QUADRUPOLE SPLITTING OF MOSSBAUER LINES DUE TO DEFECTS IN CO0

The Fe3+ lines observed in CoO Mossbauer sources may arise from the decay of Co3+ ions associated with cation vacancies in the crystal. These defects produce an electric-field gradient that causes a quadrupole splitting of the resonance line and that can, in principle, distinguish between different types of defects. The calculation of the quadrupole splitting at Fe2+ and Fe3+ sites near various vacancy clusters includes the relaxation of the lattice about the defect. This lattice polarisation and distortion is shown to be extremely important, since simple calculations based on perfect ion positions give very different field gradients at neighbouring sites. The results compared with the experiments available and the quadrupole splittings observed are close to those predicted by a vacancy model

Hall response of interacting bosonic atoms in strong gauge fields: from condensed to FQH states

Interacting bosonic atoms under strong gauge fields undergo a series of phase transitions that take the cloud from a simple Bose-Einstein condensate all the way to a family of fractional-quantum-Hall-type states [M. Popp, B. Paredes, and J. I. Cirac, Phys. Rev. A 70, 053612 (2004)]. In this work we demonstrate that the Hall response of the atoms can be used to locate the phase transitions and characterize the ground state of the many-body state. Moreover, the same response function reveals within some regions of the parameter space, the structure of the spectrum and the allowed transitions to excited states. We verify numerically these ideas using exact diagonalization for a small number of atoms, and provide an experimental protocol to implement the gauge fields and probe the linear response using a periodically driven optical lattice. Finally, we discuss our theoretical results in relation to recent experiments with condensates in artificial magnetic fields [ L. J. LeBlanc, K. Jimenez-Garcia, R. A. Williams, M. C. Beeler, A. R. Perry, W. D. Phillips, and I. B. Spielman, Proc. Natl. Acad. Sci. USA 109, 10811 (2012)] and we analyze the role played by vortex states in the Hall response.Comment: 10 pages, 7 figure

Simulation of phosphorus implantation into silicon with a single-parameter electronic stopping power model

We simulate dopant profiles for phosphorus implantation into silicon using a new model for electronic stopping power. In this model, the electronic stopping power is factorized into a globally averaged effective charge Z1*, and a local charge density dependent electronic stopping power for a proton. There is only a single adjustable parameter in the model, namely the one electron radius rs0 which controls Z1*. By fine tuning this parameter, we obtain excellent agreement between simulated dopant profiles and the SIMS data over a wide range of energies for the channeling case. Our work provides a further example of implant species, in addition to boron and arsenic, to verify the validity of the electronic stopping power model and to illustrate its generality for studies of physical processes involving electronic stopping.Comment: 11 pages, 7 figures. See http://bifrost.lanl.gov/~reed

QUADRUPOLE SPLITTING OF MOSSBAUER LINES DUE TO DEFECTS IN CO0-CORRIGENDUM

This is a Corrigendum for the article 1979 J. Phys. C: Solid State Phys. 12 382

Aulamar: Projecte escola d’oceanografia costanera

En aquest Research Café es presenten projectes on la tecnologia es posa al servei dels mars i els oceans, i que estan lligats amb els objectius ODS Vida Submarina i Acció pel clima.Objectius de Desenvolupament Sostenible::13 - Acció per al ClimaObjectius de Desenvolupament Sostenible::14 - Vida Submarin

Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

BACKGROUND: As critical mediators of local and systemic inflammatory responses, cytokines are produced in the brain following ischaemic stroke. Some have been detected in the circulation of stroke patients, but their role and source is unclear. Focusing primarily on interleukin(IL)-1-related mechanisms, we serially measured plasma inflammatory markers, and the production of cytokines by whole blood, from 36 patients recruited within 12 h and followed up to 1 year after acute ischaemic stroke (AIS). RESULTS: Admission plasma IL-1 receptor antagonist (IL-1ra) concentration was elevated, relative to age-, sex-, and atherosclerosis-matched controls. IL-1β, soluble IL-1 receptor type II, tumour necrosis factor (TNF)-α, TNF-RII, IL-10 and leptin concentrations did not significantly differ from controls, but peak soluble TNF receptor type I (sTNF-RI) in the first week correlated strongly with computed tomography infarct volume at 5–7 days, mRS and BI at 3 and 12 months. Neopterin was raised in patients at 5–7 d, relative to controls, and in subjects with significant atherosclerosis. Spontaneous IL-1β, TNF-α and IL-6 gene and protein expression by blood cells was minimal, and induction of these cytokines by lipopolysaccharide (LPS) was significantly lower in patients than in controls during the first week. Minimum LPS-induced cytokine production correlated strongly with mRS and BI, and also with plasma cortisol. CONCLUSION: Absence of spontaneous whole blood gene activation or cytokine production suggests that peripheral blood cells are not the source of cytokines measured in plasma after AIS. Increased plasma IL-1ra within 12 h of AIS onset, the relationship between sTNF-RI and stroke severity, and suppressed cytokine induction suggests early activation of endogenous immunosuppressive mechanisms after AIS