Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis

Purpose. To report favorable outcome of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with cerebral vasculitis after treatment with immunosuppressive therapy by mitoxantrone. Design. Single case report. Method. A 22-year-old man presented with acute isolated bilateral loss of vision revealing APMPPE. Corticosteroid therapy was initiated and visual acuity gradually improved. Seventeen days later, visual function deteriorated again, associated with flu-like syndrome and severe headaches. A relapse of APMPPE was diagnosed, complicated with lymphocytic meningitis and cerebral ischemia. Intravenous therapy with mitoxantrone was performed in combination with methylprednisolone. Results. Headaches disappeared in a few days whereas visual acuity gradually improved and stabilized at 20/40 in the right eye and 20/32 in the left eye. No adverse event was observed. Clinical improvement was confirmed by magnetic resonance imaging. Conclusion. Cerebral vasculitis is the most severe complication of the extraocular manifestations of APMPEE. This diagnosis should be evoked when severe headaches or behavior disorder are associated with APMPEE

Dompter le big data

Énorme, puissant, inquiétant même, le big data s’impose sur les écrans d’ordinateur, s’immisce dans la gestion de l’entreprise et changera peut- être même sa façon de penser. S’il recèle un formidable potentiel de connaissance et de développement, il reste à apprivoiser pour donner le meilleur de lui-même et ne pas outrepasser son rôle de ressource informatique

Intracardiac Vortex Dynamics by High-Frame-Rate Doppler Vortography—<italic>In Vivo</italic> Comparison With Vector Flow Mapping and 4-D Flow MRI

International audienc

Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach

AIM: To characterize the effect of donor and recipient CYP3A4, CYP3A5 and ABCB1 genotypes as well as relevant patient characteristics on tacrolimus pharmacokinetics in pediatric liver transplantation. PATIENTS & METHODS: Data from 114 pediatric liver transplant recipients were retrospectively collected during the first 3 months following transplantation. Population pharmacokinetic analysis was performed using nonlinear mixed effects modeling, including characterization of influential covariates. RESULTS: A two-compartment model with first order elimination best fitted the data. Estimates of apparent volume of the central compartment, intestinal clearance, hepatic clearance and intercompartmental clearance were 79 l, 0.01 l/h, 10.9 l/h and 105 l/h, respectively. Time post-transplantation, recipient age, donor CYP3A5 and CYP3A4 genotypes and fluconazole administration significantly influenced tacrolimus apparent clearance while bodyweight influenced volume of distribution. CONCLUSION: The proposed model displayed acceptable fitting performances and enabled identification of statistically significant and clinically relevant covariates on tacrolimus pharmacokinetics in the early pediatric post liver transplantation period

Développement de capteurs en optique intégrée pour le proche et moyen infra-rouge

International audienceDes dispositifs en optique intégrée à base de matériaux spécifiques que sont les polymères, les matériaux poreux (silicium poreux et silice poreuse) et les verres de chalcogénures sont réalisés pour démontrer des applications de capteurs dans les domaines sociétaux de la santé et de l'environnement. Ces circuits intégrés sont utilisés dans des intervalles de longueurs d'onde allant du proche infra-rouge jusqu'au moyen infra-rouge

Régions en déclin : un nouveau paradigme démographique et territorial

International audiencePrésentation de fin de projet réalisée au Parlement Europée