2,345 research outputs found

    Sea level rise adaptation: emerging lessons for local policy development

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    Many coastal communities across the United States are beginning to plan for climate-related sea level rise. While impacts and solutions will vary with local conditions, jurisdictions which have begun this process seem to pass through three common stages when developing policy for local sea level rise adaptation: l) building awareness about local sea level rise threats, 2) undertaking analyses of local vulnerabilities, and 3) developing plans and policies to deal with these vulnerabilities. The purpose of this paper is to help advance community dialogue and further inform local decision-makers about key elements and steps for addressing climate-related sea level rise. It summarizes the results of a project the Marine Policy Institute (MPI) undertook during 2011-12 to review experiences from fourteen U.S. coastal jurisdictions representing a variety of city, county, and state efforts with sea level adaptation. There are many more initiatives underway than those reflected in this sample, but the “focus jurisdictions” were selected because of the extensive information publically available on their experiences and lessons being learned that could provide insights for coastal communities, especially in Southwest Florida

    Multiscale scattering in nonlinear Kerr-type media

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    We propose a multiscale approach for a nonlinear Helmholtz problem with possible oscillations in the Kerr coefficient, the refractive index, and the diffusion coefficient. The method does not rely on structural assumptions on the coefficients and combines the multiscale technique known as Localized Orthogonal Decomposition with an adaptive iterative approximation of the nonlinearity. We rigorously analyze the method in terms of well-posedness and convergence properties based on suitable assumptions on the initial data and the discretization parameters. Numerical examples illustrate the theoretical error estimates and underline the practicability of the approach

    Target analyte quantification by isotope dilution LC-MS/MS directly referring to internal standard concentrations-validation for serum cortisol measurement

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    Isotope dilution LC-MS/MS methods used in the clinical laboratory typically involve multi-point external calibration in each analytical series. Our aim was to test the hypothesis that determination of target analyte concentrations directly derived from the relation of the target analyte peak area to the peak area of a corresponding stable isotope labelled internal standard compound [direct isotope dilution analysis (DIDA)] may be not inferior to conventional external calibration with respect to accuracy and reproducibility

    Numerical upscaling for wave equations with time-dependent multiscale coefficients

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    In this paper, we consider the classical wave equation with time-dependent, spatially multiscale coefficients. We propose a fully discrete computational multiscale method in the spirit of the localized orthogonal decomposition in space with a backward Euler scheme in time. We show optimal convergence rates in space and time beyond the assumptions of spatial periodicity or scale separation of the coefficients. Further, we propose an adaptive update strategy for the time-dependent multiscale basis. Numerical experiments illustrate the theoretical results and showcase the practicability of the adaptive update strategy

    Target analyte quantification by isotope dilution LC-MS/MS directly referring to internal standard concentrations-validation for serum cortisol measurement

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    Isotope dilution LC-MS/MS methods used in the clinical laboratory typically involve multi-point external calibration in each analytical series. Our aim was to test the hypothesis that determination of target analyte concentrations directly derived from the relation of the target analyte peak area to the peak area of a corresponding stable isotope labelled internal standard compound [direct isotope dilution analysis (DIDA)] may be not inferior to conventional external calibration with respect to accuracy and reproducibility

    An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry

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    Background: Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods: Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results: Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions: This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories

    Bewerbung um den Landeslehrpreis 2005 fĂŒr das Seminar "Erstellung psychologischer Lehrfilme"

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    In dieser Bewerbung um den Landeslehrpreis 2005 wird die didaktische Konzeption eines Seminars zur "Erstellung psychologischer Lehrfilme" dargestellt. In diesem projektorientierten Seminar zur Vermittlung psychologischer und mediengestalterischer Kompetenzen wird der "Perspektivenwechsel" als zentrales Element eingesetzt. Die Studierenden und ihre Dozenten setzen sich wissenschaftlich, filmend, schauspielernd und medienproduzierend mit ihren Fragestellungen auseinander. Diese didaktische Konzeption ist nicht nur im Bereich Psychologie umsetzbar, sondern ebenso in anderen Lehrgebieten

    Die politische Kommunikation der GrĂŒnen Wien im Web 2.0

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    Die vorliegende Arbeit befasst sich mit den Strategien politischer Kommunikation im Web 2.0 und den darin implementierten Social Media KanĂ€len. Im Mittelpunkt stehen die AktivitĂ€ten, Erwartungen, GrĂŒnde der Nutzung, Ziele sowie der Nutzen und die daraus entstehenden Erfolge der TĂ€tigkeiten der Abgeordneten der GrĂŒnen Wien. Die zentralen Thesen der Arbeit sind, dass die Nutzung der Social Media KanĂ€le die WĂ€hlerInnen zum Wahlgang motiviert, gerade Jugendliche erreicht werden und somit auch ein großes Mobilisierungspotential vorhanden ist. Auch die These der Demokratisierung durch diese Medien und die damit verbunden Partizipationsmöglichkeiten der Bevölkerung stehen dabei im Mittelpunkt. Der Abschnitt der theoretischen Grundlagen befasst sich zunĂ€chst damit, in wieweit das Internet und damit das Web 2.0 zu den Medien gezĂ€hlt werden darf, wie der/die EmpfĂ€ngerIn zum/zur SenderIn wird (nach Gerhard Maletzke) und welche Rolle dabei der Begriff der Öffentlichkeit bzw. der öffentlichen Meinung spielt – hierbei wird insbesondere auf die politische Kommunikation und ihre Bedeutung eingegangen. Zuletzt wird das Demokratisierungspotential, welches das Web 2.0 und die Social Media KanĂ€le enthĂ€lt, behandelt. Mit Hilfe von Interviews der Abgeordneten der GrĂŒnen Wien, welche mit einer qualitativen Inhaltsanalyse untersucht werden, werden die notwendigen Daten erhoben, um die oben aufgeworfenen Fragen und Hypothesen zu beantworten. Zwei ExpertInneninterviews stĂŒtzen die Daten und sorgen fĂŒr einen weiteren Blickwinkel. So ist eine GesamtĂŒbersicht ĂŒber die Web 2.0 TĂ€tigkeiten sowohl der Abgeordneten, als auch der offiziellen Öffentlichkeitsarbeit der Wiener GrĂŒnen möglich. Ein besonderes Augenmerk wird auf die Unterscheidung zwischen einem politischen Normaljahr und einem Wahljahr gelegt. Abschließend werden die Ergebnisse mit den tatsĂ€chlichen AktivitĂ€ten der Abgeordneten der GrĂŒnen Wien im Web 2.0 abgeglichen

    A Hyperlink Analysis on the Food Safety Issue in Germany

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    This article focuses on the constellations of actors engaged in the food safety debate in Germany and the potential of civil society organizations for mobilization and politicization of the issue. In an exploratory case study we assess the structure of communication between these organizations by applying hyperlink analysis. Our study sheds light on the nature of the issue network and in particular on their linkages with media and political actors. We interpret communication network patterns with respect to civil society actors' opportunities to make food safety salient on the agenda and to mobilize around it and politicize it. In fact, our empirical study shows that the structure of linkages between civil society actors, media organizations and political actors in Germany offers favourable opportunities for making the food safety issue salient and for politicizing it in the offline world
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