Mathematical model of brain tumour with glia-neuron interactions and chemotherapy treatment

Acknowledgements This study was possible by partial financial support from the following Brazilian government agencies: Fundação Araucária, EPSRC-EP/I032606/1 and CNPq, CAPES and Science Without Borders Program Process nos. 17656125, 99999.010583/2013-00 and 245377/2012-3.Peer reviewedPreprin

Bacterial enzymatic activity and bioavailability of heavy metals in sediments from Boa Viagem Beach (Guanabara Bay)

This study focuses on the quality of the organic matter that reaches the sediment from Boa Viagem Beach and through the evaluation of the total bacterial count, the electron transport system activity (ETSA), the esterase activity (EST), as well as the protein and the organic matter contents. Seasonal variations of organic matter, protein content and the number of bacteria were particularly notable in the summer. ETSA reached a maximum of 7.48 µl O2 h-1 g-1 in the summer. EST activity presented a different pattern once it reached a maximum of 0.17 µg fluorescein h-1 g-1 in the winter. The temporal variation of ETSA and EST activity indicated that biopolymers predominated in the winter, and oligomers or monomers predominated in the summer. These results suggest that organic carbon turnover is more likely to be controlled by organic matter quality. The heavy metals concentrations, especially for Cu, Zn, Ni and Cr, indicated absence of the inhibition of dehydrogenase activity, and they are not bioavailable in the EC50 valuesO trabalho enfoca a qualidade da matéria orgânica do sedimento da Praia da Boa Viagem, avaliando-se a contagem de bactérias, a atividade do sistema transportador de elétrons (ETSA), a atividade de esterases (EST) e a concentração de proteína e matéria orgânica. Variação sazonal de matéria orgânica, de proteína e número de bactérias foi significativo no verão. ETSA apresentou maior valor no verão, 7.48 µl O2 h-1 g-1. A EST foi maior no inverno, chegando a 0.17 µg fluorescein h-1 g-1. A variação temporal de ETSA e EST indicaram que biopolímeros predominaram no inverno e oligômeros e monômeros, no verão. Estes resultados sugerem que a transformação do carbono orgânico é controlado pela qualidade da matéria orgânica. As concentrações dos metais, especialmente Cu, Zn, Ni and Cr, indicam ausência de inibição da atividade das desidrogenase pois não estão biodisponíveis na concentração EC50

Analytical solutions for the short-term plasticity

Acknowledgements This study was possible by partial financial support from the following Brazilian government agencies: FAPESP (2020/04624-2, 2022/05153-9, 2022/13761-9).Peer reviewe

Eulerian-Lagrangian analysis of pollutant transport in shallow water

A numerical method for the solution of the two-dimensional, unsteady, transport equation is formulated, and its accuracy is tested.The method uses a Eulerian-Lagrangian approach, in which the transport equation is divided into a diffusion equation (solved by a finite element method) and a convection equation (solved by the method of characteristics). This approach leads to results that are free of spurious oscillations and excessive numerical damping, even in the case where advection strongly dominates diffusion. For pure diffusion problems, optimal accuracy is approached as the time-step, At, goes to zero; conversely, for pure-convection problems, accuracy improves with increasing At; for convection-diffusion problems the At leading to optimal accuracy depends on the characteristics of the spatial discretization and on the relative importance of convection and diffusion.The method is cost-effective in modeling pollutant transport in coastal waters, as demonstrated by two prototype applications: hypothetical sludge dumping in Massachusetts Bay and the thermal discharge from Brayton Point Generating Station in Narragansett Bay. Numerical diffusion is eliminated or greatly reduced, raising the need for realistic estimation of dispersion coefficients. Costs (based on CPU time) should not exceed those of conventional Eulerian methods and, in some cases (e.g., problems involving predictions over several tidal cycles), considerable savings may even be achieved

Solution of advection-dominated transport by Eulerian-Lagrangian methods using the backwards method of characteristics

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1987.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING.Includes bibliographies.by António Eugénio de Melo Baptista.Ph.D

The electroencephalogram in the parkinsonian syndrome

The electroencephalograms of 50 parkinsonian patients with no convulsive antecedents were studied. EEG abnormalities were found in 20 patients (40% of the cases). The incidence of abnormal records was larger in the bilateral parkinsonian syndrome than in the unilateral one (52% and 25%, respectively). Paroxysmal abnormalities characterized mainly by bursts of theta waves were the most frequent ones (65% of the cases). Sharp activity found in the EEG patterns of three patients is emphasized. Alterations of the base rhythm were recorded in 30% of the abnormal EEG cases. The patient's age doesn't seem to have an important role in the genesis of the electroencephalographic abnormalities.Foram estudados os eletrencefalogramas de 50 pacientes parkinsonianos livres de qualquer antecedente convulsivo, sendo registrados traçados anormais em 40% dos casos. A incidência de traçados anormais foi maior na síndrome parkinsoniana bilateral do que na unilateral (52% e 25%, respectivamente). Entre as anormalidades assinaladas foram as paroxísticas as mais freqüentes (65% dos casos), caracterizando-se predominantemente por surtos de ondas teta. O registro de anormalidades paroxísticas do tipo irritativo encontrado em três casos é salientado. Alterações da atividade de base foram assinaladas em 35% dos pacientes. A idade dos pacientes não parece ter tido importante papel na gênese das anormalidades eletrencefalográficas.Escola Paulista de Medicina Departamento de Neurologia e NeurocirurgiaUNIFESP, EPM, Depto. de Neurologia e NeurocirurgiaSciEL

Optical Current Sensors for High Power Systems: A Review

The intrinsic advantages of optical sensor technology are very appealing for high voltage applications and can become a valuable asset in a new generation of smart grids. In this paper the authors present a review of optical sensors technologies for electrical current metering in high voltage applications. A brief historical overview is given together with a more detailed focus on recent developments. Technologies addressed include all fiber sensors, bulk magneto-optical sensors, piezoelectric transducers, magnetic force sensors and hybrid sensors. The physical principles and main advantages and disadvantages are discussed. Configurations and strategies to overcome common problems, such as interference from external currents and magnetic fields induced linear birefringence and others are discussed. The state-of-the-art is presented including commercial available systems.info:eu-repo/semantics/publishedVersio

Factors affecting the bacterial community composition and heterotrophic production of Columbia River estuarine turbidity maxima

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in MicrobiologyOpen 6 (2017): e00522, doi:10.1002/mbo3.522.Estuarine turbidity maxima (ETM) function as hotspots of microbial activity and diversity in estuaries, yet, little is known about the temporal and spatial variability in ETM bacterial community composition. To determine which environmental factors affect ETM bacterial populations in the Columbia River estuary, we analyzed ETM bacterial community composition (Sanger sequencing and amplicon pyrosequencing of 16S rRNA gene) and bulk heterotrophic production (3H-leucine incorporation rates). We collected water 20 times to cover five ETM events and obtained 42 samples characterized by different salinities, turbidities, seasons, coastal regimes (upwelling vs. downwelling), locations, and particle size. Spring and summer populations were distinct. All May samples had similar bacterial community composition despite having different salinities (1–24 PSU), but summer non-ETM bacteria separated into marine, freshwater, and brackish assemblages. Summer ETM bacterial communities varied depending on coastal upwelling or downwelling conditions and on the sampling site location with respect to tidal intrusion during the previous neap tide. In contrast to ETM, whole (>0.2 μm) and free-living (0.2–3 μm) assemblages of non-ETM waters were similar to each other, indicating that particle-attached (>3 μm) non-ETM bacteria do not develop a distinct community. Brackish water type (ETM or non-ETM) is thus a major factor affecting particle-attached bacterial communities. Heterotrophic production was higher in particle-attached than free-living fractions in all brackish waters collected throughout the water column during the rise to decline of turbidity through an ETM event (i.e., ETM-impacted waters). However, free-living communities showed higher productivity prior to or after an ETM event (i.e., non-ETM-impacted waters). This study has thus found that Columbia River ETM bacterial communities vary based on seasons, salinity, sampling location, and particle size, with the existence of three particle types characterized by different bacterial communities in ETM, ETM-impacted, and non-ETM-impacted brackish waters. Taxonomic analysis suggests that ETM key biological function is to remineralize organic matter.National Science Foundation Grant Number: OCE-042460