9 research outputs found
Recommended from our members
Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease due to Chronic Inhaled Endotoxin
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 13/05/2013
- Field of study
Rationale: Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease (COPD). These obstructive lung diseases have a complex pathophysiology, making them difficult to study comprehensively in the context of endotoxin. Genome-wide gene expression studies have been used to identify a molecular snapshot of the response to environmental exposures. Identification of differentially expressed genes shared across all published murine models of chronic inhaled endotoxin will provide insight into the biology underlying endotoxin-associated lung disease. Methods: We identified three published murine models with gene expression profiling after repeated low-dose inhaled endotoxin. All array data from these experiments were re-analyzed, annotated consistently, and tested for shared genes found to be differentially expressed. Additional functional comparison was conducted by testing for significant enrichment of differentially expressed genes in known pathways. The importance of this gene signature in smoking-related lung disease was assessed using hierarchical clustering in an independent experiment where mice were exposed to endotoxin, smoke, and endotoxin plus smoke. Results: A 101-gene signature was detected in three murine models, more than expected by chance. The three model systems exhibit additional similarity beyond shared genes when compared at the pathway level, with increasing enrichment of inflammatory pathways associated with longer duration of endotoxin exposure. Genes and pathways important in both asthma and COPD were shared across all endotoxin models. Mice exposed to endotoxin, smoke, and smoke plus endotoxin were accurately classified with the endotoxin gene signature. Conclusions: Despite the differences in laboratory, duration of exposure, and strain of mouse used in three experimental models of chronic inhaled endotoxin, surprising similarities in gene expression were observed. The endotoxin component of tobacco smoke may play an important role in disease development
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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
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- Baršić Bruno
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- Basile Kim
- Bass Frances
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- Bhimani Zahra
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- Bihari Shilesh
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- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
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- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
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- Venkatesh Bala
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- Whileman Amanda
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- White Ian
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- Wibrow Bradley
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- Wilby Elizabeth
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- Wild Laura
- Wilding Laura
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- Williams Erin
- Williams Hannah
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- Williams Patricia
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- Williamson James
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- Wilson Maggie
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- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
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- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
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- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study
- Author
- Aarti R Shah
- Acosta-Baena
- Adam S Fleisher
- Aguirre-Acevedo
- Andrés Arbelaez
- Anne M Fagan
- Baron
- Bateman
- Bateman
- Bero
- Brad Dickerson
- Buckner
- Carlos Velez-Pardo
- Celone
- Chantal E Stern
- Chavez-Gutierrez
- Cirrito
- Claudia Munoz
- Dickerson
- Eric M Reiman
- Fagan
- Fagan
- Filippini
- Fleisher
- Francisco Lopera
- Gene E Alexander
- Hardy
- Ikeuchi
- Jack
- Jessica BS Langbaum
- Kenneth S Kosik
- Kewei Chen
- Knight
- Lopera
- Margarita Giraldo
- Marlene Jimenez-Del-Rio
- Matthew J Huentelman
- Mondadori
- Mosconi
- Natalia Acosta-Baena
- Pierre N Tariot
- Quiroz
- Quiroz
- Rebecca A Reiman
- Reiman
- Reiman
- Reisa A Sperling
- Ringman
- Ringman
- Sergio Alvarez
- Shaw
- Silvia
- Sperling
- Talairach
- Valla
- Victoria Tirado
- Vlassenko
- Wei
- Yakeel T Quiroz
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19 : a randomized clinical trial
- Author
- Al-Beidh Farah
- Angus Derek C.
- Annane Djillali
- Arabi Yaseen M.
- Au Carly
- Baron Rebecca M.
- Beane Abi
- Berry Lindsay R.
- Berry Scott
- Bonten Marc J.M.
- Bradbury Charlotte A.
- Brunkhorst Frank M.
- Burrell Aidan
- Buxton Meredith
- Buzgau Adrian
- Cecconi Maurizio
- Cheng Allen C.
- Cove Matthew
- Derde Lennie P.G.
- Detry Michelle A.
- Epelman Slava
- Estcourt Lise J.
- Ezekowitz Justin
- Felipe Reyes Luis
- Fitzgerald Mark
- Frankfurter Claudia
- Gattas David
- Godoy Lucas C.
- Gommans Frank
- Goossens Herman
- Gordon Anthony C.
- Green Cameron
- Grieve Richard
- Haniffa Rashan
- Harrison David A.
- Higgins Alisa M.
- Hills Thomas
- Horvat Christopher M.
- Huang David T.
- Ichihara Nao
- Kim Edy Y.
- Kwan Yvonne
- Lamontagne Francois
- Lawler Patrick R.
- Leaf David E.
- Lewis Roger J.
- Linstrum Kelsey M.
- Lorenzi Elizabeth
- Marshall John C.
- McArthur Colin J.
- McAuley Daniel F.
- McGlothlin Anna
- McGuinness Shay P.
- McQuilten Zoe
- McVerry Bryan J.
- Mouncey Paul R.
- Murthy Srinivas
- Nichol Alistair D.
- O'Neill Stephen
- Owen David R.J.
- Parke Rachael L.
- Parker Jane C.
- Pollock Katrina M.
- Puskarich Michael
- Rowan Kathryn M.
- Sadique Zia
- Saito Hiroki
- Santos Marlene S.
- Saunders Christina T.
- Seymour Christopher W.
- Shankar-Hari Manu
- Singh Vanessa
- Turgeon Alexis F.
- Turner Anne M.
- Vaduganathan Muthiah
- van Bentum-Puijk Wilma
- van de Veerdonk Frank L.
- van Kimmenade Roland
- Webb Steve A.
- Zarychanski Ryan
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with Covid-19. A randomized clinical trial
- Author
- Al-Beidh Farah
- Angus Derek C.
- Annane Djillali
- Arabi Yaseen M.
- Au Carly
- Baron Rebecca M.
- Beane Abi
- Berry Lindsay R.
- Berry Scott
- Bonten Marc J.M.
- Bradbury Charlotte A.
- Brunkhorst Frank M.
- Burrell Aidan
- Buxton Meredith
- Buzgau Adrian
- Cecconi Maurizio
- Cheng Allen C.
- Cove Matthew
- Derde Lennie P.G.
- Detry Michelle A.
- Epelmaņ Slava
- Estcourt Lise J.
- Ezekowitz Justin
- Fitzgerald Mark
- Frankfurter Claudia
- Gattas David
- Godoy Lucas C.
- Gommans Frank
- Goossens Herman
- Gordon Anthony C.
- Green Cameron
- Grieve Richard
- Haniffa Rashan
- Harrison David A.
- Higgins Alisa M.
- Hills Thomas
- Horvat Christopher M.
- Huang David T.
- Ichihara Nao
- Kim Edy Y.
- Kwan Yvonne
- Lamontagne Francois
- Lawler Patrick R.
- Leaf David E.
- Lewis Roger J.
- Linstrum Kelsey M.
- Lorenzi Elizabeth
- Marshall John C.
- McArthur Colin J.
- McAuley Daniel F.
- McGlothlin Anna
- McGuinness Shay P.
- McQuilten Zoe
- McVerry Bryan J.
- Mouncey Paul R.
- Murthy Srinivas
- Nichol Alistair D.
- O'Neill Stephen
- Owen David R.J.
- Parke Rachael L.
- Parker Jane C.
- Pollock Katrina M.
- Puskarich Michael
- Reyes Luis Felipe
- Rowan Kathryn M.
- Sadique Zia
- Saito Hiroki
- Santos Marlene S.
- Saunders Christina T.
- Seymour Christopher W.
- Shankar-Hari Manu
- Singh Vanessa
- Turgeon Alexis F.
- Turner Anne M.
- Vaduganathan Muthiah
- Van Bentum-Puijk Wilma
- Van De Veerdonk Frank L.
- Van Kimmenade Roland
- Webb Steve A.
- Zarychanski Ryan
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
Recommended from our members
Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.
- Author
- Al-Beidh Farah
- Angus Derek C
- Annane Djillali
- Arabi Yaseen M
- Au Carly
- Baron Rebecca M
- Beane Abi
- Berry Lindsay R
- Berry Scott
- Bonten Marc JM
- Bradbury Charlotte A
- Brunkhorst Frank M
- Burrell Aidan
- Buxton Meredith
- Buzgau Adrian
- Cecconi Maurizio
- Cheng Allen C
- Cove Matthew
- Derde Lennie PG
- Detry Michelle A
- Epelman Slava
- Estcourt Lise J
- Ezekowitz Justin
- Fitzgerald Mark
- Frankfurter Claudia
- Gattas David
- Godoy Lucas C
- Gommans Frank
- Goossens Herman
- Gordon Anthony C
- Green Cameron
- Grieve Richard
- Haniffa Rashan
- Harrison David A
- Higgins Alisa M
- Hills Thomas
- Horvat Christopher M
- Huang David T
- Ichihara Nao
- Kim Edy Y
- Kwan Yvonne
- Lamontagne Francois
- Lawler Patrick R
- Leaf David E
- Lewis Roger J
- Linstrum Kelsey M
- Lorenzi Elizabeth
- Marshall John C
- McArthur Colin J
- McAuley Daniel F
- McGlothlin Anna
- McGuinness Shay P
- McQuilten Zoe
- McVerry Bryan J
- Mouncey Paul R
- Murthy Srinivas
- Nichol Alistair D
- O'Neill Stephen
- Owen David RJ
- Parke Rachael L
- Parker Jane C
- Pollock Katrina M
- Puskarich Michael
- Reyes Luis Felipe
- Rowan Kathryn M
- Sadique Zia
- Saito Hiroki
- Santos Marlene S
- Saunders Christina T
- Seymour Christopher W
- Shankar-Hari Manu
- Singh Vanessa
- Turgeon Alexis F
- Turner Anne M
- Vaduganathan Muthiah
- van Bentum-Puijk Wilma
- van de Veerdonk Frank L
- van Kimmenade Roland
- Webb Steve A
- Writing Committee for the REMAP-CAP Investigators
- Zarychanski Ryan
- Publication venue
- Jamal Mohamed College
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. OBJECTIVE: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS: In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non-critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS: Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES: The primary outcome was organ support-free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS: On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support-free days among critically ill patients was 10 (-1 to 16) in the ACE inhibitor group (n = 231), 8 (-1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support-free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE: In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02735707
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel Jakša
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barbazza Leanne
- Barber Russell
- Barbier François
- Barge Deborah
- Bari Sara
- Bariola Ryan
- Barker Gareth
- Barnes Nicky
- Baron Rebecca
- Barreau Amelie
- Bart Robert
- Bartholdy Roland
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastola Sirjana
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bean Sarah
- Beane Abi
- Beard Gregory
- Beasley Richard
- Beavis Sarah
- Bedford Caroline
- Beer Deborah
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Beltran Mercedes
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Benyon Sarah
- Benzekri Dalila
- Berdaguer Fernando
- Bergin Colin
- Berry Lindsay
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bhattarai Binita
- Bhimani Zahra
- Bhonagiri Deepak
- Biddie Simon
- Bihari Shailesh
- Binnie Alexandra
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Bland Yvonne
- Blank Elisabeth
- Bloos Frank
- Board Jasmin
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Hélène
- Bojunga Jörg
- Bone Allison
- Bonner Stephen
- Bonten Marc
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brajković Ana
- Brakké Karen
- Brant Emily
- Breen Patrick
- Bremmer Pamela
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brieger Klaus-Gerd
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Louise
- Browne Troy
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank
- Brunskill Nigel
- Bryan-Morris Kayla
- Buchanan Philip
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Bélteczki János
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callender Owen
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Lewis
- Campbell Ryan
- Campisi Josie
- Campos Sara
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Frédérick
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Brittney
- Carter David
- Carter Jay
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Cecconi Maurizio
- Centofanti John
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Marianne
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Cloutier Ève
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Érin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Connolly Karen
- Constantini Elena
- Contou Damien
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Cornell Sarah
- Cort Jon
- Costerousse Olivier
- Couillard-Chénard Émilie
- Courtin Laura
- Coutts Amanda
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Cruz Raulle
- Cruz Rhoze
- Cudlipp Joanna
- Cuesta Jeronimo
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- Cviljevic Sabina
- Cárcel Sheila
- da Rocha Joana
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darshana Sri
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawda Ashlish
- Day Christopher
- de Bus Liesbet
- de Courcy-Golder Kim
- de Jong Menno
- de Jonge Evert
- de Keulenaer Adrian
- de la Fuente Carmen
- de Man Angelique
- de Neef Mark
- de Waele Jan
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declerq Pierre
- Degracia Anna
- del Prado Michael
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Demetriou Carrie
- Dempster Debra
- Denmade Craig
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie
- Deshpande Kush
- Detry Michelle
- Deye Nicolas
- Dice Julie
- Digby Stephen
- Distler Michael
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Dolman Rozzie
- Donadee Chenell
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dragija Lidija
- Drapola Debra
- Drayss Maria
- Driscoll Alana
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Dujardin Romein
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Eastgate Christine
- Ebenezer R
- Edwards Alexandra
- Effelaar Evelien
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eichinger Fred
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- English Shane
- Epelman Slava
- Eroglu Ege
- Estcourt Lise
- Estensen Kristen
- Evans Andrew
- Evans Debra
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Farnell-Ward Sarah
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazekas Ágnes
- Felton Tim
- Fennessy Gerard
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernandez Maria
- Fernando Gloria
- Fernández de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzpatrick Meghan
- Fletcher Simon
- Flint Neil
- Flor Thomas
- Florescu Simin
- Folci Marco
- Forbes Andrew
- Forbes Loretta
- Ford Megan
- Forster Elliot
- Fortune Louise
- Foster Tracy
- Fottrell-Gould Deirdre
- Foulds Angela
- Fowler Rob
- Fowler Robert
- Fox Claire
- Fox Eleonore
- Fragner Gertrud
- Frakking Thuy
- Francoeur François
- Francois Bruno
- Frankfurter Claudia
- Franz Christopher
- François Bourgerol
- Frater Alasdair
- French Craig
- Frey Anna
- Frey Christian
- Frise Matthew
- Fuchs Ralph
- Fysh Ed
- Gachet Alexandre
- Galea James
- Ganesan Arunkumar
- Ganesan Manisha
- Ganguly Saibal
- Garcia Sara
- Gardiner-Hill Caroline
- Garot Denis
- Garrard Hywel
- Garrard William
- Garrett Peter
- Garton Mark
- Gascoyne Rachel
- Gattas David
- Gauli Basanta
- Gay Alexandra
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- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Karen
- Williams Patricia
- Williams Tony
- Williams Virginie
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wiseman Sophie
- Wisniewski Mary
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Helen
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Đimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
- Bae Sang Cheol
- Baek Ae Lee
- Baglioni Gregorio
- Bai Chunlin
- Baksh Farisha
- Balaraju Swathi
- Ball Kelly
- Bamungpong Panthipa
- Banfi Elena
- Barbarash Olga
- Barbeira Pablo Saleta
- Barkowski Timothy
- Barnes Dylan
- Barnes Dylan
- Baron Esquivias Gonzalo
- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
- Barry Lisa
- Bartkowiak Radoslaw
- Bartlett Melialoha
- Bartnik Jerzy
- Basiak Marcin
- Basily Wagdy
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bastani Lisa
- Baszak Jacek
- Batalov Roman
- Batlle Javier
- Batta Claire
- Batta Claire
- Baumbach Sylvia
- Baumgartner Philipp
- Baweja Paramdeep
- Bayat Junaid
- Beattie Andre
- Becerra Munoz Victor
- Begum Haseena
- Bekieszczuk Ewa
- Belenkova Yulia
- Belenky Dmitry
- Bengtsberg Daniel
- Bennett James
- Berardi Mario
- Berg-Johansen Berg-Johansen
- Berge Eivind
- Berge Trude
- Berit Anne
- Berman Sofia Graciela
- Bernat Lukasz
- Berneau Jean-Baptiste
- Best Peggy
- Beton Osman
- Betsuyaku Tetsuo
- Beveridge Rosemary
- Bezrodna Larysa
- Bhargava Kartikeya
- Biagioli Viviana
- Bianchi Alfredo
- Biedrzycka Malgorzata
- Biedrzycka Malgorzata
- Biedrzycki Lukasz
- Biernacka Anita
- Bigcanoe Julie
- Bignell Nanci
- Bilas Roman
- Bilecen Sinan
- Billger Annelie
- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bireciklioglu Mustafa Fehmi
- Birhan MEHMET BİRHAN
- Bitakova Fatima
- Black Andrew
- Blenkhorn Adam
- Blinkova Marina
- Blombery Peter
- Blumberg Edwin
- Bockova Lucie
- Boda Zoltan
- Boehme Stefanie
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- Boersma Misannia
- Boggian Giulio
- Bonet Jorge
- Bongaerts Maarten
- Bongiorni Maria Grazia
- Bonin Kerstin
- Bonkowski Grzegorz
- Bonner Michelle
- Bonnetain Anne
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- Boos Laura
- Booysen Maria
- Borjesson Ulf
- Borras Ana Domenech
- Boshoff Cecilia
- Bosman Femmy
- Bosschaert Mike
- Bossolasco Pierdomenico
- Botha Margo
- Bottarelli Maria Luisa
- Bouzamayor Maria Belen Lage
- Bowen-Simpkins Emma
- Bowers Suzanne
- Boys Janice
- Bradshaw Colin
- Braham Simon
- Brauer Gunter
- Bray Bryan
- Breakwell Lynn
- Bremmelgaard Arne
- Breschi Marco
- Breukel Laura
- Briceno Hinojo Ana
- Brimley Jennifer
- Broad Oulton
- Brodmann Marianne
- Bronisz Marek
- Broton Elzbieta
- Brotons Cuixart Carles
- Browne Debbie
- Bruegger Jasmine
- Brugnaux Jean Philippe
- Bruin Sandra
- Brusorio Stefania
- Bruun Michael
- Bruun Michael
- Brzustowska Malgorzata
- Buckley Elizabeth
- Buiks Paul
- Bulla Claudio
- Bultas Jan
- Bunyapipat Thanita
- Burdeina Liudmyla
- Burke Elizabeth
- Burns Stephen
- Busch Florian
- Butter Keith
- Cabrera Ramos Mercedes
- Cabrini Romina
- Caimi Teresa Maria
- Calcagnoli Francesca
- Cameron Alex
- Camm A. John
- Camm A. John
- Camm A. John
- Camm A. John
- Campagna Giuseppe
- Campo Moreno Mariela
- Campo Monica
- Cancho Corchado Gema
- Cannon Claire
- Canosa Roddy
- Canova Michaela
- Cao Shiping
- Cap Austl
- Cappelli Roberto
- Capucci Alessandro
- Carlton Lesley
- Carpenedo Monica
- Carroll Lisa
- Carroll Patrick
- Cartasegna Luis Rodolfo
- Cartwright Simon
- Casanova Gil Miguel
- Casassus Frederic
- Caspar Andreas
- Cassidy Doran
- Cassimjee Soraya
- Castillo Orive Miguel
- Castro Fernandez Daniel
- Catanchin Andrei
- Cebron Jean-Pierre
- Cervellione Kelly
- Cha James
- Cha Tae-Joon
- Chabanna Olena
- Chaiyapong Thanawan
- Chami Charmaine
- Chandwani Prakash
- Chattranukulchai Pairoj
- Chauhan Kuldeep
- Chauhan Naresh
- Cheewatanakornkul Sirichai
- Chemin Frederic
- Chen Jiyan
- Chen Kangning
- Chen Xiao
- Cheryl Laurie Ferleyko
- Cheung Stephen
- Chi Andwoo Jin
- Chiba Kei
- Chibana Hidetoshi
- Ching Chi Keong
- Chizhov Petr
- Chlumsky Jaromir
- Chmielowski Artur
- Cho Amie
- Cho Jeong-Gwan
- Cho Myeong-Chan
- Choi Dong Ju
- Choi Eun A.
- Choi Eun Hee
- Choi Hee Kyung
- Choi Hee Suk
- Chojnowski Przemyslaw
- Choudhary Fiaz
- Choudhary Ulka
- Chowan Hasan
- Christie Heather
- Christoph Marian
- Chugunnaya Svetlana
- Ciabatta Carlo
- Cichomski Rafal
- Cieslak Karol
- Cieszynska Alina
- Ciliberti Giuseppe
- Cimmino Giovanni
- Citykliniken Capio
- Clark M.
- Clarke Bonnie
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- Cleveland Tracy
- Cloak Cloak
- Coates Richard
- Coates Steven
- Coates Steven
- Colomes Anne
- Colquhoun David
- Colquhoun David
- Conn Paul
- Connolly Stuart J.
- Conway Gladys
- Cooke Philip
- Cools Frank
- Cooper Krystine
- Corbalan Ramon
- Corbalan Ramon
- Cordoba Mateo
- Corrihons Estelle
- Costa Pinto Joana
- Costello Ben
- Couleru Josette
- Coulshed David
- Coulson DrWarwick
- Coutu Benoit
- Cresp Damien
- Crisby Milita
- Cristina Leone Maria
- Croucher Alexandra
- Curyllo Bartosz
- Cymerman Krzysztof
- Czamara Marcin
- D'Agostini Erika
- D'Avino Maria
- Danielsen Mark
- Danilowicz-Szymanowicz Ludmila
- Daniuk Inna
- Danse Ingrid
- DArienzo Carmela
- Darius Harald
- Darius Harald
- Dastychova Lenka
- Date Haruhiko
- Davids Aziza
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- Davies Emyr
- Davies Richard
- Davis Kent
- Dawood Dawood
- De Blasio Angelo
- De Cristofaro Raimondo
- De Graaf Judith
- de Meyer Lorinda
- Deacon Melanie
- Debordes Mirjam
- Debrunner Johann
- Debruxelles Sabrina
- Decarsin Nathalie
- Dedek Vratislav
- Dehghani Payam
- Delafontaine Patrice
- Delarche Nicolas
- Demir Mesut
- Denis Isabelle
- DePauw Jill
- Deshpande Bhakti
- Dhakrao Priyanka
- Dhillon Ripple
- Di Ancona Torrette
- Di Minno Giovanni
- Diaz Lopez Carlos Maria
- Dichristin Uta
- Diederichs Roelof
- Diercks Deborah
- Dimitri Hany
- Dixon Sue
- Dobson Simon
- Dohovits Emese
- Doiuchi Junji
- Dolman Marilyn
- Domanska Ewa
- Dominguez Helena
- Dominguez Helena
- Dominguez Ingrid
- Dooldeniya Chaminda
- Dorottya Kanizsai
- Dorsch Wilfried
- Douglas Kevin
- Douglass Shannen
- Drapkina Oksana
- Drasnar Tomas
- Dresser George
- Drexel Heinz
- Drown Jane
- Dshabrailov Janna
- du Preez Miranda
- Duff-Coots Margie
- Dumikyan Anait
- Dwivedi Pratik
- Dwyer Nathan
- Dybala Tomasz
- Dzeletovic Susanna
- Earath Manoj
- Ebert Hans-Holger
- Ebner Karl-Martin
- Eccleston David
- Eden Jane
- Eder Wolfgang
- Edin Anton
- Efe Jana
- Egilsson Arnor
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- Egyutt Mihaly
- Eikelboom John
- Eikelboom John
- Eisleben Lutherstadt
- Eissing Volker
- Ekstrand Ann-Britt
- El-Aziz Ahmed Abd
- El-Etreby Adel
- Elise Guillermet
- Elkhadem Magdi
- Ellervik Christina
- Ellis Tania
- Elmersson Micael
- Elorriaga Madariaga Ane
- Emelife Samuel
- Emura Yoko
- Endo Masato
- Engdahl Johan
- Engelbrecht Johannes
- Engelthaler Gabriella
- Epelde Gonzalo Francisco
- Erdle Werner
- Erga Knut
- Ericsson Marianne
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- Eskandari Mehdi
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- Estifanos Salah
- Eto Takuma
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- Evans Paul
- Evans Phil
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- Ewert Alayna
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- Faron Andwojciech
- Farquhar Donald
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- Ferreira-Jardim Antonio
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- Figura-Chmielewska Monika
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- Fitzmaurice David A.
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- Fox Robin
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- Girke Friederike
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- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Golino Paolo
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- Hargreaves Nick
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- Hart Nigel
- Hartmann Hermann-Josef
- Hartranft Elise
- Hasegawa Koichi
- Hauk Joachim
- Haverkamp Wilhelm
- Hawkins Benji
- Hayashi Yoshihito
- Hayes Kate
- He Ruhua
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- Headlee Marsha
- Heart Bryan
- Heath John
- Heeg Ramona
- Hegde Miyar Prathap
- Heinz Afra
- Heinz Gerd-Ulrich
- Henley Lindy
- Henrichsen Svein Hoegh
- Henriette Isberg
- Henriksson Kerstin
- Henson Lynn
- Her KyoungOk
- Heradien Marshall
- Hergdt Gunter
- Hergdt Susanne
- Hermans Walter
- Herrero Maeso Beatriz
- Herrick Christopher
- Herrman Jean-Paul
- Hesketh Leverne
- Heuer Adrienne
- Hevia Rodriguez Eduardo
- Hey Heinz
- Heyvang Nathalie
- Hibino Michitaka
- Hicks Teresa
- Hiczkiewicz Jaroslaw
- Higa Satoshi
- Higashi Takayuki
- Higgs Megan
- Higuchi Koji
- Hines Christine
- Hines Kathleen
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- Hintze Ulrik
- Hiramitsu Shinya
- Hirasawa Kunihiko
- Hirayama Hiroyoshi
- Hirose Makoto
- Hirst Rob
- Hjertesenter Vestfold
- Hlengwa Sipho
- Hoddy Sally-Anne
- Hodgins Ian
- Hole Torstein
- Honda Masaaki
- Honek Jakub
- Hongsuppinyo Siripan
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- Horie Hideki
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- Hot-Bjelak Aida
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- Iacopino Saverio
- Ido Takahisa
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- Iglesias Alonso Luis Fernando
- Iiji Osamu
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- Jang Eumi
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- Janska Lenka
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- Jansson Birgitta
- Jaremczuk-Kaczmarczyk Adriana
- Jarzebowski Artur
- Jasinski Sarah
- Jass Gabriele
- Jaufeerally Fazlur Rehman
- Jawoo Jung
- Jaworska-Drozdowska Maria
- Jefferies Angus
- Jekthammer Aase
- Jen Peter
- Jenkins Katie
- Jensen Steen
- Jeon Hui-Kyung
- Jeon Young Ran
- Jeong Hae Kyeong
- Jerabek Ondrej
- Jetten Andwesley
- Jimenez Fernandez Maria Jose
- Jimenez Navarro Manuel
- Johnson Katherine
- Jones Allison
- Jones Claire
- Jones Hywel
- Jones Kevin
- Jones Pamela
- Joshi Unnati
- Juergens Craig
- Juhasz Ferenc
- Juhasz Gizella
- Jung Byung Chun
- Jurowiecki Jaroslaw
- Kaat Josine Te
- Kadappu Krishna
- Kadouch James
- Kaewsuwanna Pinij
- Kahl Friedhelm
- Kahlon Ranjit
- Kakkar Ajay K.
- Kakkar Ajay K.
- Kakuda Hirokazu
- Kamath R.
- Kameko Masahiro
- Kamenska Ellina
- Kamin Susanne
- Kammermayer Michael
- Kamogawa Yasuyuki
- Kanai Hideaki
- Kanakaridisz Nikosz
- Kanamori Seishu
- Kanda Hirofumi
- Kaneko Masanori
- Kang Jisun
- Kangert Rose-Mari
- Kangert Rose-Mari
- Kania Grzegorz
- Kaplan Pavlo
- Kaplan Sally
- Karl Susan
- Karolyi Laszlo
- Karpenko Oleksandr
- Karsten Marinda
- Kasai Takeaki
- Kassam Imran
- Katekangplu Peerapat
- Kato Yoji
- Kato Yoji
- Katsube Yoshiki
- Katsuya Tomohiro
- Kaur Sukhjeet
- Kawada Yuka
- Kawakami Shuichi
- Kawano Yoshiyuki
- Kayani Gloria
- Kayani Gloria
- Keeling Mickie
- Kelfkens Ynez
- Kellner Bernd-Thomas
- Kelly Sheila
- Keltai Matyas
- Kemmel Agnes
- Kerr Jowanna
- Keten Murdem
- Kettles David
- Khairy Tarek
- Khattaroek Rudeewan
- Khmelyova Alina
- Khokhlov Alexander
- Khunkong Ketsanee
- Khunrong Porames
- Khyzhnyak Olena
- Kilian Jens
- Kiliszek Marek
- Kim Dae-Kyeong
- Kim Haeim
- Kim Jaeyoung
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- Kimura Teruaki
- Kinnane Tara
- Kinnane Tara
- Kira Tetsuya
- Kirby Graham
- Kirchner-Volker Karla
- Kiris Cansu
- Kis Erno
- Kitami Yutaka
- Kitazawa Hitoshi
- Kitmapawanont Usa
- Kito Tetsutaro
- Kizim Svitlana
- Kizkapan Fatih
- Klata Malgorzata
- Knaake Jennifer
- Knowles Patricia
- Ko Tenei
- Kobayashi Toshiyuki
- Koca Deniz
- Koca Deniz
- Koca Hasan
- Koch Annika
- Kochanska Ewa
- Kociolek Diana
- Kodera Kojiro
- Koeln DrWeber
- Koeniger Georg
- Koeniger Praxis Dr
- Kojima Jisho
- Kolesnikova Alla
- Kolesova Tamara
- Kolodzinska Agnieszka
- Komaki Shinichiro
- Komatsu Hiroyasu
- Komatsu Ikki
- Komlo Adam
- Kongsin Chuleerat
- Konopka Anna
- Konyukhova Irina
- Konyushenko Daria
- Koomen M.
- Kopeckova Iva
- Kopf Andreas
- Korhaz Balassa Janos
- Korhaz Szent Janos
- Korley Victoria
- Kornder Jan
- Korneeva Olga
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- Vertes Andras
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- Villani Rosanna
- Vinolas Xavier
- Vishnevsky Alexander
- Vizel Saul
- Voelkel-Babyesiza Regina
- Voigts Birgit
- Volodicheva Olga
- Volpe Massimo
- Vonbank Alexander
- Vorasettakarnkij Yongkasem
- Vormann Reinhold
- Vorster Mary
- Vorster Mary
- Vue Belle
- Vyhlidalova Veronika
- Wada Masamichi
- Wagner Helga
- Wakeling John
- Wakeman Anne
- Waldman Alla
- Walker Martin
- Walko Bogdan
- Wang Daowen
- Wang Y.
- Wang Yong
- Warke A.
- Wastling Rebecca
- Webster Chelsea
- Wegmayr Claudia
- Wegrzynowska Marta
- Wegrzynowska Marta
- Weichelt Sylvia
- Weiser Ute
- Weitbrecht Luis
- Welker James
- Wesolowska Kamila
- Wielkopolska Sroda
- Wierzbicka Aleksandra
- Wildenauer Cosmas
- Wilford Emily
- Williams Celestine
- Williams Philip
- Wilson Pete
- Wilson Vance
- Winkler Helga
- Winnik Stephan
- Wirdby Alexander
- Wisaratapong Treechada
- Wiswedel Henning
- Wohrer Claudia
- Wolf Thomas
- Wong Bennett
- Wong Mike
- Wongtheptien Andwattana
- Wood Annette
- Wood Kristine
- Woody Jill
- Worthy Vanetta
- Wozakowska-Kaplon Beata
- Wozniak-Skowerska Iwona
- Wright Debbie
- Wurziger Juergen
- Xue Li
- Yagensky Andriy
- Yakupov Eduard
- Yamada Takehiro
- Yamaguchi Hiroshi
- Yamamoto Kenichi
- Yamamoto Kentaro
- Yamamoto Kiichiro
- Yamamoto Kunihiko
- Yamamoto Taku
- Yamasawa Masanori
- Yamaura Makoto
- Yamazoe Masahiro
- Yang Jingshan
- Yang Lingli
- Yang Zhiming
- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
- Yokota Naoto
- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes