Steady-state visual evoked potentials and phase synchronization in migraine

We investigate phase synchronization in EEG recordings from migraine patients. We use the analytic signal technique, based on the Hilbert transform, and find that migraine brains are characterized by enhanced alpha band phase synchronization in presence of visual stimuli. Our findings show that migraine patients have an overactive regulatory mechanism that renders them more sensitive to external stimuli.Comment: 4 page

Dose- and substrate-dependent reduction of enteric methane and ammonia by natural additives in vitro

Ruminants contribute to global warming by emitting greenhouse gasses, particularly methane (CH4) which is a product of rumen fermentation. The use of feed additives able to modulate rumen fermentation is a promising strategy to reduce enteric CH4 and ammonia (NH3) emissions. Among the various strategies investigated, plant secondary metabolites (PSMs) have attracted attention due to their apparent potential to reduce enteric CH4 and NH3 emissions, and it would be possible to use such compounds as feed additives in organic production systems. In an in vitro system simulating rumen fermentation, we have tested the impact of different classes of naturally occurring PSMs; catechin and quercetin (flavonoids), salicylic acid (phenolic acid) and tannic acid (hydrolysable tannin). The PSMs were added to two different basal feeds (maize and grass silages) at three inclusion doses 1.5, 3 and 6% of the feed dry matter (DM). CH4 production was significantly lowered upon addition of quercetin to two basal feeds at doses of 3 and 6%, and this without changes in concentrations of total volatile fatty acid (VFA) produced during fermentation. Quercetin, as the only tested additive, reduced CH4 production, and when added to maize silage and grass silage, the reduction increased linearly with increasing dose, ie., by 51 and 43%, respectively, at a dose of 3% of feed DM and by 86 and 58%, respectively, at a dose of 6% of feed DM. Moreover, quercetin significantly reduced NH3 concentration by >12% at doses of 3 and 6% in feed DM irrespective of the basal feed used as compared to when the basal feeds were incubated alone. Although none of the other additives affected CH4 formation, several additives had significant impacts on concentrations of NH3 and VFAs in the incubated fluid after fermentation. This study demonstrated a dose-dependent ability of quercetin to reduce CH4 emission from rumen fermentation, however, the magnitude of the suppression of CH4 depended on the basal feed. Furthermore, quercetin reduced NH3 concentration irrespective of the basal feed type. These findings encourage to in vivo studies to verify whether quercetin can reduce CH4 emission also in cows

Bollettino Sismico Italiano 2011

Questo lavoro illustra lo stato della Rete Sismica Nazionale Italiana (RSNI) e le principali caratteristiche della sismicità in Italia nell’anno 2011. In tale anno, tramite i dati raccolti dalla RSNI, sono stati localizzati 16499 eventi registrati da 359 stazioni appartenenti sia all’INGV, sia ad altre reti locali e regionali connesse in tempo reale al Centro Nazionale Terremoti (CNT) di Roma. La magnitudo minima di completezza del Bollettino Sismico Italiano (BSI) è ML 1.5. La magnitudo massima è stata registrata per un evento localizzato nella pianura padano veneta (ML 4.8). Nella sismicità italiana del 2011 sono state individuate 46 sequenze sismiche rilevanti; tra esse riveste particolare interesse la sequenza nel Montefeltro: iniziata a fine maggio e durata diversi mesi, essa comprende due eventi di magnitudo ML 4.0. La sequenza del Pollino, iniziata nel 2009 e proseguita a più riprese fino al 25 ottobre 2012 con un evento di magnitudo MW 5.2, presenta a inizio 2011 un aumento della sismicità che è culminato con l’evento maggiore di quell’anno (ML 3.6). L’analisi del BSI ha inoltre permesso di individuare una nuova area caratterizzata da eventi di origine antropica (esplosioni in cava) che si aggiunge alle 16 già rilevate negli anni precedenti. In questo lavoro vengono analizzati anche i segnali prodotti da frane di crollo, molto diffuse nel nostro paese lungo gli archi montani alpini e appenninici

Bollettino Sismico Italiano 2009

Questo lavoro illustra lo stato della Rete Sismica Nazionale Italiana e descrive la sismicità italiana nell’anno 2009. Vengono evidenziate le principali sequenze sismiche occorse durante l’anno, con particolare riguardo alla sequenza sismica dell’aquilano-reatino. Nel 2009 la Rete Sismica Nazionale dell’INGV ha registrato circa 26000 terremoti avvenuti sul territorio nazionale e nelle aree limitrofe, che sono stati analizzati e localizzati dal gruppo di analisti sismologi che si occupano della redazione del Bollettino Sismico Italiano (BSI). La magnitudo minima di completezza Mc del BSI 2009, ovvero la soglia di magnitudo minima media calcolata su tutto il territorio nazionale, è risultata pari a ML 1.6 (il dato del BSI 2008 si attestava sul valore di ML 2.1). Il numero di stazioni sismiche attive (Rete Nazionale e reti locali) nel corso del 2009 è stato di 305 (279 nel 2008). Viene fornita infine una stima del numero e della magnitudo di eventi di origine antropica (esplosioni) presenti nel BSI 2009. This paper describes the status of the Italian National Seismic Network and the Italian seismicity in year 2009. We outline the main seismic sequences that occurred during the year, with particular emphasis on the L’Aquila-Rieti seismic period. The INGV National Seismic Network recorded about 26000 earthquakes in Italy and neighboring areas during 2009, which were analyzed and localized by the seismology group of analysts involved in the publication of the Italian Seismic Bulletin (BSI). The minimum magnitude of completeness Mc of the BSI 2009 is ML 1.6 (ML 2.1 in the BSI 2008). The number of active seismic stations during 2009 was 305 (279 in 2008). We provide an estimate of the number and magnitude of anthropic events (quarry-blasts) included in the BSI 2009

Bollettino Sismico Italiano 2010

This paper describes the status of the Italian National Seismic Network and the main feautures of the Italian seismicity in 2010. In that year the network counted 313 velocimeters and 107 accelerometers. More than 14500 earthquakes were located in Italy and surrounding areas and seas, with an average minimum magnitude of completeness MC = 1.6. Most of that seismicity appears in cluster (a spatio-temporal concentration of seismic events): in 2010 more than 70% of the located Italian earthquakes belongs to about 430 cluster. We selected all the cluster with at least 20 events of any magnitudes, and all the cluster with at least 10 events and at least one event of magnitude 2.5 or greater, and cluster with at least two events and one of magnitude 3.5 or greater, ending up with a list of 48 significant cluster. The Italian Seismic Bulletin contains also seismic events originated by anthropic activities (quarry explosions). Through the analysis of the last 7 years of data from the bulletin, we pinpointed 16 areas with extended extractive activities. Nevertheless the presence of quarries in Italy is so widespread that our list can be considered by no means complete. Extraction areas frequently coincide with regions affected by high seismicity rate. Records due to explosion quakes can show distinguishing characteristics (compressive first onset and a low frequency secondary phase). However, these markers are not present in all the artificial events, and are not sufficient to exclude the totality of the explosions from the bulletin. Nowadays the BSI incorporates, together with true tectonic earthquakes, a significant portion of low magnitude events due to explosions, evaluated about 5% in 2010

The prognostic role of post-induction FDG-PET in patients with follicular lymphoma: a subset analysis from the FOLL05 trial of the Fondazione Italiana Linfomi (FIL)

BACKGROUND: [18F]fluorodeoxyglucose-positron emission tomography (PET) is emerging as a strong diagnostic and prognostic tool in follicular lymphoma (FL) patients. PATIENTS AND METHODS: In a subset analysis of the FOLL05 trial (NCT00774826), we investigated the prognostic role of post-induction PET (PI-PET) scan. Patients were eligible to this study if they had a PI-PET scan carried out within 3 months from the end of induction immunochemotherapy. Progression-free survival (PFS) was the primary study end point. RESULTS: A total of 202 patients were eligible and analysed for this study. The median age was 55 years (range 33-75). Overall, PI-PET was defined as positive in 49 (24%) patients. Conventional response assessment with CT scan was substantially modified by PET: 15% (22/145) of patients considered as having a complete response (CR) after CT were considered as having partial response (PR) after PI-PET and 53% (30/57) patients considered as having a PR after CT were considered as a CR after PI-PET. With a median follow-up of 34 months, the 3-year PFS was 66% and 35%, respectively, for patients with negative and positive PI-PET (P<0.001). At multivariate analysis, PI-PET (hazard ratio 2.57, 95% confidence interval 1.52-4.34, P<0.001) was independent of conventional response, FLIPI and treatment arm. Also, the prognostic role of PI-PET was maintained within each FLIPI risk group. CONCLUSIONS: In FL patients, PI-PET substantially modifies response assessment and is strongly predictive for the risk of progression. PET should be considered in further updates of response criteria