656 research outputs found
Vector-meson contributions do not explain the rate and spectrum in K_L -> pi0 gamma gamma
We analyze the recent NA48 data for the reaction K_L -> pi0 gamma gamma with
and without the assumption of vector meson dominance (VMD). We find that the
data is well described by a three-parameter expression inspired by O(p^6)
chiral perturbation theory. We also find that it is impossible to fit the shape
of the decay distribution and the overall rate simultaneously if one imposes
the VMD constraints on the three parameters. We comment on the different fits
and their implications for the CP-conserving component of the decay K_L -> pi0
e+ e-.Comment: Version accepted for publication on Phys. Rev. D. 19 pages, LaTeX, 8
figures, uses epsf.st
Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study
Background
Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are detectable in the sputum, plasma and urine of adults with CF, suggesting that they have potential as biomarkers for P. aeruginosa infection.
Aim
To investigate systemic 2-alkyl-4-quinolones as potential biomarkers for pulmonary P. aeruginosa infection.
Methods
A multicentre observational study of 176 adults and 68 children with CF. Cross-sectionally, comparisons were made between current P. aeruginosa infection using six 2-alkyl-4-quinolones detected in sputum, plasma and urine against hospital microbiological culture results. All participants without P. aeruginosa infection at baseline were followed up for one year to determine if 2-alkyl-4-quinolones were early biomarkers of pulmonary P. aeruginosa infection.
Results
Cross-sectional analysis: the most promising biomarker with the greatest diagnostic accuracy was 2-heptyl-4-hydroxyquinoline (HHQ). In adults, areas under the ROC curves (95% confidence intervals) for HHQ analyses were 0.82 (0.75–0.89) in sputum, 0.76 (0.69–0.82) in plasma and 0.82 (0.77–0.88) in urine. In children, the corresponding values for HHQ analyses were 0.88 (0.77–0.99) in plasma and 0.83 (0.68–0.97) in urine.
Longitudinal analysis: Ten adults and six children had a new positive respiratory culture for P. aeruginosa in follow-up. A positive plasma HHQ test at baseline was significantly associated with a new positive culture for P. aeruginosa in both adults and children in follow-up (odds ratio (OR) = 6.67;-95% CI:-1.48–30.1;-p = 0.01 and OR = 70; 95% CI: 5–956;-p < 0.001 respectively).
Conclusions
AQs measured in sputum, plasma and urine may be used to diagnose current infection with P. aeruginosa in adults and children with CF. These preliminary data show that plasma HHQ may have potential as an early biomarker of pulmonary P. aeruginosa. Further studies are necessary to evaluate if HHQ could be used in clinical practice to aid early diagnosis of P. aeruginosa infection in the future
Rapid X-ray Variability of Seyfert 1 Galaxies
The rapid and seemingly random fluctuations in X-ray luminosity of Seyfert
galaxies provided early support for the standard model in which Seyferts are
powered by a supermassive black hole fed from an accretion disc. However, since
EXOSAT there has been little opportunity to advance our understanding of the
most rapid X-ray variability. Observations with XMM-Newton have changed this.
We discuss some recent results obtained from XMM-Newton observations of Seyfert
1 galaxies. Particular attention will be given to the remarkable similarity
found between the timing properties of Seyferts and black hole X-ray binaries,
including the power spectrum and the cross spectrum (time delays and
coherence), and their implications for the physical processes at work in
Seyferts.Comment: To appear in From X-ray Binaries to Quasars: Black Hole Accretion on
All Mass Scales, ed. T. J. Maccarone, R. P. Fender, and L. C. Ho (Dordrecht:
Kluwer
The Strong CP Problem and Axions
I describe how the QCD vacuum structure, necessary to resolve the
problem, predicts the presence of a P, T and CP violating term proportional to
the vacuum angle . To agree with experimental bounds, however,
this parameter must be very small ). After briefly
discussing some possible other solutions to this, so-called, strong CP problem,
I concentrate on the chiral solution proposed by Peccei and Quinn which has
associated with it a light pseudoscalar particle, the axion. I discuss in
detail the properties and dynamics of axions, focusing particularly on
invisible axion models where axions are very light, very weakly coupled and
very long-lived. Astrophysical and cosmological bounds on invisible axions are
also briefly touched upon.Comment: 14 pages, to appear in the Lecture Notes in Physics volume on Axions,
(Springer Verlag
Spontaneous CP Violating Phase as The CKM Matrix Phase
We propose that the CP violating phase in the CKM mixing matrix is identical
to the CP phases responsible for the spontaneous CP violation in the Higgs
potential. A specific multi-Higgs model with Peccei-Quinn (PQ) symmetry is
constructed to realize this idea. The CP violating phase does not vanish when
all Higgs masses become large. There are flavor changing neutral current (FCNC)
interactions mediated by neutral Higgs bosons at the tree level. However,
unlike general multi-Higgs models, the FCNC Yukawa couplings are fixed in terms
of the quark masses and CKM mixing angles. Implications for meson-anti-meson
mixing, including recent data on mixing, and neutron electric dipole
moment (EDM) are studied. We find that the neutral Higgs boson masses can be at
the order of one hundred GeV. The neutron EDM can be close to the present
experimental upper bound.Comment: 16 pages, RevTex. Several typos corrected, and one reference adde
Serological response in RT-PCR confirmed h1n1-2009 influenza a by hemagglutination inhibition and virus neutralization assays: An observational study
10.1371/journal.pone.0012474PLoS ONE58
Theta angle versus CP violation in the leptonic sector
Assuming that the axion mechanism of solving the strong CP problem does not
exist and the vanishing of theta at tree level is achieved by some
model-building means, we study the naturalness of having large CP-violating
sources in the leptonic sector. We consider the radiative mechanisms which
transfer a possibly large CP-violating phase in the leptonic sector to the
theta parameter. It is found that large theta cannot be induced in the models
with one Higgs doublet as at least three loops are required in this case. In
the models with two or more Higgs doublets the dominant source of theta is the
phases in the scalar potential, induced by CP violation in leptonic sector.
Thus, in the MSSM framework the imaginary part of the trilinear soft-breaking
parameter A_l generates the corrections to the theta angle already at one loop.
These corrections are large, excluding the possibility of large phases, unless
the universality in the slepton sector is strongly violated.Comment: 5 pages, 2 figure
Oviposition Preference and Offspring Performance In Container Breeding Mosquitoes: Evaluating the Effects of Organic Compounds and Laboratory Colonisation
1. The preference–performance hypothesis (PPH) predicts that organisms lacking parental care should oviposit in habitats that optimise offspring performance. Preference–performance relationships were investigated for the Asian tiger mosquito (Aedes albopictus Skuse) and the southern house mosquito (Culex quinquefasciatus Say) (Diptera: Culicidae), two medically important container-breeding species, in response to an organic chemical blend mimicking decaying plant matter. Additionally, the effects of long-term laboratory colonisation of Cx. quinquefasciatus using wild and laboratory strains were evaluated.
2. Oviposition bioassays were conducted by releasing gravid mosquitoes into field enclosures with automobile tires containing low and high concentrations of the chemical blend, and water controls. The offspring were then reared in water collected from the tires in which they were deposited.
3. Aedes albopictus and wild Cx. quinquefasciatus laid more eggs in the chemical blend than water controls but did not differentiate between the low and high concentrations. Conversely, laboratory Cx. quinquefasciatus only preferred the high concentration to the low concentration. No statistical associations between oviposition preference and larval survival were found, as the chemical blend did not affect survivorship of either species.
4. The oviposition preference for the chemical blend over water controls suggests that both species oviposit in the best available resource environment, but further studies are needed before conclusions regarding preference–performance relationships can be drawn.
5. It was found that long-term laboratory colonisation affects the oviposition behaviour in Cx. quinquefasciatus, suggesting that behavioural studies on laboratory strains are not always applicable to wild populations
Measuring Black Hole Spin using X-ray Reflection Spectroscopy
I review the current status of X-ray reflection (a.k.a. broad iron line)
based black hole spin measurements. This is a powerful technique that allows us
to measure robust black hole spins across the mass range, from the stellar-mass
black holes in X-ray binaries to the supermassive black holes in active
galactic nuclei. After describing the basic assumptions of this approach, I lay
out the detailed methodology focusing on "best practices" that have been found
necessary to obtain robust results. Reflecting my own biases, this review is
slanted towards a discussion of supermassive black hole (SMBH) spin in active
galactic nuclei (AGN). Pulling together all of the available XMM-Newton and
Suzaku results from the literature that satisfy objective quality control
criteria, it is clear that a large fraction of SMBHs are rapidly-spinning,
although there are tentative hints of a more slowly spinning population at high
(M>5*10^7Msun) and low (M<2*10^6Msun) mass. I also engage in a brief review of
the spins of stellar-mass black holes in X-ray binaries. In general,
reflection-based and continuum-fitting based spin measures are in agreement,
although there remain two objects (GROJ1655-40 and 4U1543-475) for which that
is not true. I end this review by discussing the exciting frontier of
relativistic reverberation, particularly the discovery of broad iron line
reverberation in XMM-Newton data for the Seyfert galaxies NGC4151, NGC7314 and
MCG-5-23-16. As well as confirming the basic paradigm of relativistic disk
reflection, this detection of reverberation demonstrates that future large-area
X-ray observatories such as LOFT will make tremendous progress in studies of
strong gravity using relativistic reverberation in AGN.Comment: 19 pages. To appear in proceedings of the ISSI-Bern workshop on "The
Physics of Accretion onto Black Holes" (8-12 Oct 2012). Revised version adds
a missing source to Table 1 and Fig.6 (IRAS13224-3809) and corrects the
referencing of the discovery of soft lags in 1H0707-495 (which were in fact
first reported in Fabian et al. 2009
Constraining neutrino oscillation parameters with current solar and atmospheric data
We analyze the impact of recent solar, atmospheric and reactor data in the
determination of the neutrino oscillation parameters, taking into account that
both the solar nu_e and the atmospheric nu_mu may convert to a mixture of
active and sterile neutrinos. We use the most recent global solar neutrino
data, including the 1496-day Super-K neutrino data sample, and we investigate
in detail the impact of the SNO neutral current, spectral and day/night data by
performing also an analysis using only the charged current rate from SNO. The
implications of the first 145.1 days of KamLAND data on the determination of
the solar neutrino parameters are also discussed in detail. We confirm the
clear preference of solar+reactor data for the pure active LMA-MSW solution of
the solar neutrino problem, and obtain that the LOW, VAC, SMA and Just-So^2
solutions are disfavored with a Delta_chi^2 = 22, 22, 36, 44, respectively.
Furthermore, we find that the global solar data constrains the admixture of a
sterile neutrino to be less than 43% at 99% CL. By performing an improved fit
of the atmospheric data, we also update the corresponding regions of
oscillation parameters. We find that the recent atmospheric Super-K (1489-day)
and MACRO data have a strong impact on constraining a sterile component in
atmospheric oscillations: if the nu_mu is restricted to the atmospheric mass
states only a sterile admixture of 16% is allowed at 99% CL, while a bound of
35% is obtained in the unconstrained case. Pure sterile oscillations are
disfavored with a Delta_chi^2 = 34.6 compared to the pure active case.Comment: 28 pages, LaTeX file using RevTEX4, 12 figures and 3 tables included.
Improved version including the new KamLAND dat
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