Laseroptische Untersuchungen zum Abrasionsverhalten moderner elektrischer Zahnbürsten nach robotergestützter Langzeitputzsimulation

Gegenstand der vorliegenden Untersuchung ist es, die Abrasivität verschiedener elektrischer Zahnbürsten in Schmelz und Dentin zu untersuchen und zu analysieren. Menschliche Zähne wurden einer Putzsimulation von fünf Jahren unterzogen. Für die Versuche wurde eine Bürstenhalterung mit einer integrierten stufenlos justierbaren Gewichtsmechanik zur Aufrechterhaltung eines einheitlichen Anpressdrucks konstruiert. Ein computergesteuerter Sechs-Achsen-Industrieroboter stellte eine natürliche Putzbewegung sicher. Vor und nach der Putzsimulation wurden Abformungen der Proben genommen und Gipsrepliken erstellt. Die Zahnoberflächen wurden laseroptisch vermessen und die Veränderungen quantifiziert. Es konnte gezeigt werden, dass die Abrasivität ein multifaktorielles Geschehen ist, bei dem der Einfluss einzelner Faktoren zu erkennen ist. Es ergeben sich deutliche Hinweise auf das Gefahrenpotential einzelner Bürsten/Bürstenkopf-Kombinationen für Zähne mit freiliegendem Dentin

An automated, geometry-based method for hippocampal shape and thickness analysis

The hippocampus is one of the most studied neuroanatomical structures due to its involvement in attention, learning, and memory as well as its atrophy in ageing, neurological, and psychiatric diseases. Hippocampal shape changes, however, are complex and cannot be fully characterized by a single summary metric such as hippocampal volume as determined from MR images. In this work, we propose an automated, geometry-based approach for the unfolding, point-wise correspondence, and local analysis of hippocampal shape features such as thickness and curvature. Starting from an automated segmentation of hippocampal subfields, we create a 3D tetrahedral mesh model as well as a 3D intrinsic coordinate system of the hippocampal body. From this coordinate system, we derive local curvature and thickness estimates as well as a 2D sheet for hippocampal unfolding. We evaluate the performance of our algorithm with a series of experiments to quantify neurodegenerative changes in Mild Cognitive Impairment and Alzheimer's disease dementia. We find that hippocampal thickness estimates detect known differences between clinical groups and can determine the location of these effects on the hippocampal sheet. Further, thickness estimates improve classification of clinical groups and cognitively unimpaired controls when added as an additional predictor. Comparable results are obtained with different datasets and segmentation algorithms. Taken together, we replicate canonical findings on hippocampal volume/shape changes in dementia, extend them by gaining insight into their spatial localization on the hippocampal sheet, and provide additional, complementary information beyond traditional measures. We provide a new set of sensitive processing and analysis tools for the analysis of hippocampal geometry that allows comparisons across studies without relying on image registration or requiring manual intervention

Microstructure and Deformation Response of TRIP-Steel Syntactic Foams to Quasi-Static and Dynamic Compressive Loads

The implementation of hollow S60HS glass microspheres and Fillite 106 cenospheres in a martensitically transformable AISI 304L stainless steel matrix was realized by means of metal injection molding of feedstock with varying fractions of the filler material. The so-called TRIP-steel syntactic foams were studied with respect to their behavior under quasi-static compression and dynamic impact loading. The interplay between matrix material behavior and foam structure was discussed in relation to the findings of micro-structural investigations, electron back scatter diffraction EBSD phase analyses and magnetic measurements. During processing, the cenospheres remained relatively stable retaining their shape while the glass microspheres underwent disintegration associated with the formation of pre-cracked irregular inclusions. Consequently, the AISI 304L/Fillite 106 syntactic foams exhibited a higher compression stress level and energy absorption capability as compared to the S60HS-containing variants. The α′ -martensite kinetic of the steel matrix was significantly influenced by material composition, strain rate and arising deformation temperature. The highest ferromagnetic α′-martensite phase fraction was detected for the AISI 304L/S60HS batches and the lowest for the TRIP-steel bulk material. Quasi-adiabatic sample heating, a gradual decrease in strain rate and an enhanced degree of damage controlled the mechanical deformation response of the studied syntactic foams under dynamic impact loading

Treating internet use disorders via the internet? Results of a two-armed randomized controlled trial

Background and aims: Internet Use Disorders (IUDs) are emerging as a societal challenge. Evidence-based treatment options are scarce. Digital health interventions may be promising to deliver psychological treatment to individuals with IUDs directly in their online setting. The aim of this study was to evaluate the efficacy of a digital health intervention for IUDs compared to a waitlist control group (WCG). Methods: In a two-armed randomized controlled trial, N = 130 individuals showing IUDs (Internet Addiction Test; IAT ≥49) were randomly allocated to the intervention group (IG; n = 65) or WCG (n = 65). The intervention consisted of 7 sessions based on cognitive behavioral therapy. The primary outcome was IUD symptom severity measured via the IAT at post treatment 7 weeks after randomization. Secondary outcomes included IUD symptoms (Compulsive Internet Use Scale; CIUS), quality of life, depressive and anxiety symptoms, and other psychosocial variables associated with IUDs. Results: Participants were on average 28.45 years old (SD = 10.59) and 50% identified as women, 49% as men, and 1% as non-binary. The IG (n = 65) showed significantly less IUD symptom severity (IAT) (d = 0.54, 95% CI 0.19–0.89) and symptoms (d = 0.57, 95% CI 0.22–0.92) than the WCG (n = 65) at post-treatment. Study attrition was 20%. Effects on all other secondary outcomes were not significant. On average, participants completed 67.5% of the intervention. Discussion and Conclusions: A digital health intervention could be a promising first step to reduce IUD symptom severity

Comparison Between Rigid Double Upright and Lace-up Ankle Braces on Ankle Range of Motion, Functional Performance, and User Satisfaction of Brace Characteristics

Background: Braces are often used before returning to activity following ankle sprains and also prophylactically in sports considered the high risk for ankle sprains. The purpose of this study was to compare range of motion (ROM) limitations, functional performance, and satisfaction of rigid double upright and lace-up braces. Subjects: In total, 30 healthy adults \u3e18 years of age (Mean, 22.6 6 2.7 years) without lower extremity injury and involved in regular physical activity participated in this study. Materials/Methods: Ankle ROM assessment and lower extremity performance testing (figure-of-8 hop, side hop, 6-m single-limb crossover, and square hop) was administered under the following 3 conditions: unbraced, rigid braces, and lace-up braces. A questionnaire was completed following the test protocol on brace characteristics and satisfaction. Repeated-measures ANOVA was used to determine the main effects on outcome variables of ROM, hop performance, and satisfaction. Tukey LSD post hoc comparisons were conducted on significant main or interaction effects (P \u3c .05) to determine differences between group by condition means. Results: In total, 30 participants completed the study. The lace-up brace limited plantarflexion and inversion ROM more than the rigid brace. When compared to the unbraced condition, both braced conditions resulted in better performance times, although not statistically significant. Higher satisfaction was reported with the lace-up brace on appearance, fit, prevention, and overall satisfaction. Conclusions and Clinical Relevance: The ankle braces primarily limited ankle plantarflexion and inversion ROM, which are motions related to common reported mechanisms of ankle sprains. The braces did not negatively affect hop performance, and user satisfaction indicated a slight preference for the lace-up brace

Standalone smartphone apps for mental health—a systematic review and meta-analysis

While smartphone usage is ubiquitous, and the app market for smartphone apps targeted at mental health is growing rapidly, the evidence of standalone apps for treating mental health symptoms is still unclear. This meta-analysis investigated the efficacy of standalone smartphone apps for mental health. A comprehensive literature search was conducted in February 2018 on randomized controlled trials investigating the effects of standalone apps for mental health in adults with heightened symptom severity, compared to a control group. A random-effects model was employed. When insufficient comparisons were available, data was presented in a narrative synthesis. Outcomes included assessments of mental health disorder symptom severity specifically targeted at by the app. In total, 5945 records were identified and 165 full-text articles were screened for inclusion by two independent researchers. Nineteen trials with 3681 participants were included in the analysis: depression (k = 6), anxiety (k = 4), substance use (k = 5), self-injurious thoughts and behaviors (k = 4), PTSD (k = 2), and sleep problems (k = 2). Effects on depression (Hedges’ g = 0.33, 95%CI 0.10–0.57, P = 0.005, NNT = 5.43, I2 = 59%) and on smoking behavior (g = 0.39, 95%CI 0.21–0.57, NNT = 4.59, P ≤ 0.001, I2 = 0%) were significant. No significant pooled effects were found for anxiety, suicidal ideation, self-injury, or alcohol use (g = −0.14 to 0.18). Effect sizes for single trials ranged from g = −0.05 to 0.14 for PTSD and g = 0.72 to 0.84 for insomnia. Although some trials showed potential of apps targeting mental health symptoms, using smartphone apps as standalone psychological interventions cannot be recommended based on the current level of evidence

An idea whose time has come

A response to An idea whose time has gone by Gregory A Petsko, Genome Biology 2007, 8:107

Case report for an internet- and mobile-based intervention for internet use disorder

Background and aimsInternet use disorder (IUD), characterized as the inability to control one’s internet use, is associated with reduced quality of life and mental health comorbidities such as depression, substance abuse, or anxiety. Evidence-based treatment options are scarce due to the novelty of the diagnosis. Internet- and mobile-based interventions (IMI) may be an effective means to deliver psychological treatment to individuals with IUD as they address affected individuals in their online setting. This study presents a newly developed IMI for IUD disclosing treatment satisfaction and preliminary effects by exemplifying with a case report.MethodsThe case of a female participant with IUD, characterized by an excessive use of social media, is analyzed. The case report follows the CARE guidelines and presents qualitative and quantitative outcomes regarding potential symptom reduction measured by the Internet Addiction Test (IAT) and Compulsive Internet Use Scale (CIUS), treatment satisfaction measured by the Client Satisfaction Questionnaire (CSQ) and feasibility by analyzing participant’s written feedback during treatment.ResultsThe case report shows that internet- and mobile-based interventions may be feasible in supporting an individual in reducing symptoms of IUD as well as depressive symptoms, anxiety and procrastination behavior. Treatment satisfaction was reported as good.Discussion and conclusionsThis case report illustrates that IMIs can have the potential to be an easily accessible and possibly effective treatment option for IUD. Case studies on IMIs may provide insights into important mechanisms for symptom change. Further studies are needed to expand our understanding of this diverse disorder to provide adequate treatment

Categorizing Challenges And Potentials Of Digital Industrial Platforms

In complex supply chains, digital platforms play an emerging role as an infrastructure for network-based collaboration of industrial companies to stay competitive. Participating in a platform business offers a range of new potentials, while also introducing new challenges. Awareness of these is crucial for both users and providers to make informed decisions. Thus, this paper provides an overview about typical challenges and potentials from the perspective of potential or actual digital industrial platform users to support decision making processes. Against that backdrop, a descriptive study is conducted in the field of industrial service platforms motivated from two sides. Expert workshops are held to examine the practical opportunities and hurdles. The findings are then compared to those identified in literature. Then, the results are organized into a category system that highlights the key challenges and potentials for users as well as providers of digital industrial platforms