1,079 research outputs found
Sources of intrinsic rotation in the low flow ordering
A low flow, gyrokinetic formulation to obtain the intrinsic
rotation profiles is presented. The momentum conservation equation in the low
flow ordering contains new terms, neglected in previous first principles
formulations, that may explain the intrinsic rotation observed in tokamaks in
the absence of external sources of momentum. The intrinsic rotation profile
depends on the density and temperature profiles and on the up-down asymmetry.Comment: 20 page
The spectrum of D_s mesons from lattice QCD
The spectrum of orbitally excited mesons is computed in the continuum
limit of quenched lattice QCD. The results are consistent with the
interpretation that the narrow resonance in the channel discovered
by the BABAR Collaboration is a meson. Furthermore, within
statistical errors, the and the mass splittings are equal,
in agreement with the chiral multiplet structure predicted by heavy hadron
chiral effective theory. On our coarsest lattice we present results from the
first study of orbitally excited mesons with two flavors of dynamical
quarks, with mass slightly larger than the strange quark mass. These results
are consistent with the quenched data.Comment: 8 pages, 2 figure
Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS)
Background: Little is known about how dependency levels have changed between generational cohorts of older people. We estimated years lived in different care states at age 65 in 1991 and 2011 and new projections of future demand for care. Methods: Two population-based studies of older people in defined geographical areas conducted two decades apart (the Cognitive Function and Ageing Studies) provided prevalence estimates of dependency in four states: high (24-hour care); medium (daily care); low (less than daily); independent. Years in each dependency state were calculated by Sullivan’s method. To project future demand, the proportions in each dependency state (by age group and sex) were applied to the 2014 England population projections. Findings: Between 1991 and 2011 there were significant increases in years lived from age 65 with low (men:1·7 years, 95%CI 1·0-2·4; women:2·4 years, 95%CI 1·8-3·1) and high dependency (men:0·9 years, 95%CI 0·2-1·7; women:1·3 years, 95%CI 0·5-2·1). The majority of men’s extra years of life were independent (36%) or with low dependency (36%) whilst for women the majority were spent with low dependency (58%), only 5% being independent. There were substantial reductions in the proportions with medium and high dependency who lived in care homes, although, if these dependency and care home proportions remain constant in the future, further population ageing will require an extra 71,000 care home places by 2025. Interpretation: On average older men now spend 2.4 years and women 3.0 years with substantial care needs (medium or high dependency), and most will live in the community. These findings have considerable implications for older people’s families who provide the majority of unpaid care, but the findings also supply valuable new information for governments and care providers planning the resources and funding required for the care of their future ageing populations
Black and White Patients with Inflammatory Bowel Disease Show Similar Biologic Use Patterns with Medicaid Insurance
Background: Prior studies have identified racial disparities in the treatment and outcomes of inflammatory bowel disease (IBD). These disparities could be secondary to differences in biology, care delivery, or access to appropriate therapy. The primary aim of this study was to compare medication use among Medicaid-insured black and white patients with IBD, given uniform access to gastroenterologists and therapies. Methods: We analyzed Medicaid Analytic eXtract data from 4 states (California, Georgia, North Carolina, and Texas) between 2006 and 2011. We compared the use of IBD-specific therapies, including analyses of postoperative therapy among patients with Crohn disease (CD). We performed bivariate analyses and multivariable logistic regression, adjusting for potential confounders. Results: We identified 14,735 patients with IBD (4672 black [32%], 8277 with CD [58%]). In multivariable analysis, there was no significant difference in the odds of anti-tumor necrosis factor use by race for CD (adjusted odds ratio [aOR] = 1.13; 95% confidence interval [CI], 0.99-1.28] or ulcerative colitis (aOR = 1.12; 95% CI, 0.96-1.32). Black patients with CD were more likely than white patients to receive combination therapy (aOR = 1.50; 95% CI, 1.15-1.96), and black patients were more likely than white patients to receive immunomodulator monotherapy after surgery for CD (31% vs 18%; P = 0.004). Conclusions: In patients with Medicaid insurance, where access to IBD-specific therapy should be similar for all individuals, there was no significant disparity by race in the utilization of IBD-specific therapies. Disparities in IBD treatment discussed in prior literature seem to be driven by socioeconomic or other issues affecting access to care
Atomic Model of Susy Hubbard Operators
We apply the recently proposed susy Hubbard operators to an atomic model. In
the limiting case of free spins, we derive exact results for the entropy which
are compared with a mean field + gaussian corrections description. We show how
these results can be extended to the case of charge fluctuations and calculate
exact results for the partition function, free energy and heat capacity of an
atomic model for some simple examples. Wavefunctions of possible states are
listed. We compare the accuracy of large N expansions of the susy spin
operators with those obtained using `Schwinger bosons' and `Abrikosov
pseudo-fermions'. For the atomic model, we compare results of slave boson,
slave fermion, and susy Hubbard operator approximations in the physically
interesting but uncontrolled limiting case of N->2. For a mixed representation
of spins we estimate the accuracy of large N expansions of the atomic model. In
the single box limit, we find that the lowest energy saddle-point solution
reduces to simply either slave bosons or slave fermions, while for higher boxes
this is not the case. The highest energy saddle-point solution has the
interesting feature that it admits a small region of a mixed representation,
which bears a superficial resemblance to that seen experimentally close to an
antiferromagnetic quantum critical point.Comment: 17 pages + 7 pages Appendices, 14 figures. Substantial revision
absorption in hadronic matter
The cross sections of absorption by and mesons are
evaluated in a meson-exchange model. Including form factors with a cutoff
parameter of 1 or 2 GeV, we find that due to the large threshold of these
reactions the thermal average of their cross sections is only about 0.2 mb at a
temperature of 150 MeV. Our results thus suggest that the absorption of
directly produced by hadronic comovers in high energy heavy ion
collisions is unimportant.Comment: 11 pages, revtex, 3 figures, added references and discussion on
higher BBbar state
Spin Gap Fixed Points in the Double Chain Problem
Applying the bosonization procedure to weakly coupled Hubbard chains we
discuss the fixed points of the renormalization group flow where all spin
excitations are gapful and a singlet pairing becomes the dominant instability.Comment: 15 pages, TeX, C Version 3.
The General Solution of Bianchi Type Vacuum Cosmology
The theory of symmetries of systems of coupled, ordinary differential
equations (ODE) is used to develop a concise algorithm in order to obtain the
entire space of solutions to vacuum Bianchi Einstein Field Equations (EFEs).
The symmetries used are the well known automorphisms of the Lie algebra for the
corresponding isometry group of each Bianchi Type, as well as the scaling and
the time re-parametrization symmetry. The application of the method to Type
VII_h results in (a) obtaining the general solution of Type VII_0 with the aid
of the third Painlev\'{e} transcendental (b) obtaining the general solution of
Type with the aid of the sixth Painlev\'{e} transcendental (c) the
recovery of all known solutions (six in total) without a prior assumption of
any extra symmetry (d) The discovery of a new solution (the line element given
in closed form) with a G_3 isometry group acting on T_3, i.e. on time-like
hyper-surfaces, along with the emergence of the line element describing the
flat vacuum Type VII_0 Bianchi Cosmology.Comment: latex2e source file, 27 pages, 2 tables, no fiure
Phi meson production in relativistic heavy ion collisions
Within a multiphase transport model we study phi meson production in
relativistic heavy ion collisions from both superposition of initial multiple
proton-proton interactions and the secondary collisions in the produced
hadronic matter. The yield of phi mesons is then reconstructed from their
decaying product of either the kaon-antikaon pairs or the dimuon pairs. Since
the kaon-antikaon pairs at midrapidity with low transverse momenta are
predominantly rescattered or absorbed in the hadronic medium, they can not be
used to reconstruct the phi meson and lead thus to a smaller reconstructed phi
meson yield than that reconstructed from the dimuon channel. With in-medium
mass modifications of kaons and phi mesons, the phi yield from dimuons is
further enhanced compared to that from the kaon-antikaon pairs. The model
result is compared with the experimental data at the CERN/SPS and RHIC energies
and its implications to quark-gluon plasma formation are discussed.Comment: Revised version, to appear in Nucl. Phys.
A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer
Purpose and methods: In human basal-like breast cancer, mutations and deletions in TP53 and BRCA1 are frequent oncogenic events. Thus, we interbred mice expressing the CRE-recombinase with mice harboring loxP sites at TP53 and BRCA1 (K14-Cre; p53 f/f Brca1 f/f ) to test the hypothesis that tissue-specific deletion of TP53 and BRCA1 would give rise to tumors reflective of human basal-like breast cancer. Results: In support of our hypothesis, these transgenic mice developed tumors that express basal-like cytokeratins and demonstrated intrinsic gene expression features similar to human basal-like tumors. Array comparative genomic hybridization revealed a striking conservation of copy number alterations between the K14-Cre; p53 f/f Brca1 f/f mouse model and human basal-like breast cancer. Conserved events included MYC amplification, KRAS amplification, and RB1 loss. Microarray analysis demonstrated that these DNA copy number events also led to corresponding changes in signatures of pathway activation including high proliferation due to RB1 loss. K14-Cre; p53 f/f Brca1 f/f also matched human basal-like breast cancer for a propensity to have immune cell infiltrates. Given the long latency of K14-Cre; p53 f/f Brca1 f/f tumors (~ 250 days), we created tumor syngeneic transplant lines, as well as in vitro cell lines, which were tested for sensitivity to carboplatin and paclitaxel. These therapies invoked acute regression, extended overall survival, and resulted in gene expression signatures of an anti-tumor immune response. Conclusion: These findings demonstrate that this model is a valuable preclinical resource for the study of human basal-like breast cancer
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