AN EXAMPLE OF MULTISENSORY TEACHING IN THE SUBJECT SOCIETY IN THE 5th GRADE OF A PRIMARY SCHOOL IN SLOVENIA

All of us who work with students (both younger and older) know that teaching is a demanding and responsible job. From the teacher it requires love and understanding of the students and the learning material, dedication to work and, finally, a vision from which he/she can draw energy in moments of weakness and uncertainty. An essential part of a teacher's development is lifelong learning, which takes place in various ways: through research, articles, books, contributions, and mutual exchange of opinions with experts from similar fields of work and activity. In the way, we spread our awareness of changes in society and are aware of the needs that the modern world demands from us and the future adults we are now teaching. Teaching in the modern world cannot take place in a formal way, but it is necessary to understand the results of researches done in the field of human development, which suggests a different way of teaching with the aim of achieving the most optimal results. The article is divided into four substantive parts: in the first part, I devote myself to the theoretical explanation of the modern way of teaching and why understanding changes is necessary. Then I will explain the importance of the mustisensory teaching method and define the learning types of students and their characteristics. This will be followed by an explanation of the importance of teacher preparation for the multisensory way of teaching. I will present an example of preparation for teaching in the subject society in the 5th grade of primary school, where I will describe my method of inclusion and consideration of the principle of multisensory. In the evaluation, I will summarize my opinion about the lesson and conclude my article by thinking about the positive sides of the mentioned teaching method

Analisis Romantisme Dalam Serial Drama Horimiya

Penelitian ini bertujuan menganalisis ciri-ciri romantisme pada serial drama Horimiya dengan menggunakan metode deskriptif analisis. Pendekatan visual juga dilakukan dengan cara mendeskripsikan suatu hal kemudian dianalisis dengan menggunakan gambar guna menunjukkan adegan-adegan yang memperlihatkan ciri-ciri romantisme. Teori yang digunakan pada penelitian ini adalah teori romantisme Russell Noyes. Dari penelitian ini diketahui terdapat lima ciri-ciri romantisme dalam serial drama horimiya, yaitu kembali ke alam, kemurungan atau melankolis, sentimentalisme, primitivisme, dan individualisme

Investigation of the allosteric pharmacology of the 5-HT3_3 receptor identifying the potent allosteric modulator 5-chloroindole

The 5-HT$_3$ receptor is a ligand-gated ion channel that mediates for example fast synaptic neurotransmission in the CNS and PNS. 5-HT$_3$ receptor antagonists are established anti-emetics in the clinic, they also offer symptomatic relief for patients with irritable bowel syndrome, yet, sometimes serious side-effects limits their use in this indication. The 5-HT$_3$ receptor is modulated allosterically by various compounds including colchicine, alcohols and volatile anaesthetics but as yet, these modulators either lack potency or selectivity, which hinders investigation. The present study reports a novel 5-HT$_3$ receptor allosteric modulator that displays relatively high potency and selectivity; 5-chloro-indole (Cl-indole). Cl-indole potentiated 5-HT$_3$ receptor mediated responses arising from heterologous expression of the h5-HT$_3$A receptor (assessed by the affinity shift of agonists to compete for the radioligand binding site and by the increase in agonist action upon the h5-HT$_3$A receptor-mediated increase in [Ca$^2$$^+$]i; the latter action was evident with a range of agonists with very low intrinsic activity to full agonists). Cl-indole was also able to modulate allosterically the mouse native 5-HT$_3$ receptor. Additional studies provided further support for the role of the C-terminus of the h5-HT$_3$A subunit to promote stability of the arising 5-HT$_3$ receptor complex and that ligand interaction with the 5-HT$_3$A receptor impacted cell surface expression. In summary, the study reports the identification of Cl-indole as a positive allosteric modulator of the 5-HT$_3$ receptor along with extensions to our knowledge concerning a structural component of the 5-HT$_3$A subunit that promotes stability and the trafficking of the subunit into the cell membrane. These studies increase our understanding of the 5-HT$_3$ receptor, which may contribute to the design of better drugs targeting this receptor for therapeutic benefit

Dietary Pattern Trajectories over Time and Diabetes among Chinese Adults

Dietary patterns, instead of single nutrients or foods, are a useful approach to study diet and diet-disease associations. However, most studies examine dietary patterns only at one point in time. The purpose of this dissertation was to identify the longitudinal changes or stability of dietary patterns and their association with Diabetes in the China Health and Nutrition Survey from 1991 to 2009 (7 waves of diet data). Aim 1: we derived two dietary patterns using factor analysis in each wave: a traditional southern pattern (rice, vegetables, meat, poultry and fish) and a modern high-wheat pattern (wheat products, nuts, fruits, eggs, milk and instant noodles/frozen dumpling). The structure of these patterns remained stable over time, but the tracking was lower and the adherence increased over time for the modern high-wheat. Aim 2: among 4,316 adults not previously diagnosed with diabetes the adjusted Odds Ratio for diabetes prevalence in 2009, comparing the highest versus the lowest dietary pattern score quartile in 2006, was 1.25 (0.78, 2.01) for the modern high-wheat pattern, 0.79 (0.51, 1.21) for the traditional southern pattern and 2.36 (1.55, 3.58) for a pattern derived with Reduced Rank Regression (with HbA1c, HOMA-IR and glucose as response variables). This pattern combined items of the modern high-wheat pattern (wheat products and soy milk) with items opposite to the traditional southern (low rice, poultry and fish). Aim 3: A score for the third dietary pattern was estimated for each subject at each wave and with Latent Class Trajectory Analysis subjects with similar trajectories of their dietary pattern's score over time were grouped in 5 classes. Among two classes with similar scores in 2006, the one with lower scores from 1991-2004, had significantly lower HbA1c [-1.64 (-3.17, -0.11)], and non-significantly lower odds of diabetes. All together our findings suggest that the popularity of a modern high-wheat pattern was increasing and that part of this pattern, when combined with low intake of rice, poultry, fish and legumes, was associated with diabetes. In addition, even if the diets were similar recently, the long-term trajectories of this dietary pattern were also associated.Doctor of Philosoph

رسم لمصطفى بشري: دراسة سميوطيقية

مستخلص البحث إينول هى إحدى المغّنى دانج دوت فى الأندونيسيا. هى تشهر بذبذبتها التى تستطيع الناظر أن ينسى حوله وهى تصير رمزا غزاليا. وكان الشيخ مصطفى بشري يصور عن اينول بذبذبتها مع العلماء. إينول والعلماء هما شيئان متناقضان، يعتقدها سلبية والعلماء هو إيجابي. وهذا ظهر موافق و تضاد فى أوسط انجتمع الاندونيسي. والهدف هذا البحث هو لمعرفة العلامات التى توجد في الرسم " Berdzikir Bersama Inul" لمصطفى بشرى و لمعرفة معانى تلك العلامات من جهة سميوطيقا. نوع البحث الذى استخدمت الباحثة هو البحث الوصفى الكيفي التفسيري (Qualitative-Interpretation). وأما مدخل الذى تستعمله الباحثة فهي نظرية سميوطيقية عند تشارلس ساندر بيرسCharles Sander Pie ce عن أقسام العلامة من حيث الدال والمدلول يعنى الأيقونة والمؤشر والرمز. وهذا البحث من دراسة المكتبية .(Library Research) ونتائج هذا البحث فى الرسم "Berdzikir Bersama Inul" لمصطفى بشرى أن يكون 19 العلامات، منها 10 الأيقونة و 7 المؤشر و 2 الرمز

Simultaneous ammonium and phosphate recovery and stabilization from urban sewage sludge anaerobic digestates using reactive sorbents

The use of low-cost inorganic sorbents as a new sustainable strategy to enhance the valorization of nutrients (N-P-K), from the urban water cycle (e.g., side streams from sewage sludge anaerobic digestion), in agriculture applications is presented. The simultaneous recovery and stabilization of ammonium and phosphate by using a mixture of two reactive sorbents (Na and K zeolites and magnesium oxide) was evaluated. The nutrients stabilization process, favoured at alkaline pH values, is carried out by a) the precipitation of phosphate ions with magnesium and/or ammonium ions and b) the sorption of ammonium by Na- and K-zeolites. MgO(s) promoted the stabilization of phosphate as bobierrite (Mg3(PO4)2(s)) or struvite (MgNH4PO4(s)) depending on the applied dose. Doses with the stoichiometric molar ratio of Mg/P promote the formation of bobierrite, while molar ratios higher than 3 favour the formation of struvite. Na zeolites (NaP1-NA, NaP1-IQE) demonstrated efficiency on ammonium stabilization between 60 ± 2 (for 15 gZ/L) to 90 ± 3% (for 50 gZ/L). The ammonium recovery efficiency is limited by the zeolite sorption capacity. If the target of the fertilizing criteria should include K, then the use of a K-zeolite (e.g., 5AH-IQE) provides a good solution. The optimum pH for the precipitation of struvite and bobierrite is 9.5 and the optimum pH for ammonium removal is between 4 and 8.5. N is present in higher concentrations (up 0.7–1 g NH4+/L) when pH is ranged between 8.2 and 8.6. The ammonium recovery ratios were better than those previously reported using only magnesium oxide or even a more expensive reagent as newberrite (MgHPO4(s)). The recovery mechanisms described generate low-solubility stabilized nutrients forms that potentially can be applied as slow-release fertilizers in agriculture. Thus, the use in agriculture of blends of digested sludge with low-solubility stabilized nutrients forms will improve soils quality properties in terms of organic matter and nutrients availability.Peer ReviewedPostprint (author's final draft

First-Year Evaluation of Mexico’s Tax on Nonessential Energy-Dense Foods: An Observational Study

In an effort to prevent continued increases in obesity and diabetes, in January 2014, the Mexican government implemented an 8% tax on nonessential foods with energy density ≥275 kcal/100 g and a peso-per-liter tax on sugar-sweetened beverages (SSBs). Limited rigorous evaluations of food taxes exist worldwide. The objective of this study was to examine changes in volume of taxed and untaxed packaged food purchases in response to these taxes in the entire sample and stratified by socioeconomic status (SES)

Patterns of Red and Processed Meat Consumption Across North America: A Nationally Representative Cross-Sectional Comparison of Dietary Recalls from Canada, Mexico, and the United States

Close economic ties encourage production and trade of meat between Canada, Mexico, and the US. Understanding the patterns of red and processed meat consumption in North America may inform policies designed to reduce meat consumption and bolster environmental and public health efforts across the continent. We used nationally-representative cross-sectional survey data to analyze consumption of unprocessed red meat; processed meat; and total red and processed meat. Generalized linear models were used to separately estimate probability of consumption and adjusted mean intake. Prevalence of total meat consumers was higher in the US (73.6, 95% CI: 72.3–74.8%) than in Canada (65.6, 63.9–67.2%) or Mexico (62.7, 58.1–67.2%). Men were more likely to consume unprocessed red, processed, and total meat, and had larger estimated intakes. In Mexico, high wealth individuals were more likely to consume all three categories of meat. In the US and Canada, those with high education were less likely to consume total and processed meat. Estimated mean intake of unprocessed red, processed, and total meat did not differ across sociodemographic strata. Overall consumption of red and processed meat remains high in North America. Policies to reduce meat consumption are appropriate for all three countries

Lack of predictive tools for conventional and targeted cancer therapy:barriers to biomarker development and clinical translation

Predictive tools, utilising biomarkers, aim to objectively assess the potential response to a particular clinical intervention in order to direct treatment. Conventional cancer therapy remains poorly served by predictive biomarkers, despite being the mainstay of treatment for most patients. In contrast, targeted therapy benefits from a clearly defined protein target for potential biomarker assessment. We discuss potential data sources of predictive biomarkers for conventional and targeted therapy, including patient clinical data and multi-omic biomarkers (genomic, transcriptomic and protein expression). Key examples, either clinically adopted or demonstrating promise for clinical translation, are highlighted. Following this, we provide an outline of potential barriers to predictive biomarker development; broadly discussing themes of approaches to translational research and study/trial design, and the impact of cellular and molecular tumor heterogeneity. Future avenues of research are also highlighted