Uji Efektivitas Antiinflamasi Infus Herba Suruhan (Peperomia Pellucida L.) Pada Tikus Putih (Rattus Norvegicus)

Telah dilakukan penelitian uji efektivitas antiinflamasi infus herba Suruhan (Peperomia pellucida L.) pada tikus putih (Rattus norvegicus). Inflamasi merupakan gangguan yang sering terjadi pada manusia dan hewan. Herba Suruhan mengandung kalsium oksalat yang berkhasiat mengobati bengkak dan nyeri pada rematik gout. Penelitian ini bertujuan untuk mengetahui efek antiinflamasi infus herba Suruhan pada tikus putih. Jenis penelitian ini adalah eksperimen laboratorium dengan rancangan Pretest and Postest with Control Group Design. Subyek penelitian adalah tikus putih (Rattus norvegicus) sebanyak 25 ekor dan dibagi 5 kelompok dengan perlakuan kelompok I sebagai kontrol negatif diberi aquadest, kelompok II diberi fenilbutason sebagai kontrol positif dan kelompok III, IV dan V diberi infus herba Suruhan dengan konsentrasi 15%, 30% dan 60%. Pengujian antiinflamasi dilakukan pada telapak kaki tikus putih yang diinduksi 0,5 mL larutan putih telur 10% dan pemberian perlakuan 3 x sehari selama 3 hari. Pengukuran volume telapak kaki tikus dilakukan sebelum perlakuan dan sesudah 1 hari, 2 hari dan 3 hari perlakuan. Data dianalisis mengunakan uji Anova. Hasil penelitian menunjukkan bahwa infus herba Suruhan memiliki efek antiinflamasi pada tikus putih (p < 0,05)

Anticancer Activity Of Plant Genus Clerodendrum (Lamiaceae): A Review

Plants of the genus Clerodendrum (Lamiaceae) is widespread in tropical and subtropical regions. Plants of this genus are used both empirically and scientifically as anti-inflammatory, antidiabetic, antimalarial, antiviral, antihypertensive, hypolipidemic, antioxidant, and antitumor. Results of the molecular docking simulation of chemical content of these plants could potentially provide an anticancer effect. This paper aims to review the anticancer activity of plant genus Clerodendrum based on scientific data. The method used in this study is the literature study. Searches were conducted online (in the database PubMed, Science Direct and Google Scholar) and on various books (Farmakope Herbal Indonesia and PROSEA). A total 12 plants of the genus Clerodendrum have anticancer activity in vitro and in vivo, thus potentially to be developed as a source of new active compounds with anticancer activity

Spatio of lungs Tuberculosis (Tb Lungs) in East Java Using Geographically Weighted Poisson Regression (GWPR)

Pulmonary tuberculosis patients lose nearly 40% of their productive time. This results in reduced productivity if he is the head of the family or productive. In addition, pulmonary tuberculosis patients become highly dangerous transmitters if they do not pay attention to handling the correct cough and being in a location with a high sexual percentage. Likewise, people who are hurt, will have great information, contracting, if any, and very experienced. This study aims to map the grouping of tuberculosis patients and who are at risk of contracting by time rather than looking at the factors that influence it by using poisson regression that address the presence of GWPR over dispersion. The results obtained there are 5 grouping of areas, with the most significant factors of the district plus the ratio of Trenggalek basic health facilities (Z2) and the percentage of school (Z4) and poor population (X1), BTA + (X2), HIV/AIDS incidence rate (X3) incidence of diabetes mellitus (X4), population density (X5) and ratio of health personnel (X6)

Uji Tuberkulosis Laten Pada Kontak Serumah Pasien BTA Positif Dengan Metode Mantoux Test

Background. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Latent tuberculosis is one of the conditions that occur when exposed to TB bacteria but does not show clinical symptoms. Vulnerable family members infected with TB due to difficulty avoiding contact with patients. The tuberculin skin test is one of the tests used to diagnose latent TB. The purpose of this study was to determine the description of latent TB in-home contact with smear-positive TB patients. Determine the relationship between latent TB with age, gender, education, occupation, and smoking status. Method. The type of research is correlation analytic research with a cross-sectional design with a total sample of 22 people. Results. Based on the results of the study as many as 15 people (68.2%) with induration > 10 mm, and 7 people (31, 8%) with induration <10 mm. While based on the results of statistical tests to see the relationship between the influence of age, sex, education level, occupation and smoking status with latent TB status obtained approx significant> 0.05. Conclusion. Thus the prevalence of latent TB at home contact with positive smear patients was 68.2% and there was no relationship between age, sex, education level, occupation and smoking status with TB status.Latar Belakang. Tuberkulosis adalah suatu penyakit infeksi yang disebabkan oleh bakteri Mycobacterium tuberculosis. Tuberkulosis laten adalah salah satu keadaan yang terjadi ketika terpapar dengan bakteri TB namun tidak menunjukan gejala klinis. Anggota keluarga rentan tertular TB dikarenakan sulit menghindari kontak dengan penderita. Uji tuberculin skin test adalah salah satu uji yang dipakai untuk mendiagnosa TB laten. Tujuan. Tujuan penelitian ini adalah untuk mengetahui gambaran TB laten pada kontak serumah dengan pasien TB BTA positif.  Menentukan hubungan antara TB laten dengan umur, jenis kelamin, pendidikan, pekerjaan dan status merokok. Metode.  Jenis penelitian yang digunakan adalah penelitian analitik korelasi dengan desain cros sectional dengan jumlah sampel sebanyak 22 orang. Hasil. Berdasarkan hasil penelitian  sebanyak 15 orang (68,2%) dengan indurasi > 10 mm, dan  7 orang (31, 8%) dengan indurasi < 10 mm . Sedangkan berdasarkan hasil uji statistik untuk melihat hubungan antara pengaruh umur, jenis kelamin, tingkat pendidikan, pekerjaan dan status merokok dengan status TB laten diperoleh approx signifikan > 0,05. Kesimpulan. Dengan demikian prevalensi TB laten pada kontak serumah pasien BTA positif sebesar 68,2% dan tidak terdapat hubungan antara umur, jenis kelamin, tingkat pendidikan, pekerjaan dan status merokok dengan status TB

Anticancer activities of sewewanua leaf extracts (Clerodendrum fragrans (Vent.) Wild) againts A549 lung cancer cell

Cancer is one of the leading causes of non-communicable diseases in the world. In 2015, about 8.8 million cancer deaths worldwide and lung cancer was the most common type of cancer and the highest cause of death. Therapy for lung cancer can be either conventional therapy or molecular targeted therapy still has many limitations. It is therefore important to explore new sources of anticancer activity, including those from plants. One plant that is thought to have anticancer activity is Sesewanua (Clerodendrum fragrans [Vent.] Willd. Syn. Clerodendrum chinense [Osbeck] Mabb. Family Lamiaceae). This research is a laboratory experiment. The sample used is the C. fragrans leaves obtained in Malalayang I Timur Village, Malalayang District, Manado City, North Sulawesi Province, while the subjects in this study were A549 lung cancer cells from Cell-Culture Laboratory, Faculty of Pharmacy, Universitas Padjadjaran Bandung. Anticancer activity test was using the MTT Tetrazolium Assay Method. Data in the form of a percentage (%) inhibition of cell proliferation, then determined the value the concentration of 50% proliferation inhibition (IC50) using a computer program online