3,392 research outputs found

    21st century social work: reducing re-offending - key practice skills

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    This literature review was commissioned by the Scottish Executive’s Social Work Services Inspectorate in order to support the work of the 21st Century Social Work Review Group. Discussions in relation to the future arrangements for criminal justice social work raised issues about which disciplines might best encompass the requisite skills for reducing re-offending in the community. Rather than starting with what is known or understood about the skills of those professionals currently involved in such interventions, this study sought to start with the research evidence on effective work with offenders to reduce re-offending and then work its way back to the skills required to promote this outcome

    Improving water utilization from a catchment perspective

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    Water management / Water scarcity / Water use efficiency / Catchment areas / Calibrations / Hydrology / Models / River basins / Participatory management / Water balance / Case studies / Asia / Africa / South Africa / Zimbabwe

    European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.

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    © American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It brings together the capabilities of the industry, academics, hospitals, and regulators within a common platform in order to scope the solid understanding of the major issues, which will underpin the progress towards the future of paediatric medicines we want.The EuPFI was formed in parallel to the adoption of regulations within the EU and USA and has served as a community that drives research and dissemination through publications and the organisation of annual conferences. The membership and reach of this group have grown since its inception in 2007 and continue to develop and evolve to meet the continuing needs and ambitions of research into and development of age appropriate medicines. Five diverse workstreams (age-appropriate medicines, Biopharmaceutics, Administration Devices, Excipients and Taste Assessment & Taste Masking (TATM)) direct specific workpackages on behalf of the EuPFI. Furthermore, EuPFI interacts with multiple diverse professional groups across the globe to ensure efficient working in the area of paediatric medicines. Strong commitment and active involvement of all EuPFI stakeholders have proved to be vital to effectively address knowledge gaps related to paediatric medicines, discuss potential areas for further research and identify issues that need more attention and analysis in the future.Peer reviewedFinal Accepted Versio

    Hydrodynamic phase-locking of swimming microorganisms

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    Some microorganisms, such as spermatozoa, synchronize their flagella when swimming in close proximity. Using a simplified model (two infinite, parallel, two-dimensional waving sheets), we show that phase-locking arises from hydrodynamics forces alone, and has its origin in the front-back asymmetry of the geometry of their flagellar waveform. The time-evolution of the phase difference between co-swimming cells depends only on the nature of this geometrical asymmetry, and microorganisms can phase-lock into conformations which minimize or maximize energy dissipation

    Internal relaxation time in immersed particulate materials

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    We study the dynamics of the solid to liquid transition for a model material made of elastic particles immersed in a viscous fluid. The interaction between particle surfaces includes their viscous lubrication, a sharp repulsion when they get closer than a tuned steric length and their elastic deflection induced by those two forces. We use Soft Dynamics to simulate the dynamics of this material when it experiences a step increase in the shear stress and a constant normal stress. We observe a long creep phase before a substantial flow eventually establishes. We find that the typical creep time relies on an internal relaxation process, namely the separation of two particles driven by the applied stress and resisted by the viscous friction. This mechanism should be relevant for granular pastes, living cells, emulsions and wet foams

    NeatVision: a development environment for machine vision engineers

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    This Chapter will detail a free image analysis development environment for machine vision engineers. The environment provides high-level access to a wide range of image manipulation, processing and analysis algorithms (over 300 to date) through a well-defined and easy to use graphical interface. Users can extend the core library using the developer’s interface, a plug-in, which features, automatic source code generation, compilation with full error feedback and dynamic algorithm updates. The Chapter will also discuss key issues associated with the environment and outline the advantages in adopting such a system for machine vision application developmen

    Capillary rise of a liquid between two vertical plates making a small angle.

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    The penetration of a wetting liquid in the narrow gap between two vertical plates making a small angle is analyzed in the framework of the lubrication approximation. At the beginning of the process, the liquid rises independently at different distances from the line of intersection of the plates except in a small region around this line where the effect of the gravity is negligible. The maximum height of the liquid initially increases as the cubic root of time and is attained at a point that reaches the line of intersection only after a certain time. At later times, the motion of the liquid is confined to a thin layer around the line of intersection whose height increases as the cubic root of time and whose thickness decreases as the inverse of the cubic root of time. The evolution of the liquid surface is computed numerically and compared with the results of a simple experiment

    Large-wavelength instabilities in free-surface Hartmann flow at low magnetic Prandtl numbers

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    We study the linear stability of the flow of a viscous electrically conducting capillary fluid on a planar fixed plate in the presence of gravity and a uniform magnetic field. We first confirm that the Squire transformation for MHD is compatible with the stress and insulating boundary conditions at the free surface, but argue that unless the flow is driven at fixed Galilei and capillary numbers, the critical mode is not necessarily two-dimensional. We then investigate numerically how a flow-normal magnetic field, and the associated Hartmann steady state, affect the soft and hard instability modes of free surface flow, working in the low magnetic Prandtl number regime of laboratory fluids. Because it is a critical layer instability, the hard mode is found to exhibit similar behaviour to the even unstable mode in channel Hartmann flow, in terms of both the weak influence of Pm on its neutral stability curve, and the dependence of its critical Reynolds number Re_c on the Hartmann number Ha. In contrast, the structure of the soft mode's growth rate contours in the (Re, alpha) plane, where alpha is the wavenumber, differs markedly between problems with small, but nonzero, Pm, and their counterparts in the inductionless limit. As derived from large wavelength approximations, and confirmed numerically, the soft mode's critical Reynolds number grows exponentially with Ha in inductionless problems. However, when Pm is nonzero the Lorentz force originating from the steady state current leads to a modification of Re_c(Ha) to either a sublinearly increasing, or decreasing function of Ha, respectively for problems with insulating and conducting walls. In the former, we also observe pairs of Alfven waves, the upstream propagating wave undergoing an instability at large Alfven numbers.Comment: 58 pages, 16 figure

    Electrophoresis of a polyelectrolyte through a nanopore

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    A hydrodynamic model for determining the electrophoretic speed of a polyelectrolyte through a nanopore is presented. It is assumed that the speed is determined by a balance of electrical and viscous forces arising from within the pore and that classical continuum electrostatics and hydrodynamics may be considered applicable. An explicit formula for the translocation speed as a function of the pore geometry and other physical parameters is obtained and is shown to be consistent with experimental measurements on DNA translocation through nanopores in silicon membranes. Experiments also show a weak dependence of the translocation speed on polymer length that is not accounted for by the present model. It is hypothesized that this is due to secondary effects that are neglected here.Comment: 5 pages, 2 column, 2 figure

    Large-time Behavior of Solutions to the Inflow Problem of Full Compressible Navier-Stokes Equations

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    Large-time behavior of solutions to the inflow problem of full compressible Navier-Stokes equations is investigated on the half line R+=(0,+∞)R^+ =(0,+\infty). The wave structure which contains four waves: the transonic(or degenerate) boundary layer solution, 1-rarefaction wave, viscous 2-contact wave and 3-rarefaction wave to the inflow problem is described and the asymptotic stability of the superposition of the above four wave patterns to the inflow problem of full compressible Navier-Stokes equations is proven under some smallness conditions. The proof is given by the elementary energy analysis based on the underlying wave structure. The main points in the proof are the degeneracies of the transonic boundary layer solution and the wave interactions in the superposition wave.Comment: 27 page
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