FEM/SINDA: Combining the strengths of NASTRAN, SINDA, I-DEAS, and PATRAN for thermal and structural analysis

This paper describes the interface/integration between FEM/SINDA, a general purpose geometry driven thermal analysis code, and the FEM software: I-DEAS, PATRAN, and NASTRAN. FEM/SINDA brings together the advantages of the finite element method to model arbitrary geometry and anisotropic materials and SINDA's finite difference capability to model thermal properties, loads, and boundary conditions that vary with time or temperature. I-DEAS and PATRAN thermal entities are directly supported since FEM/SINDA uses the nodes of the FEM model as the point at which the temperature is determined. Output from FEM/SINDA (as well as the FEM/SINDA input deck) can be used directly by NASTRAN for structural analysis

POSSIBLE ASSOCIATION BETWEEN BENIGN HEPATOMAS AND ORAL CONTRACEPTIVES

Seven cases of hepatic adenoma are presented, all in women on oral contraceptives. It seems likely that oral contraceptives play a role in the development of this lesion. Although benign, the tumour may cause serious or fatal haemorrhage. Hepatic arteriography allows prompt and precise diagnosis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33799/1/0000054.pd

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells

The roles of CYP lipid-metabolizing pathways in endothelial cells are poorly understood. Human endothelial cells expressed CYP2J2 and soluble epoxide hydrolase (sEH) mRNA and protein. The TLR-4 agonist LPS (1 μg/ml; 24 h) induced CYP2J2 but not sEH mRNA and protein. LC–MS/MS analysis of the stable commonly used human endothelial cell line EA.Hy926 showed active epoxygenase and epoxide hydrolase activity: with arachidonic acid (stable epoxide products 5,6-DHET, and 14,15-DHET), linoleic acid (9,10-EPOME and 12,13-EPOME and their stable epoxide hydrolase products 9,10-DHOME and 12,13-DHOME), docosahexaenoic acid (stable epoxide hydrolase product 19,20-DiHDPA) and eicosapentaenoic acid (stable epoxide hydrolase product 17,18-DHET) being formed. Inhibition of epoxygenases using either SKF525A or MS-PPOH induced TNFα release, but did not affect LPS, IL-1β, or phorbol-12-myristate-13-acetate (PMA)-induced TNFα release. In contrast, inhibition of soluble epoxide hydrolase by AUDA or TPPU inhibited basal, LPS, IL-1β and PMA induced TNFα release, and LPS-induced NFκB p65 nuclear translocation. In conclusion, human endothelial cells contain a TLR-4 regulated epoxygenase CYP2J2 and metabolize linoleic acid > eicosapentaenoic acid > arachidonic acid > docosahexaenoic acid to products with anti-inflammatory activity

Zuchtmaterialerstellung durch Erschließung und Selektion bisher nicht erfasster Anbau - und Verwertungsmerkmale in bisher nicht genutzten genetischen Ressourcen der Schmalblättrigen Lupine (Lupinus angustifolius L.)

An züchterisch bisher nicht genutzten, alkaloidreichen Genbankakzessionen der Schmalblättrigen Lupine des Vavilov Institutes der Pflanzenindustrie, St. Petersburg, wurden neben agronomischen Merkmalen die Merkmalskomplexe Rhizodeposition und Methioningehalt evaluiert. Für diese Merkmale wird im aktuellen, bitterstoffarmen Zuchtmaterial keine ausreichende, züchterisch nutzbare Variabilität mehr gefunden. Für den Merkmalskomplex Rhizodeposite konnten mittels Pyrolyse-Feldionisation Massenspektrometrie (Py-FIMS) lyophilisierter Rhizodeposite sowohl Genotypen mit erhöhter mikrobieller Abbaubarkeit zur Förderung der Rhizosphärenaktivität als auch mit erhöhten Konzentrationen antimikrobieller Komponenten identifiziert werden. Für den Merkmalskomplex Methioningehalt konnten die Schlüsselgene des Methioninstoffwechsels identifiziert und sequenziert werden. Für zwei der vier Schlüsselgene liegen allerdings so viele Kopien im Genom vor, dass sie züchterisch nur sehr schwer nutzbar sind. Es konnten mittels Transkript-Profiling keine hoch aktiven Allele der Schlüsselgene der Methioninbiosynthese identifiziert werden. Demgegenüber konnten in jungen Samen jedoch hochaktive Allele von Genen gefunden werden, die für methioninreiche Speicherproteine codieren. Für die folgenden agronomisch wichtigen Merkmale konnte im untersuchten Schmalblättrigen Lupinenmaterial eine erhebliche Variabilität gefunden werden, die weit über die in Blauen Süßlupinen noch gefundene Streuung hinaus geht: Kornertrag, Kornform, Grünmasseleistung, Rohproteingehalt, Boden-pH-Toleranz, sichere und synchrone Abreife der Hülsen, synchrone Laub- und Strohreife, Standfestigkeit, Platzfestigkeit, Resistenz gegenüber Anthraknose und Verticillium, Kornform. Die gefundene Variabilität gilt es jetzt züchterisch zu nutzen und die positiven Merkmalseigenschaften in neuen Sorten zu kombinieren

Formations of European modernity: a historical and political sociology of Europe

This book seeks to provide an interpretation of the idea of Europe through an analysis of the course of European history. It aims to discover the structure of qualitative shifts in the relation between state, society and individual, how they occurred and what were their consequences for the formation of social and culture structures for European history. The book makes a major contribution to the debate on the idea of Europe and offers an interdisciplinary approach drawing especially from history, sociology and political theory, but also from geography and anthropology. The theoretical objective of is to make sense of the course of European history through an account of the formation of a European cultural model that emerges out of the legacies of the inter-civilizational background. It considers how in relation to this cultural model a societal structure takes shape. The tension between both gives form to Europe’s path to modernity and defines the specificity of its heritage. The structuring process that has shaped Europe made possible a model of modernity that has placed a strong emphasis on the values of social justice and solidarity. These values have been reflectively appropriated in different periods to produce different interpretations, societal outcomes and a multiplicity of projects of modernity

FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0

The aim of this guideline is to provide a minimum standard for the acquisition and interpretation of PET and PET/CT scans with [18F]-fluorodeoxyglucose (FDG). This guideline will therefore address general information about [18F]-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) and is provided to help the physician and physicist to assist to carrying out, interpret, and document quantitative FDG PET/CT examinations, but will concentrate on the optimisation of diagnostic quality and quantitative information

Contrasting perspectives of strategy making: applications in 'Hyper' environments

We revisit the original meaning of turbulence in the socioecological tradition of organization studies and outline a perspective on strategy making grounded in that tradition. This entails a contrast of the socioecological perspective with the more well-known neoclassical perspective on strategy, based on their core decision premises and their different understandings of environmental turbulence. We argue that while some mainstream strategy approaches have taken important strides toward addressing advanced turbulence, many others remain tethered to the neoclassical origins of the strategy discipline and are insufficiently responsive to the new landscape of strategy that now characterizes many industries. This new landscape is construed as the ‘hyper environment’, in which positive feedback processes and emergent field effects produce high volatility. We use two case illustrations from the US healthcare sector to examine how neoclassical and socioecological perspectives contribute to strategizing in hyper environments. Implications for strategic management theory and practice flow from this analysis

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure