HIV infection and domestic smoke exposure, but not human papillomavirus, are risk factors for esophageal squamous cell carcinoma in Zambia: a case-control study

(c) 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited

Continuously Crossing u=z in the H3+ Boundary CFT

For AdS boundary conditions, we give a solution of the H3+ two point function involving degenerate field with SL(2)-label b^{-2}/2, which is defined on the full (u,z) unit square. It consists of two patches, one for z<u and one for u<z. Along the u=z "singularity", the solutions from both patches are shown to have finite limits and are merged continuously as suggested by the work of Hosomichi and Ribault. From this two point function, we can derive b^{-2}/2-shift equations for AdS_2 D-branes. We show that discrete as well as continuous AdS_2 branes are consistent with our novel shift equations without any new restrictions.Comment: version to appear in JHEP - 12 pages now; sign error with impact on some parts of the interpretation fixed; material added to become more self-contained; role of bulk-boundary OPE in section 4 more carefully discussed; 3 references adde

Calculation of some determinants using the s-shifted factorial

Several determinants with gamma functions as elements are evaluated. This kind of determinants are encountered in the computation of the probability density of the determinant of random matrices. The s-shifted factorial is defined as a generalization for non-negative integers of the power function, the rising factorial (or Pochammer's symbol) and the falling factorial. It is a special case of polynomial sequence of the binomial type studied in combinatorics theory. In terms of the gamma function, an extension is defined for negative integers and even complex values. Properties, mainly composition laws and binomial formulae, are given. They are used to evaluate families of generalized Vandermonde determinants with s-shifted factorials as elements, instead of power functions.Comment: 25 pages; added section 5 for some examples of application

Microbiological influences on fracture surfaces of intact mudstone and the implications for geological disposal of radioactive waste

The significance of the potential impacts of microbial activity on the transport properties of host rocks for geological repositories is an area of active research. Most recent work has focused on granitic environments. This paper describes pilot studies investigating changes in transport properties that are produced by microbial activity in sedimentary rock environments in northern Japan. For the first time, these short experiments (39 days maximum) have shown that the denitrifying bacteria, Pseudomonas denitrificans, can survive and thrive when injected into flow-through column experiments containing fractured diatomaceous mudstone and synthetic groundwater under pressurized conditions. Although there were few significant changes in the fluid chemistry, changes in the permeability of the biotic column, which can be explained by the observed biofilm formation, were quantitatively monitored. These same methodologies could also be adapted to obtain information from cores originating from a variety of geological environments including oil reservoirs, aquifers and toxic waste disposal sites to provide an understanding of the impact of microbial activity on the transport of a range of solutes, such as groundwater contaminants and gases (e.g. injected carbon dioxide)

Indirect RKKY interaction in any dimensionality

We present an analytical method which enables one to find the exact spatial dependence of the indirect RKKY interaction between the localized moments via the conduction electrons for the arbitrary dimensionality $n$. The corresponding momentum dependence of the Lindhard function is exactly found for any $n$ as well. Demonstrating the capability of the method we find the RKKY interaction in a system of metallic layers weakly hybridized to each other. Along with usual $2k_F$ in-plane oscillations the RKKY interaction has the sign-reversal character in a direction perpendicular to layers, thus favoring the antiferromagnetic type of layers' stacking.Comment: 3 pages, REVTEX, accepted to Phys.Rev.

Effect of irradiation on Akt signaling in atrophying skeletal muscle

Muscle irradiation (IRR) exposure can accompany unloading during spaceflight or cancer treatment, and this has been shown to be sufficient by itself to induce skeletal muscle signaling associated with a remodeling response. Although protein kinase B/Akt has an established role in the regulation of muscle growth and metabolism, there is a limited understanding of how Akt signaling in unloaded skeletal muscle is affected by IRR. Therefore, we examined the combined effects of acute IRR and short-term unloading on muscle Akt signaling. Female C57BL/6 mice were subjected to load bearing or hindlimb suspension (HS) for 5 days (n = 6/group). A single, unilateral hindlimb IRR dose (0.5 Gy X-ray) was administered on day 3. Gastrocnemius muscle protein expression was examined. HS resulted in decreased AktT308 phosphorylation, whereas HS+IRR resulted in increased AktT308 phosphorylation above baseline. HS resulted in reduced AktS473 phosphorylation, which was rescued by HS+IRR. Interestingly, IRR alone resulted in increased phosphorylation of AktS473, but not that of AktT308. HS resulted in decreased mTORC1 signaling, and this suppression was not altered by IRR. Both IRR and HS resulted in increased MuRF-1 expression, whereas atrogin-1 expression was not affected by either condition. These results demonstrate that either IRR alone or when combined with HS can differentially affect Akt phosphorylation, but IRR did not disrupt suppressed mTORC1 signaling by HS. Collectively, these findings highlight that a single IRR dose is sufficient to disrupt the regulation of Akt signaling in atrophying skeletal muscle

Hot Electron Capture Dissociation Distinguishes Leucine from Isoleucine in a Novel Hemoglobin Variant, Hb Askew, β54(D5)Val→Ile

Population migration has led to the global dispersion of human hemoglobinopathies and has precipitated a need for their identification. An effective mass spectrometry-based procedure involves analysis of the intact α- and β-globin chains to determine their mass, followed by location of the variant amino acid residue by direct analysis of the enzymatically digested chains and low-energy collision induced dissociation of the variant peptide. Using this procedure, a variant was identified as either β54Val→Leu or β54Val→Ile, since the amino acids leucine and isoleucine cannot be distinguished using low-energy collisions. Here, we describe how hot electron capture dissociation on a Fourier transform-ion cyclotron resonance mass spectrometer was used to distinguish isoleucine from leucine and identify the mutation as β54(D5)Val→Ile. This is a novel variant, and we have named it Hb Askew

Gauged Nambu-Jona-Lasinio model with extra dimensions

We investigate phase structure of the D (> 4)-dimensional gauged Nambu-Jona-Lasinio (NJL) model with $\delta(=D-4)$ extra dimensions compactified on TeV scale, based on the improved ladder Schwinger-Dyson (SD) equation in the bulk. We assume that the bulk running gauge coupling in the SD equation for the SU(N_c) gauge theory with N_f massless flavors is given by the truncated Kaluza-Klein effective theory and hence has a nontrivial ultraviolet fixed point (UVFP). We find the critical line in the parameter space of two couplings, the gauge coupling and the four-fermion coupling, which is similar to that of the gauged NJL model with fixed (walking) gauge coupling in four dimensions. It is shown that in the presence of such walking gauge interactions the four-fermion interactions become ``nontrivial'' even in higher dimensions, similarly to the four-dimensional gauged NJL model. Such a nontriviality holds only in the restricted region of the critical line (``nontrivial window'') with the gauge coupling larger than a non-vanishing value (``marginal triviality (MT)'' point), in contrast to the four-dimensional case where such a nontriviality holds for all regions of the critical line except for the pure NJL point. In the nontrivial window the renormalized effective potential yields a nontrivial interaction which is conformal invariant. The exisitence of the nontrivial window implies ``cutoff insensitivity'' of the physics prediction in spite of the ultraviolet dominance of the dynamics. In the formal limit D -> 4, the nontrivial window coincides with the known condition of the nontriviality of the four-dimensional gauged NJL model, $9/(2N_c) < N_f - N_c < 9/2 N_c$.Comment: 34 pages, 6 figures, references added, to appear in Phys.Rev.D. The title is changed in PR

Higher-order binding corrections to the Lamb shift of 2P states

We present an improved calculation of higher-order corrections to the one-loop self energy of 2P states in hydrogen-like systems with small nuclear charge Z. The method is based on a division of the integration with respect to the photon energy into a high- and a low-energy part. The high-energy part is calculated by an expansion of the electron propagator in powers of the Coulomb field. The low-energy part is simplified by the application of a Foldy-Wouthuysen transformation. This transformation leads to a clear separation of the leading contribution from the relativistic corrections and removes higher order terms. The method is applied to the 2P_{1/2} and 2P_{3/2} states in atomic hydrogen. The results lead to new theoretical values for the Lamb shifts and the fine structure splitting.Comment: 18 pages, LaTeX. In comparison to the journal version, it contains an added note (2000) which reflects the current status of Lamb shift calculation

Principal forms X^2 + nY^2 representing many integers

In 1966, Shanks and Schmid investigated the asymptotic behavior of the number of positive integers less than or equal to x which are represented by the quadratic form X^2+nY^2. Based on some numerical computations, they observed that the constant occurring in the main term appears to be the largest for n=2. In this paper, we prove that in fact this constant is unbounded as n runs through positive integers with a fixed number of prime divisors.Comment: 10 pages, title has been changed, Sections 2 and 3 are new, to appear in Abh. Math. Sem. Univ. Hambur