La danse de salon ou danse sociale: un outil du travailleur social pour favoriser l’insertion sociale de la personne marginalisée sur l’espace public et/ou en institution

Ce travail de Bachelor a pour thématique la danse de salon en lien avec la marginalité. Le travailleur social en lien avec la population marginalisée peut-il inclure la danse de salon comme outil éducatif ? Cette recherche vise aussi à découvrir si la danse de salon peut favoriser la socialisation des personnes marginalisées. Ayant pratiqué les bases de la danse de salon, j’ai observé un potentiel important de bénéfices que cela peut apporter à l’individu. Est-ce adapté et/ou adaptable à la population marginalisée

A multilevel approach for assessing business strategies on climate change

The need for an interdisciplinary and integrative approach for doing research on business strategies and climate change is gaining increasing recognition. However, there is a consensus that such crossfertilization is currently missing. Multilevel research methods by virtue of being interdisciplinary in nature may address this need. This paper proposes to advance the adoption of multilevel research approach in the context of business strategies and climate change. As a guide for conducting multilevel assessment, a flexible analytical framework is presented. The framework is developed through a process of structured literature review. The framework consists of thirteen contextual factors spread across five levels and identifies the key multilevel relationships that moderate organisational level climate change related strategy formulation. Level specificities of several theories across these five levels are also identified to facilitate application of the framework in building multilevel hypotheses for business strategies on climate change. In addition, a concise summary of the fundamental concepts of multilevel modelling techniques is provided to help researchers in selecting suitable multilevel models during the operationalization of the framework. The operationalization of the framework is demonstrated by building and testing a three level hypotheses on corporate lobbying activities on climate change issues. It is observed that irrespective of their locations, financially underperforming companies with a larger workforce and belonging to sectors with higher Green House Gas emission intensities particularly lobby intensely on climate change issues. In conclusion, the potential challenges and opportunities in applying the framework for building multilevel theories in the context of business strategies and climate change are discussed. (C) 2017 The Authors. Published by Elsevier Ltd

Multi-Atlas Segmentation using Partially Annotated Data: Methods and Annotation Strategies

Multi-atlas segmentation is a widely used tool in medical image analysis, providing robust and accurate results by learning from annotated atlas datasets. However, the availability of fully annotated atlas images for training is limited due to the time required for the labelling task. Segmentation methods requiring only a proportion of each atlas image to be labelled could therefore reduce the workload on expert raters tasked with annotating atlas images. To address this issue, we first re-examine the labelling problem common in many existing approaches and formulate its solution in terms of a Markov Random Field energy minimisation problem on a graph connecting atlases and the target image. This provides a unifying framework for multi-atlas segmentation. We then show how modifications in the graph configuration of the proposed framework enable the use of partially annotated atlas images and investigate different partial annotation strategies. The proposed method was evaluated on two Magnetic Resonance Imaging (MRI) datasets for hippocampal and cardiac segmentation. Experiments were performed aimed at (1) recreating existing segmentation techniques with the proposed framework and (2) demonstrating the potential of employing sparsely annotated atlas data for multi-atlas segmentation

Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status

Cell competition induces the elimination of less-fit “loser” cells by fitter “winner” cells. In Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are outcompeted by wild-type cells. Rp/+ cells display proteotoxic stress and the oxidative stress response, which drive the loser status. Minute cell competition also requires the transcription factors Irbp18 and Xrp1, but how these contribute to the loser status is partially understood. Here we provide evidence that initial proteotoxic stress in RpS3/+ cells is Xrp1-independent. However, Xrp1 is sufficient to induce proteotoxic stress in otherwise wild-type cells and is necessary for the high levels of proteotoxic stress found in RpS3/+ cells. Surprisingly, Xrp1 is also induced downstream of proteotoxic stress, and is required for the competitive elimination of cells suffering from proteotoxic stress or overexpressing Nrf2. Our data suggests that a feed-forward loop between Xrp1, proteotoxic stress, and Nrf2 drives Minute cells to become losers

Proteotoxic stress is a driver of the loser status and of cell competition

Cell competition allows “winner” cells to eliminate less fit “loser” cells in tissues. In Minute cell competition, cells heterozygous mutant in ribosome genes, such as RpS3 (+/-) cells, are eliminated by wild-type cells. How cells are primed as losers is partially understood and it has been proposed that reduced translation underpins the loser status of ribosome mutant, or Minute, cells. Here, using Drosophila, we show that reduced translation does not cause cell competition. Instead, we identify proteotoxic stress as the underlying cause of the loser status for Minute competition and competition induced by mahjong, an unrelated loser gene. RpS3 (+/-) cells exhibit reduced autophagic and proteasomal flux, accumulate protein aggregates, and can be rescued from competition by improving their proteostasis. Conversely, inducing proteotoxic stress is sufficient to turn otherwise wild-type cells into losers. Thus, we propose that tissues may preserve their health through a proteostasis-based mechanism of cell competition and cell selection

Multidimensional Outcome Parameters in a Cress Seedling-CuCl2 Crystallization Assay to Corroborate Specific Effects of Stannum metallicum 30x Compared to Lactose 30x.

BACKGROUND  Previously we developed a test system which yielded highly significant evidence for specific effects of a Stannum metallicum 30x preparation in a multi-center replication trial. This test system is based on cress seed germination in homeopathic or control samples, CuCl2 crystallization of the cress extract, and subsequent digital textural image analysis of the resulting crystallization patterns. OBJECTIVES  The current study aimed to investigate whether three novel outcome parameters could further corroborate and possibly characterize the specific effects of Stannum metallicum 30x. METHODS  To this end, (1) cress seedling length, (2) a second texture analysis parameter, entropy and (3) the local connected fractal dimension (LCFD) of crystallization patterns as a measure of complexity were considered. The stability of the experimental setup was monitored throughout the entire investigation with systematic negative control (SNC) experiments. RESULTS  Cress length and entropy revealed a time-modulated potency treatment effect, in the absence of a significant main treatment effect. This indicated that the effect of the potency treatment varied significantly across the different experimental days. LCFD yielded a highly significant potency treatment effect. In addition, a significant interaction of treatment with experimental day seems to indicate a modulation of this effect. No significant effects were observed in any of the evaluations of the SNC experiments, indicative of a stable experimental setup and a reliable and specific treatment effect. Neither significant nor strong correlations were found between the four parameters, indicating that they reflect different effects of Stannum metallicum 30x on the organism treated. CONCLUSION  This quadruple characterization of the biological effects of Stannum metallicum 30x provides an unprecedented opportunity for basic homeopathy research into, among others, the presumed specificity of homeopathic preparations