51 research outputs found

    Features of a NeuroQueer existential-phenomenology

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    This paper provides a phenomenological description of what is being experienced, and encountered, at the intersections between queer and neurodivergent existence. The description includes an exploration of our emergent pluralities, non-linearity and immersion in existence. It further delves into our existing-being-worlds, and provides a more detailed articulation of the movements, positions and paradoxes that we encounter there. Finally, we offer implications for existential-phenomenological (critical) psychopathology and psychotherapeutic practice

    Intergenerational feminism and media: a roundtable

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    This is the edited text of a roundtable held at City University London, UK in November 2014, organised by Alison Winch and Jo Littler. The event aimed to pay attention to the ways in which age and generation shape mediated conversation about feminist politics: to problematise the dominant media representations of intergenerational “cat fights,” or feminist bickering, while simultaneously interrogating the ways in which mediated conflicts and connections shape the potential to work together to enact feminist social change. It therefore aimed to explore a number of different questions in relation to this issue, including: what kind of shared conversations do women have across age groups, and how do these circulate in media cultures? How can intergenerational alliances be built while still remaining sensitive to differences of experience? How are feminist connections being formed by digital media, technology, and platforms? How is feminist conflict mediated, and how might it operate productively

    Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

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    IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

    Depression and/or oppression? Bisexuality and mental health

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    The following paper is a write-up of the keynote talk which I presented at UK BiReCon in 2012, and then – in a revised form – at the first US BiReCon in 2013. My gratitude to Alex Iantaffi and Lauren Beach for enabling me to attend the latter, and to all the attendees for making me so welcome and for engaging so fully with our discussions around compassion and self-care. Given this paper’s origins, I hope that readers will forgive the tone for being somewhat more informal and polemic than that of a standard academic article in places, as well as the tendency to draw heavily on my own work over the years as expected in a keynote talk. Perhaps the most important, and consistent, finding in existing research on bisexuality is the fact that bisexual people are more prone to mental health problems than either heterosexual, or lesbian and gay, people. This finding has been replicated across many different countries and contexts, as readers of this journal will be well aware (e.g. Jorm et al., 2002; King & McKeown, 2003; Schrimshaw et al., 2013; Colledge et al., in prep)Therefore, in presenting a keynote talk on bisexuality it seemed appropriate – even essential – to focus on issues of mental health. My interest in this topic is threefold: First I am an academic who is interested in both sexuality and mental health, and has written on both areas over the last decade; secondly as a therapists I work with largely LGBTQ clients; and finally as an individual I have – perhaps inevitably given the aforementioned findings – struggled with these matters on a personal level, and within the bisexual and other sexual and gender communities that I am a part of. This paper considers bisexual mental health from both an individual, and a community, perspective. It asks how we, as individuals, generally understand mental health, and what ideas might be useful in relation to this. It also asks how the bisexual and wider LGBTQ communities that we are located in can relate to the ways in which we engage with mental health
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