Advancing the Smart Region Digital Twin: The Case of UNESCO GEOfood

Organic food waste recycling is one of the final frontiers for a sustainable food lifecycle. Digital twins may be helpful to close the loop in more advanced food supply chains, but there is a lack of guidelines on how to adopt this emerging technology in community composting. This paper presents a digital twin-driven design to address this need in a UNESCO-protected region with geological relevance (Geopark). The design science research project offers the foundations for creating intelligent composting networks supported by digital technologies. Six initial design principles are suggested for developing digital twins at a regional level. This study contributes to the deployment of layered digital twins in sustainable regional development. Moreover, our proposal assists the integration of local food producers in regional food supply chains and increases the impact of sustainability brands like GEOfood

Photocatalytic Difluoromethylation Reactions of Aromatic Compounds and Aliphatic Multiple C-C Bonds

Among the realm of visible light photocatalytic transformations, late-stagedifluoromethylation reactions (introduction of difluoromethyl groups in the last stages of syntheticprotocols) have played relevant roles as the CF2X group substitutions exert positive impacts on thephysical properties of organic compounds including solubility, metabolic stability, andlipophilicity, which are tenets of considerable importance in pharmaceutical, agrochemical, andmaterials science. Visible-light-photocatalyzed difluoromethylation reactions are shown to beaccomplished on (hetero)aromatic and carbon?carbon unsaturated aliphatic substrates under mildand environmentally benign conditions.Fil: Barata Vallejo, Sebastian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Postigo, Jose Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentin

Photocatalytic fluoroalkylation reactions of organic compounds

Photocatalytic methods for fluoroalkyl-radical generation provide more convenient alternatives to the classical perfluoroalkyl-radical (Rf) production through chemical initiators, such as azo or peroxide compounds or the employment of transition metals through a thermal electron transfer (ET) initiation process. The mild photocatalytic reaction conditions tolerate a variety of functional groups and, thus, are handy to the late-stage modification of bioactive molecules. Transition metal-photocatalytic reactions for Rf radical generation profit from the redox properties of coordinatively saturated Ru or Ir organocomplexes to act as both electron donor and reductive species, thus allowing for the utilization of electron accepting and donating fluoroalkylating agents for Rf radical production. On the other hand, laboratory-available and inexpensive photoorgano catalysts (POC), in the absence of transition metals, can also act as electron exchange species upon excitation, resulting in ET reactions that produce Rf radicals. In this work, a critical account of transition metal and transition metal-free Rf radical production will be described with photoorgano catalysts, studying classical examples and the most recent investigations in the field.Fil: Barata Vallejo, Sebastian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bonesi, Sergio Mauricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Postigo, Jose Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Synthetic strategies for fluorosulfonylated compounds: application to click chemistry reactions

The syntheses and applications of fluorosulfonylated organic compounds have flourished in the last ten years due to their versatility to participate in click chemistry (SuFEx) reactions. Also, organic architectures that combine the SO2F group and other ancillary functional moieties such as olefins, alkynes, etc. (i.e.: bis-electrophiles) have augmented the applications and diversity of the end compounds. To this effect, the association of an alkyne functionality and the SuFExable group within one structure has been shown to encompass two-in-one click chemistry sequential protocols with the aim of building on the diversity of scaffolds by two consecutive click processes. We next examine the syntheses of (hetero)aromatic-, alkyl-, alkenyl-, and alkynyl-sulfonyl fluorides and β-keto-sulfonyl fluorides and the syntheses of compounds bearing N-SO2F and O-SO2F bonds through diverse catalytic methods, illustrating examples of their SuFEx click chemistry and other ancillary functional group reactivity.Fil: Barata Vallejo, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consiglio Nazionale delle Ricerche. Istituto per la Sintesi Organica e la Fotoreattività; ItaliaFil: Yerien, Damián Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; ArgentinaFil: Postigo, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentin

Bioinspired Photocatalyzed Organic Synthetic Transformations. The Use of Natural Pigments and Vitamins in Photocatalysis

Due to the necessity for more environmentally benign processes in synthetic organic chemistry, and in particular in photocatalysis, a recourse to photocatalysts that are also found in nature and mimic natural processes to accomplish organic transformations is very appealing. Synthetic useful reactions such as oxidations, reductions, carbon-oxygen, carbon-carbon and carbon-sulfur bond formation reactions, and E-to-Z geometrical isomerization reactions photocatalyzed by biological natural pigments, vitamins, cofactors, and compounds with antiviral activity will be discussed in this account. Interestingly, due to the remarkable redox properties and triplet energies of some of these catalysts that are found in nature, both electron transfer (ET)- and energy transfer (EnT)-driven photocatalytic processes can be accomplished.Fil: Barata Vallejo, Sebastian. Consiglio Nazionale delle Ricerche; Italia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Yerien, Damián Emilio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Postigo, Jose Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Da frustração ao ódio: a construção da imagem da mulher em Hóspede, de Pardal Mallet

Este trabalho retoma o romance de estreia de Pardal Mallet, Hóspede, discutindo de que forma se constrói a imagem da mulher na narrativa, que vai da frustração ao ódio. Para tanto, discutimos a aclimatação do gênero romance, no Brasil, e a crítica que se estabeleceu sobre a estética Naturalismo. Utilizamos como referencia teórico, dentre outros autores, as obras de Telles (2000) Sade (2002) Abreu (2003), Siti (2009)

Visible Light-catalyzed Fluoroalkylation Reactions of Free Aniline Derivatives

The electron-rich nature of aminoaromatic compounds and the electrophilic characterof fluoroalkyl R F radicals allow for a special match in substitution reactions. Weherein present visible light-photocatalyzed fluoroalkylation reactions of anilinederivatives, with a study of the reaction mechanisms. The examples evaluated makeuse of different photocatalysts, such as polypyridyl complexes of Ir or Ru transitionmetals, organic dyes such as Rose Bengal, phthalocyanine-metal organocatalysts, orvisible-light activated complexes. Different visible light sources that span from the blueregion of the electromagnetic spectrum to low power red light irradiation sourcesdeliver the excited photocatalysts that ensue into the production of fluoroalkyl R Fradicals. In turn, many sources of R F radicals can be employed, such as fluoroalkylhalides, Togni s reagents, Umemoto s reagent, etc. All these protocol variantsdemonstrate the expansion of the methodology and the versatility of photocatalytictechniques applied to a special family of organic compounds such as aminoaromaticsubstrates, which has been studied by different groups. Contributions from our ownlaboratory will be given.Fil: Lantaño, Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; ArgentinaFil: Yerien, Damián Emilio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Barata Vallejo, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; ArgentinaFil: Postigo, Jose Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentin

Approach to Adapt a Legacy Manufacturing System Into the IoT Paradigm

This work has been supported by Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, by Uninova-CTS research unit and by national funds through FCT -Fundação para a Ciência e a Tecnologia within the research unit CTS - Centro de Tecnologia e Sistemas (project UID/EEA/00066/2013). The authors would like to thank all the institutions.Enterprises are adopting the Internet of Things paradigm as a strategy to improve competitiveness. But enterprises also need to rely on their legacy systems, which are of vital importance to them and normally difficult to reconfigure or modify, their mere replacement being usually not affordable. These systems constitute, therefore, barriers to agility and competitiveness, raising the need to develop cost-effective ways for IoT adaptation. An approach for adapting legacy manufacturing systems into the IoT realm is proposed in this research. The methodology is twofold: an adaptation board is firstly designed to provide IoT connectivity, allowing to remotely invoke the “legacy” functionality as services. Then, the board itself can leverage the legacy system by developing additional functionalities inside it, as the update process is usually triggered by the need of new functionality from these systems. An experiment, which consists of adapting to IoT a small distribution line that is controlled by an aged Programmable Logic Controller, is developed to illustrate how straightforward, affordable and cost effective the adaptation approach is, allowing to holistically achieve a new system with more sophisticated functionality.publishersversionpublishe