Telemarketing – perswazja a manipulacja

Artykuł przedstawia omówienie sytuacji retorycznej, jaką jest rozmowa telemarketingowa. Ze względu na rosnącą popularność tej formy kontaktu z klientami, ważną kwestią staje się analiza, na ile mamy tu do czynienia z perswazją, a na ile z manipulacją. Autor przedstawia podstawowe techniki wpływu osadzając je w kontekście rozmowy sprzedażowej. Omawia uwarunkowania procesu perswazji i analizuje skrypt sprzedażowy w ujęciu teorii dwutorowości przekazu

DAMAGE DETECTION IN COMPOSITE CYLINDRICAL PANEL BASED ON FORCED VIBRATION ANALYSIS

The current work is devoted to the damage detecting inside the composite cylindrical panels. The applied method is based on the analysis of the natural vibration and corresponding mode shapes. The analysis is performed with use of finite element method. The internal defect is modeled by the reduction of the composite material stiffness and density in arbitrary chosen elements. In the first step the natural frequencies of the intact structure are computed with use of the modal analysis. Next, the corresponding mode shapes are determined (harmonic analysis) for the damage and intact structure. For the each mode shape the curvature in the longitudinal and circumferential direction are determined. In the location of the damage the change of mode shape curvature are quite different in comparison with intact structure. The proposed method of the damage detecting in the investigated here multilayered cylindrical panel are very sensitive. Even single small flaws with relatively low reduction of the material stiffness as well as its position can be effectively detected and localized

Versatile and efficient synthesis of omega-functionalized asymmetric disulfides via sulfenyl bromide adducts

Various types of asymmetric disulfides can be synthesized under mild conditions and in excellent yields by a method involving dialkoxylthiophosphoranesulfenyl halide precursors. This straightforward, rapid procedure is used to prepare a series of disulfides bearing neutral, acidic, and basic terminal groups as well as groups commonly used in biospecific self-assembled monolayers

Effects Induced by the Temperature and Chemical Environment on the Fluorescence of Water-Soluble Gold Nanoparticles Functionalized with a Perylene-Derivative Dye

We developed a fluorescent molecular probe based on gold nanoparticles functionalized with N,N′-bis(2-(1-piperazino)ethyl)-3,4,9,10-perylenetetracarboxylic acid diimide dihydrochloride, and these probes exhibit potential for applications in microscopic thermometry. The intensity of fluorescence was affected by changes in temperature. Chemical environments, such as different buffers with the same pH, also resulted in different fluorescence intensities. Due to the fluorescence intensity changes exhibited by modified gold nanoparticles, these materials are promising candidates for future technologies involving microscopic temperature measurements

Single anastomosis sleeve ileal bypass (SASI) : a single-center initial report

INTRODUCTION: Single anastomosis sleeve ileal (SASI) bypass is a recently introduced bariatric procedure that combines the advantages of restrictive and malabsorptive operations, at the same time reducing the risk of nutrient deficiencies by maintaining passage through all the alimentary tract. AIM: To present the outcomes of the first group of patients that underwent the SASI bypass in our clinic and assess the safety and efficiency of the procedure. MATERIAL AND METHODS: We analyzed patients qualified for SASI bypass between January 2020 and February 2021. Retrospective analysis was performed and outpatient treatment results were evaluated. RESULTS: A group of nineteen patients (18 women) underwent SASI bypass. The mean preoperative body mass index was 40.3 ±3.74 kg/m(2), mean age: 43.3 ±7.83. The mean excess weight loss (% EWL) after 3, 6, 9 and 12 months of follow-up was 43%, 56%, 72.5%, 88.83% respectively. Remission of obesity related diseases was as followed: hypertension in 8 patients (80%, p < 0.05), type II diabetes in 6 patients (100%, p < 0.05), pre-diabetes in 4 patients (50%, p = 0.13). Complications occurred in 4 cases: hematemesis, dysphagia, diarrhea, short bowel syndrome. A patient who developed symptoms of short bowel syndrome was reoperated on and gastrointestinal anastomosis was disconnected. Postoperatively, unwanted symptoms resolved and a good bariatric effect was preserved. CONCLUSIONS: Our first experience is consistent with that reported in previous studies: very good EWL and a rapid resolution of obesity related diseases after SASI bypass as well as safety of the procedure

Mixed-Charge Nanocarriers Allow for Selective Targeting of Mitochondria by Otherwise Nonselective Dyes

Targeted delivery of molecular cargos to specific organelles is of paramount importance for developing precise and effective therapeutics and imaging probes. This work describes a disulfide-based delivery method in which mixed-charged nanoparticles traveling through the endolysosomal tract deliver noncovalently bound dye molecules selectively into mitochondria. This system comprises three elements: (1) The nanoparticles deliver their payloads by a kiss-and-go mechanism. that is, they drop off their dye cargos proximate to mitochondria but do not localize therein; (2) - the dye molecules are by themselves nonspecific to any cellular structures but become so with the help of mixed-charge nanocarriers; and (3) the dye is engineered in such a way as to remain in mitochondria for a long time, up to days, allowing for observing dynamic remodeling of mitochondrial networks and long-term tracking of mitochondria even in dividing cells. The selectivity of delivery and long-lasting staining derive from the ability to engineer charge-imbalanced, mixed [+/-] on-particle monolayers and from the structural features of the cargo. Regarding the former, the balance of [+] and [-] ligands can be adjusted to limit cytotoxicity and control the number of dye molecules adsorbed onto the particles&apos; surfaces. Regarding the latter, comparative studies with multiple dye derivatives we synthesized rationalize the importance of polar groups, long alkyl chains, and disulfide moieties in the assembly of fluorescent nanoconstructs and long-lasting staining of mitochondria. Overall, this strategy could be useful for delivering hydrophilic and/or anionic small-molecule drugs difficult to target to mitochondria by classical approaches