Two loops calculation in chiral perturbation theory and the unitarization program of current algebra

In this paper we compare two loop Chiral Perturbation Theory (ChPT) calculation of pion-pion scattering with the unitarity second order correction to the current algebra soft-pion theorem. It is shown that both methods lead to the same analytic structure for the scattering amplitude.Comment: 13 pages, Revtex 3.0, no figures, submitted to Phys. Lett.

Bioelectrochemical systems (BESs) towards conversion of carbon monoxide/syngas: A mini-review

Microbial conversion of carbon monoxide (CO)/syngas has been extensively investigated. The microbial conversion of CO/syngas offers numerous advantages over chemically catalyzed processes e.g. the specificity of the biocatalysts, the operation at ambient conditions and high conversion efficiencies. Bioelectrochemical systems (BESs) exploit the capacity of electrochemically active bacteria (EAB) to use insoluble electron acceptors or donors to produce electricity or added-value compounds. Electricity production from different organic sources in BESs has been broadly demonstrated, whereas electricity production from CO/syngas has been very little reported. Acetate oxidation by a consortium of carboxydotrophic and CO-tolerant EAB has been suggested to be the main pathway responsible for indirect electricity generation from CO/syngas. Although electricity production in BESs from several organic sources has been widely investigated, the interest on BESs research is currently moving to the production of added-value compounds by electro-fermentation (EF) processes. EF allows to modify redox balances by the use of electric circuits to fine tune metabolic pathways towards obtaining products with high economic value. Although EF has been widely studied, the potential of use CO-rich gas streams as substrate has been under explored. This review presents and discusses current advances on microbial conversion of CO/syngas in BESs.This study was supported by the Portuguese Foundation for Science and Technology (FCT), within the scope of the project “INNOVsyn - Innovative strategies for syngas fermentation” (POCI-01-0145-FEDER- 033177). This study was also supported by the FCT under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte oper-ation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte.info:eu-repo/semantics/publishedVersio

Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges

Gastric cancer (GC) pathogenesis is complex and heterogeneous, reflecting morphological, molecular and genetic diversity. Diffuse gastric cancer (DGC) and intestinal gastric cancer (IGC) are the major histological types. GC may be sporadic or hereditary; sporadic GC is related to environmental and genetic low-risk factors and hereditary GC is caused by inherited high-risk mutations, so far identified only for the diffuse histotype. DGC phenotypic heterogeneity challenges the current understanding of molecular mechanisms underlying carcinogenesis. The definition of a DGC-specific mutational profile remains controversial, possibly reflecting the heterogeneity of DGC-related histological subtypes [signet-ring cell carcinoma (SRCC) and poorly cohesive carcinoma not otherwise specified (PCC-NOS)]. Indeed, DGC and DGC-related subtypes may present specific mutational profiles underlying the particularly aggressive behaviour and dismal prognosis of DGC vs IGC and PCC-NOS vs SRCC. In this systematic review, we revised the histological presentations, molecular classifications and approved therapies for gastric cancer, with a focus on DGC. We then analysed results from the most relevant studies, reporting mutational analysis data specifying mutational frequencies, and their relationship with DGC and IGC histological types, and with specific DGC subtypes (SRCC and PCC-NOS). We aimed at identifying histology-associated mutational profiles with an emphasis in DGC and its subtypes (DGC vs IGC; sporadic vs hereditary DGC; and SRCC vs PCC-NOS). We further used these mutational profiles to identify the most commonly affected molecular pathways and biological functions, and explored the clinical trials directed specifically to patients with DGC. This systematic analysis is expected to expose a DGC-specific molecular profile and shed light into potential targets for therapeutic intervention, which are currently missing.The authors acknowledge the support of the National Infrastructure ‘GenomePT’ – National Laboratory for Genome Sequencing and Analysis (POCI-01-0145-FEDER-022184). J.G-P acknowledges the support of Faculty of Medicine from University of Porto, specifically by the Doctoral Programme in Biomedicine and the Solve-RD Project (H2020-SC1-2017-Single-Stage-RTD) for his PhD fellowship. R.B-M. acknowledges the support of Institute of Biomedical Sciences Abel Salazar from University of Porto, specifically by the Doctoral Programme BiotechHealth and the FCT – Fundação para a Ciência e a Tecnologia for her PhD fellowship (ref. SFRH/BD/145132/2019). This research and its authors were funded by FEDER – Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 – Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT – Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação in the framework of the project ‘Institute for Research and Innovation in Health Sciences’ (POCI-01-0145-FEDER-007274). This work was also financed by the projects NORTE-01-0145-FEDER-000003 (DOCnet) and NORTE-01-0145-FEDER-000029 (CANCER) – supported by Norte Portugal Regional Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) – project POCI-01-0145-FEDER-016390 (CancelStem) and PTDC/BTM-TEC/30164/2017 (3DChroMe), funded by ERDF, POCI and FCT

On assessment of processing variables on vertical centrifugal casting technique

The aim of the present study is to investigate the influence of the vertical centrifugal casting technique over mechanical and metallurgical properties of a hypereutectic Al–18Si alloy. Due to the inherent vibration of the centrifugal casting technique, and in order to study and understand the individual effects of the equipment vibration and the centrifugal force itself (pressure or fluid dynamics), as well as the combined effect of both, three different tests were performed: gravity casting, gravity casting with vibration and centrifugal casting. It was concluded that the metallurgical and mechanical properties of castings obtained by the centrifugal casting process depend on the combined effect of the centrifugal pressure and/or fluid dynamics and on the inherent vibration of the technique itself. Correlations between the different casting techniques and obtained mechanical and metallurgical properties are presentedFCT - Fundação para a Ciência e Tecnologi

Cultivo in vitro de ápices caulinares de limoeiro Rugoso Mazoe em meio WPM suplementado com ANA e BAP.

Apesar da posição de destaque que detém a citricultura brasileira, são diversas as doenças sistêmicas que podem afetar a sua produção. As técnicas biotecnológicas podem reparar os problemas associados ao melhoramento das espécies cítricas, a exemplo do cultivo de ápices caulinares, que vem sendo bastante utilizada na produção de plantas livres de doenças. O emprego desta técnica, avaliando-se as condições de cultivo, pode fornecer melhores possibilidades para o desenvolvimento de plantas de citros via organogênese