121 research outputs found
Next-to-leading order QCD corrections to electroweak Zjj production in the POWHEGBOX
We present an implementation of electroweak Z-boson production in association
with two jets at hadron colliders in the POWHEG framework, a method that allows
the interfacing of NLO-QCD calculations with parton-shower Monte Carlo
programs. We focus on the leptonic decays of the weak gauge boson, and take
photonic and non-resonant contributions to the matrix elements fully into
account. We provide results for observables of particular importance for the
suppression of QCD backgrounds to vector-boson fusion processes by means of
central-jet-veto techniques. While parton-shower effects are small for most
observables associated with the two hardest jets, they can be more pronounced
for distributions that are employed in central-jet-veto studies.Comment: 12 pages, 5 figure
Once-daily intrapleural urokinase treatment of complicated parapneumonic effusion in pediatric patients
In this paper, we describe our experience in the treatment of childhood empyema using urokinase. Patients' ages ranged from 2 to 12 years. Urokinase (dosage: 3,100 IU/kg/day) was diluted in normal saline to produce 1000 IU/ml (maximum dosage 100,000 IU in 100 ml of normal saline). After 2 hours, the clamped catheters were released and connected to water-seal suction at a negative pressure of 10 cm H2O. Pleural irrigations were continued once a day until thoracostomy tube output decreased to less than 10 ml/day (urokinase treatment mean duration: 11.5 days). The complete resolution of the chest effusion was assessed on chest ultrasound scan and radiographs. None of the patients experienced any side effects due to urokinase. It would now seem reasonable to advocate small chest tube thoracostomy and intrapleural urokinase as first-line treatment of pleural empyema in children, with surgery indicated as a secondaryintervention
Slepton pair production in the POWHEG BOX
We present an implementation for slepton pair production at hadron colliders
in the POWHEG BOX, a framework for combining next-to-leading order QCD
calculations with parton-shower Monte-Carlo programs. Our code provides a SUSY
Les Houches Accord interface for setting the supersymmetric input parameters.
Decays of the sleptons and parton-shower effects are simulated with PYTHIA.
Focussing on a representative point in the supersymmetric parameter space we
show results for kinematic distributions that can be observed experimentally.
While next-to-leading order QCD corrections are sizable for all distributions,
the parton shower affects the color-neutral particles only marginally.
Pronounced parton-shower effects are found for jet distributions.Comment: 10 pages, 4 figure
Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold
Two novel series of compounds based on the 4,5,6,7-tetrahydrothieno[2,3-c]pyridine and 4,5,6,7-tetrahydrobenzo[b]thiophene molecular skeleton, characterized by the presence of a 3′,4′,5′-trimethoxyanilino moiety and a cyano or an alkoxycarbonyl group at its 2- or 3-position, respectively, were designed, synthesized, and evaluated for antiproliferative activity on a panel of cancer cell lines and for selected highly active compounds, inhibition of tubulin polymerization, and cell cycle effects. We have identified the 2-(3′,4′,5′-trimethoxyanilino)-3-cyano-6-methoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivative 3a and its 6-ethoxycarbonyl homologue 3b as new antiproliferative agents that inhibit cancer cell growth with IC50 values ranging from 1.1 to 4.7 μM against a panel of three cancer cell lines. Their interaction with tubulin at micromolar levels leads to the accumulation of cells in the G2/M phase of the cell cycle and to an apoptotic cell death. The cell apoptosis study found that compounds 3a and 3b were very effective in the induction of apoptosis in a dose-dependent manner. These two derivatives did not induce cell death in normal human peripheral blood mononuclear cells, suggesting that they may be selective against cancer cells. Molecular docking studies confirmed that the inhibitory activity of these molecules on tubulin polymerization derived from binding to the colchicine site
Modeling Multi-Wavelength Stellar Astrometry. I. SIM Lite Observations of Interacting Binaries
Interacting binaries consist of a secondary star which fills or is very close
to filling its Roche lobe, resulting in accretion onto the primary star, which
is often, but not always, a compact object. In many cases, the primary star,
secondary star, and the accretion disk can all be significant sources of
luminosity. SIM Lite will only measure the photocenter of an astrometric
target, and thus determining the true astrometric orbits of such systems will
be difficult. We have modified the Eclipsing Light Curve code (Orosz &
Hauschildt 2000) to allow us to model the flux-weighted reflex motions of
interacting binaries, in a code we call REFLUX. This code gives us sufficient
flexibility to investigate nearly every configuration of interacting binary. We
find that SIM Lite will be able to determine astrometric orbits for all
sufficiently bright interacting binaries where the primary or secondary star
dominates the luminosity. For systems where there are multiple components that
comprise the spectrum in the optical bandpass accessible to SIM Lite, we find
it is possible to obtain absolute masses for both components, although
multi-wavelength photometry will be required to disentangle the multiple
components. In all cases, SIM Lite will at least yield accurate inclinations,
and provide valuable information that will allow us to begin to understand the
complex evolution of mass-transferring binaries. It is critical that SIM Lite
maintains a multi-wavelength capability to allow for the proper deconvolution
of the astrometric orbits in multi-component systems.Comment: 12 pages, 6 figures, 6 tables. Accepted for publication in the
Astrophysical Journa
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors
The structureeactivity relationship of new 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as adenosine receptors (ARs) antagonists has been explored. The introduction of a benzylamino group at C5 with a free amino group at C7 increases the affinity toward all the ARs subtypes (10: KihA1 \ubc 94.6 nM; KihA2A \ubc 1.11 nM; IC50hA2B \ubc 2214 nM; KihA3 \ubc 30.8 nM). Replacing the free amino group at C7 with a phenylureido moiety yields a potent and quite selective hA2A AR antagonist (14: hA2A AR Ki \ubc 1.44 nM; hA1/hA2A \ubc 216.0; hA3/hA2A \ubc 20.6). This trend diverges from the analysis on the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine series previously reported. With the help of an in silico receptor-driven approach, we have rationalized these observations and elucidated from a molecular point of view the role of the benzylamino group at C5 in determining affinity toward the hA2A AR
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile
In the last 5 years, many efforts have been conducted searching potent and selective human A3 adenosine antagonists. In this field several different classes of compounds, possessing very good affinity (nM range) and with a broad range of selectivity, have been proposed. Recently, our group synthesized a new series of pyrazolo-triazolo-pyrimidines bearing different substitutions at the N5 and N8 positions, which have been described as highly potent and selective human A3 adenosine receptor antagonists. The present review summarizes available data and provides an overview of the structure–activity relationships found for this class of human A3 adenosine receptor antagonists
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