Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

Survivin is an essential chromosomal passenger protein required for mitotic progression. It is also an inhibitor of apoptosis and can prevent caspase-mediated cell death. In addition, survivin levels are elevated in cancer cells where its presence correlates with increased resistance to chemo- and radio-therapy, which makes it an attractive target for novel anti-cancer strategies. Interestingly, survivin is phosphorylated by the mitotic kinase, cdk1, and a non-phosphorylatable form, survivin(T34A), cannot inhibit apoptosis. Here we rigorously test the ability of survivin(T34A) and its corresponding phosphomimetic, survivin(T34E), to promote cell viability through survivin's dual roles. The effects of these mutations are diametrically opposed: survivin(T34A) accelerates cell proliferation and promotes apoptosis, whereas survivin(T34E) retards growth and promotes survival. Thus the phosphorylation status of survivin at T34 is pivotal to a cell's decision to live or die

Coherent radiation of atoms and a channeling particle

New mechanism of radiation emitted at channeling of a relativistic particle in a crystal is studied. Superposition of coherent radiation of the atoms in a crystal lattice which are excited by a channeling particle and radiation of the channeling particle itself is considered. It is shown that coherent radiation of the chain of oscillating atoms forms a resonance peak on the background of radiation of the channeling particle.Comment: 7 pages, 4 figure

A New Recursion Relation for the 6j-Symbol

The 6j-symbol is a fundamental object from the re-coupling theory of SU(2) representations. In the limit of large angular momenta, its asymptotics is known to be described by the geometry of a tetrahedron with quantized lengths. This article presents a new recursion formula for the square of the 6j-symbol. In the asymptotic regime, the new recursion is shown to characterize the closure of the relevant tetrahedron. Since the 6j-symbol is the basic building block of the Ponzano-Regge model for pure three-dimensional quantum gravity, we also discuss how to generalize the method to derive more general recursion relations on the full amplitudes.Comment: 10 pages, v2: title and introduction changed, paper re-structured; Annales Henri Poincare (2011

The Case for Quantum Key Distribution

Quantum key distribution (QKD) promises secure key agreement by using quantum mechanical systems. We argue that QKD will be an important part of future cryptographic infrastructures. It can provide long-term confidentiality for encrypted information without reliance on computational assumptions. Although QKD still requires authentication to prevent man-in-the-middle attacks, it can make use of either information-theoretically secure symmetric key authentication or computationally secure public key authentication: even when using public key authentication, we argue that QKD still offers stronger security than classical key agreement.Comment: 12 pages, 1 figure; to appear in proceedings of QuantumComm 2009 Workshop on Quantum and Classical Information Security; version 2 minor content revision

Violation of local realism vs detection efficiency

We put bounds on the minimum detection efficiency necessary to violate local realism in Bell experiments. These bounds depends of simple parameters like the number of measurement settings or the dimensionality of the entangled quantum state. We derive them by constructing explicit local-hidden variable models which reproduce the quantum correlations for sufficiently small detectors efficiency.Comment: 6 pages, revtex. Modifications in the discussion for many parties in section 3, small erros and typos corrected, conclusions unchange

An evaluation of the stimulants and impediments to innovation within PFI/PPP projects

This paper identifies the theoretical stimulants and impediments associated with the implementation of PFI/PPP (Private Finance Initiative/Public Private Partnership) projects. A current defect of this procurement approach is the unintentional constraint upon the innovations incorporated into the development of PFI projects. A critical evaluation of the published literature has been utilized to synthesize a theoretical model. The paper proposes a theoretical model for the identification of potential innovation stimulants and impediments within this type of procurement. This theoretical model is then utilised to evaluate four previously completed PFI projects. These project case-studies have been examined in detail. The evaluation demonstrates how ineffective current procedures are. The application of this model before project letting could eliminate unintentional constraints and stimulate improved innovation within the process. The implementation of the model could improve the successful delivery of innovation within the entire PFI/PPP procurement process

GA Pilot Perceptions of Speech Systems to Transcribe and Submit PIREPs

Flying into hazardous weather can be a cause of aviation incidents and accidents. Accidents involving general aviation (GA) pilots who are not instrument rated who fly into instrument meteorological conditions (IMC) are often fatal. Pilot weather reports (PIREPs) can increase the accuracy and timeliness of current and forecasted weather conditions. They are an essential tool used by pilots to avoid flying into hazardous weather as well as meteorologists to develop and update aviation forecasts. Thus, a large number of accurate PIREPs with the best source of current weather coming from pilots and air traffic controllers are needed. Pilots are often unable to make PIREPs because of workload in the cockpit or because it is cumbersome to leave the air traffic control (ATC) frequency to contact flight the flight service station (FSS). Currently, air traffic controllers must solicit and disseminate PIREPs. However, air traffic controllers’ primary obligation is to provide traffic separation and traffic alerts. During poor weather, when PIREPs are needed the most, controllers are often too busy to solicit and disseminate PIREPs (NTSB, 2017a). This study administered a descriptive survey to inquire about how likely pilots would be to use a speech recognition system (SRS) to transcribe and submit PIREPs automatically while flying in three distinct flight regimes: instrument flight rules (IFR), visual flight rules (VFR) with flight following, and VFR without flight following. The survey employed cross-section design and included Likert scale questions. For each flight regime, additional information was obtained through an open-ended follow-up question. The Likert scale responses indicated that pilots were neutral about using a SRS to transcribe and submit PIREPs in each flight regime.Spradley’s (1979) domain analysis was used to identify common themes and patterns from the open-ended responses. Major findings from flying IFR were that pilots found it easier to speak directly to air traffic control, or pilots were too busy to submit PIREPs while flying IFR. Major findings from flying VFR with flight following were that pilots thought it was easier to report PIREPs directly to air traffic control or to a flight service station, and it was more accurate to report PIREPs directly to an aviation professional. However, they were willing to try a SRS. Major findings from flying VFR without flight following were that pilots wanted the opportunity to review a PIREP submission for accuracy and were willing to try the system. Significant differences were determined by making a comparison between the three groups

The controlled teleportation of an arbitrary two-atom entangled state in driven cavity QED

In this paper, we propose a scheme for the controlled teleportation of an arbitrary two-atom entangled state $|\phi>_{12}=a|gg>_{12}+b|ge>_{12}+c|eg>_{12}+d|ee>_{12}$ in driven cavity QED. An arbitrary two-atom entangled state can be teleported perfectly with the help of the cooperation of the third side by constructing a three-atom GHZ entangled state as the controlled channel. This scheme does not involve apparent (or direct) Bell-state measurement and is insensitive to the cavity decay and the thermal field. The probability of the success in our scheme is 1.0.Comment: 10 page

Collective ferromagnetism in two-component Fermi-degenerate gas trapped in finite potential

Spin asymmetry of the ground states is studied for the trapped spin-degenerate (two-component) gases of the fermionic atoms with the repulsive interaction between different components, and, for large particle number, the asymmetric (collective ferromagnetic) states are shown to be stable because it can be energetically favorable to increase the fermi energy of one component rather than the increase of the interaction energy between up-down components. We formulate the Thomas-Fermi equations and show the algebraic methods to solve them. From the Thomas-Fermi solutions, we find three kinds of ground states in finite system: 1) paramagnetic (spin-symmetric), 2) ferromagnetic (equilibrium) and 3) ferromagnetic (nonequilibrium) states. We show the density profiles and the critical atom numbers for these states obtained analytically, and, in ferromagnetic states, the spin-asymmetries are shown to occur in the central regions of the trapped gas, and grows up with increasing particle number. Based on the obtained results, we discuss the experimental conditions and current difficulties to realize the ferromagnetic states of the trapped atom gas, which should be overcome.Comment: submit to PR

INSIG1 influences obesity-related hypertriglyceridemia in humans

In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the region. Insulin-induced genes (INSIGs) are feedback mediators of cholesterol and fatty acid synthesis in animals, but their role in human lipid regulation is unclear. In our cohort, the INSIG1 promoter SNP rs2721 was associated with TG levels (P = 2 × 10−3 in 1,560 individuals of the original linkage cohort, P = 8 × 10−4 in 920 unrelated individuals of the replication cohort, combined P = 9.9 × 10−6). Individuals homozygous for the T allele had 9% higher TG levels and 2-fold lower expression of INSIG1 in surgical liver biopsy samples when compared with individuals homozygous for the G allele. Also, the T allele showed additional binding of nuclear proteins from HepG2 liver cells in gel shift assays. Finally, the variant rs7566605 in INSIG2, the only homolog of INSIG1, enhances the effect of rs2721 (P = 0.00117). The variant rs2721 alone explains 5.4% of the observed linkage in our cohort, suggesting that additional, yet-undiscovered genes and sequence variants in the QTL interval also contribute to alterations in TG levels in humans