Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.

Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients. Several human and mouse studies have provided unequivocal evidence that the over-activation of the WNT/β-catenin signalling pathway underlies the molecular aetiology of these tumours. Recently, research using genetically modified mouse models of human ACP have revealed a critical and unexpected non-cell autonomous role for pituitary stem cells in ACP tumourigenesis, which has expanded the cancer stem cell paradigm. As the result of this basic research, the pathogenesis of ACP is being unveiled, with promising implications for the development of novel treatments against these childhood neoplasms. These benign tumours may additionally represent a unique model to provide insights into the initial steps of oncogenesis

Accretion disk coronae of Intermediate Polar Cataclysmic Variables - 3D MagnetoHydro-Dynamic modeling and thermal X-ray emission

IPCVs contain a magnetic, rotating white dwarf surrounded by a magnetically truncated accretion disk. To explain their strong flickering X-ray emission, accretion has been successfully taken into account. Nevertheless, observations suggest that accretion phenomena could not be the only process behind it. An intense flaring activity occurring on the surface of the disk may generate a corona, contribute to the thermal X-ray emission and influence the system stability. Our purposes are: investigating the formation of an extended corona above the accretion disk, due to an intense flaring activity occurring on the disk surface; studying its effects on the disk and stellar magnetosphere; assessing its contribution to the observed X-ray flux. We have developed a 3D MHD model of a IPCV. The model takes into account gravity, disk viscosity, thermal conduction, radiative losses and coronal flare heating. To perform a parameter space exploration, several system conditions have been considered, with different magnetic field intensity and disk density values. From the results of the evolution of the model, we have synthesized the thermal X-ray emission. The simulations show the formation of an extended corona, linking disk and star. The flaring activity is capable of strongly influencing the disk configuration and its stability, effectively deforming the magnetic field lines. Hot plasma evaporation phenomena occur in the layer immediately above the disk. The flaring activity gives rise to a thermal X-ray emission in both the [0.1-2.0] keV and the [2.0-10] keV bands. An intense coronal activity occurring on the disk surface of an IPCV can affect the structure of the disk depending noticeably on the density of the disk and the magnetic field of the central object. Moreover, the synthesis of the thermal X-ray fluxes shows that this flaring activity may contribute to the observed thermal X-ray emission

Advances on creep–fatigue damage assessment in notched components

In this paper, the extended Direct Steady Cyclic Analysis method (eDSCA) within the Linear Matching Method Framework (LMMF) is combined with the Stress Modified Ductility Exhaustion method and the modified Cavity Growth Factor (CGF) for the first time. This new procedure is used to systematically investigate the effect of several load parameters including load level, load type and creep dwell duration on the creep–fatigue crack initiation process in a notched specimen. The results obtained are verified through a direct comparison with experimental results available in the literature demonstrating great accuracy in predicting the crack initiation life and the driving mechanisms. Furthermore, this extensive numerical study highlighted the possible detrimental effect of the creep–ratchetting mechanism on the crack growth process. This work has a significant impact on structural integrity assessments of complex industrial components and for the better understanding of creep–fatigue lab scale tests

On the Weights of Nations: Assigning Voting Weights in a Heterogeneous Union

Consider a voting procedure where countries, states, or districts comprising a union each elect representatives who then participate in later votes at the union level on their behalf. The countries, provinces, and states may vary in their populations and composition. If we wish to maximize the total expected utility of all agents in the union, how to weight the votes of the representatives of the different countries, states or districts at the union level? We provide a simple characterization of the efficient voting rule in terms of the weights assigned to different districts and the voting threshold (how large a qualified majority is needed to induce change versus the status quo). Next, in the context of a model of the correlation structure of agents preferences, we analyze how voting weights relate to the population size of a country. We then analyze the voting weights in Council of the European Union under the Nice Treaty and the recently proposed constitution, and contrast them under different versions of our model, and compare them to the weights derived from poll data.Majority rule, Voting, Weighted voting, European Union

Low-wage Workers Are Older and Better Educated than Ever

Relative to any of the most common benchmarks -- the cost of living, the wages of the average worker, or average productivity levels -- the current federal minimum wage of $7.25 per hour is well below its historical value. These usual reference points, however, understate the true erosion in the minimum wage in recent decades because the average low-wage worker today is both older and much better educated than the average low-wage worker was in the past

The Initial Mass Function of Early-type Galaxies: no correlation with [Mg/Fe]

The Initial Mass Function (IMF) of early-type galaxies (ETGs) has been found to feature systematic variations by both dynamical and spectroscopic studies. In particular, spectral line strengths, based on gravity-sensitive features, suggest an excess of low-mass stars in massive ETGs, i.e. a bottom-heavy IMF. The physical drivers of IMF variations are currently unknown. The abundance ratio of alpha elements, such as [Mg/Fe], has been suggested as a possible driver of the IMF changes, although dynamical constraints do not support this claim. In this letter, we take advantage of the large SDSS database. Our sample comprises 24,781 high-quality spectra, covering a large range in velocity dispersion (100<sigma0<320 km/s) and abundance ratio (-0.1<[Mg/Fe]<+0.4). The large volume of data allows us to stack the spectra at fixed values of sigma0 and [Mg/Fe]. Our analysis -- based on gravity-sensitive line strengths -- gives a strong correlation with central velocity dispersion and a negligible variation with [Mg/Fe] at fixed sigma0. This result is robust against individual elemental abundance variations, and seems not to raise any apparent inconsistency with the alternative method based on galaxy dynamics.Comment: 5 pages, 2 figures, 2 tables. MNRAS Letters, in pres

Choosing How to Choose: Self Stable Majority Rules

We consider the endogenous choice of a voting rule, characterized by the majority size needed to elect change over the status quo, by a society who will use the rule to make future decisions. Under simple assumptions on the uncertainty concerning the future alternatives that will be voted upon, voters' have induced preferences over voting rules that are single-peaked and intermediate. We explore the existence of self-stable voting rules, i.e., voting rules such that there is no alternative rule that would beat the given voting rule if the given voting rule is used to choose between the rules. There are situations where self-stable voting rules do not exist. We explore conditions that guarantee existence, as well as issues relating to efficiency and constitutional design.

Effect of injection depth of digestate liquid fraction on soil carbon dioxide emission and maize biomass production

The aim of this study was to evaluate, in open field conditions, the effect of injection depth of digestate liquid fraction (10 cm, 25 cm and 35 cm) in clay loam soil, on CO2 emission. An un-amended soil was considered as control. The study was performed in 2014 on a farm located in Terrasa Padovana, Veneto region (Italy) distributing digestate before maize sowing. Digestate injection determined a high soil CO2 emission in the first hour after application, followed by a progressive reduction in as early as 24 h, reaching significantly lower values, similar to those measured in the un-amended control, after 48 h. Gas emissions measured 1 h after digestate application decreased as injection depth increased with significantly higher emission values in the 10 cm treatment (median value 23.7 g CO2 m\u20132 h\u20131) than in the 35 cm one (median value 2.5 g CO2 m\u20132 h\u20131). In the 3 days between digestate distribution and maize sowing, soil CO2 emission was significantly higher in the amended treatments than un-amended one, with median values of 1.53 g CO2 m\u20132 h\u20131 and 0.46 g CO2 m\u20132 h\u20131 respectively. During maize growing season, no significant soil CO2 emission difference was monitored among treatments, with a median value of 0.33 g CO2 m\u20132 h\u20131. Digestate application significantly improved maize aboveground dry biomass with an average yield of 22.0 Mg ha\u20131 and 16.2 Mg ha\u20131 in amended and un-amended plots, respectively, due to the different amount of nutrients supplied

Filamentary Switching: Synaptic Plasticity through Device Volatility

Replicating the computational functionalities and performances of the brain remains one of the biggest challenges for the future of information and communication technologies. Such an ambitious goal requires research efforts from the architecture level to the basic device level (i.e., investigating the opportunities offered by emerging nanotechnologies to build such systems). Nanodevices, or, more precisely, memory or memristive devices, have been proposed for the implementation of synaptic functions, offering the required features and integration in a single component. In this paper, we demonstrate that the basic physics involved in the filamentary switching of electrochemical metallization cells can reproduce important biological synaptic functions that are key mechanisms for information processing and storage. The transition from short- to long-term plasticity has been reported as a direct consequence of filament growth (i.e., increased conductance) in filamentary memory devices. In this paper, we show that a more complex filament shape, such as dendritic paths of variable density and width, can permit the short- and long-term processes to be controlled independently. Our solid-state device is strongly analogous to biological synapses, as indicated by the interpretation of the results from the framework of a phenomenological model developed for biological synapses. We describe a single memristive element containing a rich panel of features, which will be of benefit to future neuromorphic hardware systems