COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. Objective To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. Methods We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. Results Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. Conclusion Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity

ANNUAL REVIEW OF IMMUNOLOGY

Mitt syfte med den här uppsatsen är att få en djupare kunskap om vilka behov yngre elever med ett annat modersmål har av modersmåls- och andraspråksundervisning. Jag har använt mig av kvalitativa intervjuer med elever och pedagoger för att få kunskap om hur de ser på modersmålsundervisning och svenska som andraspråk. Eleverna går på en mångkulturell skola. De elever som jag intervjuade var 6-8 år gamla och var alla födda här i Sverige av utländska föräldrar. Alla eleverna pratade både svenska och sitt modersmål. Pedagogerna arbetar på samma skola där eleverna går. Resultaten från elevintervjuerna blev ganska lika. Av de fyra som jag intervjuade fick tre stycken elever modersmålsundervisning. De tyckte att det var bra att ha den valmöjligheten i skolan. Men de ansåg att de fick den bästa undervisningen i hemmet av föräldrarna själva. Pedagogerna anser att det väldigt viktigt med modersmålsundervisning för att underlätta för eleverna vid andraspråksinlärningen