Projet collectif de recherche : cartographie de l'espace parisien

Rapport final d'activité du PCR 2005-200

Epidemiology for primary brain tumors: a nationwide population-based study

International audiencePrimary central nervous system tumors (PCNST) are rare tumors responsible for high mortality and morbidity. Their epidemiology is poorly known, and clinical data are scarcely analyzed at a national level. In this study, we aimed at providing descriptive epidemiological data and incidence rates for all histological subtypes of PCNST according to the WHO classification. We conducted a nationwide population-based study of all newly diagnosed and histologically confirmed PCNST in France, between 2006 and 2011. A total of 57,816 patients were included: male 46.4%, median age at diagnosis 56 years old (range 0-99). For all newly diagnosed PCNST with histological confirmation the crude incidence rate was 15.5/105 per 100,000 person-years. To enable international comparisons, standardized rates were calculated: 14.1/105 (population of reference: USA), 14.5/105 (population of reference: Europe), and 12.0/105 (population of reference: world). 23.4% of samples were cryopreserved. Resection was performed in 79.1% of cases. Results are detailed (incidence rate, sex ratio, median age at diagnosis, number of cryopreserved samples, and type of surgery) for each of the 143 histological subtypes of PCNST, including all rare tumors. For example, incidence rates (population of reference: USA) were 0.018/105 for anaplastic gangliogliomas, 0.054/105 for malignant meningiomas, and 0.036/105 for hemangiopericytomas. Our study is the first to describe incidence rates and epidemiological data for all histological subtypes of PCNST, including rare tumors, at a national level. Its methodology ensures the exhaustiveness of the data collection for histologically-proven cases. Histological population-based studies have many perspectives in the field of clinical epidemiology and research

Erratum to: Epidemiology for primary brain tumors: a nationwide population-based study

International audienc

An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008–2013

International audienc

Association of patterns of care, prognostic factors, and use of radiotherapy–temozolomide therapy with survival in patients with newly diagnosed glioblastoma: a French national population-based study

International audienceBACKGROUND:Glioblastoma is the most frequent primary malignant brain tumor. In daily practice and at whole country level, oncological care management for glioblastoma patients is not completely known.OBJECTIVES:To describe oncological patterns of care, prognostic factors, and survival for all patients in France with newly-diagnosed and histologically confirmed glioblastoma, and evaluate the impact of extended temozolomide use at the population level.METHODS:Nationwide population-based cohort study including all patients with newly-diagnosed and histologically confirmed glioblastoma in France in 2008 and followed until 2015.RESULTS:Data from 2053 glioblastoma patients were analyzed (male/female ratio 1.5, median age 64 years). Median overall survival (OS) was 11.2 [95% confidence interval (CI) 10.7-11.9] months. The first-line therapy and corresponding median survival (MS, in months) were: 13% did not receive any oncological treatment (biopsy only) (MS = 1.8, 95% CI 1.6-2.1), 27% received treatment without the combination of radiotherapy (RT)-temozolomide (MS = 5.9, 95% CI 5.5-6.6), 60% received treatment including the initiation of the concomitant phase of RT-temozolomide (MS = 16.4, 95% CI 15.2-17.4) whom 44% of patients initiated the temozolomide adjuvant phase (MS = 18.9, 95% CI 18.0-19.8). Only 22% patients received 6 cycles or more of adjuvant temozolomide (MS = 25.5, 95% CI 24.0-28.3). The multivariate analysis showed that the risk of mortality was significantly higher for the non-progressive patients who stopped at 6 cycles (standard protocol) than those who continued the treatment, hazard ratio = 1.5 (95% CI 1.2-1.9).CONCLUSION:In non-progressive patients, prolonging the adjuvant temozolomide beyond 6 cycles may improve OS

La ferme du Colombier à Varennes-sur-Seine (XVIe-XVIIIe siècles)

National audienceThe Colombier farm was located on the right bank of the Seine River, not far from its confluence with the Yonne River, in the middle of the swamp. It was created during the 16th century and disappeared during the 18th century. Discovered and studied by Inrap from 2004 to 2007, this modern rural establishment benefited from its excavation over a large surface (4 ha) and its good preservation conditions, especially of organic remains. The data recovered are the object of a multidisciplinary archaeological, paleoenvironmental, historical and archaeo-geographic study. By replacing the archaeological data in a historical and sociological framework, the authors reconstruct, beyond a “fortified house”, the totality and economy of a site, an environment, a territory and the social practices of its inhabitants. This research traces the construction and rise of small rural elites and illustrates one of the little know aspects of the mutations of the rural world between the end of the Medieval period and the Modern period.This approach is original and exemplary of current developments in “modern” archaeology.Sur la rive gauche de la Seine, non loin de sa confluence avec l’Yonne, au milieu des marais, s’étendait jadis la ferme dite du Colombier, créée au XVIe siècle, et disparue au XVIIIe siècle. Découvert et étudié par l’Inrap entre 2004 et 2007, cet établissement rural moderne a bénéficié d’une fouille de grande surface (4 ha) et de conditions de conservation propices, s’agissant notamment des restes organiques. L’ensemble des données recueillies a fait l’objet d’une exploitation interdisciplinaire archéologique, paléoenvironnementale, historique et archéogéographique. En replaçant les données archéologiques dans un propos historique et sociologique, les auteurs restituent, plus qu’une « maison forte », la globalité et l’économie d’un site, d’un milieu, d’un territoire, ainsi que les pratiques sociales de ses habitants. Cette analyse permet en outre de retracer la construction et l’ascension de petites élites rurales, un des aspects peu connus des mutations du monde rural entre la fin de l’époque médiévale et celle de l’Époque moderne. Une approche originale et emblématique des développements actuels de l’« archéologie moderne »

Clinical epidemiology for childhood primary central nervous system tumors.

International audienceThis work was conducted by the French Brain Tumor Data Bank (FBTDB) and aims to prospectively record all primary central nervous system tumors (PCNST), in France, for which histological diagnosis is available. Results concerning children are presented. This study analyzes the childhood cases (0-19 years) of newly diagnosed and histologically confirmed PCNST (during the years 2004-2006) which have been recorded by the FBTDB. All French neuropathology and neurosurgery departments participated in this program. Neurosurgeons and neuropathologists completed a data file containing socio-demographic, clinical, radiologic and anatomopathologic information. The Tumor Registry from Herault was authorized to compile the data files with personal identifiers. About 1,017 cases (533 boys and 484 girls) of newly diagnosed childhood PCNST have been recorded (gliomas: 52%, all other neuroepithelial tumors: 31%, craniopharyngioma: 5%, germ cell tumors, meningioma and neurinoma: approximately 3% each, all histological subtypes have been detailed). Tumor resections were performed in 83.3%, and biopsies in 16.7%. The distributions by histology, cryopreservation of the samples, age, sex, tumor site and surgery have been detailed. To our knowledge, this work is the first databank in Europe dedicated to PCNST that includes the collection of clinical, radiological and histological data (including cryopreservation of the specimen). The long term goals of the FBTDB are to create a national registry and a network to perform epidemiological studies, to implement clinical and basic research protocols, and to evaluate and harmonize the healthcare of children and adult patients affected by PCNST