Improved impact performance of marine sandwich panels using through-thickness reinforcement: Experimental results

This paper presents results from a test developed to simulate the water impact (slamming) loading of sandwich boat structures. A weighted elastomer ball is dropped from increasing heights onto rigidly supported panels until damage is detected. Results from this test indicate that honeycomb core sandwich panels, the most widely used material for racing yacht hulls, start to damage due to core crushing at impact energies around 550 J. Sandwich panels of the same areal weight and with the same carbon/epoxy facings but using a novel foam core reinforced in the thickness direction with pultruded carbon fibre pins, do not show signs of damage until above 1200 J impact energy. This suggests that these will offer significantly improved resistance to wave impact. Quasi-static test results cannot be used to predict impact resistance here as the crush strength of the pinned foam is more sensitive to loading rate than that of the honeycomb core

Can Blended Learning Address Indian Academic Issues?

Over the years, India has implemented social reforms aimed at providing education to all. This is observed from the growth in GER (Gross Enrollment Ratio) over the years that has resulted in a decrease in the number of students absent in schools. Coronavirus, nonetheless, has disturbed this scenario and is testing the functions, efficiencies, and practices of India\u27s schooling framework. This research paper, written for stakeholders in government, and the education sector, anticipate the extent to which there is a need of continuing the imparting of education. The main objective of this paper is to provide an overview of the newer ways that may help continue the process of learning and teaching amidst this lockdown situation that is prevailing across the world. This disruption of education has forced pushed the policymakers to consider another way of imparting quality education (both primary and secondary). This has resulted in the use of a ‘blended (mixed) learning methodology’ that incorporates one-to-one learning (classroom) as well as one-to-many (e-learning). In this context, the authors would like to emphasize the need of strengthening the basic education framework that imparts education to all

Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot

The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics. Therefore, it is important to elucidate the general principles governing their thermodynamics/folding mechanisms. Here, we combine experiments and simulations to examine the folding/unfolding pathways of the VPK pseudoknot, a variant of the Mouse Mammary Tumor Virus (MMTV) PK involved in ribosomal frameshifting. Fluorescent nucleotide analogs (2-aminopurine and pyrrolocytidine) placed at different stem/loop positions in the PK, and laser temperature-jump approaches serve as local probes allowing us to monitor the order of assembly of VPK with two helices with different intrinsic stabilities. The experiments and molecular simulations show that at 50 mM KCl the dominant folding pathway populates only the more stable partially folded hairpin. As the salt concentration is increased a parallel folding pathway emerges, involving the less stable hairpin structure as an alternate intermediate. Notably, the flux between the pathways is modulated by the ionic strength. The findings support the principle that the order of PK structure formation is determined by the relative stabilities of the hairpins, which can be altered by sequence variations or salt concentrations. Our study not only unambiguously demonstrates that PK folds by parallel pathways, but also establishes that quantitative description of RNA self-assembly requires a synergistic combination of experiments and simulations.Comment: Supporting Information include

Modeling Stable Matching Problems with Answer Set Programming

The Stable Marriage Problem (SMP) is a well-known matching problem first introduced and solved by Gale and Shapley (1962). Several variants and extensions to this problem have since been investigated to cover a wider set of applications. Each time a new variant is considered, however, a new algorithm needs to be developed and implemented. As an alternative, in this paper we propose an encoding of the SMP using Answer Set Programming (ASP). Our encoding can easily be extended and adapted to the needs of specific applications. As an illustration we show how stable matchings can be found when individuals may designate unacceptable partners and ties between preferences are allowed. Subsequently, we show how our ASP based encoding naturally allows us to select specific stable matchings which are optimal according to a given criterion. Each time, we can rely on generic and efficient off-the-shelf answer set solvers to find (optimal) stable matchings.Comment: 26 page

Weak and strong disjunction in possibilistic asp

Abstract. Possibilistic answer set programming (PASP) unites answer set programming (ASP) and possibilistic logic (PL) by associating certainty values with rules. The resulting framework allows to combine both non-monotonic reasoning and reasoning under uncertainty in a single framework. While PASP has been well-studied for possibilistic definite and possibilistic normal programs, we argue that the current semantics of possibilistic disjunctive programs are not entirely satisfactory. The problem is twofold. First, the treatment of negation-as-failure in existing approaches follows an all-or-nothing scheme that is hard to match with the graded notion of proof underlying PASP. Second, we advocate that the notion of disjunction can be interpreted in several ways. In particular, in addition to the view of ordinary ASP where disjunctions are used to induce a non-deterministic choice, the possibilistic setting naturally leads to a more epistemic view of disjunction. In this paper, we propose a semantics for possibilistic disjunctive programs, discussing both views on disjunction. Extending our earlier work, we interpret such programs as sets of constraints on possibility distributions, whose least specific solutions correspond to answer sets.

Magnetic order in the two-dimensional metal-organic framework manganese pyrazinecarboxylate with Mn-Mn dimers

The magnetic properties of [Mn(pyrazinecarboxylate)2]n (Mn-pyrazine), empirical formula C10H6MnN4O4, are investigated through susceptibility, heat capacity and neutron scattering measurements. The structure of Mn-pyrazine consists of Mn-Mn dimers linked on a distorted 2D hexagonal structure. The weak out of plane interactions create a quasi-2D magnetic material within the larger three dimensional metal organic framework (MOF) structure. We show that this material undergoes a two stage magnetic transition, related to the low dimensionality of the Mn lattice. First at 5 K, which is assigned to the initial development of short range order in the 2D layers. This is followed by long range order at 3.3 K. Applied field measurements reveal the potential to induce magnetic transitions in moderately small fields of 2 T. Neutron powder diffraction enabled the determination of a unique magnetic space group P21'/c (#14.77) at 1.5 K. This magnetic structure consists of antiferromagnetically coupled Mn-Mn dimers with spins principally along the out of plane a-axis

Medical Waste Storage Practice in Health Care Institutions of Pokhara Sub-metropolitan City

Introduction: Medical wastes include all the waste generated by health care establishments, research facilities, and laboratories. Medi­cal waste is any waste that is generated in the diagnosis, treatment or immunization of human beings or animals, in research pertaining there to or in the productions or testing of biological culture. Methods: The fourteen numbers of health care institutions (HCIs) having inpatient facilities, were sampled for the study. After taking ob­servation, the collected information was entered into a computer. Basi­cally, the percentages, projection analysis, simple average, and scenario analysis were used as an analysis tools. Results: Out of the HCIs surveyed, only 21.43% of them had a separate room assigned for primary storage of all sorts of waste and remaining 78.57% of them had open storage facilities for un-segregated mass of waste nearby the incineration area or open burning area. Conclusion: There was lack of appropriate information on waste stor­age practices, and unaware of designing central storage system in HCIs. In most of the HCIs, a separate storage room was not assigned for stor­age of all sorts of waste. Journal of Gandaki Medical College Vol. 10, No. 1, 2017, page: 31-3

Translation and validation of the Nepalese version of Derriford appearance scale (DAS-59)

Objectives: To establish a valid and reliable translated version of Derriford Appearance Scale (DAS 59) for Nepali population.Methods: A standard translation-back-translation procedure was used followed by evaluation of semantic, conceptual and society equivalence by the committee and changes were made according to recommendations. This corrected version was pretested and a final version was developed. A validation study was performed using the final version on 424 patients including 212 patients with clinical appearance problems and similar number of young adults who had no concern for facial appearance. Reliability was assessed by cronbach’s alpha value and test-retest correlation coefficient. Discriminate and convergent validity were assessed by comparison between clinical and normal population and correlation with Beck’s Anxiety Inventory(BAI), Beck’s Depression Inventory(BDI)and General Health questionnaire (GHQ) Results: The results indicated excellent internal consistency (Cronbach’s alpha = 0.98) and good test –retest reliability (0.91 for clinical population, 0.86 for normal population). The Discriminate validity was good with statistically significant differences between clinical and normal population .The convergent validity was confirmed by good correlation with other related psychometric tools.Conclusion: A valid and reliable Nepali DAS59 version was developed which can be used for research and clinical assessment of patients with appearance problems and concerns

NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain

The interaction between the acidic transactivation domain of the human tumor suppressor protein p53 (p53TAD) and the 70 kDa subunit of human replication protein A (hRPA70) was investigated using heteronuclear magnetic resonance spectroscopy. A (1)H–(15)N heteronuclear single quantum coherence (HSQC) titration experiment was performed on a (15)N-labeled fragment of hRPA70, containing the N-terminal 168 residues (hRPA70(1–168)) and p53TAD. HRPA70(1–168) residues important for binding were identified and found to be localized to a prominent basic cleft. This binding site overlapped with a previously identified single-stranded DNA-binding site, suggesting that a competitive binding mechanism may regulate the formation of p53TAD–hRPA70 complex. The amide (1)H and (15)N chemical shifts of an uniformly (15)N-labeled sample of p53TAD were also monitored before and after the addition of unlabeled hRPA70(1–168). In the presence of unlabeled hRPA70(1–168), resonance lineshapes increased and corresponding intensity reductions were observed for specific p53TAD residues. The largest intensity reductions were observed for p53TAD residues 42–56. Minimal binding was observed between p53TAD and a mutant form of hRPA70(1–168), where the basic cleft residue R41 was changed to a glutamic acid (R41E), demonstrating that ionic interactions play an important role in specifying the binding interface. The region of p53TAD most affected by binding hRPA70(1–168) was found to have some residual alpha helical and beta strand structure; however, this structure was not stabilized by binding hRPA70(1–168). (15)N relaxation experiments were performed to monitor changes in backbone dynamics of p53TAD when bound to hRPA70(1–168). Large changes in both the transverse (R(2)) and rotating frame (R(1ρ)) relaxation rates were observed for a subset of the p53TAD residues that had (1)H–(15)N HSQC resonance intensity reductions during the complex formation. The folding of p53TAD upon complex formation is suggested by the pattern of changes observed for both R(2) and R(1ρ). A model that couples the formation of a weak encounter complex between p53TAD and hRPA70(1–168) to the folding of p53TAD is discussed in the context of a functional role for the p53–hRPA70 complex in DNA repair

Localization of binary neutron star mergers with a single Cosmic Explorer

Next-generation ground-based gravitational-wave detectors, such as Cosmic Explorer (CE), are expected to be sensitive to gravitational-wave signals with frequencies as low as 5 Hz, allowing signals to spend a significant amount of time in the detector frequency band. As a result, the effects caused by the rotation of the Earth become increasingly important for such signals. Additionally, the length of the arms of these detectors can be comparable to the wavelength of detectable gravitational waves, which introduces frequency-dependent effects that are not significant in current-generation detectors. These effects are expected to improve the ability to localize compact binary coalescences in the sky even when using only one detector. This study aims to understand how much these effects can help in localization. We present the first comprehensive Bayesian parameter estimation framework that accounts for all these effects using \textsc{Bilby}, a commonly used Bayesian parameter estimation tool. We focus on sky localization constraints for binary neutron star events with an optimal signal-to-noise ratio of 1000 with one detector at the projected CE sensitivity. We find that these effects help localize sources using one detector with sky areas as low as 10 square degrees. Moreover, we explore and discuss how ignoring these effects in the parameter estimation can lead to biases in the inference.Comment: Version accepted by PR