Citation Flows in the Zones of Influence of Scientific

Domestic citation to papers from the same country and the greater citation impact of documents involving international collaboration are two phenomena that have been extensively studied and contrasted. Here, however, we showthat it is not somuch a national bias,but that papers have a greater impact on their immediate environments, an impact that is diluted as that environment grows. For this reason, the greatest biases are observed in countries with a limited production. Papers that involve international collaboration have a greater impact in general, on the one hand, because they have multiple “immediate environments,” and on the other because of their greater quality or prestige. In short, one can say that science knows no frontiers. Certainly there is a greater impact on the authors’ immediate environment, but this does not necessarily have to coincide with their national environments, which fade in importance as the collaborative environment expands

Early hospital readmissions post‐kidney transplantation are associated with inferior clinical outcomes

Unplanned hospital readmissions are common early post‐kidney transplantation. We investigated the relationship between early hospital readmissions and clinical outcomes in a single‐center retrospective study that included all adult kidney transplant patients between 2004 and 2008 with follow‐up to December 2012. The early hospital readmissions within the first 30 d were numbered and the diagnosis ascertained. Patients were grouped as none, once, and twice or more readmissions. Predictors of early readmissions were assessed, and clinical outcomes and patient and death‐censored kidney survival were compared. Among 1064 patients, 203 (19.1%) patients had once and 83 (7.8%) patients had twice or more readmissions within 30 d. Surgical complications, infections, and acute kidney injuries/acute rejection were three most common diagnoses. The length of initial hospital stay and African American race were among the variables associated significantly with readmissions. Patients with early readmissions had lower baseline renal function (p < 0.01) and more early acute rejection (p < 0.01). During follow‐up, only frequent readmissions, twice or more, within 30 d were associated with increased risk of death ( AHR 1.75, p   =   0.01) and death‐censored kidney failure ( AHR 2.20, p < 0.01). Frequent early hospital readmissions post‐transplantation identify patients at risk for poor long‐term outcomes, and more studies are needed to understand the mechanisms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106830/1/ctr12347.pd

Avaliação de impactos ambientais de diferentes sistemas de produção de cana-de-açúcar: convencional e conservacionista.

Resumo: O setor sucroenergético brasileiro é responsável pela produção anual de mais de 38 milhões de toneladas de açúcar e cerca de 27 bilhões de litros de etanol. A pressão social por práticas ambientalmente mais aceitáveis tem levado o setor a modificar seu atual sistema de produção. Neste contexto de mudança se inclui a interrupção da queima pré-colheita, que por sua vez possibilita a adoção de técnicas já consolidadas em outros setores agrícolas, como o plantio direto. O objetivo deste trabalho foi comparar o desempenho ambiental de dois sistemas de cultivo de cana-de-açúcar, convencional e plantio direto em rotação com soja, especificamente quanto às etapas de pré-plantio e plantio. Ambos os sistemas foram empregados em uma usina paulista, localizada em área tradicional, mas sob bioma de cerrado. Os resultados mostraram que o sistema convencional implica em maior impacto na categoria "Mudanças Climáticas", e o de plantio direto na "Depleção Fóssil". Contudo, observou-se um melhor desempenho do sistema conservacionista, que agrega um produto adicional (e que apresenta menor carga ambiental), com amesma ocupação de terras. Conclui-se que é de extrema importância a busca por práticas agrícolas mais sustentáveis na cultura canavieira, que já começa a mostrar resultados positivos

Interview investigation of insecure attachment styles as mediators between poor childhood care and schizophrenia-spectrum phenomenology

Background Insecure attachment styles have received theoretical attention and some initial empirical support as mediators between childhood adverse experiences and psychotic phenomena; however, further specificity needs investigating. The present interview study aimed to examine (i) whether two forms of poor childhood care, namely parental antipathy and role reversal, were associated with subclinical positive and negative symptoms and schizophrenia-spectrum personality disorder (PD) traits, and (ii) whether such associations were mediated by specific insecure attachment styles. Method A total of 214 nonclinical young adults were interviewed for subclinical symptoms (Comprehensive Assessment of At-Risk Mental States), schizophrenia-spectrum PDs (Structured Clinical Interview for DSM-IV Axis II Disorders), poor childhood care (Childhood Experience of Care and Abuse Interview), and attachment style (Attachment Style Interview). Participants also completed the Beck Depression Inventory-II and all the analyses were conducted partialling out the effects of depressive symptoms. Results Both parental antipathy and role reversal were associated with subclinical positive symptoms and with paranoid and schizotypal PD traits. Role reversal was also associated with subclinical negative symptoms. Angry-dismissive attachment mediated associations between antipathy and subclinical positive symptoms and both angry-dismissive and enmeshed attachment mediated associations of antipathy with paranoid and schizotypal PD traits. Enmeshed attachment mediated associations of role reversal with paranoid and schizotypal PD traits. Conclusions Attachment theory can inform lifespan models of how adverse developmental environments may increase the risk for psychosis. Insecure attachment provides a promising mechanism for understanding the development of schizophrenia-spectrum phenomenology and may offer a useful target for prophylactic intervention

Desempenho ambiental e eficiência energética do óleo de pinhão-manso, pela abordagem da avaliação do ciclo de vida.

Resumo: A sociedade vem buscando cada vez mais fontes renováveis de energia para substituição dos combustíveis fósseis, devido ao seu inevitável esgotamento futuro e à sua contribuição ao fenômeno do aquecimento global. Em função disso, o incentivo para a produção de combustíveis de base vegetal cresceu no Brasil, merecendo atenção, dentre as culturas oleaginosas, o pinhão-manso (Jatropha curcas L.), conhecido por sua elevada produção de óleo, alta rusticidade e adaptabilidade a condições de solo e clima nos quais a produção de alimentos é impraticável. Visando o desenvolvimento de tal cultura para a produção de biodiesel, os seus impactos ambientais potenciais devem ser analisados. No presente trabalho, diferentes eficiências de produção de grãos e óleo de pinhão-manso e diferentes opções de aproveitamento de resíduos foram estudados, por meio da metodologia de Avaliação do Ciclo que Vida (ACV), buscando-se identificar as alternativas mais sustentáveis para esta cadeia produtiva. No que se refere à Demanda Cumulativa de Energia e às Mudanças Climáticas, a produtividade agrícola e a eficiência da extração de óleo foram determinantes para o bom desempenho do sistema. O cenário de aproveitamento de resíduos mais favorável foi o que empregou resíduos agrícolas e industriais em substituição aos fertilizantes. Abstract: The seek for renewable energy sources to replace fossil fuels, due to its inevitable future depletion and its contribution to the global warming phenomenon, is a worldwide pursuit. As a result, the incentive for the production of plant-based fuels expanded in Brazil, deserving attention, among oilseed crops, the jatropha (Jatropha curcas L.), known for its high oil yield, high rusticity and adaptability to conditions of soil and climate in which food production is impracticable. Aiming at the development of the jatropha crop for the production of biodiesel, its potential environmental impacts should be evaluated. In this study, efficiency of jatropha grain production and of oil production, and options for reuse of the residues were evaluated, using the methodology of Life Cycle Assessment (LCA), seeking to identify more sustainable alternatives to this production chain. Concerning the impact categories of Cumulative Energy Demand and Climate Change, the crop yield and the efficiency of oil extraction were crucial to the performance of the whole system. Considering the reuse of residues, the scenario where the agricultural and industrial residues were used to replace fertilizers shown to be more favorable

Avaliação do ciclo de vida da produção de algodão em dois sistemas de rotação de culturas.

Resumo: Os nanomateriais, por suas propriedades físico-químicas únicas, podem estabelecer interações imprevistas com substâncias naturalmente presentes nos componentes ambientais, fazendo-se indispensável a avaliação dos seus potenciais impactos ambientais. O objetivo deste trabalho foi avaliar a contribuição da fase agrícola da produção de algodão - matéria-prima para obtenção de nanomateriais ? no desempenho ambiental desta tecnologia. Consideraram-se dois sistemas de produção de algodão por plantio direto: em rotação com o milheto e em rotação com soja e capim Mombaça. O método adotado foi a Avaliação do Ciclo de Vida (ACV). Para ambos os sistemas, a fase mais impactante foi a produção agrícola de algodão, de modo que para o sistema em rotação com o milheto, maiores efeitos foram encontrados nas categorias de impacto de mudanças climáticas; ecotoxicidade aquática e terrestre; e toxicidade humana. Para o sistema em rotação com soja e capim, os impactos ambientais mais relevantes foram eutrofização de água doce e mudanças climáticas. Notou-se ainda que a soja, pelo fato de ser uma cultura beneficiada pelas bactérias fixadoras de nitrogênio, diminui o aporte de fertilizantes nitrogenados, reduzindo os impactos ambientais decorrentes da sua produção

Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor

Cholesterol influences ion-channel function, distribution and clustering in the membrane, endocytosis, and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report the occurrence of a cholesterol recognition motif, here coined “CARC”, in the transmembrane regions of AChR subunits that bear extensive contact with the surrounding lipid, and are thus optimally suited to convey cholesterol-mediated signaling from the latter. Three cholesterol molecules could be docked on the transmembrane segments of each AChR subunit, rendering a total of 15 cholesterol molecules per AChR molecule. The CARC motifs contribute each with an energy of interaction between 35 and 52 kJ.mol−1, adding up to a total of about 200 kJ.mol−1 per receptor molecule, i.e. ∼40% of the lipid solvation free energy/ AChR molecule. The CARC motif is remarkably conserved along the phylogenetic scale, from prokaryotes to human, suggesting that it could be responsible for some of the above structural/functional properties of the AChR

Citation Flows in the Zones of Influence of Scientific

Domestic citation to papers from the same country and the greater citation impact of documents involving international collaboration are two phenomena that have been extensively studied and contrasted. Here, however, we showthat it is not somuch a national bias,but that papers have a greater impact on their immediate environments, an impact that is diluted as that environment grows. For this reason, the greatest biases are observed in countries with a limited production. Papers that involve international collaboration have a greater impact in general, on the one hand, because they have multiple “immediate environments,” and on the other because of their greater quality or prestige. In short, one can say that science knows no frontiers. Certainly there is a greater impact on the authors’ immediate environment, but this does not necessarily have to coincide with their national environments, which fade in importance as the collaborative environment expands