Cost-effectiveness of infant vaccination with RIX4414 (Rotarix) in the UK.

This study estimated the cost-effectiveness of infant rotavirus vaccination with Rotarix in the UK, taking into account community rotavirus infections that do not present to the healthcare system. A Markov model compared the costs and outcomes of vaccination versus no vaccination in a hypothetical birth cohort of children followed over a lifetime, from a societal perspective and the perspective of the National Health Service (NHS). The model estimated costs and quality-adjusted life-years (QALYs) lost due to death, hospitalisation, general practitioner (GP) consultation, emergency attendance and calls to NHS Direct for rotavirus infection in children aged <5 years. Time lost from work and parents' travel costs were also included in the societal perspective. The base case cost-effectiveness ratio for vaccination compared with no vaccination was pound23,298/QALY from the NHS perspective and pound11,459 from the societal perspective. In sensitivity analysis, the most important parameters were hospitalisation cost and number of GP consultations. Addition of Rotarix to the paediatric vaccination schedule would be a cost-effective policy option in the UK at the threshold range ( pound20,000-30,000/QALY) currently adopted by the National Institute for Health and Clinical Excellence

The properties of \bar{K} in the nuclear medium

The self-energy of the K^- meson in nuclear matter is calculated in a self-consistent microscopic approach, using a \bar{K}N interaction obtained from the lowest-order meson-baryon chiral Lagrangian. The effective \bar{K}N interaction in the medium is derived by solving the coupled-channel Bethe-Salpeter equation including Pauli blocking on the nucleons, mean-field binding potentials for the baryons and the self-energy of the \pi and \bar{K} mesons. The incorporation of the self-consistent {\bar K} self-energy in the description, in addition to the Pauli blocking effects, yields a weaker attractive in-medium {\bar K}N interaction and a \Lambda(1405) which dissolves faster with increasing matter density, as a result of the {\bar K} spectral function being spread out over a wide range of energies. These effects are further magnified when the intermediate pions are dressed.Comment: 23 pages, 7 figures, ReVTe

Photoproduction of the Lambda(1405) on the proton and nuclei

We study the gamma p ---> K^+ Lambda(1405) reaction at energies close to threshold using a chiral unitary model where the resonance is generated dynamically from K^-p interaction with other channels constructed from the octets of baryons and mesons. Predictions are made for cross sections into several channels and it is shown that the detection of the K^+ is sufficient to determine the shape and strength of the Lambda(1405) resonance. The determination of the resonance properties in nuclei requires instead the detection of the resonance decay channels. Pauli blocking effects on the resonance, which have been shown to be very important for the resonance at rest in the nucleus, are irrelevant here where the resonance is produced with a large momentum. The nuclear modifications here would thus offer information on the resonance and K^- nucleus dynamics complementary to the one offered so far by K^- atoms.Comment: 9 pages, 4 postscripts figure

Kˉ\bar K nuclear bound states in a dynamical model

A comprehensive data base of K- atom level shifts and widths is re-analyzed in order to study the density dependence of the Kbar-nuclear optical potential. Significant departure from a t*rho form is found only for nuclear densities about and less than 20% of nuclear-matter density, and extrapolation to nuclear-matter density yields an attractive potential, about 170 MeV deep. Partial restoration of chiral symmetry compatible with pionic atoms and low-energy pion-nuclear data plays no role at the relevant low-density regime, but this effect is not ruled out at high densities. Kbar-nuclear bound states are generated across the periodic table self consistently, using a relativistic mean-field model Lagrangian which couples the Kbar to the scalar and vector meson fields mediating the nuclear interactions. The reduced phase space available for Kbar absorption from these bound states is taken into account by adding an energy-dependent imaginary term which underlies the corresponding Kbar-nuclear level widths, with a strength required by fits to the atomic data. Substantial polarization of the core nucleus is found for light nuclei, and the binding energies and widths calculated in this dynamical model differ appreciably from those calculated for a static nucleus. A wide range of binding energies is spanned by varying the Kbar couplings to the meson fields. Our calculations provide a lower limit of Gamma(Kbar) = 50 +/- 10 MeV on the width of nuclear bound states for Kbar binding energy in the range B(Kbar) = 100 - 200 MeV. Comments are made on the interpretation of the FINUDA experiment at DAFNE, Frascati, which claimed evidence for deeply bound (K- pp) states in light nuclei.Comment: Added 2 figures and discussion. Version accepted for publication in NP

Psychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies.

In this narrative overview of the evidence linking psychosocial factors with future suicide risk, we collected results from published reports of prospective studies with verified suicide events (mortality or, less commonly, hospitalisation) alongside analyses of new data. There is abundant evidence indicating that low socioeconomic position, irrespective of the economic status of the country in question, is associated with an increased risk of suicide, including the suggestion that the recent global economic recession has been responsible for an increase in suicide deaths and, by proxy, attempts. Social isolation, low scores on tests of intelligence, serious mental illness (both particularly strongly), chronic psychological distress, and lower physical stature (a marker of childhood exposures) were also consistently related to elevated suicide rates. Although there is some circumstantial evidence for psychosocial stress, personality disposition, and early-life characteristics such as bullying being risk indices for suicide, the general paucity of studies means it is not currently possible to draw clear conclusions about their role. Most suicide intervention strategies have traditionally not explored the modification of psychosocial factors, partly because evidence linking psychosocial factors with suicide risk is, as shown herein, largely in its infancy, or, where is does exist, for instance for intelligence and personality disposition, the characteristics in question do not appear to be easily malleable

Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study

ObjectiveWhile several studies have reported on the relation of diabetes status with pancreatic cancer risk, the predictive value of this disorder for other malignancies is unclear. Methods: The Whitehall study, a 25year follow-up for mortality experience of 18,006 men with data on post-challenge blood glucose and self-reported diabetes, allowed us to address these issues. Results: There were 2158 cancer deaths at follow-up. Of the 15 cancer outcomes, diabetes status was positively associated with mortality from carcinoma of the pancreas and liver, while the relationship with lung cancer was inverse, after controlling for a range of potential covariates and mediators which included obesity and socioeconomic position. After excluding deaths occurring in the first 10years of follow-up to examine the effect of reverse causality, the magnitude of the relationships for carcinoma of the pancreas and lung was little altered, while for liver cancer it was markedly attenuated. Conclusions: In the present study, diabetes status was related to pancreatic, liver, and lung cancer risk. Cohorts with serially collected data on blood glucose and covariates are required to further examine this area

Partial wave analysiss of pbar-p -> piminus-piplus, pizero-pizero, eta-eta and eta-etaprime

A partial wave analysis is presented of Crystal Barrel data on pbar-p -> pizero-pizero, eta-eta and eta-etaprime from 600 to 1940 MeV/c, combined with earlier data on d\sigma /d\Omega and P for pbar-p->piminus-piplus. The following s-channel I=0 resonances are identified: (i) J^{PC} = 5^{--} with mass and width (M,\Gamma) at (2295+-30,235^{+65}_{-40}) MeV, (ii) J^{PC} = 4^{++} at (2020+-12, 170+-15) MeV and (2300+-25, 270+-50) MeV, (iii) 3D3 JPC = 3^{--} at (1960+-15, 150+-25) MeV and (2210+-4$, 360+-55) MeV, and a 3G3 state at (2300 ^{+50}_{-80}, 340+-150) MeV, (iv) JPC = 2^{++} at (1910+-30, 260+-40) MeV, (2020+-30, 275+-35) MeV, (2230+-30, 245+-45) MeV, and (2300+-35, 290+-50) MeV, (v) JPC = 1^{--} at (2005+-40, 275+-75) MeV, and (2165+-40, 160 ^{+140}_{-70}) MeV, and (vi) JPC = 0^{++} at (2005+-30, 305+-50) MeV, (2105+-15, 200+-25) MeV, and (2320+-30, 175+-45) MeV. In addition, there is a less well defined 6^{++} resonance at 2485+-40 MeV, with Gamma = 410+-90 MeV. For every JP, almost all these resonances lie on well defined linear trajectories of mass squared v. excitation number. The slope is 1.10+-0.03 Gev^2 per excitation. The f_0(2105) has strong coupling to eta-\eta, but much weaker coupling to pizero-pizero. Its flavour mixing angle between q-qbar and s-sbar is (59-71.6)deg, i.e. dominant decays to s-sbar. Such decays and its strong production in pbar-p interactions strongly suggest exotic character.Comment: Makes available the combined fit to Crystal Barrel data on pbar-p -> 2-body final states. 29 pages, 11 figures. Typo corrected in version

Households’ responses to spousal job loss: ‘all change’ or ‘carry on as usual’?

Economic theory suggests that when a primary earner within a couple loses their job, one potential response is for the secondary earner to seek additional paid work to bolster their household finances. The empirical quantitative evidence regarding any such ‘added worker effect’ is mixed, and, to investigate why this might be, the article explores processes behind couples’ responses to job loss. Drawing on in-depth qualitative interviews conducted with a purposive sample selected from the Understanding Society Innovation Panel, the analysis examines: (a) anticipation surrounding job loss and job search responses; (b) the extent to which couples adopt long- or short-term labour market perspectives; and (c) whether couples seek to preserve their established division of paid and unpaid labour or re-configure their joint labour supply. Findings indicate that the use of additional spousal labour is only one response among many alternatives and it is typically invoked in cases of serious financial hardship. </jats:p

Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder: A Preliminary Report

Objective: Structural and functional abnormalities have been noted in the prefrontal cortex of individuals with neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD). Cortical thickness and gyrification, both of which have been reported as abnormal in the prefrontal cortex in ADHD, are thought to be modulated by genetic influences during neural development. This study aimed to investigate the effects of a polymorphism of the dopamine DRD4 gene (the 7-repeat (7R) “risk” allele) on thickness and gyrification as distinct parameters of prefrontal cortical structure in children with ADHD.Method: Structural images and genetic samples were obtained from 49 children aged 9–15 years (25 with ADHD and 24 matched controls), and measures of cortical thickness and gyrification for inferior, middle, and superior frontal cortex were calculated.Results: A significant interaction between diagnosis and genotype on prefrontal gyrification was observed, largely driven by reduced inferior frontal gyrification in patients who carried the DRD4 7R allele. Furthermore, inferior frontal gyrification—but not thickness—related to everyday executive functioning in 7R allele carriers across groups.Conclusions: Prefrontal gyrification is reduced in children with ADHD who also carry the DRD4 7R allele, and it relates to critical functional skills in the executive domain in carriers of the risk allele. More broadly, these effects highlight the importance of considering precise neurodevelopmental mechanisms through which risk alleles influence cortical neurogenesis and migration