Diagnóstico integral de mercadeo aplicado a la empresa agroindustrial Hunzahua Ltda.

Administrador (a) de EmpresasPregrad

T cell activity in successful treatment of chronic urticaria with omalizumab

Omalizumab, a humanized monoclonal anti-IgE antibody has the potential to alter allergen processing. Recently, it has been postulated the assessment of PHA-stimulated adenosine triphosphate (ATP) activity as maker of CD4+ T cells activity in peripheral blood cells. We present the case report of a 35-year-old woman with a history of chronic idiopathic urticaria and angioedema of 8 years of development with poor response to treatment. The patient was partially controlled with cyclosporine at doses of 100 mg/12 h. However, she was still developing hives daily. Finally treatment with omalizumab was started at dose of 300 mg every 2 weeks. The patient experienced a decrease in urticarial lesions 2 days after starting therapy. We also evaluated the effects of omalizumab therapy on the activity of peripheral blood CD4+ T cells from the patient, in order to determine the potential modification of anti-IgE therapy on the process of antigen presentation-recognition. Activity of CD4+ cells by ATP release was clearly increased demonstrating an enlarged CD4 activity. Omalizumab may be useful in the treatment of severe chronic urticaria. ATP activity of peripheral blood CD4+ T cells might be a non-subjective method to assess Omalizumab activity

Satisfacción laboral, equilibrio trabajo-familia y bienestar psicológico en una empresa del rubro forestal de la Región del Maule

87 p.El presente estudio tuvo como objetivo analizar la relación entre satisfacción laboral,equilibrio trabajo-familia y bienestar psicológico en una empresa forestal de la región del Maule. Contemplando como hipótesis que existe relación positiva y significativa entre estas variables y la influencia del equilibrio trabajo-familia y bienestar psicológico sobre satisfacción laboral. En el proceso se realizó la aplicación de tres cuestionarios en un total de 98 trabajadores de una empresa del rubro forestal de la comuna de Maule. Para la medición de la variable satisfacción laboral se utilizó el cuestionario S10/12, posteriormente se utilizó el cuestionario de interacción trabajo familia (SWING) y finalmente se aplicó la escala de bienestar psicológico Ryff. A partir de los resultados obtenidos se concluyó que existe una correlación positiva y significativa entre equilibrio trabajo-familia y satisfacción laboral (r = 0,396), satisfacción laboral y bienestar psicológico (r = 0,255) y finalmente bienestar psicológico y equilibrio trabajo-familia (r = 0,437). Por otra parte se obtuvo un modelo que incluye la variable equilibrio trabajo- familia como principal predictor de satisfacción laboral (R2 = 0,157), mientras que la variable bienestar psicológico no fue incluida en el modelo, puesto que su influencia sobre variable dependiente no es significativa. Palabras Claves: Satisfacción laboral, equilibrio trabajo familia y bienestar psicológic

The impact of associated tenotomies on the outcome of incomplete phalangeal osteotomies for lesser toe deformities

Partial or incomplete osteotomy (IO) of the phalanx is recently described in the literature. However, the clinical outcome and the rate of complications when applied to lesser toe deformities (LTD) have been never addressed. This study aims to find out if the association of tenotomies to incomplete or partial phalanx osteotomies has a significant impact on the clinical outcomes, the occurrence of complications, and the recovery time after surgery. Methods: A retrospective review of two cohorts of cases operated in our institution for hallux abductus valgus (HAV) and associated LTD from 2008 to 2014 was carried out. The surgical correction of both HAV and the associated LTD was always performed by minimally invasive techniques. The study included a total of 223 patients (723 IO in 556 toes). In 129 cases, the IO for LTD correction was performed without tenotomies, and in 94, the procedure was combined with flexor and/or extensor tenotomies. Patients were assessed with the American Orthopaedic Foot and Ankle Society (AOFAS) questionnaire before surgery and at 6- and 12-month follow-up. Results: The mean preoperative AOFAS score before surgery was similar in both cohorts. At 12-month follow-up, the cohort without tenotomies showed better recovery (95.7 ± 2.8 versus 92.5 ± 6.8; p < 0.01). AOFAS scores decreased as the number of associated LTD increased (r = − 0.814; p < 0.001). Cases operated on by PO + tenotomy showed a high rate of complications such as delayed union of the osteotomy (p < 0.01), hypertrophic callus (p < 0.01), phalangeal fracture at the osteotomy site (p < 0.01), and lack of correction (p < 0.05). The overall occurrence of adverse events was 38.6% in cases operated by PO + tenotomy and 13.9% in cases receiving PO alone (p < 0.0001). Cases operated on without tenotomy showed a shorter time to complete recovery for daily life activities (37.4 ± 2.3 versus 43.0 ± 1.7 days; p < 0.01). Conclusion: The performance of associated tenotomies to incomplete phalanx osteotomies provides worse clinical outcomes, higher complication rates, and longer recovery time as compared to similar forefoot surgeries without tenotomies.Podologí

Podocytopathy in patients with monoclonal gammopathy: three patients and literature review

Focal segmental glomerulosclerosis; Multiple myeloma; PodocytopathyGlomeruloesclerosis segmentaria focal; Mieloma múltiple; PodocitopatíaGlomeruloesclerosi focal segmentària; Mieloma múltiple; PodocitopatiaBackground Renal manifestations of monoclonal gammopathies are of increasing interest among nephrologists. Typical manifestations include light chain cast nephropathy, amyloidosis or renal damage mediated by monoclonal immunoglobulin deposition. Podocytopathies in the setting of an underlying monoclonal gammopathy constitute a rare manifestation of these diseases and, although being described in the literature, remain a challenge since most data derive from case reports. Methods A retrospective review of the clinical data of Hospital del Mar and Hospital Vall d’Hebron was performed to identify patients with minimal change disease (MCD) or focal and segmental glomerulosclerosis (FSGS) in the setting of neoplasms that produce monoclonal (M) protein. Additionally, a literature review on this topic was performed. This study aims to describe the clinical characteristics and outcomes of these patients. Results Three patients were identified to have podocytopathy and monoclonal gammopathy between the years 2013 and 2020. All three were males and >65 years of age. Two patients were diagnosed with MCD and one patient was diagnosed with FSGS. All patients underwent a kidney biopsy and light and electron microscopic studies were performed. The underlying causes of monoclonal gammopathy were multiple myeloma in two cases and Waldeström macroglobulinemia in one case. Two patients developed nephrotic syndrome during the follow-up. All patients were under active hematological treatment. One patient presented a complete remission of proteinuria whereas the other two presented a partial remission. Conclusions Podocytopathies may infrequently be found in patients with monoclonal gammopathies. Patients with overt glomerular proteinuria and hematological disorders with M protein should undergo a kidney biopsy for prompt diagnosis and to specify a prognosis. In addition, further study on this matter must be done to understand the pathophysiology and treat these patients appropriately

Toward real applicability of electro-ozonizers: Paying attention to the gas phase using actual commercial PEM electrolyzers technology

This work focuses on increasing the TRL of electro-ozonizer technology by evaluating the effect of electrolyte composition and operation conditions on the production of ozone, using an actual commercial cell, CONDIAPURE®, in conditions similar to what could be expected in a real application. Not only is attention paid to the changes in the concentration of ozone in the liquid phase, but also to those observed in the gas phase. The electrolyte and its recirculation flowrate, as well as operation temperatures and pressures are found to have significant influence on production rates. The most efficient way to produce ozone is operating at low temperatures and high pressures. In this work, 0.25 and 0.21 mg O3/min were obtained operating at 10 A in electrolytes consisting of aqueous solutions of perchloric and sulfuric acid, respectively, in tests carried out at 13 °C and 2 bars of gauge pressure. The negative effect of scavengers that appear electrochemically along the production of ozone is very important and seems to be partially compensated when organics are present in the solution due to the competition between the reaction of these scavengers with ozone or organics.Este trabajo se enfoca en incrementar el TRL de la tecnología de electro-ozonizadores mediante la evaluación del efecto de la composición del electrolito y las condiciones de operación en la producción de ozono, utilizando una celda comercial real, CONDIAPURE®, en condiciones similares a las que se podrían esperar en una aplicación real. No solo se presta atención a los cambios en la concentración de ozono en la fase líquida, sino también a los observados en la fase gaseosa. Se ha encontrado que el electrolito y su caudal de recirculación, así como las temperaturas y presiones de operación tienen una influencia significativa en las tasas de producción. La forma más eficiente de producir ozono es operando a bajas temperaturas y altas presiones. En este trabajo, 0.25 y 0.21 mg O 3/min operando a 10 A en electrolitos consistentes en soluciones acuosas de ácido perclórico y sulfúrico, respectivamente, en ensayos realizados a 13 °C y 2 bares de presión manométrica. El efecto negativo de los secuestrantes que aparecen electroquímicamente a lo largo de la producción de ozono es muy importante y parece ser parcialmente compensado cuando los orgánicos están presentes en la solución debido a la competencia entre la reacción de estos secuestrantes con el ozono o los orgánicos

New insights about the electrochemical production of ozone

Ozone is a rather attractive oxidant, it is very efficient in the oxidation of pollutants and in the killing of pathogens and does not generate any hazardous waste during its use. Its generation has been constantly sought in an effective way, focusing on obtaining high concentrations of ozone at the lowest possible cost. Recently, electrochemical production of ozone show advantages over conventional corona discharge generation, since this technology do not need very high voltages, feeding oxygen or pure air or dissolving the ozone into wastewater to be treated. However, it is still at early development stage and there is still a long way to reach the high technology readiness levels needed to complete its value chain. Equipment considerations and operation conditions are the key points that need to be understood in order to increase efficiently. Recent novelties in the state of the art of research are summarized in this work

Electrochemical generation of ozone using a PEM electrolyzer at acidic pHs

This work focuses on the electrochemical production of ozone at acidic pHs, evaluating the influence of the salts in the electrolyte, temperature and pressure on the efficiency of its production. Results demonstrate that electrolysis with electrolytes containing perchlorate salts allow obtaining higher concentrations of ozone than electrolytes containing sulfates. Adding to that, the increase in the operation pressure and the decrease in temperature have a positive effect on the production of ozone. This indicates that not only the oxidation of water, but also the oxidation of oxygen is important to explain the electrochemical production of ozone. A simple model considering all these processes is formulated and validated with the experimental results that allow explaining the fundamentals of ozone production in acidic conditions

Los Estudios Sociales de la Ciencia y la Tecnología en Colombia: grupos de investigación y colaboración

Using bibliometric methods, this work identifies some of the main socio-cognitive characteristics of the academic community of Social Studies of Science and Technology (STS) in Colombia. The analysis, based on information reported in the ScienTI platform run by the Ministry of Science, Technology, and Innovation, focuses on 248 research articles published by the members of ten research groups identified as STS. Pajek, Ucinet and, Vosviewer analysis tools were used to analyze and visualize the collaborative relationships between the groups included in the study. The results suggest that, despite having similar lines of research, there is little collaboration among the STS research groups in Colombia. We identified higher rates of collaboration between STS group members with non-STS identified research academics than between STS group members. The co-authorship network is composed of STS academics and non-STS academics, where those serving as nodes connect with mostly non-STS-academics. When there is a collaboration among STS groups, those belong to the same city. These results offer preliminary elements for the description of this community, but also show the need to broaden the exploration to other types of production, as well as to try to identify groups and researchers who, even without explicitly identifying themselves as dedicated to STS, use the theoretical-methodological repertoires and make contributions to this field

Understanding ozone generation in electrochemical cells at mild pHs

In this work, the production of ozone at mild pH conditions using a commercial electrochemical PEM cell CONDIAPURE Ⓡ is evaluated, at once a phenomenological model is proposed to understand the basis of the processes that occur inside the cell. At these pH conditions, the production of ozone can be explained from the oxidation of water, while the decomposition of ozone is found to be extremely important to explain the global experimental behavior observed. Not only is this decomposition a chemical but also an electrochemically assisted process which, in turn, can be related to the production of other oxidants in the cell which interact with ozone behaving as predators. The model formulated explains and satisfactorily reproduces the influence of the operation mode, the current intensity applied and presence and destruction of organics, with regression coefficients (r2) ranging from 0.88 to 0.99, helping to understand how the production of ozone should be promoted during electrochemical processes