Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway

we read with great interest the paper by Dr. Chen et al1, recently published in European Review for Medical and Pharmacological Sciences and titled ‘‘Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway’’. Authors concluded that lncRNA00673 is highly expressed and may be a potential target for the treatment of Hepatocellular Carcinoma (HCC). Moreover, according to authors, it can promote the proliferation and metastasis of HCC by the regulation of Notch signaling pathway. We congratulate the authors for their interesting work

La régulation du comportement d’exercice et les raisons de l’activité physique: la validation italienne des questionnaires BREQ et MPAM-R

Based on self-determination theory, the purpose of the present study was to provide the first Italian validation of two different instrument to assess the exercise behaviour: the Mullan et al.'s (1997) BREQ which measures external, introjected, identified and intrinsic forms of regulation and Ryan et al.'s (1997) MPAM-R, which assesses five distinct motives for physical activity (appearance, health and fitness, social, competence, and enjoyment). Confirmatory factor analysis conducted on data collected from 1995 students attending three different secondary schools empirically supported respectively the four-factor structure of behavioural regulation and the five-factor structure of motives for physical activity, supporting convergent and discriminant validity of both scales. Furthermore, multi-group confirmatory factor analysis showed the invariance of the factor structures, structural parameters and correlations of the two scales across gender. Criterion-related validity of the scales also received partial empirical support. Finally, the factor structure of behavioural regulation and motives for physical activity was empirically supported when both constructs were included in a single measurement model.Sur la base de la théorie de l’auto-détermination, le but de cette étude est de proposer la validation de deux instruments différents pour l’évaluation du comportement d’exercice : le BREQ de Mullan et a. (1997), qui mesure les formes externe, introjectée, identifiée, et intrinsèque de la régulation, et le MPAM-R de Ryan et al. (1997), qui évalue cinq raisons distingués de l’activité physique (apparence, santé et forme physique, sociale, compétence, et amusement). L’analyse factorielle confirmatoire, conduite auprès de 1995 étudiants inscrits à trois lycées différents, a soutenu empiriquement la structure à quatre facteurs de la régulation du comportement ainsi que la structure à cinq facteurs des raisons de l’activité physique. De plus, l’analyse confirmatoire multi-groupe a montré l’invariance des structures factorielles, des paramètres structuraux, et des corrélations des deux échelles en relation au genre sexuel. La validité critériée des échelles a aussi reçu un soutien empirique partiel. Enfin, la structure factorielle de la régulation du comportement et des raisons de l’activité physique a été soutenue empiriquement lorsque les deux construits ont été inclus dans le même modèle de mesure

Multi-mode TES bolometer optimization for the LSPE-SWIPE instrument

In this paper we explore the possibility of using transition edge sensor (TES) detectors in multi-mode configuration in the focal plane of the Short Wavelength Instrument for the Polarization Explorer (SWIPE) of the balloon-borne polarimeter Large Scale Polarization Explorer (LSPE) for the Cosmic Microwave Background (CMB) polarization. This study is motivated by the fact that maximizing the sensitivity of TES bolometers, under the augmented background due to the multi-mode design, requires a non trivial choice of detector parameters. We evaluate the best parameter combination taking into account scanning strategy, noise constraints, saturation power and operating temperature of the cryostat during the flight.Comment: in Journal of Low Temperature Physics, 05 January 201

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation

The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers. Furthermore, functional studies revealed a pivotal role for HOTAIR in the epithelial-to-mesenchymal transition, as this RNA is causal for the repressive activity of the master factor SNAIL on epithelial genes. Despite the proven oncogenic role of HOTAIR, its transcriptional regulation is still poorly understood. Here hepatocyte nuclear factor 4-α (HNF4α), as inducer of epithelial differentiation, was demonstrated to directly repress HOTAIR transcription in the mesenchymal-to epithelial transition. Mechanistically, HNF4α was found to cause the release of a chromatin loop on HOTAIR regulatory elements thus exerting an enhancer-blocking activity

Detailed study of the microwave emission of the supernova remnant 3C 396

We have observed the supernova remnant 3C~396 in the microwave region using the Parkes 64-m telescope. Observations have been made at 8.4 GHz, 13.5 GHz, and 18.6 GHz and in polarisation at 21.5 GHz. We have used data from several other observatories, including previously unpublished observations performed by the Green Bank Telescope at 31.2 GHz, to investigate the nature of the microwave emission of 3C 396. Results show a spectral energy distribution dominated by a single component power law emission with $\alpha=(-0.364 \pm 0.017)$. Data do not favour the presence of anomalous microwave emission coming from the source. Polarised emission at 21.5 GHz is consistent with synchrotron-dominated emission. We present microwave maps and correlate them with infrared (IR) maps in order to characterise the interplay between thermal dust and microwave emission. IR vs. microwave TT plots reveal poor correlation between mid-infrared and microwave emission from the core of the source. On the other hand, a correlation is detected in the tail emission of the outer shell of 3C 396, which could be ascribed to Galactic contamination.Comment: published in MNRA

New radio observations of anomalous microwave emission in the HII region RCW175

We have observed the HII region RCW175 with the 64m Parkes telescope at 8.4GHz and 13.5GHz in total intensity, and at 21.5GHz in both total intensity and polarization. High angular resolution, high sensitivity, and polarization capability enable us to perform a detailed study of the different constituents of the HII region. For the first time, we resolve three distinct regions at microwave frequencies, two of which are part of the same annular diffuse structure. Our observations enable us to confirm the presence of anomalous microwave emission (AME) from RCW175. Fitting the integrated flux density across the entire region with the currently available spinning dust models, using physically motivated assumptions, indicates the presence of at least two spinning dust components: a warm component with a relatively large hydrogen number density n_H=26.3/cm^3 and a cold component with a hydrogen number density of n_H=150/cm^3. The present study is an example highlighting the potential of using high angular-resolution microwave data to break model parameter degeneracies. Thanks to our spectral coverage and angular resolution, we have been able to derive one of the first AME maps, at 13.5GHz, showing clear evidence that the bulk of the AME arises in particular from one of the source components, with some additional contribution from the diffuse structure. A cross-correlation analysis with thermal dust emission has shown a high degree of correlation with one of the regions within RCW175. In the center of RCW175, we find an average polarized emission at 21.5GHz of 2.2\pm0.2(rand.)\pm0.3(sys.)% of the total emission, where we have included both systematic and statistical uncertainties at 68% CL. This polarized emission could be due to sub-dominant synchrotron emission from the region and is thus consistent with very faint or non-polarized emission associated with AME.Comment: Accepted for publication in the Astrophysical Journa

Cosmic Microwave Background Temperature at Galaxy Clusters

We have deduced the cosmic microwave background (CMB) temperature in the Coma cluster (A1656, $z=0.0231$), and in A2163 ($z=0.203$) from spectral measurements of the Sunyaev-Zel'dovich (SZ) effect over four passbands at radio and microwave frequencies. The resulting temperatures at these redshifts are $T_{Coma} = 2.789^{+0.080}_{-0.065}$ K and $T_{A2163} = 3.377^{+0.101}_{-0.102}$ K, respectively. These values confirm the expected relation $T(z)=T_{0}(1+z)$, where $T_{0}= 2.725 \pm 0.002$ K is the value measured by the COBE/FIRAS experiment. Alternative scaling relations that are conjectured in non-standard cosmologies can be constrained by the data; for example, if $T(z) = T_{0}(1+z)^{1-a}$ or $T(z)=T_{0}[1+(1+d)z]$, then $a=-0.16^{+0.34}_{-0.32}$ and $d = 0.17 \pm 0.36$ (at 95% confidence). We briefly discuss future prospects for more precise SZ measurements of $T(z)$ at higher redshifts.Comment: 13 pages, 1 figure, ApJL accepted for publicatio

Phosphoenolpyruvate carboxykinase in cherry (Prunus avium L.) fruit during development

n/

Produção de biomassa e óleo essencial em manjericão sob diferentes formas de adubação.

Avaliou-se a influência de sistemas de adubação na produção de biomassa e no teor de óleos essenciais de Ocimum basilicum, em casa de vegetação em Campo Grande (MS)