Keramikken og ovnen fra Barmer samt brændingsforløbet

The pottery and kiln from Barmer and the result of the firing By Rikke Barlebo In 1984 the remains of two medieval pottery kilns were found at Barmer, southwest of Aalborg. On the basis of the knowledge revealed by the archaeological excavation in 1985 and results from other European finds of medieval pottery kilns, a reconstruction of the Barmer kiln was made in the spring of 1987 at the Prehistoric Museum, Moesgaard, in Aarhus. The kiln was filled with a number of pots that were reconstructions of the pots excavated at Barmer. The result of the firing was successful, though a few details had to be adjusted to achieve a kiln which would work to full satisfaction. Barmer kiln II was built in the Spring of 1989 at Poulstrup, south of Aalborg, giving us a chance to make the necessary adjustments. The firing of Barmerkiln II was very successful, and indicated that with this construction of the kiln, we had come very close to the kiln used by the medieval potter at Barmer

Vidensledelse på universiteterne: når viden både skal produceres og anvendes

Fremtidens vidensleder skal kunne meget. Artiklens pointe er, at en vigtig ledelsesopgave i fremtidens vidensbaserede virksomheder bliver at forholde sig til, at man både skal producere og anvende viden – på samme tid. Ved at studere forskningsledelse på universiteterne kan man se, at vidensproduktion og anvendelse faktisk er i potentiel konflikt, samtidig med at man kan få inspiration til, hvordan man som leder kan håndtere denne konflikt. Inspirationen peger i retning af balancering af forholdet mellem autonomi og styring, samt fokus på ledelsens tillidsdimension

Development of grease tackiness test

A test to evaluate the tackiness of grease has been developed using a standard tribometer. There is currently no standard test of tackiness. A preliminary study determined the test parameters to use in the subsequent experiments. Twelve different greases were tested and the results showed how the developed test method was able to differentiate between different greases. The results were linked to the application of grease to a rail using a scaled wheel rig developed at the University of Sheffield. The developed test method showed the same relationship as the larger scale tests, leading to the conclusion that the developed method can be used to inform larger scale tests that are more costly and time consuming. The effect of “working” the grease prior to the test showed that the working had a significant effect on the tackiness of the grease. The test method was shown to be sensitive to small changes in the grease by adding small amounts of tackifier additive (0.1% increments) to the grease

Detection of copy number alterations in cell-free tumor DNA from plasma

Background: Somatic copy number alterations (SCNAs) occurring in tumors can provide information about tumor classification, patient's outcome or treatment targets. Liquid biopsies, incl. plasma samples containing circulating cell-free tumor DNA (ccfDNA) can be used to assess SCNAs for clinical purposes, however specify and reliability of methods have to be tested. Methods: SNP microarrays (Affymetrix) were used to generate whole-genome copy number profiles from plasma ccfDNA (OncoScan) and paired tumor biopsies (CytoScan) from ten patients with metastatic cancers. Numerical, segmental and focal SCNAs were assessed using ASCAT/TuScan and SNP-FASST2. Results: Aberrations in ccfDNA in 4 patients resembled numerical (76%) and segmental (80%) aberrations in tDNA. Three patients represented low correlation due to postponed sampling time, ccfDNA quality and possible treatment interference. Breakpoints of high-amplitude amplification were assessed with high accuracy and relative breakpoints difference of only 7% (0.02–37%). Similarly, biallelic losses were reliably detected. Array was 100% successful in detection of SCNAs on clinically relevant genes compared to SCNAs in tumor biopsies. Tracking of SCNAs changes during the treatment course of one patient also indicated that apoptosis/necrosis of non-cancerous cells presumably induced by treatment can influence ccfDNA composition and introduce false-negative findings into the analysis of liquid biopsies. Conclusions: Genomic alterations detected in ccfDNA from liquid biopsies by comprehensive SNP array are reliable source for information for stratification of patients for targeted treatment. General significance: Clinically relevant SCNAs can be detected in ccfDNA with high resolution and can therefore serve as an alternative to tumor biopsy in defining treatment targets