Feasibility study of an Integrated Program for Aerospace vehicle Design (IPAD). Volume 3: Support of the design process

The user requirements for computer support of the IPAD design process are identified. The user-system interface, language, equipment, and computational requirements are considered

Guidelines for the management of chronic obstructive pulmonary disease : Working group of the South African pulmonology society

Objective: This guideline has been developed in order to optimise the management of patients with chronic obstructive pulmonary disease (COPD) at all levels health care systems in South Africa. It contains an action plan for early recognition and appropriate treatment of this common condition.Options: Treatment regimens are recommended for patients with mild (stage I), and severe (stage III) disease.Outcomes: Optimal management of patients with COPD may achieve a reduction in breathlessness, improved quality of life, prevention of complications and limitation of disease progression.Evidence: The working Group comprised mainly pulmonologists, but included an anaesthetist, a pharmacologist and physiotherapist. Detailed literature review with particular attention to similar guideline documents from Europe and the USA was performed before the meeting.Recommendations: Steps in the management of patients with COPD include early recognition of the disease, smoking cessation, treatment of airflow obstruction with appropriate drugs (singly or in combination), education and pulmonary rehabilitation, and limitation of disease progression and complications. Detailed recommendations are made with regard to the use and interpretation of a trial of oral corticosteroid therapy. Indications for hospitalisation, intensive care unit admission and ventilatory support are provided.Validation: This guideline is similar to those recommended by other groups outside South Africa. It was developed by a working group of the South Africa Pulmonology Society and is endorsed by the Medical Association of South Africa.Sponsors: The meeting of the Working Group was sponsored by Boehringer Ingelheim. This sponsorship did not influence the activities of the Group

A probabilistic approach to some results by Nieto and Truax

In this paper, we reconsider some results by Nieto and Truax about generating functions for arbitrary order coherent and squeezed states. These results were obtained using the exponential of the Laplacian operator; more elaborated operational identities were used by Dattoli et al. \cite{Dattoli} to extend these results. In this note, we show that the operational approach can be replaced by a purely probabilistic approach, in the sense that the exponential of derivatives operators can be identified with equivalent expectation operators. This approach brings new insight about the kinks between operational and probabilistic calculus.Comment: 2nd versio

Asthma - is survival good enough?

Advances in asthma management, particularly the introduction of controller medication of which inhaled corticosteroids are the most important, has resulted in a steady decline in asthma mortality in most countries. This is usually accompanied by a decline in episodes of near-fatal asthma attacks and hospitalisations, and a reduction in other indicators of asthma morbidity. These gains have led to a shift in thinking on the management of asthma, away from simply preventing death and hospitalisations, toward achieving and maintaining sustained control of all clinical features

The functional integral with unconditional Wiener measure for anharmonic oscillator

In this article we propose the calculation of the unconditional Wiener measure functional integral with a term of the fourth order in the exponent by an alternative method as in the conventional perturbative approach. In contrast to the conventional perturbation theory, we expand into power series the term linear in the integration variable in the exponent. In such a case we can profit from the representation of the integral in question by the parabolic cylinder functions. We show that in such a case the series expansions are uniformly convergent and we find recurrence relations for the Wiener functional integral in the $N$ - dimensional approximation. In continuum limit we find that the generalized Gelfand - Yaglom differential equation with solution yields the desired functional integral (similarly as the standard Gelfand - Yaglom differential equation yields the functional integral for linear harmonic oscillator).Comment: Source file which we sent to journa

Finite Euler Hierarchies And Integrable Universal Equations

Recent work on Euler hierarchies of field theory Lagrangians iteratively constructed {}from their successive equations of motion is briefly reviewed. On the one hand, a certain triality structure is described, relating arbitrary field theories, {\it classical\ts} topological field theories -- whose classical solutions span topological classes of manifolds -- and reparametrisation invariant theories -- generalising ordinary string and membrane theories. On the other hand, {\it finite} Euler hierarchies are constructed for all three classes of theories. These hierarchies terminate with {\it universal\ts} equations of motion, probably defining new integrable systems as they admit an infinity of Lagrangians. Speculations as to the possible relevance of these theories to quantum gravity are also suggested.Comment: (replaces previous unprintable version corrupted mailer) 13 p., (Plain TeX), DTP-92/3

Fuels treatment and wildfire effects on runoff from Sierra Nevada mixed-conifer forests

We applied an eco-hydrologic model (Regional Hydro-Ecologic Simulation System [RHESSys]), constrained with spatially distributed field measurements, to assess the impacts of forest-fuel treatments and wildfire on hydrologic fluxes in two Sierra Nevada firesheds. Strategically placed fuels treatments were implemented during 2011–2012 in the upper American River in the central Sierra Nevada (43 km2) and in the upper Fresno River in the southern Sierra Nevada (24 km2). This study used the measured vegetation changes from mechanical treatments and modelled vegetation change from wildfire to determine impacts on the water balance. The well-constrained headwater model was transferred to larger catchments based on geologic and hydrologic similarities. Fuels treatments covered 18% of the American and 29% of the Lewis catchment. Averaged over the entire catchment, treatments in the wetter central Sierra Nevada resulted in a relatively light vegetation decrease (8%), leading to a 12% runoff increase, averaged over wet and dry years. Wildfire with and without forest treatments reduced vegetation by 38% and 50% and increased runoff by 55% and 67%, respectively. Treatments in the drier southern Sierra Nevada also reduced the spatially averaged vegetation by 8%, but the runoff response was limited to an increase of less than 3% compared with no treatment. Wildfire following treatments reduced vegetation by 40%, increasing runoff by 13%. Changes to catchment-scale water-balance simulations were more sensitive to canopy cover than to leaf area index, indicating that the pattern as well as amount of vegetation treatment is important to hydrologic response

Does data-independent acquisition data contain hidden gems? A case study related to Alzheimer\u27s disease

One of the potential benefits of using data-independent acquisition (DIA) proteomics protocols is that information not originally targeted by the study may be present and discovered by subsequent analysis. Herein, we reanalyzed DIA data originally recorded for global proteomic analysis to look for isomerized peptides, which occur as a result of spontaneous chemical modifications to long-lived proteins. Examination of a large set of human brain samples revealed a striking relationship between Alzheimer\u27s disease (AD) status and isomerization of aspartic acid in a peptide from tau. Relative to controls, a surprising increase in isomer abundance was found in both autosomal dominant and sporadic AD samples. To explore potential mechanisms that might account for these observations, quantitative analysis of proteins related to isomerization repair and autophagy was performed. Differences consistent with reduced autophagic flux in AD-related samples relative to controls were found for numerous proteins, including most notably p62, a recognized indicator of autophagic inhibition. These results suggest, but do not conclusively demonstrate, that lower autophagic flux may be strongly associated with loss of function in AD brains. This study illustrates that DIA data may contain unforeseen results of interest and may be particularly useful for pilot studies investigating new research directions. In this case, a promising target for future investigations into the therapy and prevention of AD has been identified