Contact stresses, pressure and area in a fixed-bearing total ankle replacement: a finite element analysis

Mobile-bearing ankle implants with good clinical results continued to increase the popularity of total ankle arthroplasty to address endstage ankle osteoarthritis preserving joint movement. Alternative solutions used fixed-bearing designs, which increase stability and reduce the risk of bearing dislocation, but with a theoretical increase of contact stresses leading to a higher polyethylene wear. The purpose of this study was to investigate the contact stresses, pressure and area in the polyethylene component of a new total ankle replacement with a fixed-bearing design, using 3D finite element analysis

Predictive modeling of the virtual Hemi-Fontan operation for second stage single ventricle palliation: Two patient-specific cases

Single ventricle hearts are congenital cardiovascular defects in which the heart has only one functional pumping chamber. The treatment for these conditions typically requires a three-staged operative process where Stage 1 is typically achieved by a shunt between the systemic and pulmonary arteries, and Stage 2 by connecting the superior venous return to the pulmonary circulation. Surgically, the Stage 2 circulation can be achieved through a procedure called the Hemi-Fontan, which reconstructs the right atrium and pulmonary artery to allow for an enlarged confluence with the superior vena cava. Based on pre-operative data obtained from two patients prior to Stage 2 surgery, we developed two patient-specific multi-scale computational models, each including the 3D geometrical model of the surgical junction constructed from magnetic resonance imaging, and a closed-loop systemic lumped-parameter network derived from clinical measurements. “Virtual” Hemi-Fontan surgery was performed on the 3D model with guidance from clinical surgeons, and a corresponding multi-scale simulation predicts the patient\u27s post-operative hemodynamic and physiologic conditions. For each patient, a post-operative active scenario with an increase in the heart rate (HR) and a decrease in the pulmonary and systemic vascular resistance (PVR and SVR) was also performed. Results between the baseline and this “active” state were compared to evaluate the hemodynamic and physiologic implications of changing conditions. Simulation results revealed a characteristic swirling vortex in the Hemi-Fontan in both patients, with flow hugging the wall along the SVC to Hemi-Fontan confluence. One patient model had higher levels of swirling, recirculation, and flow stagnation. However, in both models, the power loss within the surgical junction was less than 13% of the total power loss in the pulmonary circulation, and less than 2% of the total ventricular power. This implies little impact of the surgical junction geometry on the SVC pressure, cardiac output, and other systemic parameters. In contrast, varying HR, PVR, and SVR led to significant changes in theses clinically relevant global parameters. Adopting a work-flow of customized virtual planning of the Hemi-Fontan procedure with patient-specific data, this study demonstrates the ability of multi-scale modeling to reproduce patient specific flow conditions under differing physiological states. Results demonstrate that the same operation performed in two different patients can lead to different hemodynamic characteristics, and that modeling can be used to uncover physiologic changes associated with different clinical conditions

Contact Stresses in a Fixed-Bearing Total Ankle Replacement

Category: Ankle, Ankle Arthritis, Basic Sciences/Biologics Introduction/Purpose: Third-generation ankle implants with good clinical results continued to increase the popularity of total ankle arthroplasty (TAA) to address end-stage ankle osteoarthritis preserving joint movement. Newer TAA used fixed-bearing designs, with a theoretical increase of contact stresses leading to a higher polyethylene wear. The purpose of this study was to investigate the contact stresses in the polyethylene component of a new third-generation TAA, with a fixed-bearing design, using 3D finite element analysis. Methods: A three-dimensional finite element model was developed based on the Zimmer Trabecular Metal Total Ankle (ZTMTA) and a finite element analysis was employed to evaluate the contact pressure, contact area and Von Mises stress in the polyethylene articular surface in the stance phase of the gait cycle. Results: The peak values were found at the anterior regions of the articulating surface, where reached 19.8 MPa at 40% of gait cycle. The average contact pressure during the stance phase of gait was 6.9 MPa. The maximum von Mises stress of 14.1 MPa in the anterior section was reached at 40% of the gait cycle. For the central section the maximum von Mises stress of 10.8 MPa was reached at 37% of the gait cycle, whereas for posterior section the maximum of 5.4 MPa was reached at the end of the stance phase (60% of the gait cycle). Conclusion: Although, the average von Mises stress was less than 10 MPa, high peak pressure values were recorded. Advanced models to quantitatively estimate the wear are needed to assess polyethylene and metal component survivorship

An integrated approach to patient-specific predictive modeling for single ventricle heart palliation

International audienceIn patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi- scale modeling

An integrated approach to patient-specific predictive modeling for single ventricle heart palliation

In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi-scale modeling

Examining Profiles of the Big Five and Sensation Seeking among Competitive Climbers

The present study sought to identify distinct personality profiles in competitive climbers (N = 331, Mean age = 29.85, SD = 10.92), and also sought to explore whether these climbers differed in their sensation seeking tendencies based on these personality profiles. Employing a cross-sectional design, participants completed measures of the big five personality dimensions (agreeableness; conscientiousness; extraversion; neuroticism; openness to experience) and sensation seeking (boredom susceptibility; experience seeking; disinhibition; thrill and adventure seeking). Latent profile analysis identified four distinct big five personality profiles (Curious and Impulsive; Emotionally Unstable; Healthy; and Measured and Compliant). MANCOVA and follow-up ANCOVAs demonstrated significant differences between the four personality profiles in relation to thrill and adventure seeking, experience seeking, and disinhibition. The findings suggest that the identification of distinct personality profiles using a person-centred approach is a useful way of distinguishing and optimizing typical behaviors and preferences in adventure sports in the future

Predictive modeling of the virtual Hemi-Fontan operation for second stage single ventricle palliation: Two patient-specific cases.

For the Modeling Of Congenital Hearts Alliance (MOCHA) - Investigators: Andrew Taylor, MD; Alessandro Giardini, MD; Sachin Khambadkone, MD; Silvia Schievano, Ph.D.; Marc de Leval, MD; and T.-Y. Hsia, MD (Institute of Cardiovascular Sciences, UCL, London, UK); Edward Bove, MD and Adam Dorfman, MD (University of Michigan, Ann Arbor, MI, USA); G. Hamilton Baker, MD and Anthony Hlavacek (Medical University of South Carolina, Charleston, SC, USA); Francesco Migliavacca, Ph.D., Giancarlo Pennati, Ph.D., and Gabriele Dubini, Ph.D. (Politecnico di Milano, Milan, Italy); Alison Marsden, Ph.D. (University of California, San Diego, CA, USA); Jeffrey Feinstein, MD (Stanford University, Stanford, CA, USA); Irene Vignon-Clementel (INRIA, Paris, France); Richard Figliola, Ph.D., and John McGregor, Ph.D. (Clemson University, Clemson, SC, USA).International audienceSingle ventricle hearts are congenital cardiovascular defects in which the heart has only one functional pumping chamber. The treatment for these conditions typically requires a three-staged operative process where Stage 1 is typically achieved by a shunt between the systemic and pulmonary arteries, and Stage 2 by connecting the superior venous return to the pulmonary circulation. Surgically, the Stage 2 circulation can be achieved through a procedure called the Hemi-Fontan, which reconstructs the right atrium and pulmonary artery to allow for an enlarged confluence with the superior vena cava. Based on pre-operative data obtained from two patients prior to Stage 2 surgery, we developed two patient-specific multi-scale computational models, each including the 3D geometrical model of the surgical junction constructed from magnetic resonance imaging, and a closed-loop systemic lumped-parameter network derived from clinical measurements. "Virtual" Hemi-Fontan surgery was performed on the 3D model with guidance from clinical surgeons, and a corresponding multi-scale simulation predicts the patient's post-operative hemodynamic and physiologic conditions. For each patient, a post-operative active scenario with an increase in the heart rate (HR) and a decrease in the pulmonary and systemic vascular resistance (PVR and SVR) was also performed. Results between the baseline and this "active" state were compared to evaluate the hemodynamic and physiologic implications of changing conditions. Simulation results revealed a characteristic swirling vortex in the Hemi-Fontan in both patients, with flow hugging the wall along the SVC to Hemi-Fontan confluence. One patient model had higher levels of swirling, recirculation, and flow stagnation. However, in both models, the power loss within the surgical junction was less than 13% of the total power loss in the pulmonary circulation, and less than 2% of the total ventricular power. This implies little impact of the surgical junction geometry on the SVC pressure, cardiac output, and other systemic parameters. In contrast, varying HR, PVR, and SVR led to significant changes in theses clinically relevant global parameters. Adopting a work-flow of customized virtual planning of the Hemi-Fontan procedure with patient-specific data, this study demonstrates the ability of multi-scale modeling to reproduce patient specific flow conditions under differing physiological states. Results demonstrate that the same operation performed in two different patients can lead to different hemodynamic characteristics, and that modeling can be used to uncover physiologic changes associated with different clinical conditions