognitive ability and specific deficits in visuospatial skills or phoneme deletion at 6 years were predictive of mathematics and reading attainment at 11 years in both extremely preterm and term children. Phonological processing, attention, and executive functions at 6 years were also associated with academic attainment in children born extremely preterm. Furthermore, social factors, neonatal factors (necrotizing enterocolitis, breech delivery, abnormal cerebral ultrasound, early breast milk provision), and developmental factors at 30 months (head circumference, cognitive development), were independent predictors of educational outcomes at 11 years. Neonatal complications combined with assessments of early cognitive function provide moderate prediction for educational outcomes in children born extremely preterm