3,402 research outputs found
21st century social work: reducing re-offending - key practice skills
This literature review was commissioned by the Scottish Executiveâs Social Work Services Inspectorate in order to support the work of the 21st Century Social Work Review Group. Discussions in relation to the future arrangements for criminal justice social work raised issues about which disciplines might best encompass the requisite skills for reducing re-offending in the community. Rather than starting with what is known or understood about the skills of those professionals currently involved in such interventions, this study sought to start with the research evidence on effective work with offenders to reduce re-offending and then work its way back to the skills required to promote this outcome
Improving water utilization from a catchment perspective
Water management / Water scarcity / Water use efficiency / Catchment areas / Calibrations / Hydrology / Models / River basins / Participatory management / Water balance / Case studies / Asia / Africa / South Africa / Zimbabwe
European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.
© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It brings together the capabilities of the industry, academics, hospitals, and regulators within a common platform in order to scope the solid understanding of the major issues, which will underpin the progress towards the future of paediatric medicines we want.The EuPFI was formed in parallel to the adoption of regulations within the EU and USA and has served as a community that drives research and dissemination through publications and the organisation of annual conferences. The membership and reach of this group have grown since its inception in 2007 and continue to develop and evolve to meet the continuing needs and ambitions of research into and development of age appropriate medicines. Five diverse workstreams (age-appropriate medicines, Biopharmaceutics, Administration Devices, Excipients and Taste Assessment & Taste Masking (TATM)) direct specific workpackages on behalf of the EuPFI. Furthermore, EuPFI interacts with multiple diverse professional groups across the globe to ensure efficient working in the area of paediatric medicines. Strong commitment and active involvement of all EuPFI stakeholders have proved to be vital to effectively address knowledge gaps related to paediatric medicines, discuss potential areas for further research and identify issues that need more attention and analysis in the future.Peer reviewedFinal Accepted Versio
Hydrodynamic phase-locking of swimming microorganisms
Some microorganisms, such as spermatozoa, synchronize their flagella when
swimming in close proximity. Using a simplified model (two infinite, parallel,
two-dimensional waving sheets), we show that phase-locking arises from
hydrodynamics forces alone, and has its origin in the front-back asymmetry of
the geometry of their flagellar waveform. The time-evolution of the phase
difference between co-swimming cells depends only on the nature of this
geometrical asymmetry, and microorganisms can phase-lock into conformations
which minimize or maximize energy dissipation
Internal relaxation time in immersed particulate materials
We study the dynamics of the solid to liquid transition for a model material
made of elastic particles immersed in a viscous fluid. The interaction between
particle surfaces includes their viscous lubrication, a sharp repulsion when
they get closer than a tuned steric length and their elastic deflection induced
by those two forces. We use Soft Dynamics to simulate the dynamics of this
material when it experiences a step increase in the shear stress and a constant
normal stress. We observe a long creep phase before a substantial flow
eventually establishes. We find that the typical creep time relies on an
internal relaxation process, namely the separation of two particles driven by
the applied stress and resisted by the viscous friction. This mechanism should
be relevant for granular pastes, living cells, emulsions and wet foams
NeatVision: a development environment for machine vision engineers
This Chapter will detail a free image analysis development environment for machine vision engineers. The environment provides high-level access to a wide range of image manipulation, processing and analysis algorithms (over 300 to date) through a well-defined and easy to use graphical interface. Users can extend the core library using the developerâs interface, a plug-in, which features, automatic source code generation, compilation with full error feedback and dynamic algorithm updates. The Chapter will also discuss key issues associated with the environment and outline the advantages in adopting such a system for machine vision application developmen
Large-wavelength instabilities in free-surface Hartmann flow at low magnetic Prandtl numbers
We study the linear stability of the flow of a viscous electrically
conducting capillary fluid on a planar fixed plate in the presence of gravity
and a uniform magnetic field. We first confirm that the Squire transformation
for MHD is compatible with the stress and insulating boundary conditions at the
free surface, but argue that unless the flow is driven at fixed Galilei and
capillary numbers, the critical mode is not necessarily two-dimensional. We
then investigate numerically how a flow-normal magnetic field, and the
associated Hartmann steady state, affect the soft and hard instability modes of
free surface flow, working in the low magnetic Prandtl number regime of
laboratory fluids. Because it is a critical layer instability, the hard mode is
found to exhibit similar behaviour to the even unstable mode in channel
Hartmann flow, in terms of both the weak influence of Pm on its neutral
stability curve, and the dependence of its critical Reynolds number Re_c on the
Hartmann number Ha. In contrast, the structure of the soft mode's growth rate
contours in the (Re, alpha) plane, where alpha is the wavenumber, differs
markedly between problems with small, but nonzero, Pm, and their counterparts
in the inductionless limit. As derived from large wavelength approximations,
and confirmed numerically, the soft mode's critical Reynolds number grows
exponentially with Ha in inductionless problems. However, when Pm is nonzero
the Lorentz force originating from the steady state current leads to a
modification of Re_c(Ha) to either a sublinearly increasing, or decreasing
function of Ha, respectively for problems with insulating and conducting walls.
In the former, we also observe pairs of Alfven waves, the upstream propagating
wave undergoing an instability at large Alfven numbers.Comment: 58 pages, 16 figure
Capillary rise of a liquid between two vertical plates making a small angle.
The penetration of a wetting liquid in the narrow gap between two vertical plates making a small angle is analyzed in the framework of the lubrication approximation. At the beginning of the process, the liquid rises independently at different distances from the line of intersection of the plates except in a small region around this line where the effect of the gravity is negligible. The maximum height of the liquid initially increases as the cubic root of time and is attained at a point that reaches the line of intersection only after a certain time. At later times, the motion of the liquid is confined to a thin layer around the line of intersection whose height increases as the cubic root of time and whose thickness decreases as the inverse of the cubic root of time. The evolution of the liquid surface is computed numerically and compared with the results of a simple experiment
Electrophoresis of a polyelectrolyte through a nanopore
A hydrodynamic model for determining the electrophoretic speed of a
polyelectrolyte through a nanopore is presented. It is assumed that the speed
is determined by a balance of electrical and viscous forces arising from within
the pore and that classical continuum electrostatics and hydrodynamics may be
considered applicable. An explicit formula for the translocation speed as a
function of the pore geometry and other physical parameters is obtained and is
shown to be consistent with experimental measurements on DNA translocation
through nanopores in silicon membranes. Experiments also show a weak dependence
of the translocation speed on polymer length that is not accounted for by the
present model. It is hypothesized that this is due to secondary effects that
are neglected here.Comment: 5 pages, 2 column, 2 figure
Turbulent Pair Diffusion
Kinematic Simulations of turbulent pair diffusion in planar turbulence with a
-5/3 energy spectrum reproduce the results of the laboratory measurements of
Jullien Phys. Rev. Lett. 82, 2872 (1999), in particular the stretched
exponential form of the PDF of pair separations and their correlation
functions. The root mean square separation is found to be strongly dependent on
initial conditions for very long stretches of times. This dependence is
consistent with the topological picture of turbulent pair diffusion where pairs
initially close enough travel together for long stretches of time and separate
violently when they meet straining regions around hyperbolic points. A new
argument based on the divergence of accelerations is given to support this
picture
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