Development of therapeutic and cosmetic formulations based on sardine-based products

Sardine is one of the most common fish of the Portuguese coast and has important nutritional features. Sardine oil is also a source of nutrients with proven benefits for human health, being rich in polyunsaturated fatty acids (PUFAs) [1]. Several studies show that there is a direct link between a diet enriched in omega-3 and the prevention of diseases such as cardiovascular disease, inflammatory conditions such as rheumatoid arthritis or asthma, mental disorders and prevention of various types of cancer [2]. The aim of this work was to characterize in a systematic way the potential protective role of sardine oil and derived PUFAs. To evaluate the antioxidant and antiinflammatory effect of sardine oil and PUFAs, human fibroblasts (BJ-5ta), human melanocytes (A375) and human keratinocytes (NCTC2544) were used. Cell viability was affected for concentrations higher than 8mg/ml for sardine oil and higher than 0.1mg/ml for PUFAs. However and regarding PUFAs, melanocytes revealed a higher susceptibility. With the lowest tested concentrations, sardine-based compounds promoted cell proliferation and protected cells from induced oxidative stress, with higher protection conferred by PUFAs. These results open the opportunity to develop new therapeutic and cosmetic applications based on sardine-derived compounds. Their incorporation in topical creams may contribute to a better treatment of inflammation and in the prevention of skin aging

Validity of numerical trajectories in the synchronization transition of complex systems

We investigate the relationship between the loss of synchronization and the onset of shadowing breakdown {\it via} unstable dimension variability in complex systems. In the neighborhood of the critical transition to strongly non-hyperbolic behavior, the system undergoes on-off intermittency with respect to the synchronization state. There are potentially severe consequences of these facts on the validity of the computer-generated trajectories obtained from dynamical systems whose synchronization manifolds share the same non-hyperbolic properties.Comment: 4 pages, 4 figure

Demographic and Clinical Characteristics of Human Immunodeficiency Virus-Infected Patients Receiving Dialysis in Portugal: a Nationwide Multicentre Survey

Background: Data on human immunodeficiency virus (HIV) infected patients receiving dialysis in Portugal is scarce. Methods: This nationwide epidemiological survey retrospectively evaluates HIV-infected patients on chronic dialysis in Portugal between 1997 and 2002. Results: Sixty-six patients were evaluated (mean age: 39.1±1.6 years, 47 men, 35 black African). Sixty-two patients started dialysis and 4 patients who were receiving dialysis had HIV seroconversion. Eighty-five percent of patients were treated in Lisbon. The annual incidence of HIV-infected patients on chronic dialysis was 0.5% in 1997 and 0.9% in 2002. Seventy-eight percent of patients were HIV-1 infected , 13% had hepatitis B and 31% hepatitis C. Sexual contact was the mode of transmission of HIV in 53% of cases. Four patients had biopsy-proved HIV-associated nephropathy. Ninety-five percent of patients were on chronic hemodialysis. Fifty percent of patients had acquired immunodeficiency syndrome. At follow-up, 12 patients died. HIV-infected CKD patient survival after starting dialysis was 80% at 3 years. Conclusion: The incidence of HIV-infected patients on chronic dialysis in Portugal has almost doubled. Widespread use of highly active antiretroviral therapy and the increasing number of black Africans from former overseas Portuguese colonies now living in Portugal are possible reasons for this large increase

Dinâmicas investigativas no CIDTFF: problematizar o paradigma da investigação face ao desenvolvimento sustentável

Sem resumo disponível.publishe

Efeito da redução ou ampliação de doses de nitrogênio e potássio aplicadas através da fertirrigação em relação às recomendadas para adubação convencional em pimentão (Capsicum annum L.).

O trabalho teve como objetivo avaliar o efeito da redução de 25% e 50% ou aumento de 25% nas doses de nitrogênio e potássio aplicadas através da fertirrigação em relação às recomendadas para adubação convencional na cultura do pimentão considerando o desenvolvimento das plantas e produtividade dos frutos

Estimating stellar population and emission line properties in S-PLUS galaxies

We present tests of a new method to simultaneously estimate stellar population and emission line (EL) properties of galaxies out of S-PLUS photometry. The technique uses the AlStar code, updated with an empirical prior which greatly improves its ability to estimate ELs using only the survey's 12 bands. The tests compare the output of (noise-perturbed) synthetic photometry of SDSS galaxies to properties derived from previous full spectral fitting and detailed EL analysis. For realistic signal-to-noise ratios, stellar population properties are recovered to better than 0.2 dex in masses, mean ages, metallicities and $\pm 0.2$ mag for the extinction. More importantly, ELs are recovered remarkably well for a photometric survey. We obtain input $-$ output dispersions of 0.05--0.2 dex for the equivalent widths of $[\mathrm{O}\,\rm{II}]$, $[\mathrm{O}\,\rm{III}]$, H$\beta$, H$\alpha$, $[\mathrm{N}\,\rm{II}]$, and $[\mathrm{S}\,\rm{II}]$, and even better for lines stronger than $\sim 5$ $\mathring{A}$. These excellent results are achieved by combining two empirical facts into a prior which restricts the EL space available for the fits: (1) Because, for the redshifts explored here, H$\alpha$ and $[\mathrm{N}\,\rm{II}]$ fall in a single narrow band (J0660), their combined equivalent width is always well recovered, even when $[\mathrm{N}\,\rm{II}]$/H$\alpha$ is not. (2) We know from SDSS that $W_{H\alpha+[\mathrm{N}\,\rm{II}]}$ correlates with $[\mathrm{N}\,\rm{II}]$/H$\alpha$, which can be used to tell if a galaxy belongs to the left or right wings in the classical BPT diagnostic diagram. Example applications to integrated light and spatially resolved data are also presented, including a comparison with independent results obtained with MUSE-based integral field spectroscopy.Comment: MNRAS accepte

Treatment planning systems dosimetry auditing project in Portugal

BACKGROUND AND PURPOSE: The Medical Physics Division of the Portuguese Physics Society (DFM_SPF) in collaboration with the IAEA, carried out a national auditing project in radiotherapy, between September 2011 and April 2012. The objective of this audit was to ensure the optimal usage of treatment planning systems. The national results are presented in this paper. MATERIAL AND METHODS: The audit methodology simulated all steps of external beam radiotherapy workflow, from image acquisition to treatment planning and dose delivery. A thorax CIRS phantom lend by IAEA was used in 8 planning test-cases for photon beams corresponding to 15 measuring points (33 point dose results, including individual fields in multi-field test cases and 5 sum results) in different phantom materials covering a set of typical clinical delivery techniques in 3D Conformal Radiotherapy. RESULTS: All 24 radiotherapy centers in Portugal have participated. 50 photon beams with energies 4-18 MV have been audited using 25 linear accelerators and 32 calculation algorithms. In general a very good consistency was observed for the same type of algorithm in all centres and for each beam quality. CONCLUSIONS: The overall results confirmed that the national status of TPS calculations and dose delivery for 3D conformal radiotherapy is generally acceptable with no major causes for concern. This project contributed to the strengthening of the cooperation between the centres and professionals, paving the way to further national collaborations