The Tempo Indications of Mozart. By Jean-Pierre Marty

Bauman discusses and reviews Marty\u27s 1988 book

Reasons to rethink the use of audio and video lectures in online courses

Recent technological developments allow any instructor to create audio and video lectures for the use in online classes. However, it is questionable if it is worth the time and effort that faculty put into preparing those lectures. This paper presents thirteen factors that should be considered before preparing and using audio and video lectures in online classes. In addition, recommendations for when and how to use lectures in online classes are presented. DOI: 10.18870/hlrc.v3i4.16

Neuron numbers increase in the human amygdala from birth to adulthood, but not in autism.

Remarkably little is known about the postnatal cellular development of the human amygdala. It plays a central role in mediating emotional behavior and has an unusually protracted development well into adulthood, increasing in size by 40% from youth to adulthood. Variation from this typical neurodevelopmental trajectory could have profound implications on normal emotional development. We report the results of a stereological analysis of the number of neurons in amygdala nuclei of 52 human brains ranging from 2 to 48 years of age [24 neurotypical and 28 autism spectrum disorder (ASD)]. In neurotypical development, the number of mature neurons in the basal and accessory basal nuclei increases from childhood to adulthood, coinciding with a decrease of immature neurons within the paralaminar nucleus. Individuals with ASD, in contrast, show an initial excess of amygdala neurons during childhood, followed by a reduction in adulthood across nuclei. We propose that there is a long-term contribution of mature neurons from the paralaminar nucleus to other nuclei of the neurotypical human amygdala and that this growth trajectory may be altered in ASD, potentially underlying the volumetric changes detected in ASD and other neurodevelopmental or neuropsychiatric disorders

1970 Problems in Legal Education

Five problems in legal education, much discussed recently, were posed by the Editors of this Review to a number of administrative figures in the law school world. These questions were and are frankly difficult and controversial, but their answers are important to our system of legal education and to our society. Capsule answers given by these concerned legal education administrators are believed to be interesting and significant. Each is a personal rather than a representative opinion. Brief answers such as these, of course, are not expected to be, nor do they pretend to be, complete or profound. Their purpose is to indicate succinctly the approach of some law school administrative opinion makers to difficult policy problems of legal education

1970 Problems in Legal Education

Five problems in legal education, much discussed recently, were posed by the Editors of this Review to a number of administrative figures in the law school world. These questions were and are frankly difficult and controversial, but their answers are important to our system of legal education and to our society. Capsule answers given by these concerned legal education administrators are believed to be interesting and significant. Each is a personal rather than a representative opinion. Brief answers such as these, of course, are not expected to be, nor do they pretend to be, complete or profound. Their purpose is to indicate succinctly the approach of some law school administrative opinion makers to difficult policy problems of legal education

Selenoprotein W : Purification and characterization of its interaction with calmodulin

Selenoprotein W (SeW) is a protein whose function is unknown, but potentially plays a vital role in calcium metabolism, as an indirect link has been established with white muscle disease (WMD). White muscle disease occurs in selenium deficient animals, and is characterized by the precipitation of calcium in muscle, leading to paralysis and death. This thesis details efforts to purify and characterize SeW. This includes investigations into calcium binding, phosphorylation, and interaction with calmodulin (CaM). The main portion of the thesis consists of two manuscripts, the first dealing with the purification and production of SeW with and without bound glutathione, the second manuscript addresses SeW-CaM interaction. Supplemental material as well as the results of calcium binding studies and phosphorylation studies, are located in the appendices. Abstracts from the two manuscripts, follow. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) and electrospray ionization mass spectrometry (ESI MS) analysis of a 6x Histagged recombinant form of rat mutant selenoprotein W (RMSW) reveals that aerobic growth conditions primarily produce a form of RMSW without bound glutathione (10305 Da) whereas anaerobic conditions produce a glutathionebound (305 Da) form (10610 Da). Purification of RMSW was achieved with a procedure employing acetone precipitation and DEAE-cellulose chromatography, in addition to Ni-NTA agarose chromatography. Additional steps, including polyvalent metal ion binding (PMIB) resin chromatography and CM-cellulose chromatography, were necessary after elution from the Ni-NTA agarose column, in order to maintain solubility of the purified protein. Experiments applying partially purified extracts containing either rat mutant selenoprotein W (RMSW, Selenocysteine → cysteine, His₆ tag) or native rabbit selenoprotein W (SeW) to a calmodulin-sepharose column revealed that SeW interacts with calmodulin in a calcium dependent manner. Fluorescence polarization experiments with fluorescently labeled calmodulin and purified RMSW with and without bound glutathione revealed a Kd of 1.3 ± .1 X 10⁻⁶M for both forms of the protein. Competitive binding assays with myosin light chain kinase (MLCK) and fluorescently labeled calmodulin were performed for three peptide sequences (Nterm: GYKPKYLQLKEKL-NH2:, Rmid: VTVAGKLVHSKKRG-NH2, and Cterm: KFRKLVTAIKAALAQ-NH₂) which occur within proposed calmodulin binding sequences in rat SeW. The concentration of each peptide at which half-displacement of MLCK was achieved ([P]₅₀) was determined to be 5.5 nM, 6.3 nM, and 1.60 nM respectively. These values were used to estimate the dissociation constant of the peptide-calmodulin complex (Kr). The K values for Nterm and Rmid were determined to be < I nM, whereas the K for Cterm was determined to be 18 nM. In addition, during a preliminary test for specifity, a 100 fold excess of beef cardiac troponin C, a protein related to calmodulin, was unable to outcompete calmodulin for RMSW

Who is my neighbour? Understanding indifference as a vice

Indifference is often described as a vice. Yet who is indifferent; to what; and in what way is poorly understood, and frequently subject to controversy and confusion. This paper proposes a framework for the interpretation and analysis of ethically problematic forms of indifference in terms of how different states of indifference can be either more or less dynamic, or more or less sensitive to the nature and state of their object

Evaluation of a novel point-of-care cryptococcal antigen test on serum, plasma, and urine from patients with HIV-associated cryptococcal meningitis.

BACKGROUND: Many deaths from cryptococcal meningitis (CM) may be preventable through early diagnosis and treatment. An inexpensive point-of-care (POC) assay for use with urine or a drop of blood would facilitate early diagnosis of cryptococcal infection in resource-limited settings. We compared cryptococcal antigen (CRAG) concentrations in plasma, serum, and urine from patients with CM, using an antigen-capture assay for glucuronoxylomannan (GXM) and a novel POC dipstick test. METHODS: GXM concentrations were determined in paired serum, plasma, and urine from 62 patients with active or recent CM, using a quantitative sandwich enzyme-linked immunosorbent assay (ELISA). A dipstick lateral-flow assay developed using the same monoclonal antibodies for the sandwich ELISA was tested in parallel. Correlation coefficients were calculated using Spearman rank test. RESULTS: All patients had detectable GXM in serum, plasma, and urine using the quantitative ELISA. Comparison of paired serum and plasma showed identical results. There were strong correlations between GXM levels in serum/urine (r(s) = 0.86; P < .001) and plasma/urine (r(s) = 0.85; P < .001). Levels of GXM were 22-fold lower in urine than in serum/plasma. The dipstick test was positive in serum, plasma, and urine in 61 of 62 patients. Dipstick titers correlated strongly with ELISA. Correlations between the methods were 0.93 (P < .001) for serum, 0.94 (P < .001) for plasma, and 0.94 (P < .001) for urine. CONCLUSIONS: This novel dipstick test has the potential to markedly improve early diagnosis of CM in many settings, enabling testing of urine in patients presenting to health care facilities in which lumbar puncture, or even blood sampling, is not feasible

The Ursinus Weekly, May 26, 1958

MSGA plans tentative 1958 customs program • Junior advisory committee named • Big-little sister committee asks for applicants • Many U.C. seniors accepted at post-grad schools • Last Y commission meetings are held to plan for next Fall semester • R.G. Dunlop to speak at June 9th graduation • Ursinus\u27 Rowe gets scholarship • Editorial: Customs • Letters to the editor • Are fraternities? • Cindermen whip Mules, Dutchmen; Take three meets • Netmen finish season; Defeat Elizabethtown, 6-3 • Bears win 10th game; Lose final tilt by 8-1 • Girls\u27 tennis team beats Penn; Finish undefeated • Beta Sigma Lambda beats Sigma Rho Lambda in 9th • New Library accessionshttps://digitalcommons.ursinus.edu/weekly/1409/thumbnail.jp

Strangers of the north: South Asians, cricket and the culture of ‘Yorkshireness’

As a county, Yorkshire is what Wagg and Russell refer to as a ‘cultural region’: an imagined space, where culture is constructed, refined and articulated by a set of discursive relationships between local populations and a whole range of cultural forms. In this context however, culture is conceived as something which belongs to, and is only accessible by, certain groups of people. Our focus in this article is on the culture of Yorkshire cricket. Historically, Yorkshire cricket has been linked with white male privilege and some studies have shown that people within Yorkshire take a degree of pride in this. Consequently, the county and its cricket club have faced frequent accusations from minority ethnic communities of inveterate and institutionalised racism. Drawing upon Bauman’s notion of ‘liquid modernity’, we argue that the processes of deregulation and individualisation championed by New Right policies have led to a divorce between power and politics, a corner stone of the old solid modern world. This in turn has led to an erosion of the state, causing individuals to navigate turbulent life projects which are consistently haunted by the spectres of fear and insecurity. Such an environment has caused cricket to be pushed further behind gated social spaces, in an attempt to maintain a semblance of ‘community’