Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits

This study was designed to investigate the effect of an extract of Nigella sativa L. on the heart rate and  some haematological values in alloxan-induced diabetic rabbits. Fifteen New Zealand male rabbits were  divided into three experimental groups: control, diabetic and N. sativa L.-treated diabetic. At the end of the  experimental period (2 months), animals in all three groups were fasted for 12 hours and blood samples  were taken for the determination of glucose levels, RBC and WBC (red and white blood cell) counts,  packed cell volume (PCV), and haemoglobin (Hb) concentration. Heart rates were also measured by a  direct-writing electrocardiograph before the blood withdrawals. It was found that N. sativa L. treatment  increased the lowered RBC and WBC counts, PCV and neutrophil percentage in diabetic rabbits. However,  the WBC count of the N. sativa L. treated diabetic group was still lower than the control. N. sativa L.  treatment also decreased the elevated heart rate and glucose concentration of diabetic rabbits. It is concluded  that oral N. sativa L. treatment might decrease the diabetes-induced disturbances of heart rate and some  haematological parameters of alloxan-induced diabetic rabbits.

Digital Transformation in Higher Education: Maturity and Challenges Post COVID-19

Digital transformation in higher education, especially after COVID-19 is inevitable. This research explores digital transformation maturity and challenges post COVID-19. The significance of the study does not only stem from the critical role of higher education in building the workforce and knowledge economy. This study triangulates the findings of multiple research instruments, including survey, interviews, case study, and direct observation. The research findings show a significant variance between the respondents’ perception of digital transformations maturity levels, and the core requirements of digital transformation maturity. The findings also show the lack of holistic vision, digital transformation competency, and data structure and processing as the leading challenges of digital transformation

Prevalence of nail biting and its association with mental health in a community sample of children

<p>Abstract</p> <p>Background</p> <p>This study evaluates onychophagia or nail biting (NB) prevalence and association with mental health of a community sample of children from Shiraz, Iran.</p> <p>Findings</p> <p>The parents of 743 primary school children, selected by random sampling, reported NB behavior of their children and themselves. Children's mental health problem was assessed using the Strengths and Difficulties Questionnaire (SDQ). 22.3% (95% CI: 19.3 to 25.3) of children had NB behavior in the last three months (girls: 20.1% (95% CI: 15.9 to 24.2). The rate in boys was 24.4% (95% CI: 20.1 to 28.7). 36.8% of the children with NB had at least one family member with nail biting. Older age was associated with a higher prevalence of NB while a higher score on the prosocial score was associated with a lower prevalence of NB.</p> <p>Conclusions</p> <p>NB is a very common behavior in both genders in children and their family members. Children with NB have less prosocial ability than those without it.</p

Chronic Melatonin Administration Reduced Oxidative Damage and Cellular Senescence in the Hippocampus of a Mouse Model of Down Syndrome

Previous studies have demonstrated that melatonin administration improves spatial learning and memory and hippocampal long-term potentiation in the adult Ts65Dn (TS) mouse, a model of Down syndrome (DS). This functional benefit of melatonin was accompanied by protection from cholinergic neurodegeneration and the attenuation of several hippocampal neuromorphological alterations in TS mice. Because oxidative stress contributes to the progression of cognitive deficits and neurodegeneration in DS, this study evaluates the antioxidant effects of melatonin in the brains of TS mice. Melatonin was administered to TS and control mice from 6 to 12 months of age and its effects on the oxidative state and levels of cellular senescence were evaluated. Melatonin treatment induced antioxidant and antiaging effects in the hippocampus of adult TS mice. Although melatonin administration did not regulate the activities of the main antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase) in the cortex or hippocampus, melatonin decreased protein and lipid oxidative damage by reducing the thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC) levels in the TS hippocampus due to its ability to act as a free radical scavenger. Consistent with this reduction in oxidative stress, melatonin also decreased hippocampal senescence in TS animals by normalizing the density of senescence-associated â-galactosidase positive cells in the hippocampus. These results showed that this treatment attenuated the oxidative damage and cellular senescence in the brain of TS mice and support the use of melatonin as a potential therapeutic agent for age-related cognitive deficits and neurodegeneration in adults with DS

Protective effect of L-carnitine on alcoholic fatty liver in rats

We have investigated the protective effects of L-carnitine against experimental alcoholic fatty liver in terms of steatosis, liver damage, lipid peroxidation and lipid levels. 36 male Wistar rats were divided into three groups. One group received a liquid diet and the other two the liquid diet supplemented with ethanol for 6 weeks. One of the groups given alcohol also received L-carnitine (250 mg/kg, i.m., 3 times/week) and the other isotonic saline (i.m., 3 times/week) as placebo. All of the rats given alcohol developed fatty liver, presenting different grades at the end of the 6 weeks. The levels of steatosis, inflammation and necrosis in the livers of alcohol + L-carnitine animals were significantly lower (P < 0.001) compared to the alcohol + saline animals' livers. The levels of tissue malondialdehyde (MDA) in the liver and plasma were significantly lower in the L-carnitine + alcohol group (P < 0.001) than in the saline + alcohol group. Moreover, the activity of alanine aminotransferase (ALT) and levels of triglycerides and LDL-cholesterol were significantly lower in the L-carnitine + alcohol group (P < 0.05, P < 0.01 and P < 0.01, respectively) compared to the alcohol + saline group. Based on these results, it is possible to postulate that L-carnitine may have a preventive role against alcohol-induced steatosis and liver damage. Med Sci Res 27:475-478 (C) 1999 Lippincott Williams & Wilkins