A Tool for Improving Privacy in Software Development

Privacy is considered a necessary requirement for software development. It is necessary to understand how certain software vulnerabilities can create problems for organizations and individuals. In this context, privacy-oriented software development plays a primary role to reduce some problems that can arise simply from individuals’ interactions software applications, even when the data being processed is not directly linked to identifiable. The loss of confidentiality, integrity, or availability at some point in the data processing, such as data theft by external attackers or the unauthorized access or use of data by employees., represent some types of cybersecurity-related privacy events. Therefore, this research work discusses the formalization of 5 key privacy elements (Privacy by Design Principles, Privacy Design Strategies, Privacy Pattern, Vulnerabilities and Context) in software development and presents a privacy tool that supports developers’ decisions to integrate privacy and security requirements in all software development phases

Relationship between prolactin plasma levels and white matter volume in women with multiple sclerosis

BACKGROUND: The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS: We employed a chemiluminescence immunoassay for measuring plasma levels of PRL. We used a 1.5 T scanner to acquire images and Jim 4.0 and SIENAX software to analyse them. RESULTS: We included 106 women with relapsing remitting (RR) MS and stable disease in the last two months. There was no difference in PRL plasma levels between patients with and without gadolinium enhancement on MRI. PRL plasma levels correlated with white matter volume (WMV) (rho = 0.284, p = 0.014) but not with grey matter volume (GMV). Moreover, PRL levels predicted changes in WMV (Beta: 984, p = 0.034). CONCLUSIONS: Our data of a positive association between PRL serum levels and WMV support the role of PRL in promoting myelin repair as documented in animal models of demyelination. The lack of an increase of PRL in the presence of gadolinium enhancement, contrasts with the view considering this hormone as an immune-stimulating and detrimental factor in the inflammatory process associated with MS

La mobilità sostenibile nelle smart city: Prospettive, sfide e soluzioni

Le città di tutto il mondo affrontano sfide crescenti in termini di congestione del traffico, inquinamento atmosferico e cambiamenti climatici. La smart mobility è emersa come una risposta cruciale a queste sfide, e le smart city offrono un terreno fertile per l'innovazione in questo settore. Questo studio si propone di esaminare il ruolo della mobilità sostenibile nelle smart city, analizzando prospettive, sfide e soluzioni. Cities around the world face growing challenges in terms of traffic congestion, air pollution and climate change. Smart mobility has emerged as a crucial response to these challenges, and smart cities offer fertile ground for innovation in this area. This study aims to examine the role of sustainable mobility in smart cities, analysing perspectives, challenges and solutions

Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers

Aims. To evaluate UFT and cyclophosphamide (CTX) based metronomic chemotherapy plus celecoxib (CXB) for the treatment of patients with heavily pre-treated advanced gastrointestinal malignancies. Methods. Thirty-eight patients received 500 mg/mq2 CTX i.v bolus on day 1 and, from day 2, 50 mg/day CTX p.o. plus 100 mg/twice a day UFT p.o. and 200 mg/twice a day CXB p.o. Tegafur, 5-FU, 5-FUH2, GHB and uracil pharmacokinetics were assessed. Plasma vascular endothelial growth factor (VEGF), soluble VE-cadherin (sVE-C) and thrombospondin-1 (TSP-1) levels were detected by ELISA and real-time PCR of CD133 gene expression on peripheral blood mononuclear cell was also performed. Results Seventeen patients (45%) obtained stable disease (SD) with a median duration of 5.8 ms (range, 4.2–7.4). Median progression free survival (PFS) and overall survival (OS) were 2.7 ms (95% CI, 1.6–3.9 ms) and 7.1 ms (95% CI, 4.3–9.9 ms), respectively. No toxicities of grade >1 were observed. Pharmacokinetics of 27 patients (13/14, SD/progressive disease, PD) after the first treatment of UFT revealed that 5-FU AUC and Cmax values greater than 1.313 h x microg/ml and 0.501 microg/ml, respectively, were statistically correlated with stabilization of disease and prolonged PFS/OS. VEGF and sVE-C plasma levels were greater in the PD group when compared to SD group. CD133 expression increased only in the PD patients. Conclusion. Metronomic UFT and CTX with CXB in heavily pre-treated gastrointestinal patients were well tolerated and associated with interesting activity. Potential predictive pharmacokinetic parameters and pharmacodynamic biomarkers have been found

Non-pegylated liposomal doxorubicin in older adjuvant early breast cancer patients: cardiac safety analysis and final results of the COLTONE study

Aims: To explore the cardiac safety of adjuvant Non-Pegylated Liposomal Doxorubicin (NPL-DOX) plus Cyclophosphamide (CTX) followed by weekly Paclitaxel, in elderly women (≥ 65 years) with high-risk breast cancer. Previously, we described no symptomatic cardiac events within the first 12 months from starting treatment. We now reported the updated results after a median follow-up 76 months. Methods: The cardiac activity was evaluated with left ventricular ejection fraction (LVEF) echocardiograms assessments, before starting chemotherapy and every 6 months, until 30 months from baseline, then yearly for at least 5 years. Results: Forty-seven women were recruited by two Units of Medical Oncology (Ethics Committee authorization CESM-AOUP, 3203/2011; EudraCT identification number: 2010-024067-41, for Pisa and Pontedera Hospitals). An episode of grade 3 CHF (NCI-CTCAE, version 3.0) occurred after 18 months the beginning of chemotherapy. The echocardiograms assessments were performed comparing the LVEF values of each patient evaluated at fixed period of time, compared to baseline. We observed a slight changed in terms of mean values at 48, 60, 72 and 84 months. At these time points, a statistically significant reduction of - 3.2%, - 4.6%, - 6.4% and - 7.1%, respectively, was observed. However, LVEF remained above 50% without translation in any relevant clinical signs. No other cardiac significant episodes were reported. To this analysis, in 13 patients (28%) occurred disease relapse and,  of them, 11 (23%) died due to metastatic disease. Eight patients died of cancer-unrelated causes. Conclusions: The combination including NPL-DOX in elderly patients revealed low rate of cardiac toxic effects. Comparative trials are encouraged

A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America

Background: Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. Methods: Eleven LS hereditary cancer registries and 34 published LS databases were used to identify unrelated families that fulfilled the Amsterdam II (AMSII) criteria and/or the Bethesda guidelines or suggestive of a dominant colorectal (CRC) inheritance syndrome. Results: We performed a thorough investigation of 15 countries and identified 6 countries where germline genetic testing for LS is available and 3 countries where tumor testing is used in the LS diagnosis. The spectrum of pathogenic MMR variants included MLH1 up to 54%, MSH2 up to 43%, MSH6 up to 10%, PMS2 up to 3% and EPCAM up to 0.8%. The Latin America MMR spectrum is broad with a total of 220 different variants which 80% were private and 20% were recurrent. Frequent regions included exons 11 of MLH1 (15%), exon 3 and 7 of MSH2 (17 and 15%, respectively), exon 4 of MSH6 (65%), exons 11 and 13 of PMS2 (31% and 23%, respectively). Sixteen international founder variants in MLH1, MSH2 and MSH6 were identified and 41 (19%) variants have not previously been reported, thus representing novel genetic variants in the MMR genes. The AMSII criteria was the most used clinical criteria to identify pathogenic MMR carriers although microsatellite instability, immunohistochemistry and family history are still the primary methods in several countries where no genetic testing for LS is available yet. Conclusion: The Latin America LS pathogenic MMR variants spectrum included new variants, frequently altered genetic regions and potential founder effects, emphasizing the relevance implementing Lynch syndrome genetic testing and counseling in all of Latin America countries.Radium Hospital Foundation (Oslo, Norway) in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript, Helse Sør-Øst (Norway) in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript, the French Association Recherche contre le Cancer (ARC) in the analysis, and interpretation of data, the Groupement des Entreprises Françaises dans la Lutte contre le Cancer (Gefluc) in the analysis, and interpretation of data, the Association Nationale de la Recherche et de la Technologie (ANRT, CIFRE PhD fellowship to H.T.) in the analysis, and interpretation of data and by the OpenHealth Institute in the analysis, and interpretation of data. Barretos Cancer Hospital received financial support by FINEP-CT-INFRA (02/2010)info:eu-repo/semantics/publishedVersio

Integrating security and privacy in software development

As a consequence to factors such as progress made by the attackers, release of new technologies and use of increasingly complex systems, threats to applications security have been continuously evolving. Security of code and privacy of data must be implemented in both design and programming practice to face such scenarios. In such a context, this paper proposes a software development approach, Privacy Oriented Software Development (POSD), that complements traditional development processes by integrating the activities needed for addressing security and privacy management in software systems. The approach is based on 5 key elements (Privacy by Design, Privacy Design Strategies, Privacy Pattern, Vulnerabilities, Context). The approach can be applied in two directions forward and backward, for developing new software systems or re-engineering an existing one. This paper presents the POSD approach in the backward mode together with an application in the context of an industrial project. Results show that POSD is able to discover software vulnerabilities, identify the remediation patterns needed for addressing them in the source code and design the target architecture to be used for guiding privacy-oriented system reengineering

Teaching Cyber Security: The Hack-Space Integrated Model

Nowadays cyber security is becoming an ever more stringent requirement and warned by organizations and companies all over the world. Furthermore, the educational offer on the topic is still modest and universities are struggling to design training courses capable of producing professionals directly employable. In this work, this need is addressed with the proposal of an integrated model "The Hack Space", developed within the Master of Science in Computer Security of the University of Bari, composed of four main elements: Organization, Knowledge, Skills/Tools and Collaboration. The Hack Space aims to create professionals capable of dealing with security at various levels, with clear ideas on what are the processes, functions and controls useful for security, using an in-depth knowledge structure of the company

Privacy Knowledge Base for Supporting Decision-Making in Software Development

Integrating security and privacy requirements at every stage of the software development cycle is critical to guarantee the confidentiality, integrity and availability of the system and consequently of the data. Developers need to be supported in this challenge, as many different skills are required to respond effectively to the growing number of cyber-attacks. In such a context, this research study endeavors to define the key elements that support decision-making in privacy oriented software development. A Privacy Knowledge Base (PKB) is defined to support developers’ decisions in all software development phases, and a prototype (PKB-Tool) is developed to operationally integrate privacy and security requirements into the development of new systems and the re-engineering of legacy systems. An ongoing experimentation in the context of an industrial project is presented to validate the efficacy of the 5 key elements in supporting developers in integrating privacy and security requirements in the software life cycle