Linking the trans-Planckian and the information loss problems in black hole physics

The trans-Planckian and information loss problems are usually discussed in the literature as separate issues concerning the nature of Hawking radiation. Here we instead argue that they are intimately linked, and can be understood as "two sides of the same coin" once it is accepted that general relativity is an effective field theory.Comment: 10 pages, 2 figures. Replaced with the version to be published in General Relativity and Gravitatio

Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes

In acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at high risk of recurrent cardiovascular events and premature death. We described patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in 10 contemporary European registries. In the 10 registries there were 28,899 with and 97,505 without without DM. In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 100.0% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52)

2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.

Item does not contain fulltex

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. This article provides an overview of the major topics discussed at this special meeting and underscores the huge importance and impact, the discovery of IPC has made in the field of cardiovascular research. © 2016, The Author(s)