81 research outputs found

    MDSC: Towards Evaluating the Style Consistency Between Music and

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    We propose MDSC(Music-Dance-Style Consistency), the first evaluation metric which assesses to what degree the dance moves and music match. Existing metrics can only evaluate the fidelity and diversity of motion and the degree of rhythmic matching between music and motion. MDSC measures how stylistically correlated the generated dance motion sequences and the conditioning music sequences are. We found that directly measuring the embedding distance between motion and music is not an optimal solution. We instead tackle this through modelling it as a clustering problem. Specifically, 1) we pre-train a music encoder and a motion encoder, then 2) we learn to map and align the motion and music embedding in joint space by jointly minimizing the intra-cluster distance and maximizing the inter-cluster distance, and 3) for evaluation purpose, we encode the dance moves into embedding and measure the intra-cluster and inter-cluster distances, as well as the ratio between them. We evaluate our metric on the results of several music-conditioned motion generation methods, combined with user study, we found that our proposed metric is a robust evaluation metric in measuring the music-dance style correlation. The code is available at: https://github.com/zixiangzhou916/MDSC.Comment: 17 pages, 17 figur

    A Unified Framework for Multimodal, Multi-Part Human Motion Synthesis

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    The field has made significant progress in synthesizing realistic human motion driven by various modalities. Yet, the need for different methods to animate various body parts according to different control signals limits the scalability of these techniques in practical scenarios. In this paper, we introduce a cohesive and scalable approach that consolidates multimodal (text, music, speech) and multi-part (hand, torso) human motion generation. Our methodology unfolds in several steps: We begin by quantizing the motions of diverse body parts into separate codebooks tailored to their respective domains. Next, we harness the robust capabilities of pre-trained models to transcode multimodal signals into a shared latent space. We then translate these signals into discrete motion tokens by iteratively predicting subsequent tokens to form a complete sequence. Finally, we reconstruct the continuous actual motion from this tokenized sequence. Our method frames the multimodal motion generation challenge as a token prediction task, drawing from specialized codebooks based on the modality of the control signal. This approach is inherently scalable, allowing for the easy integration of new modalities. Extensive experiments demonstrated the effectiveness of our design, emphasizing its potential for broad application.Comment: 19 pages, 18 figure

    AvatarGPT: All-in-One Framework for Motion Understanding, Planning, Generation and Beyond

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    Large Language Models(LLMs) have shown remarkable emergent abilities in unifying almost all (if not every) NLP tasks. In the human motion-related realm, however, researchers still develop siloed models for each task. Inspired by InstuctGPT, and the generalist concept behind Gato, we introduce AvatarGPT, an All-in-One framework for motion understanding, planning, generations as well as other tasks such as motion in-between synthesis. AvatarGPT treats each task as one type of instruction fine-tuned on the shared LLM. All the tasks are seamlessly interconnected with language as the universal interface, constituting a closed-loop within the framework. To achieve this, human motion sequences are first encoded as discrete tokens, which serve as the extended vocabulary of LLM. Then, an unsupervised pipeline to generate natural language descriptions of human action sequences from in-the-wild videos is developed. Finally, all tasks are jointly trained. Extensive experiments show that AvatarGPT achieves SOTA on low-level tasks, and promising results on high-level tasks, demonstrating the effectiveness of our proposed All-in-One framework. Moreover, for the first time, AvatarGPT enables a principled approach by iterative traversal of the tasks within the closed-loop for unlimited long-motion synthesis.Comment: 22 pages, 21 figure

    Three photosynthetic patterns characterized by cluster analysis of gas exchange data in two rice populations

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    AbstractPlant photosynthetic rate is affected by stomatal status and internal CO2 carboxylation. Understanding which process determines photosynthetic rate is essential for developing strategies for breeding crops with high photosynthetic efficiency. In this study, we identified different physiological patterns of photosynthetic rate in two different rice populations. Photosynthetic gas exchange parameters were measured during the flowering stage in two rice populations. Clustering and correlation analyses were performed on the resulting data. Five or six groups were defined by K-means clustering according to differences in net photosynthetic rates (Pn). According to differences in stomatal conductance (gs) and carboxylation efficiency (CE), each group was clustered into three subgroups characterized by physiological patterns stomatal pattern, carboxylation pattern, and intermediate pattern. Pn was significantly correlated with gs (r=0.810) and CE (r=0.531). Pn was also significantly correlated with gs and CE in the three physiological patterns. The correlation coefficients were highest in the stomatal pattern (0.905 and 0.957) and lowest in the carboxylation pattern (0.825 and 0.859). Higher correlation coefficients between Pn and gs or CE in the three physiological patterns indicate that clustering is very important for understanding factors limiting rice photosynthesis

    PatDNN: Achieving Real-Time DNN Execution on Mobile Devices with Pattern-based Weight Pruning

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    With the emergence of a spectrum of high-end mobile devices, many applications that formerly required desktop-level computation capability are being transferred to these devices. However, executing the inference of Deep Neural Networks (DNNs) is still challenging considering high computation and storage demands, specifically, if real-time performance with high accuracy is needed. Weight pruning of DNNs is proposed, but existing schemes represent two extremes in the design space: non-structured pruning is fine-grained, accurate, but not hardware friendly; structured pruning is coarse-grained, hardware-efficient, but with higher accuracy loss. In this paper, we introduce a new dimension, fine-grained pruning patterns inside the coarse-grained structures, revealing a previously unknown point in design space. With the higher accuracy enabled by fine-grained pruning patterns, the unique insight is to use the compiler to re-gain and guarantee high hardware efficiency. In other words, our method achieves the best of both worlds, and is desirable across theory/algorithm, compiler, and hardware levels. The proposed PatDNN is an end-to-end framework to efficiently execute DNN on mobile devices with the help of a novel model compression technique (pattern-based pruning based on extended ADMM solution framework) and a set of thorough architecture-aware compiler- and code generation-based optimizations (filter kernel reordering, compressed weight storage, register load redundancy elimination, and parameter auto-tuning). Evaluation results demonstrate that PatDNN outperforms three state-of-the-art end-to-end DNN frameworks, TensorFlow Lite, TVM, and Alibaba Mobile Neural Network with speedup up to 44.5x, 11.4x, and 7.1x, respectively, with no accuracy compromise. Real-time inference of representative large-scale DNNs (e.g., VGG-16, ResNet-50) can be achieved using mobile devices.Comment: To be published in the Proceedings of Twenty-Fifth International Conference on Architectural Support for Programming Languages and Operating Systems (ASPLOS 20

    Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection

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    Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens. To date, there are few reports on the host proteins interacting with HEV and being involved in viral infection. Previous pull-down assay combining mass spectrometry indicated that cell division control protein 42 (CDC42), a member belonging to the Rho GTPase family, was pulled down by avian HEV capsid protein. We confirmed the direct interaction between CDC42 and avian and mammalian HEV capsid proteins. The interaction can increase the amount of active guanosine triphosphate binding CDC42 state (GTP-CDC42). Subsequently, we determined that the expression and activity of CDC42 were positively correlated with HEV infection in the host cells. Using the different inhibitors of CDC42 downstream signaling pathways, we found that CDC42-MRCK (a CDC42-binding kinase)-non-myosin IIA (NMIIA) pathway is involved in naked avian and mammalian HEV infection, CDC42-associated p21-activated kinase 1 (PAK1)-NMIIA/Cofilin pathway is involved in quasi-enveloped mammalian HEV infection and CDC42-neural Wiskott-Aldrich syndrome protein-actin-polymerizing protein Arp2/3 pathway (CDC42-(N-)WASP-Arp2/3) pathway participates in naked and quasi-enveloped mammalian HEV infection. Collectively, these results demonstrated for the first time that HEV capsid protein can directly bind to CDC42, and non- and quasi-enveloped HEV use different CDC42 downstream signaling pathways to participate in viral infection. The study provided some new insights to understand the life cycle of HEV in host cells and a new target of drug design for combating HEV infection

    Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.

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    Avian hepatitis E virus (HEV) causes liver diseases and multiple extrahepatic disorders in chickens. However, the mechanisms involved in avian HEV entry remain elusive. Herein, we identified the RAS-related protein 1b (Rap1b) as a potential HEV-ORF2 protein interacting candidate. Experimental infection of chickens and cells with an avian HEV isolate from China (CaHEV) led to upregulated expression and activation of Rap1b both in vivo and in vitro. By using CaHEV capsid as mimic of virion to treat cell in vitro, it appears that the interaction between the viral capsid and Rap1b promoted cell membrane recruitment of the downstream effector Rap1-interacting molecule (RIAM). In turn, RIAM further enhanced Talin-1 membrane recruitment and retention, which led to the activation of integrin α5/β1, as well as integrin-associated membrane protein kinases, including focal adhesion kinase (FAK). Meanwhile, FAK activation triggered activation of downstream signaling molecules, such as Ras-related C3 botulinum toxin substrate 1 RAC1 cell division cycle 42 (CDC42), p21-activated kinase 1 (PAK1), and LIM domain kinase 1 (LIMK1). Finally, F-actin rearrangement induced by Cofilin led to the formation of lamellipodia, filopodia, and stress fibers, contributes to plasma membrane remodeling, and might enhance CaHEV virion internalization. In conclusion, our data suggested that Rap1b activation was triggered during CaHEV infection and appeared to require interaction between CaHEV-ORF2 and Rap1b, thereby further inducing membrane recruitment of Talin-1. Membrane-bound Talin-1 then activates key Integrin-FAK-Cofilin cascades involved in modulation of actin kinetics, and finally leads to F-actin rearrangement and membrane remodeling to potentially facilitate internalization of CaHEV virions into permissive cells. IMPORTANCE Rap1b is a multifunctional protein that is responsible for cell adhesion, growth, and differentiation. The inactive form of Rap1b is phosphorylated and distributed in the cytoplasm, while active Rap1b is prenylated and loaded with GTP to the cell membrane. In this study, the activation of Rap1b was induced during the early stage of avian HEV infection under the regulation of PKA and SmgGDS. Continuously activated Rap1b recruited its effector RIAM to the membrane, thereby inducing the membrane recruitment of Talin-1 that led to the activation of membrane α5/β1 integrins. The triggering of the signaling pathway-associated Integrin α5/β1-FAK-CDC42&RAC1-PAK1-LIMK1-Cofilin culminated in F-actin polymerization and membrane remodeling that might promote avian HEV virion internalization. These findings suggested a novel mechanism that is potentially utilized by avian HEV to invade susceptible cells

    Chicken Organic Anion-Transporting Polypeptide 1A2, a Novel Avian Hepatitis E Virus (HEV) ORF2-Interacting Protein, Is Involved in Avian HEV Infection

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    Avian hepatitis E virus (HEV) is the main causative agent of big liver and spleen disease in chickens. Due to the absence of a highly effective cell culture system, there are few reports about the interaction between avian HEV and host cells. In this study, organic anion-transporting polypeptide 1A2 (OATP1A2) from chicken liver cells was identified to interact with ap237, a truncated avian HEV capsid protein spanning amino acids 313 to 549, by a glutathione S-transferase (GST) pulldown assay. GST pulldown and indirect enzyme-linked immunosorbent assays (ELISAs) further confirmed that the extracellular domain of OATP1A2 directly binds with ap237. The expression levels of OATP1A2 in host cells are positively correlated with the amounts of ap237 attachment and virus infection. The distribution of OATP1A2 in different tissues is consistent with avian HEV infection in vivo. Finally, when the functions of OATP1A2 in cells are inhibited by its substrates or an inhibitor or blocked by ap237 or anti-OATP1A2 sera, attachment to and infection of host cells by avian HEV are significantly reduced. Collectively, these results displayed for the first time that OATP1A2 interacts with the avian HEV capsid protein and can influence viral infection in host cells. The present study provides new insight to understand the process of avian HEV infection of host cells

    Multiphysics and Thermodynamic Formulations for Equilibrium and Non-equilibrium Interactions: Non-linear Finite Elements Applied to Multi-coupled Active Materials

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    [EN] Combining several theories this paper presents a general multiphysics framework applied to the study of coupled and active materials, considering mechanical, electric, magnetic and thermal fields. The framework is based on thermodynamic equilibrium and non-equilibrium interactions, both linked by a two-temperature model. The multi-coupled governing equations are obtained from energy, momentum and entropy balances; the total energy is the sum of thermal, mechanical and electromagnetic parts. The momentum balance considers mechanical plus electromagnetic balances; for the latter the Abraham rep- resentation using the Maxwell stress tensor is formulated. This tensor is manipulated to automatically fulfill the angular momentum balance. The entropy balance is for- mulated using the classical Gibbs equation for equilibrium interactions and non-equilibrium thermodynamics. For the non-linear finite element formulations, this equation requires the transformation of thermoelectric coupling and conductivities into tensorial form. The two-way thermoe- lastic Biot term introduces damping: thermomechanical, pyromagnetic and pyroelectric converse electromagnetic dynamic interactions. Ponderomotrix and electromagnetic forces are also considered. The governing equations are converted into a variational formulation with the resulting four-field, multi-coupled formalism implemented and val- idated with two custom-made finite elements in the research code FEAP. Standard first-order isoparametric eight-node elements with seven degrees of freedom (dof) per node (three displacements, voltage and magnetic scalar potentials plus two temperatures) are used. Non-linearities and dynamics are solved with Newton-Raphson and New- mark-b algorithms, respectively. Results of thermoelectric, thermoelastic, thermomagnetic, piezoelectric, piezomag- netic, pyroelectric, pyromagnetic and galvanomagnetic interactions are presented, including non-linear depen- dency on temperature and some second-order interactions.This research was partially supported by grants CSD2008-00037 Canfranc Underground Physics, Polytechnic University of Valencia under programs PAID 02-11-1828 and 05-10-2674. The first author used the grant Generalitat Valenciana BEST/2014/232 for the completion of this work.Pérez-Aparicio, JL.; Palma, R.; Taylor, R. (2016). Multiphysics and Thermodynamic Formulations for Equilibrium and Non-equilibrium Interactions: Non-linear Finite Elements Applied to Multi-coupled Active Materials. Archives of Computational Methods in Engineering. 23:535-583. https://doi.org/10.1007/s11831-015-9149-9S53558323Abraham M (1910) Sull’elettrodinamica di Minkowski. 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