10 research outputs found
Engineered polyester-PEG nanoparticles prepared through a “grafting through” strategy and post-functionalization via Michael type addition
Free radical polymerization (FRP) is widely used in industrial processes as an efficient and versatile method to engineer polymeric nanoparticles (PNPs) of controlled size, narrowly distributed, and of well-defined surface properties. Functional Poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) can be utilized as macromonomers in FRP in combination with a co-polymerizable poly(ethylene glycol) (PEG), to achieve aqueous dispersions of PNPs composed of a hydrophobic polyester core and a hydrophilic PEG shell of tuneable size. For several industrial and biological applications, PNPs also need surface functionalization to provide specific physicochemical characteristics, including stimuli-responsiveness, and bioactivity. In this work, a flexible “grafting through” strategy based on Ring opening polymerization (ROP) and FRP was proposed to obtain engineered polyester-PEG nanoparticles functionalized with acrylate groups on the hydrophilic shell. The presence of acrylates allows a versatile surface functionalization through Michael-type addition with a thiolated ligand (peptide), in aqueous solution under physiological pH, with the advantage of high conversion and absence of reaction side products. A cysteine-containing cyclic RGD was used as model peptide for conjugation, due to its potential application as ligand for endothelial cells. Results indicated that active cell targeting can be achieved by using this surface functionalization approach
Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression
International audienc
Germline TIM-3 Mutations Characterize Sub-Cutaneous Panniculitis T-Cell Lymphomas with Hemophagocytic Lymphohistiocytic Syndrome
International audienc
Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome
International audienc
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Correction: The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms (vol 36, pg 1720, 2022)
10.1038/s41375-023-01962-5LEUKEMIA3791944-195
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Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge
Gliomas are the most common primary brain malignancies, with different
degrees of aggressiveness, variable prognosis and various heterogeneous
histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic
core, active and non-enhancing core. This intrinsic heterogeneity is also
portrayed in their radio-phenotype, as their sub-regions are depicted by
varying intensity profiles disseminated across multi-parametric magnetic
resonance imaging (mpMRI) scans, reflecting varying biological properties.
Their heterogeneous shape, extent, and location are some of the factors that
make these tumors difficult to resect, and in some cases inoperable. The amount
of resected tumor is a factor also considered in longitudinal scans, when
evaluating the apparent tumor for potential diagnosis of progression.
Furthermore, there is mounting evidence that accurate segmentation of the
various tumor sub-regions can offer the basis for quantitative image analysis
towards prediction of patient overall survival. This study assesses the
state-of-the-art machine learning (ML) methods used for brain tumor image
analysis in mpMRI scans, during the last seven instances of the International
Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we
focus on i) evaluating segmentations of the various glioma sub-regions in
pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue
of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO
criteria, and iii) predicting the overall survival from pre-operative mpMRI
scans of patients that underwent gross total resection. Finally, we investigate
the challenge of identifying the best ML algorithms for each of these tasks,
considering that apart from being diverse on each instance of the challenge,
the multi-institutional mpMRI BraTS dataset has also been a continuously
evolving/growing dataset
Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge
Gliomas are the most common primary brain malignancies, with different
degrees of aggressiveness, variable prognosis and various heterogeneous
histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic
core, active and non-enhancing core. This intrinsic heterogeneity is also
portrayed in their radio-phenotype, as their sub-regions are depicted by
varying intensity profiles disseminated across multi-parametric magnetic
resonance imaging (mpMRI) scans, reflecting varying biological properties.
Their heterogeneous shape, extent, and location are some of the factors that
make these tumors difficult to resect, and in some cases inoperable. The amount
of resected tumor is a factor also considered in longitudinal scans, when
evaluating the apparent tumor for potential diagnosis of progression.
Furthermore, there is mounting evidence that accurate segmentation of the
various tumor sub-regions can offer the basis for quantitative image analysis
towards prediction of patient overall survival. This study assesses the
state-of-the-art machine learning (ML) methods used for brain tumor image
analysis in mpMRI scans, during the last seven instances of the International
Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we
focus on i) evaluating segmentations of the various glioma sub-regions in
pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue
of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO
criteria, and iii) predicting the overall survival from pre-operative mpMRI
scans of patients that underwent gross total resection. Finally, we investigate
the challenge of identifying the best ML algorithms for each of these tasks,
considering that apart from being diverse on each instance of the challenge,
the multi-institutional mpMRI BraTS dataset has also been a continuously
evolving/growing dataset