283 research outputs found
Prosthetic rehabilitation for older dysvascular people following a unilateral transfemoral amputation
From a Thousand Learners to a Thousand Markers: Scaling Peer Feedback with Adaptive Comparative Judgement
No abstract available
Hopf monads on monoidal categories
We define Hopf monads on an arbitrary monoidal category, extending the
definition given previously for monoidal categories with duals. A Hopf monad is
a bimonad (or opmonoidal monad) whose fusion operators are invertible. This
definition can be formulated in terms of Hopf adjunctions, which are comonoidal
adjunctions with an invertibility condition. On a monoidal category with
internal Homs, a Hopf monad is a bimonad admitting a left and a right antipode.
Hopf monads generalize Hopf algebras to the non-braided setting. They also
generalize Hopf algebroids (which are linear Hopf monads on a category of
bimodules admitting a right adjoint). We show that any finite tensor category
is the category of finite-dimensional modules over a Hopf algebroid. Any Hopf
algebra in the center of a monoidal category C gives rise to a Hopf monad on C.
The Hopf monads so obtained are exactly the augmented Hopf monads. More
generally if a Hopf monad T is a retract of a Hopf monad P, then P is a cross
product of T by a Hopf algebra of the center of the category of T-modules
(generalizing the Radford-Majid bosonization of Hopf algebras). We show that
the comonoidal comonad of a Hopf adjunction is canonically represented by a
cocommutative central coalgebra. As a corollary, we obtain an extension of
Sweedler's Hopf module decomposition theorem to Hopf monads (in fact to the
weaker notion of pre-Hopf monad).Comment: 45 page
Experience Report: Thinkathon -- Countering an "I Got It Working" Mentality with Pencil-and-Paper Exercises
Goal-directed problem-solving labs can lead a student to believe that the most important achievement in a first programming course is to get programs working. This is counter to research indicating that code comprehension is an important developmental step for novice programmers. We observed this in our own CS-0 introductory programming course, and furthermore, that students weren't making the connection between code comprehension in labs and a final examination that required solutions to pencil-and-paper comprehension and writing exercises, where sound understanding of programming concepts is essential. Realising these deficiencies late in our course, we put on three 3-hour optional revision evenings just days before the exam. Based on a mastery learning philosophy, students were expected to work through a bank of around 200 pencil-and-paper exercises. By comparison with a machine-based hackathon, we called this a Thinkathon. Students completed a pre and post questionnaire about their experience of the Thinkathon. While we find that Thinkathon attendance positively influences final grades, we believe our reflection on the overall experience is of greater value. We report that: respected methods for developing code comprehension may not be enough on their own; novices must exercise their developing skills away from machines; and there are social learning outcomes in programming courses, currently implicit, that we should make explicit
TaqMan real time RT-PCR assays for detecting ferret innate and adaptive immune responses
AbstractThe ferret is an excellent model for many human infectious diseases including influenza, SARS-CoV, henipavirus and pneumococcal infections. The ferret is also used to study cystic fibrosis and various cancers, as well as reproductive biology and physiology. However, the range of reagents available to measure the ferret immune response is very limited. To address this deficiency, high-throughput real time RT-PCR TaqMan assays were developed to measure the expression of fifteen immune mediators associated with the innate and adaptive immune responses (IFNα, IFNβ, IFNγ, IL1α, IL1β, IL2, IL4, IL6, IL8, IL10, IL12p40, IL17, Granzyme A, MCP1, TNFα), as well as four endogenous housekeeping genes (ATF4, HPRT, GAPDH, L32). These assays have been optimized to maximize reaction efficiency, reduce the amount of sample required (down to 1ng RNA per real time RT-PCR reaction) and to select the most appropriate housekeeping genes. Using these assays, the expression of each of the tested genes could be detected in ferret lymph node cells stimulated with mitogens or infected with influenza virus in vitro. These new tools will allow a more comprehensive analysis of the ferret immune responses following infection or in other disease states
Evaluating sustainability: a retrospective cohort analysis of the Oxfordshire therapeutic community
Background: Therapeutic communities (TCs) could reduce the health care use of people with personality disorder
(Davies S, Campling P and Ryan K, Psychiatrist 23:79–83, 1999; Barr W, Kirkcaldy A, Horne A, Hodge S, Hellin K and
Göpfert M, J Ment Health 19:412–421, 2010) and in turn reduce the financial and environmental costs of services.
Our hypothesis is that 3 years following entry to a TC service, patients have reduced subsequent health care use
and associated reductions in financial costs and carbon footprint.
Methods: A retrospective 4-year cohort study examined changes in health care use following entry to the
Oxfordshire TC service. Comparative analysis was undertaken on a treated (n = 40) and a control group (referred but
who declined treatment; n = 45). Financial costs and carbon footprint of health care use were calculated using
national tariffs and standard carbon conversion factors. Mean changes in these outcomes were compared over 1, 2
and 3 years and adjusted for costs and carbon footprints in the year prior to joining the TC service.
Results: Compared to baseline, the group receiving TC care had greater reductions in financial costs and carbon
footprint associated with A&E attendances (p = 0.04) and crisis mental health appointments (p = 0.04) than the
control group. There were significantly greater reductions in carbon footprint for all secondary health care use, both
physical and mental health care, after 3 years (p = 0.04) in the TC group.
Conclusions: TC services may have the potential to reduce the financial cost and carbon footprint of health car
Best paper award: Experience report: thinkathon - countering an 'I got it working' mentality with pencil-and-paper exercises
Goal-directed problem-solving labs can lead a student to believe that the most important achievement in a first programming course is to get programs working. This is counter to research indicating that code comprehension is an important developmental step for novice programmers. We observed this in our own CS-0 introductory programming course, and furthermore, that students weren’t making the connection between code comprehension in labs and a final examination that required solutions to pencil-and-paper comprehension and writing exercises, where sound understanding of programming concepts is essential. Realising these deficiencies late in our course, we put on three 3-hour optional revision evenings just days before the exam. Based on a mastery learning philosophy, students were expected to work through a bank of around 200 pencil-and-paper exercises. By comparison with a machine-based hackathon, we called this a Thinkathon. Students completed a pre and post questionnaire about their experience of the Thinkathon. While we find that Thinkathon attendance positively influences final grades, we believe our reflection on the overall experience is of greater value. We report that: respected methods for developing code comprehension may not be enough on their own; novices must exercise their developing skills away from machines; and there are social learning outcomes in programming courses, currently implicit, that we should make explicit
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