Accommodating Innovation In A Juvenile Court

In an attempt to reduce the number of adjudicated juveniles being committed to the state for placement, the juvenile court in Wayne CountyMichigan implemented three intensive supervision programs to serve as alternatives to commitment. A four-year, randomized evaluation of the programs found them to be cost-effective. An analysis of court processes, however, suggested that the programs gradually came to supplement rather than to displace commitments as intended. The results of this study illustrate how juvenile justice organizations adapt to the presence of alternative programs in ways that dilute their impact.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68050/2/10.1177_088740349000400204.pd

Evaluating the impact of design decisions on the financial performance of manufacturing companies

Product design decisions can have a significant impact on the financial and operation performance of manufacturing companies. Therefore good analysis of the financial impact of design decisions is required if the profitability of the business is to be maximised. The product design process can be viewed as a chain of decisions which links decisions about the concept to decisions about the detail. The idea of decision chains can be extended to include the design and operation of the 'downstream' business processes which manufacture and support the product. These chains of decisions are not independent but are interrelated in a complex manner. To deal with the interdependencies requires a modelling approach which represents all the chains of decisions, to a level of detail not normally considered in the analysis of product design. The operational, control and financial elements of a manufacturing business constitute a dynamic system. These elements interact with each other and with external elements (i.e. customers and suppliers). Analysing the chain of decisions for such an environment requires the application of simulation techniques, not just to any one area of interest, but to the whole business i.e. an enterprise simulation. To investigate the capability and viability of enterprise simulation an experimental 'Whole Business Simulation' system has been developed. This system combines specialist simulation elements and standard operational applications software packages, to create a model that incorporates all the key elements of a manufacturing business, including its customers and suppliers. By means of a series of experiments, the performance of this system was compared with a range of existing analysis tools (i.e. DFX, capacity calculation, shop floor simulator, and business planner driven by a shop floor simulator)

Pterodactyl: Control Architectures Development for Integrated Control Design of a Mechanically Deployed Entry Vehicle

The need to return high mass payloads is driving the development of a new class of vehicles, Deployable Entry Vehicles (DEV) for which feasible and optimized control architectures have not been developed. The Pterodactyl project, seeks to advance the current state-of-the-art for entry vehicles by developing a design, test, and build capability for DEVs that can be applied to various entry vehicle configurations. This paper details the efforts on the NASA-funded Pterodactyl project to investigate multiple control techniques for the Lifting Nano-ADEPT (LNA) DEV. We design and implement multiple control architectures on the LNA and evaluate their performance in achieving varying guidance commands during entry.First we present an overview of DEVs and the Lifting Nano-ADEPT (LNA), along with the physical LNA configuration that influences the different control designs. Existing state-of-the-art for entry vehicle control is primarily propulsive as reaction control systems (RCS) are widely employed. In this work, we analyze the feasibility of using both propulsive control systems such as RCS to generate moments, and non-propulsive control systems such as aerodynamic control surfaces and internal moving mass actuations to shift the LNA center of gravity and generate moments. For these diverse control systems, we design different multi-input multi-output (MIMO) state-feedback integral controllers based on linear quadratic regulator (LQR) optimal control methods. The control variables calculated by the controllers vary, depending on the control system being utilized and the outputs to track for the controller are either the (i) bank angle or the (ii) angle of attack and sideslip angle as determined by the desired guidance trajectory. The LQR control design technique allows the relative allocation of the control variables through the choice of the weighting matrices in the cost index. Thus, it is easy to (i) specify which and how much of a control variable to use, and (ii) utilize one control design for different control architectures by simply modifying the choice of the weighting matrices.By providing a comparative analysis of multiple control systems, configurations, and performance, this paper and the Pterodactyl project as a whole will help entry vehicle system designers and control systems engineers determine suitable control architectures for integration with DEVs and other entry vehicle types

Pterodactyl: Development and Comparison of Control Architectures for a Mechanically Deployed Entry Vehicle

The Pterodactyl project, seeks to advance the current state-of-the-art for entry vehicles by developing novel guidance and control technologies for Deployable Entry Vehicles (DEVs) that can be applied to various entry vehicle configurations. This paper details the efforts on the NASA-funded Pterodactyl project to investigate and implement multiple control techniques for an asymmetric mechanical DEV. We design multiple control architectures for a Pterodactyl Baseline Vehicle (PBV) and evaluate their performance in achieving varying guidance commands during entry. The control architectures studied are (i) propulsive control systems such as reaction control systems and (ii) non-propulsive control systems such as aerodynamic control surfaces and internal moving masses. For each system, state-feedback integral controllers based on linear quadratic regulator (LQR) optimal control methods are designed to track guidance commands of either (i) bank angle or (ii) angle of attack and sideslip angle as determined by the desired guidance trajectory. All control systems are compared for a lunar return reference mission and by providing a comparative analysis of these systems, configurations, and performance, the efforts detailed in this paper and the Pterodactyl project as a whole will help entry vehicle system designers determine suitable control architectures for integration with DEVs and other entry vehicle types

Patent Landscape of Influenza A Virus Prophylactic Vaccines and Related Technologies

Executive Summary: This report focuses on patent landscape analysis of technologies related to prophylactic vaccines targeting pandemic strains of influenza. These technologies include methods of formulating vaccine, methods of producing of viruses or viral subunits, the composition of complete vaccines, and other technologies that have the potential to aid in a global response to this pathogen. The purpose of this patent landscape study was to search, identify, and categorize patent documents that are relevant to the development of vaccines that can efficiently promote the development of protective immunity against pandemic influenza virus strains. The search strategy used keywords which the team felt would be general enough to capture (or “recall”) the majority of patent documents which were directed toward vaccines against influenza A virus. After extensive searching of patent literature databases, approximately 33,500 publications were identified and collapsed to about 3,800 INPADOC families. Relevant documents, almost half of the total, were then identified and sorted into the major categories of vaccine compositions (about 570 families), technologies which support the development of vaccines (about 750 families), and general platform technologies that could be useful but are not specific to the problems presented by pandemic influenza strains (about 560 families). The first two categories, vaccines and supporting technologies, were further divided into particular subcategories to allow an interested reader to rapidly select documents relevant to the particular technology in which he or she is focused. This sorting process increased the precision of the result set. The two major categories (vaccines and supporting technologies) were subjected to a range of analytics in order to extract as much information as possible from the dataset. First, patent landscape maps were generated to assess the accuracy of the sorting procedure and to reveal the relationships between the various technologies that are involved in creating an effective vaccine. Then, filings trends are analyzed for the datasets. The country of origin for the technologies was determined, and the range of distribution to other jurisdictions was assessed. Filings were also analyzed by year, by assignee, and by inventor. Finally, the various patent classification systems were mapped to find which particular classes tend to hold influenza vaccine-related technologies. Besides the keywords developed during the searches and the landscape map generation, the classifications represent an alternate way for further researchers to identify emerging influenza technologies. The analysis included creation of a map of keywords, as shown above, describing the relationship of the various technologies involved in the development of prophylactic influenza A vaccines. The map has regions corresponding to live attenuated virus vaccines, subunit vaccines composed of split viruses or isolated viral polypeptides, and plasmids used in DNA vaccines. Important technologies listed on the map include the use of reverse genetics to create reassortant viruses, the growth of viruses in modified cell lines as opposed to the traditional methods using eggs, the production of recombinant viral antigens in various host cells, and the use of genetically-modified plants to produce virus-like particles. Another major finding was that the number of patent documents related to influenza being published has been steadily increasing in the last decade, as shown in the figure below. Until the mid-1990s, there were only a few influenza patent documents being published each year. The number of publications increased noticeably when TRIPS took effect, resulting in publication of patent applications. However, since 2006 the number of vaccine publications has exploded. In each of 2011 and 2012, about 100 references disclosing influenza vaccine technologies were published. Thus, interest in developing new and more efficacious influenza vaccines has been growing in recent years. This interest is probably being driven by recent influenza outbreaks, such as the H5N1 (bird flu) epidemic that began in the late 1990s and the 2009 H1N1 (swine flu) pandemic. The origins of the vaccine-related inventions were also analyzed. The team determined the country in which the priority application was filed, which was taken as an indication of the country where the invention was made or where the inventors intended to practice the invention. By far, most of the relevant families originated with patent applications filed in the United States. Other prominent priority countries were the China and United Kingdom, followed by Japan, Russia, and South Korea. France was a significant priority country only for supporting technologies, not for vaccines. Top assignees for these families were mostly large pharmaceutical companies, with the majority of patent families coming from Novartis, followed by GlaxoSmithKline, Pfizer, U.S. Merck (Merck, Sharpe, & Dohme), Sanofi, and AstraZeneca. Governmental and nonprofit institutes in China, Japan, Russia, South Korea and the United States also are contributing heavily to influenza vaccine research. Lastly, the jurisdictions were inventors have sought protection for their vaccine technologies were determined, and the number of patent families filing in a given country is plotted on the world map shown on page seven. The United States, Canada, Australia, Japan, South Korea and China have the highest level of filings, followed by Germany, Brazil, India, Mexico and New Zealand. However, although there are a significant number of filings in Brazil, the remainder of Central and South America has only sparse filings. Of concern, with the exception of South Africa, few other African nations have a significant number of filings. In summary, the goal of this report is to provide a knowledge resource for making informed policy decisions and for creating strategic plans concerning the assembly of efficacious vaccines against a rapidly-spreading, highly virulent influenza strain. The team has defined the current state of the art of technologies involved in the manufacture of influenza vaccines, and the important assignees, inventors, and countries have been identified. This document should reveal both the strengths and weaknesses of the current level of preparedness for responding to an emerging pandemic influenza strain. The effects of H5N1 and H1N1 epidemics have been felt across the globe in the last decade, and future epidemics are very probable in the near future, so preparations are necessary to meet this global health threat

California Water Myths

Presents eight common myths about water supply, ecosystems, and the legal and political aspects of governing California's water system and explains how each myth drives the debate, the reality, and alternatives for better informed policy discussions

Influence of Timber Harvesting Operations and Streamside Management Zone Effectiveness on Sediment Delivery to Headwater Streams in Appalachia

Disturbances created by timber harvesting equipment and associated haul roads and skid trails can create overland sediment flows (sediment paths), especially in steeply sloping terrain, leading to stream sedimentation. This study investigated the effect of variables associated with GPS tracked harvest equipment movement, skid trail development and retirement, topography, and streamside management zone (SMZ) width and tree retention on sediment delivery to streams. While the intensity of harvest equipment traffic was not correlated with sediment path development, the presence and location of skid trails were. All of the sediment paths were found to originate at water control structures, influenced by microtopographic features, on the skid trails directly adjacent to SMZs. Mesic slopes were associated with increased sediment path development across all SMZ configurations. Two factors, the accumulation of coarse logging debris in the SMZ and the increased distance of skid trails to streams, were both correlated with decreased sediment path development. The study provides insight into how these variables interact and can be used to develop site-specific guidelines for SMZs in steeply sloping terrain that could improve their efficiency and effectiveness

Outcome of Hyperkalemia in the Emergency Department: Impact of Hyperkalemic Severity, Renal Function and CHF on Survival

Background: Hyperkalemia is common and lethal electrolyte disorder with little known long-term consequences. This was retrospective, observational study of hospitalized patients with initial serum K \u3e 5.3 mEq/L. 143 consecutive episodes of hyperkalemia were analyzed in 133 patients. Survival was analyzed by parameters of renal dysfunction (admit eGFR), CHF, admit K and EKG abnormalities. Methods: Hazard ratios (HR) for mortality were computed by Cox proportional hazards multivariate regression. Primary end point, all-cause mortality determined by Social Security Death Index and medical record review. Results: Admit eGFR was the most powerful predictor of mortality. The effect of renal function was nonlinear(figure 1). Highest mortality is eGFR group of 15-59 HR 6.92. More severe renal impairment with eGFR(HD) HR 3.67. ESRD had lower mortality HR 1.33(table 1). Hyperkalemic severity had a modest effect(figure 2). Compared to patients Admit K 5.3-5.9 mEq/L, patients with K 6-7, HR 2.21 (p=0.0210) and K \u3e7.0, HR 2.62 (p=0.0521). History of CHF, increased mortality by univariate analysis (p Conclusions: Survival in hyperkalemic patients is predicted by lower admit eGFR in a non-linear fashion. ESRD patients exhibited lower mortality perhaps reflecting adaptation to chronic hyperkalemia. CHF has an additive effect on mortality in non HD patients. We emphasize that 86% of the mortality was after discharge. This extraordinary mortality necessitates the need to develop risk stratification strategies in the long-term care of the hyperkalemic patients

Interactive effects of fire and large herbivores on web-building spiders

Altered disturbance regimes are a major driver of biodiversity loss worldwide. Maintaining or re-creating natural disturbance regimes is therefore the focus of many conservation programmes. A key challenge, however, is to understand how co-occurring disturbances interact to affect biodiversity. We experimentally tested for the interactive effects of prescribed fire and large macropod herbivores on the web-building spider assemblage of a eucalypt forest understorey and investigated the role of vegetation in mediating these effects using path analysis. Fire had strong negative effects on the density of web-building spiders, which were partly mediated by effects on vegetation structure, while negative effects of large herbivores on web density were not related to changes in vegetation. Fire amplified the effects of large herbivores on spiders, both via vegetation-mediated pathways and by increasing herbivore activity. The importance of vegetation-mediated pathways and fire–herbivore interactions differed for web density and richness and also differed between web types. Our results demonstrate that for some groups of web-building spiders, the effects of co-occurring disturbance drivers may be mostly additive, whereas for other groups, interactions between drivers can amplify disturbance effects. In our study system, the use of prescribed fire in the presence of high densities of herbivores could lead to reduced densities and altered composition of web-building spiders, with potential cascading effects through the arthropod food web. Our study highlights the importance of considering both the independent and interactive effects of disturbances, as well as the mechanisms driving their effects, in the management of disturbance regimes